Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat

European Journal of Pharmacology

Volumn 378, Issue 3, 1999, Pages 249-258

  Adan, Roger A H ^a,b   Szklarczyk, Arkadiusz W ^a,b   Oosterom, Julia ^a,b   Brakkee, Jan H ^a,b   Nijenhuis, Wouter A J ^a,b   Schaaper, Wim M M ^a,b   Meloen, Rob H ^a,b   Gispen, Willem Hendrik ^a,b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

ACTH (adrenocorticotrope hormone); Grooming behavior; Ligand receptor interaction; Melanocortin receptor; MSH (melanocyte stimulating hormone); Stress

Indexed keywords

ALPHA INTERMEDIN; BRAIN RECEPTOR; CORTICOTROPIN; INTERMEDIN; LIGAND; MELANOCORTIN RECEPTOR; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE]; RMI 2005; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; BINDING AFFINITY; BODY TEMPERATURE; CONTROLLED STUDY; FOOD INTAKE; GROOMING; INFLAMMATION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LIGAND BINDING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; STRESS;

ALPHA-GALACTOSIDASE; ALPHA-MSH; AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; CATHETERIZATION; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; GROOMING; HUMANS; INJECTIONS, INTRAVENOUS; INJECTIONS, INTRAVENTRICULAR; LIGANDS; MELANOCYTE-STIMULATING HORMONES; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTOR, MELANOCORTIN, TYPE 3; RECEPTOR, MELANOCORTIN, TYPE 4; RECEPTORS, CORTICOTROPIN; RECEPTORS, MELANOCORTIN; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TIME FACTORS;

EID: 0032809011     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00465-3     Document Type: Article

References (33)

