Selective melanocortin MC4 receptor blockage reduces immobilization stress-induced anorexia in rats

European Journal of Pharmacology

Volumn 369, Issue 1, 1999, Pages 11-15

  Vergoni, Anna Valeria ^a   Bertolini, Alfio ^a   Wikberg, Jarl E S ^b   Schiöth, Helgi B ^b  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Anorexia; Food intake; HS014; Immobilization stress; Melanocortin receptor; MSH (melanocyte stimulating hormone)

Indexed keywords

BETA INTERMEDIN[11-22][11 (N ACETYLCYSTEINE) 14 [3 (2 NAPHTHYL) DEXTRO ALANINE] 18 CYSTEINE 22 ASPARTIC ACID AMIDE] 11,18 CYCLIC DISULFIDE; INTERMEDIN DERIVATIVE; MELANOCORTIN RECEPTOR; UNCLASSIFIED DRUG; CORTICOTROPIN RECEPTOR; CYCLOPEPTIDE; HS014 CYCLIC PEPTIDE; MELANOCORTIN 4 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANOREXIA; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FOOD INTAKE; IMMOBILIZATION STRESS; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; TACHYPHYLAXIS; WEIGHT GAIN; ANIMAL; BODY WEIGHT; DRUG ANTAGONISM; EATING; IMMOBILIZATION; MENTAL STRESS; TIME;

ANIMALS; ANOREXIA; BODY WEIGHT; EATING; IMMOBILIZATION; INJECTIONS, INTRAVENTRICULAR; MALE; PEPTIDES, CYCLIC; RATS; RECEPTOR, MELANOCORTIN, TYPE 4; RECEPTORS, CORTICOTROPIN; STRESS, PSYCHOLOGICAL; TIME FACTORS; WEIGHT GAIN;

EID: 0032588789     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00045-X     Document Type: Article

References (20)

1. Adan R.A., Gispen W.H. Brain melanocortin receptors: from cloning to function. Peptides. 18:1997;1279-1287.
2. Al-Obeidi F., Castrucci A.L., Hadley M.E., Hruby V.J. Potent and prolonged acting cyclic lactam analogues of a-melanotropin: design based on molecular dynamics. J. Med. Chem. 3:1989;2555-2561.
3. Assenmacher I., Barbanel G., Gaillet S., Givalois L., Ixart G., Malaval F., Mekaouche M., Siaud P., Szafarczyk A. Central regulation of ACTH release in stress. N.Y. Acad. Sci. 771:1995;41-54.
4. Eberle, A.N., 1988. The Melanotropins: Chemistry, Physiology and Mechanisms of Action. Karger, Basel, Switzerland, pp. 173-208.
5. 2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors. J. Med. Chem. 38:1995;3454-3461.
6. Huszar D., Lynch C.A., Fairchild-Huntress V., Dunmore J.H., Fang Q., Berkemeier L.R., Gu W., Kesterson R.A., Boston B.A., Cone R.D., Smith F.J., Campfield L.A., Burn P., Lee F. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell. 88:1997;131-141.
7. Kask A., Rägo L., Korrovits P., Wikberg J.E.S., Schiöth H.B. Evidence that orexigenic effects of melanocortin 4 receptor antagonist HS014 are mediated by neuropeptide Y. Biochem. Biophys. Res. Commun. 248:1998;245-249.
8. Kask A., Rägo L., Mutulis F., Phäkla R., Wikberg J.E.S., Schiöth H.B. Selective antagonist for the melanocortin 4 receptor (HS014) increases food intake in free-feeding rats. Biochem. Biophys. Res. Commun. 245:1998;90-93.
9. Kask A., Rägo L., Wikberg J.E.S., Schiöth H.B. Evidence for involvement of the melanocortin 4 receptor in the effects of lepin on food intake. Eur. J. Pharmacol. 360:1998;15-19.
10. Kristensen P., Judge M.E., Thim L., Ribel U., Christjansen K.N., Wulff B.S., Clausen J.T., Jensen P.B., Madsen O.D., Vrang N., Larsen P.J., Hastrup S. Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature. 393:1998;72-76.
11. Paxinos, G., Watson, C., 1982. The Rat Brain in Stereotaxic Coordinates. Academic Press, Sidney.
12. Poggioli R., Vergoni A.V., Bertolini A. ACTH-(1-24) and alpha-MSH antagonize feeding behavior stimulated by kappa opiate agonists. Peptides. 7:1986;843-848.
13. Sakurai T., Amemiya A., Ishii M., Matsuzaki H., Chemelli R., Tanaka H., Williams S.C., Richardson J.A., Kozlowski G.P., Wilson S., Arch J.R.S., Buckingham R.E., Haynes A.C., Carr S.A., Annan R.S., McNulty D.E., Liu W.-S., Terrett J.A., Elshourbagy N.A., Bergsma D.J. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell. 92:1998;573-585.
14. Seeley R.J., Yagaloff K.A., Fisher S.L., Burn P., Thiele T.E., van Dijk G., Baskin D.G., Schwartz M.W. Melanocortin receptors in leptin effects. Nature. 390:1997;349.
15. Schiöth H.B., Muceniece R., Wikberg J.E.S. Characterisation of melanocortin 4 receptor by radioligand binding analysis. Pharmacol. Toxicol. 79:1996;161-165.
16. 7] substituted MSH analogues for the melanocortin receptors. Peptides. 18:1997;1009-1013.
17. Schiöth H.B., Mutulis F., Muceniece R., Prusis P., Wikberg J.E.S. Discovery of novel melanocortin 4 receptor selective MSH analogues. Br. J. Pharmacol. 124:1998;75-82.
18. Vergoni A.V., Poggioli R., Bertolini A. Corticotropin inhibits food intake in rats. Neuropeptides. 7:1986;153-158.
19. Vergoni A.V., Bertolini A., Mutulis F., Wikberg J.E.S., Schiöth H.B. A differential influence of a selective melanocortin 4 receptor antagonist (HS014) on melanocortin-induced behavioral effects in rats. Eur. J. Pharmacol. 362:1998;95-101.
20. Von Frijtag J.C., Croiset G., Gispen W.H., Adan R.A., Wiegant V.M. The role of central melanocortin receptors in the activation of the hypothalamus-pituitary-adrenal axis and the induction of excessive grooming. Br. J. Pharmacol. 123:1998;1503-1508.