Selective, high affinity peptide antagonists of α-melanotropin action at human melanocortin receptor 4: Their synthesis and biological evaluation in vitro

Journal of Medicinal Chemistry

Volumn 44, Issue 22, 2001, Pages 3665-3672

  Bednarek, M A ^a   Macneil, T ^a   Kalyani, R N ^a   Tang, R ^a   Van der Ploeg, L H T ^a   Weinberg, D H ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL 4 NORLEUCINE CYCLO[5 ASPARTIC ACID 6 HISTIDINE DEXTRO (2') 7 NORALANINE 8 ARGININE 9 TRYPTOPHAN 10 LYSINE] AMIDE; ACETYL 4 NORLEUCINE CYCLO[6 SUCCINYL DEXTRO (2') 7 NORALANINE 8 ARGININE 9 TRYPTOPHAN 10 LYSINE] AMIDE; ALPHA INTERMEDIN; MELANOCORTIN RECEPTOR; PEPTIDE DERIVATIVE; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHO CELL; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; IC 50; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ALPHA-MSH; ANIMALS; BINDING, COMPETITIVE; CHO CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRICETINAE; CYCLIC AMP; HUMANS; MOLECULAR CONFORMATION; PEPTIDES, CYCLIC; RECEPTOR, MELANOCORTIN, TYPE 3; RECEPTOR, MELANOCORTIN, TYPE 4; RECEPTORS, CORTICOTROPIN; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035950087     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010165y     Document Type: Article

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