Structure-Activity Relationships of γ-MSH Analogues at the Human Melanocortin MC3, MC4, and MC5 Receptors. Discovery of Highly Selective hMC3R, hMC4R, and hMC5R Analogues

Journal of Medicinal Chemistry

Volumn 46, Issue 23, 2003, Pages 4965-4973

  Balse Srinivasan, Preeti ^a,b   Grieco, Paolo ^a,c   Cai, Minying ^a   Trivedi, Dev ^a   Hruby, Victor J ^a  

^a University of Arizona   (United States)

^b Bexel Pharmaceuticals Inc   (United States)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERMEDIN; GLYCINE; HISTIDYLPHENYLALANYLARGINYLTRYPTOPHAN; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; MELANOCORTIN 5 RECEPTOR; TETRAPEPTIDE; TYROSYLVALYL CYCLO[CYSTEINYLGLYCYLHISTIDYLPHENYLALANYLARGINYLTRYPTOPHYLCYSTEINYL]ARGINYLPHENY LALANYLGLYCINAMIDE; TYROSYLVALYLNORLEUCYL CYCLO[ASPARTYLHISTIDYLPHENYLALANYLARGINYLTRYPTOPHYLLYSYL]ARGINYLPHENYLALANYLGLYC INAMIDE; TYROSYLVALYLNORLEUCYL CYCLO[CYSTEINYLHISTIDYLPHENYLALANYLARGINYLTRYPHTOPHYLCYSTEINYL]ARGINYLPHENYLALAN YLGLYCINAMIDE; TYROSYLVALYLNORLEUCYLGLYCYLAMINOISOBUTYRIC ACID PHENYLALANYLARGINYL DEXTRO NAPHTHYLAMINE(2') ASPARTYLARGINYLPHENYLALANYLGLYCINAMIDE; TYROSYLVALYLNORLEUCYLGLYCYLHISTIDYLPHENYLALANYLARGINYL DEXTRO NAPHTHYLAMINE(2') ASPARTYLARGINYLPHENYLALANYLGLYCINAMIDE; TYROSYLVALYLNORLEUCYLGLYCYLPROLYL DEXTRO NAPHTHYLAMINE(2') ARGINYLTRYPTOPHYLASPARTYLARGINYLPHENYLALANYLGLYCINAMIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CYCLIZATION; DRUG ACTIVITY; DRUG DESIGN; DRUG DETERMINATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; LIPID STORAGE; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 0242331072     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030119t     Document Type: Article

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