Targeted disruption of the microsomal epoxide hydrolase gene. Microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12- dimethylbenz[a]anthracene

Journal of Biological Chemistry

Volumn 274, Issue 34, 1999, Pages 23963-23968

  Miyata, Masaaki ^a,b   Kudo, Gen ^a,c   Lee, Ying Hue ^a,d   Yang, Tian J ^a   Gelboin, Harry V ^a   Fernandez Salguero, Pedro ^a,e   Kimura, Shioko ^a   Gonzalez, Frank J ^a,f  

^a NATIONAL CANCER INSTITUTE   (United States)

^b TOHOKU UNIVERSITY   (Japan)

^c DAIICHI SANKYO CO   (Japan)

^d INSTITUTE OF MOLECULAR BIOLOGY   (Taiwan)

^e UNIVERSITY OF EXTREMADURA   (Spain)

^f NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; CARCINOGEN; COMPLEMENTARY DNA; EPOXIDE HYDROLASE; MICROSOME ENZYME;

ANIMAL TISSUE; ARTICLE; CHEMICAL CARCINOGENESIS; ENZYME ACTIVITY; GENE EXPRESSION; GENOTYPE; LIVER MICROSOME; MICROSOME; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; RAT; SKIN CANCER; SKIN CARCINOGENESIS;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CARCINOGENS; CYTOCHROME P-450 ENZYME SYSTEM; EPOXIDE HYDROLASES; FEMALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSOMES, LIVER; SKIN NEOPLASMS;

ANIMALIA; RODENTIA;

EID: 0033588227     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.34.23963     Document Type: Article

References (47)

