Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1- dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl] -2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 15, 2005, Pages 3501-3505

  Ye, Zhixiong ^a   Guo, Liangqin ^a   Barakat, Khaled J ^a   Pollard, Patrick G ^a   Palucki, Brenda L ^a   Sebhat, Iyassu K ^a   Bakshi, Raman K ^a   Tang, Rui ^a   Kalyani, Rubana N ^a   Vongs, Aurawan ^a   Chen, Airu S ^a   Chen, Howard Y ^a   Rosenblum, Charles I ^a   MacNeil, Tanya ^a   Weinberg, David H ^a   Peng, Qianping ^a   Tamvakopoulos, Constantin ^a   Miller, Randy R ^a   Stearns, Ralph A ^a   Cashen, Doreen E ^a   Martin, William J ^a   Metzger, Joseph M ^a   Strack, Alison M ^a   MacIntyre, D Euan ^a   Van Der Ploeg, Lex H T ^a   Patchett, Arthur A ^a   Wyvratt, Matthew J ^a   Nargund, Ravi P ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Food intake; Isoquinuclidines; Melanocortin

Indexed keywords

HORMONE RECEPTOR STIMULATING AGENT; MELANOCORTIN 4 RECEPTOR; N [2 [4 CYCLOHEXYL 4 [[(1,1 DIMETHYLETHYL)AMINO]CARBONYL] 1 PIPERIDINYL] 1 [(4 FLUOROPHENYL)METHYL] 2 OXOETHYL] 2 METHYL 2 AZABICYCLO[2.2.2]OCTANE 6 CARBOXAMIDE; RY 764; UNCLASSIFIED DRUG;

ANIMAL CELL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG STRUCTURE; FOOD INTAKE; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PENIS ERECTION; RAT; RODENT;

ANIMALS; AZA COMPOUNDS; EATING; HUMANS; MALE; MICROSOMES, LIVER; PENILE ERECTION; PIPERAZINES; PIPERIDINES; PROTEIN BINDING; QUINUCLIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, MELANOCORTIN, TYPE 4; RODENTIA; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

RODENTIA;

EID: 21744461441     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.05.109     Document Type: Article

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