1. Adan R.A.H., Cone R.D., Burbach J.P.H., Gispen W.H. Differential effects of melanocortin peptides on neural melanocortin receptors. Mol. Pharmacol. 46:1994;1182-1190.
2. Adan R.A.H., Oosterom J., Ludvigsdottir G., Brakkee J.H., Burbach J.P.H., Gispen W.H. Identification of antagonists for MC3, MC4 and MC5 receptors. Eur. J. Pharmacol. 269:1994;331-337.
3. Alvaro J.S., Tatro J.B., Quillan J.M., Fogliano M., Eisenhard M., Lerner M.R., Nestler E.J., Duman R.J. Morphine down-regulates melanocortin-4 receptor expression in brain regions that mediate opiate addiction. Mol. Pharmacol. 50:1996;583-591.
4. Brakkee J.H., Wiegant V.M., Gispen W.H. A simple technique for rapid implantation of a permanent cannula into the rat brain ventricular system. Lab. Anim. Sci. 29:1979;78-81.
5. Chen W., Shields T.S., Stork P.J.S., Cone R.D. A colorimetric assay for measuring activation of Gs and Gq coupled signaling pathways. Anal. Biochem. 226:1995;349-354.
6. Chhajlani V., Muceniece R., Wikberg J.E.S. Molecular cloning of a novel human melanocortin receptor. Biochem. Biophys. Res. Commun. 195:1993;866-873.
7. De Wied D., Jolles J. Neuropeptides derived form pro-opiomelanocortin: behavioral, physiological, and neurochemical effects. Physiol. Rev. 62:1982;976-1059.
8. Dunn A.J., Green E.J., Isaacson R.L. Intracerebral adreno-corticotrope hormone mediates novelty-induced grooming in the rat. Science. 203:1979;281-283.
9. Fan W., Boston B.A., Kesterson R.A., Hruby V.J., Cone R.D. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature. 385:1997;165-168.
10. Ferrari W. Behavioural changes in animals after intracisternal injection with adrenocorticotrophic hormone and melanocyte stimulating hormone. Nature (London). 181:1958;925-926.
11. Fong T.M., Mao C., MacNeil T., Kalyani R., Smith T., Weinberg D., Tota M.R., Van der Ploeg L.H. ART (protein product of agouti-related transcript) as an antagonist of MC-3 and MC-4 receptors. Biochem. Biophys. Res. Commun. 237:1997;629-631.
12. Gispen, W.H., Isaacson, R.L., 1986, Excessive grooming in response to ACTH. In: De Wied, D., Gispen, W.H., Van Wimersma Greidanus, Tj.B. (Eds.), Neuropeptides and Behavior. Vol. 1, Pergamon, Oxford, p. 273.
13. Gispen W.H., Wiegant V.M., Greven H.M., De Wied D. The induction of excessive grooming in the rat by intraventricular application of peptides derived from ACTH: structure-activity studies. Life Sci. 17:1975;645-652.
14. Hadley M.E., Hruby V.J., Jiang J., Sharma S.D., Fink J.L., Haskell-Luevano C., Bentley D.L., Al-Obeidi F., Sawyer T.K. Melanocortin receptors: identification and characterization by melanotropic peptide agonists and antagonists. Pigm. Cell Res. 9:1996;213-234.
15. Hruby V.J., Sharma S.D., Toth K., Jaw J.Y., Al-Obeidi F., Sawyer T.K., Hadley M.E. Design, synthesis, and conformation of superpotent and prolonged acting melanotropins. Ann. NY Acad. Sci. 680:1993;51-63.
16. 2 with bulkyaromatic amino acids at position 7 show high potency and selectivity at specific melanocortin receptors. J. Med. Chem. 38:1995;3454-3460.
17. Huang Q.H., Entwistle M.L., Alvaro J.D., Duman R.S., Hruby V.J., Tatro J.B. Antipyretic role of endogenous melanocortins mediated by central melanocortin receptors during endotoxin-induced fever. J. Neurosci. 17:1997;3343-3351.
18. Huszar D., Lynch C.A., Fairchild-Huntress V., Dunmore J.H., Fang Q., Berkemeier L.R., Gu W., Kesterson R.A., Boston B.A., Cone R.D., Smith F.J., Campfield L.A., Burn P., Lee F. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell. 88:1997;131-141.
19. Low M.J., Simerley R.B., Cone R.D. Receptors for the melanocortin peptides in the central nervous system. Curr. Opin. Endocrinol. Diab. 1:1994;79-88.
20. Lu D., Willard D., Patel I.R., Kadwell S., Overton S., Kost T., Luther M., Chen W., Woychik R.P., Wilkison W.O., Cone R.D. Agouti protein is an antagonist of the melanocortin-stimulating-hormone receptor. Nature. 371:1994;799-802.
21. Mountjoy K.G., Mortrud M.T., Low M.J., Simerley R.B., Cone R.D. Cloning and functional characterization of a melanocortin receptor (MC4-R) localized in neuroendocrine and autonomic circuitry in the brain. Mol. Endocrinol. 8:1994;1298-1308.
22. Ollmann M.M., Wilson B.D., Yang Y.K., Kerns J.A., Chen Y., Gantz I., Barsh G.S. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science. 278:1997;135-138.
23. Roselli-Rehfuss L., Mountjoy K.G., Robbins L.S., Mortrud M.T., Low M.J., Tatro J.B., Entwistle M.L., Simerly R.B., Cone R.D. Identification of a receptor for melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system. Proc. Natl. Acad. Sci. U.S.A. 90:1993;8856-8860.
24. Sawyer T.K., Sanfilippo P.J., Hruby V.J., Engel M.H., Heward C.B., Burnett J.B., Hadley M.E. 4-Norleucine,7-D-phenylalanine-α-melanocyte-stimulating hormone: a highly potent α-melanotropin with ultralong biological activity. Proc. Natl. Acad. Sci. U.S.A. 77:1980;5754-5758.
25. Schaaper W.M.M., Adan R.A.H., Posthuma T.A., Oosterom J., Gispen W.H., Meloen R.H. Synthesis of cyclic α-MSH peptides. Letters in Peptide Science. 5:1998;1-4.
26. Schioth H.B., Mutulis F., Muceniece R., Prusis P., Wikberg J.E. Discovery of novel melanocortin4 receptor selective MSH analogues. Br. J. Pharmacol. 124:1998;75-82.
27. Shutter J.R., Graham M., Kinsey A.C., Scully S., Luthy R., Stark K.L. Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. Genes Dev. 11:1997;593-602.
28. Spampinato S., Canossa M., Carboni L., Campana G., Leanza G., Ferri S. Inhibition of proopiomelanocortin expression by an oligonucleotide complementary to beta-endorphin mRNA. Proc. Natl. Acad. Sci. U.S.A. 91:1994;8072-8076.
29. Spruijt B.M., De Graan P.N.E., Eberle A.N., Gispen W.H. Comparison of structural requirements of αMSH and ACTH for inducing excessive grooming and pigment dispersion. Peptides. 6:1985;1185-1189.
30. Spruijt B.M., Van Hooff J.A.R.A.M., Gispen W.H. Ethology and neurobiology of grooming behavior. Physiol. Rev. 72:1992;825-852.
31. Tatro J.B. Melanotropin receptors in the brain are differentially distributed and recognize both corticotropin and α-melanocyte stimulating hormone. Brain Res. 536:1990;124-132.
32. Vergoni A.V., Bertolini A., Mutulis F., Wikberg J.E., Schioth H.B. Differential influence of a selective melanocortin MC4 receptor antagonist (HS014) on melanocortin-induced behavioral effects in rats. Eur. J. Pharmacol. 362:1998;95-101.
33. Von Frijtag J.C., Croiset G., Gispen W.H., Adan R.A.H., Wiegant V.M. The role of central melanocortin receptors in the activation of the hypothalamus-pituitary-adrenal-axis and the induction of excessive grooming. Br. J. Pharmacol. 123:1998;1503-1508.