Structure-activity relationships of the unique and potent agouti-related protein (AGRP)-melanocortin chimeric Tyr-c[β-Asp-His-DPhe-Arg-Trp-Asn-Ala- Phe-Dpr]-Tyr-NH2 peptide template

Journal of Medicinal Chemistry

Volumn 48, Issue 8, 2005, Pages 3060-3075

  Wilczynski, Andrzej ^a   Wilson, Krista R ^a   Scott, Joseph W ^a   Edison, Arthur S ^a   Haskell Luevano, Carrie ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI RELATED PROTEIN; CHIMERIC PROTEIN; G PROTEIN COUPLED RECEPTOR; HISTIDINE; MELANOCORTIN; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; MELANOCORTIN RECEPTOR; PHENYLALANINE; PROLINE; TYROSYL CYCLO[BETA ASPARTYLHISTIDYL DEXTRO PHENYLALANYLARGINYLTRYPTOPHYLASPARAGINYLALANYLPHENYLALANYL DEXTRO PROLYL]TYROSINAMIDE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; MOLECULAR MODEL; NONHUMAN; PROTEIN ANALYSIS; PROTEIN MODIFICATION; PROTEIN SECONDARY STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; REGULATORY MECHANISM; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ALPHA-MSH; ANIMALS; BINDING, COMPETITIVE; CELL LINE; DRUG DESIGN; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MODELS, MOLECULAR; OLIGOPEPTIDES; PEPTIDES, CYCLIC; PROTEIN STRUCTURE, SECONDARY; PROTEINS; RECEPTOR, MELANOCORTIN, TYPE 3; RECEPTOR, MELANOCORTIN, TYPE 4; RECEPTORS, MELANOCORTIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 17444417871     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049010r     Document Type: Article

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