Structure-activity relationships of piperazinebenzylamines as potent and selective agonists of the human melanocortin-4 receptor

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 17, 2004, Pages 4417-4423

  Pontillo, Joseph ^a   Tran, Joseph A ^a   Arellano, Melissa ^a   Fleck, Beth A ^a   Huntley, Rajesh ^a   Marinkovic, Dragan ^a   Lanier, Marion ^a   Nelson, Jodie ^a   Parker, Jessica ^a   Saunders, John ^a   Tucci, Fabio C ^a   Jiang, Wanlong ^a   Chen, Caroline W ^a   White, Nicole S ^a   Foster, Alan C ^a   Chen, Chen ^a  

^a NEUROCRINE BIOSCIENCES INC   (United States)

Author keywords

Agonist; MC4R; Melanocortin

Indexed keywords

BENZYLAMINE DERIVATIVE; MELANOCORTIN 4 RECEPTOR; NITROGEN; TRIAZOLE;

ARTICLE; ATOM; BINDING AFFINITY; DRUG BINDING; DRUG POTENCY; EMBRYO; HUMAN; HUMAN CELL; LIPOPHILICITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZYLAMINES; CELL LINE; CHO CELLS; CRICETINAE; HUMANS; PIPERAZINES; RECEPTOR, MELANOCORTIN, TYPE 4; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 4043089172     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.06.059     Document Type: Article

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