-
1
-
-
0026470429
-
Contributions of heme and non-heme iron to human nutritions
-
Carpenter CE, Mahoney AW. Contributions of heme and non-heme iron to human nutritions. Crit Rev Food Sci Nutr 1992;31:333-67.
-
(1992)
Crit Rev Food Sci Nutr
, vol.31
, pp. 333-367
-
-
Carpenter, C.E.1
Mahoney, A.W.2
-
2
-
-
24744436353
-
Mechanisms of haem and non-haem iron absorption: Lessons from inherited disorders of iron metabolism
-
Anderson GJ, Frazer DM, McKie AT, Vulpe CD, Smith A. Mechanisms of haem and non-haem iron absorption: lessons from inherited disorders of iron metabolism. Bio-Metals 2005;18:339-48.
-
(2005)
Bio-Metals
, vol.18
, pp. 339-348
-
-
Anderson, G.J.1
Frazer, D.M.2
McKie, A.T.3
Vulpe, C.D.4
Smith, A.5
-
3
-
-
0035793856
-
An iron-regulated ferric reductase associated with the absorption of dietary iron
-
McKie AT, Barrow D, Latunde-Dada GO, et al. An iron-regulated ferric reductase associated with the absorption of dietary iron. Science 2001;291:1755-59.
-
(2001)
Science
, vol.291
, pp. 1755-1759
-
-
McKie, A.T.1
Barrow, D.2
Latunde-Dada, G.O.3
-
4
-
-
27144507493
-
Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice
-
Gunshin H, Starr CN, DiRenzo C, Flemming MD, Jin J, Greer EL, Sellers VM, Galica SM, Andrews NC. Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice. Blood 2005;106:2879-83.
-
(2005)
Blood
, vol.106
, pp. 2879-2883
-
-
Gunshin, H.1
Starr, C.N.2
DiRenzo, C.3
Flemming, M.D.4
Jin, J.5
Greer, E.L.6
Sellers, V.M.7
Galica, S.M.8
Andrews, N.C.9
-
5
-
-
0030763856
-
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene
-
Flemming MD, Trenor CC, Su MA, Foernzler D, Beier DR, Dietrich WF, Andrews NC. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet 1997;16:383-6.
-
(1997)
Nat Genet
, vol.16
, pp. 383-386
-
-
Flemming, M.D.1
Trenor, C.C.2
Su, M.A.3
Foernzler, D.4
Beier, D.R.5
Dietrich, W.F.6
Andrews, N.C.7
-
6
-
-
0030755366
-
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
-
Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollan JL, Hediger MA. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 1997;388:482-8.
-
(1997)
Nature
, vol.388
, pp. 482-488
-
-
Gunshin, H.1
Mackenzie, B.2
Berger, U.V.3
Gunshin, Y.4
Romero, M.F.5
Boron, W.F.6
Nussberger, S.7
Gollan, J.L.8
Hediger, M.A.9
-
7
-
-
0033861745
-
A novel duodenal iron-regulated transporter, IREG, implicated in the basolateral transfer if iron to the circulation
-
McKie AT, Marciani P, Rolfs A, et al. A novel duodenal iron-regulated transporter, IREG, implicated in the basolateral transfer if iron to the circulation. Mol Cell 2000;5:299-309.
-
(2000)
Mol Cell
, vol.5
, pp. 299-309
-
-
McKie, A.T.1
Marciani, P.2
Rolfs, A.3
-
8
-
-
33644810795
-
Comparative studies of duodenal and macrophage ferroportin proteins
-
Canonne-Hergaux F, Donovan A, Delaby C, Wang H, Gros P. Comparative studies of duodenal and macrophage ferroportin proteins. Am J Physiol Gastrointest Liver Physiol 2006;290:G156-63.
-
(2006)
Am J Physiol Gastrointest Liver Physiol
, vol.290
-
-
Canonne-Hergaux, F.1
Donovan, A.2
Delaby, C.3
Wang, H.4
Gros, P.5
-
9
-
-
0032909207
-
Hephaestin: A ceruloplasmin homologue implicated in intestinal iron uptake and its defect in the sla mouse
-
Vulpe CD, Kuo Y-M, Libina N, Gitschier J, Askwith C, Murphy TL, Cowley L, Anderson GJ. Hephaestin: a ceruloplasmin homologue implicated in intestinal iron uptake and its defect in the sla mouse. Nat Genet 1999;21:195-9.
-
(1999)
Nat Genet
, vol.21
, pp. 195-199
-
-
Vulpe, C.D.1
Kuo, Y.-M.2
Libina, N.3
Gitschier, J.4
Askwith, C.5
Murphy, T.L.6
Cowley, L.7
Anderson, G.J.8
-
10
-
-
0014691028
-
Mobilization of liver iron by ferroxidase (ceruloplasmin)
-
Osaki S, Johnson DA. Mobilization of liver iron by ferroxidase (ceruloplasmin). J Biol Chem 1969;244:5757-65.
-
(1969)
J Biol Chem
, vol.244
, pp. 5757-5765
-
-
Osaki, S.1
Johnson, D.A.2
-
11
-
-
33645070287
-
Unexpected role of ceruloplasmin in intestinal iron absorption
-
Cherukuri S, Potla R, Sarkar J, Nurko S, Harris LZ, Fox PL. Unexpected role of ceruloplasmin in intestinal iron absorption. Cell Metab 2005:309-19.