1. Seidegard, J., and DePierre, J. W. (1983) Biochim. Biophys. Acta 695, 251-270
2. Guengerich, F. P. (1982) Rev. Biochem. Toxicol. 4, 5-30
3. Cresteil, T., Beaune, P., Kremers, P., Celier, C., Guengerich, F. P., and Leroux, J. P. (1985) Eur. J. Biochem. 151, 345-350
4. Pacifici, G. M., Colizzi, C., Giuliani, L., and Rane, A. (1983) Arch. Toxicol. 54, 331-341
5. Omiecinski, C. J., Aicher, L., and Swenson, L. (1994) J. Pharmacol. Exp. Ther. 269, 417-423
6. Vogel-Bindel, U., Bentley, P., and Oesch, F. (1982) Eur. J. Biochem. 126, 425-431
7. von Dippe, P., Amoui, M., Stellwagen, R. H., and Levy, D. (1996) J. Biol. Chem. 271, 18176-18180
8. Kaneko, S. (1991) Reprod. Toxicol. 5, 179-198
9. Guenthner, T. M. (1990) in Conjugation Reactions in Drug Metabolism (Mulder, G. J., ed), pp. 365-404, Taylor & Francis Ltd., London
10. Jerina, D. M. (1983) Drug. Metab. Dispos. 11, 1-4
11. Oesch, F. (1983) Prog. Clin. Biol. Res. 135, 81-105
12. Phillips, D. H., and Grover, P. L. (1994) Drug. Metab. Rev. 26, 443-467
13. Christou, M., Savas, U., Spink, D. C., Gierthy, J. F., and Jefcoate, C. R. (1994) Carcinogenesis 15, 725-732
14. Dipple, A., and Nebzydoski, J. A. (1978) Chem. Biol. Interact. 20, 17-26
15. Tierney, B., Hewer, A., MacNicoll, A. D., Giovanni Gervasi, P., Rattle, H., Walsh, C., Grover, P. L., and Sims, P. (1978) Chem. Biol. Interact. 23, 243-257
16. Wislocki, P. G., Gadek, K. M., Chou, M. W., Yang, S. K., and Lu, A. Y. (1980) Cancer Res. 40, 3661-3664
17. Christou, M., Jovanovich, M. C., and Jefcoate, C. R. (1989) Carcinogenesis 10, 1883-1890
18. Lau, H. H., Coffing, S. L., Lee, H., Harvey, R. G., and Baird, W. M. (1995) Chem. Res. Toxicol. 8, 970-978
19. DiGiovanni, J., Slaga, T. J., and Boutwell, R. K. (1980) Carcinogenesis 1, 381-389
20. Hennings, H., Devor, D., Wenk, M. L., Slaga, T. J., Former, B., Colburn, N. H., Bowden, G. T., Elgjo, K., and Yuspa, S. H. (1981) Cancer Res. 41, 773-779
21. Gonzalez, F. J., and Kasper, C. B. (1981) J. Biol. Chem. 256, 4697-4700
22. Grant, D. F., Storms, D. H., and Hammock, B. D. (1993) J. Biol. Chem. 268, 17628-17633
23. Lee, S. S., Pineau, T., Drago, J., Lee, E. J., Owens, J. W., Kroetz, D. L., Fernandez-Salguero, P. M., Westphal, H., and Gonzalez, F. J. (1995) Mol. Cell. Biol. 15, 3012-3022
24. Laird, P. W., Zijderveld, A., Linders, K., Rudnicki, M. A., Jaenisch, R., and Berna, A. (1991) Nucleic Acids Res. 19, 4293
25. Skehan, P., Storeng, R., Scudiero, D., Monks, A., McMahon, J., Vistica, D., Warren, J. T., Bokesch, H., Kenney, S., and Boyd, M. R. (1990) J. Natl. Cancer Inst. 82, 1107-1112
26. Shou, M., Korzekwa, K. R., Krausz, K. W., Buters, J. T., Grogan, J., Goldfarb, I., Hardwick, J. P., Gonzalez, F. J., and Gelboin, H. V. (1996) Mol. Carcinogen. 17, 241-249
27. Eltom, S. E., Larsen, M. C., and Jefcoate, C. R. (1998) Carcinogenesis 19, 1437-1444
28. Hassett, C., Robinson, K. B., Beck, N. B., and Omiecinski, C. J. (1994) Genomics 23, 433-442
29. Falany, C. N., McQuiddy, P., and Kasper, C. B. (1987) J. Biol. Chem. 262, 5924-5930
30. Oesch, F., Glatt, H., and Schimassmann, H. (1977) Biochem. Pharmacol. 26, 603-607
31. Porter, T. D., Beck, T. W., and Kasper, C. B. (1986) Arch. Biochem. Biophys. 248, 121-129
32. Skoda, R. C., Demierre, A., McBride, O. W., Gonzalez, F. J., and Meyer, U. A. (1988) J. Biol. Chem. 263, 1549-1554
33. Hassett, C., Turnblom, S. M., DeAngeles, A., and Omiecinski, C. J. (1989) Arch. Biochem. Biophys. 271, 380-389
34. Lim, S. K., Sigmund, C. D., Gross, K. W., and Maquat, L. E. (1992) Mol. Cell. Biol. 12, 1149-1161
35. Zhang, J., and Maquat, L. E. (1996) RNA 2, 235-243
36. Reiners, J. J., Jr., and Singh, K. P. (1997) Carcinogenesis 18, 593-597
37. Hennings, H., Lowry, D. T., Yuspa, S. H., Mock, B., and Potter, M. (1997) Mol. Carcinogen. 20, 143-150
38. Friedberg, T., Becker, R., Oesch, F., and Glatt, H. R. (1994) Carcinogenesis 15, 171-175
39. Frenkel, K., Wei, L., and Wei, H. (1995) Free. Radical Biol. Med. 19, 373-380
40. Ogura, K., Sohtome, T., Sugiyama, A., Okuda, H., Hiratsuka, A., and Watabe, T. (1990) Mol. Pharmacol. 37, 848-854
41. Buters, J. T., Sakai, S., Richter, T., Pineau, T., Alexander, D. L., Savas, U., Doehmer, J., Ward, J. M., Jefcoate, C. R., and Gonzalez, F. J. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 1977-1982
42. Hassett, C., Lin, J., Carty, C. L., Laurenzana, E. M., and Omiecinski, C. J. (1997) Arch. Biochem. Biophys. 337, 275-283
43. Gaedigk, A., Speilberg, S. P., and Grant, D. M. (1994) Pharmacogenetics 4, 142-153
44. Hassett, C., Aicher, L., Sidhu, J. S., and Omiecinski, C. J. (1994) Hum. Mol. Genet. 23, 433-442
45. Buehler, B. A., Delimont, D., van Waes, M., and Finnell, R. H. (1990) N. Engl. J. Med. 322, 1567-1572
46. McGlynn, K. A., Rosvold, E. A., Lustbader, E. D., Hu, Y., Clapper, M. L., Zhou, T., Wild, C. P., Xia, X. L., Baffoe-Bonnie, A., Ofori-Adjei, P., Chen, G. C., London, W. T., Shen, F. M., and Beutow, K. H. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 2384-2387
47. Smith, C. A., and Harrison, D. J. (1997) Lancet 350, 630-633