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Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 20, 2005, Pages 4615-4618

Optimization of piperazinebenzylamines with a N-(1-methoxy-2-propyl) side chain as potent and selective antagonists of the human melanocortin-4 receptor

(11) Pontillo, Joseph a Marinkovic, Dragan a Tran, Joe A a Arellano, Melissa a Fleck, Beth A a Wen, Jenny a Tucci, Fabio C a Nelson, Jodie a Saunders, John a Foster, Alan C a Chen, Chen a

a NEUROCRINE BIOSCIENCES INC (United States)

Author keywords

Antagonist; Melanocortin 4; Piperazinebenzylamine; Synthesis

Indexed keywords

BENZYLAMINE DERIVATIVE; FENCLONINE; HORMONE RECEPTOR BLOCKING AGENT; MELANOCORTIN 4 RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STABILITY; DRUG SYNTHESIS; EMBRYO; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; BENZYLAMINES; BIOLOGICAL AVAILABILITY; CELL LINE; HUMANS; MICE; PIPERAZINES; RECEPTOR, MELANOCORTIN, TYPE 4;

EID: 24344442403 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2005.06.058 Document Type: Article

Times cited : (15)

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