Structure-activity studies of the melanocortin peptides: Discovery of potent and selective affinity antagonists for the hMC3 and hMC4 receptors

Journal of Medicinal Chemistry

Volumn 45, Issue 24, 2002, Pages 5287-5294

  Grieco, Paolo ^a,c   Lavecchia, Antonio ^c   Cai, Minying ^a   Trivedi, Devendra ^a   Weinberg, David ^b   MacNeil, Tanya ^b   Van der Ploeg, L H T ^b   Hruby, Victor J ^a  

^a University of Arizona   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; LACTAM DERIVATIVE; MELANOCORTIN 1 RECEPTOR; MELANOCORTIN 3 RECEPTOR ANTAGONIST; MELANOCORTIN 4 RECEPTOR ANTAGONIST; MELANOCORTIN 5 RECEPTOR; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE]; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CYCLIZATION; DRUG DESIGN; DRUG SYNTHESIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ALPHA-MSH; ANIMALS; CHO CELLS; CRICETINAE; CYCLIC AMP; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PEPTIDE FRAGMENTS; PEPTIDES, CYCLIC; RECEPTOR, MELANOCORTIN, TYPE 3; RECEPTOR, MELANOCORTIN, TYPE 4; RECEPTORS, CORTICOTROPIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037153235     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0202526     Document Type: Article

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