-
(2005)
Cell Metab
, pp. 309-319
-
-
Cherukuri, S.1
Potla, R.2
Sarkar, J.3
Nurko, S.4
Harris, L.Z.5
Fox, P.L.6
-
12
-
-
0033103978
-
The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes
-
Gruenheid S, Canonne-Hergaux F, Gauthier S, Hackam DJ, Grinstein S, Gros P. The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes. J Exp Med 1999;189:831-41.
-
(1999)
J Exp Med
, vol.189
, pp. 831-841
-
-
Gruenheid, S.1
Canonne-Hergaux, F.2
Gauthier, S.3
Hackam, D.J.4
Grinstein, S.5
Gros, P.6
-
13
-
-
27644455133
-
Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells
-
Ohgami RS, Campagna DR, Greer EL, Antiochos B, McDonald A, Chen J, Sharp JJ, Fujiwara Y, Barker JE, Fleming MD. Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat Genet 2005;37:1264-69.
-
(2005)
Nat Genet
, vol.37
, pp. 1264-1269
-
-
Ohgami, R.S.1
Campagna, D.R.2
Greer, E.L.3
Antiochos, B.4
McDonald, A.5
Chen, J.6
Sharp, J.J.7
Fujiwara, Y.8
Barker, J.E.9
Fleming, M.D.10
-
14
-
-
0035823573
-
Tumor necrosis factor-induced adipose-related protein (TIARP), a cell-surface protein that is highly induced by tumor necrosis factor-α and adipose conversion
-
Moldes M, Lasnier F, Gauthereau X, Klein C, Pairault J, Feve B, Chambaut-Guerin A-M. Tumor necrosis factor-induced adipose-related protein (TIARP), a cell-surface protein that is highly induced by tumor necrosis factor-α and adipose conversion. J Biol Chem 2001;276:33 938-46.
-
(2001)
J Biol Chem
, vol.276
, Issue.33
, pp. 938-946
-
-
Moldes, M.1
Lasnier, F.2
Gauthereau, X.3
Klein, C.4
Pairault, J.5
Feve, B.6
Chambaut-Guerin, A.-M.7
-
15
-
-
0036849009
-
Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate
-
Porkka KP, Helenius MA, Visakorpi T. Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate. Lab Invest 2002;82:1573-82.
-
(2002)
Lab Invest
, vol.82
, pp. 1573-1582
-
-
Porkka, K.P.1
Helenius, M.A.2
Visakorpi, T.3
-
16
-
-
24144459870
-
Identification of an intestinal heme transporter
-
Shayeghi M, Latunde-Dada GO, Oakhill JS, et al. Identification of an intestinal heme transporter. Cell 2005;122:789-801.
-
(2005)
Cell
, vol.122
, pp. 789-801
-
-
Shayeghi, M.1
Latunde-Dada, G.O.2
Oakhill, J.S.3
-
17
-
-
0034284595
-
LEAP-1, a novel highly disulfide-bonded peptide, exhibits antimicrobial activity
-
Krause A, Neitz S, Mägert HJ, Schulz A, Forssmann WG, Schulz-Knappe P, Adermann K. LEAP-1, a novel highly disulfide-bonded peptide, exhibits antimicrobial activity. FEBS Lett 2000;480:147-50.
-
(2000)
FEBS Lett
, vol.480
, pp. 147-150
-
-
Krause, A.1
Neitz, S.2
Mägert, H.J.3
Schulz, A.4
Forssmann, W.G.5
Schulz-Knappe, P.6
Adermann, K.7
-
18
-
-
0035896642
-
Hepcidin, a urinary antimicrobial peptide synthesized in the liver
-
Park CH, Valore AJ, Waring AJ, Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 2001;276:7806-10.
-
(2001)
J Biol Chem
, vol.276
, pp. 7806-7810
-
-
Park, C.H.1
Valore, A.J.2
Waring, A.J.3
Ganz, T.4
-
19
-
-
0035896581
-
A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
-
Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, Loreal O. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 2001;276:7811-19.
-
(2001)
J Biol Chem
, vol.276
, pp. 7811-7819
-
-
Pigeon, C.1
Ilyin, G.2
Courselaud, B.3
Leroyer, P.4
Turlin, B.5
Brissot, P.6
Loreal, O.7
-
20
-
-
0038662619
-
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
-
Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2003;101:2461-3.
-
(2003)
Blood
, vol.101
, pp. 2461-2463
-
-
Nemeth, E.1
Valore, E.V.2
Territo, M.3
Schiller, G.4
Lichtenstein, A.5
Ganz, T.6
-
21
-
-
27144475517
-
Novel urine hepcidin assay by mass spectrometry
-
Kemna E, Tjalsma H, Laarakkers C, Nemeth E, Willems H, Swinkels D. Novel urine hepcidin assay by mass spectrometry. Blood 2005;106:3268-70.
-
(2005)
Blood
, vol.106
, pp. 3268-3270
-
-
Kemna, E.1
Tjalsma, H.2
Laarakkers, C.3
Nemeth, E.4
Willems, H.5
Swinkels, D.6
-
22
-
-
30144432585
-
The N-terminus of hepcidin is essential for its interaction with ferroportin: Structure-function study
-
Nemeth E, Preza GC, Jung C-L, Kaplan J, Waring AJ, Ganz T. The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study. Blood 2006;107:328-33.
-
(2006)
Blood
, vol.107
, pp. 328-333
-
-
Nemeth, E.1
Preza, G.C.2
Jung, C.-L.3
Kaplan, J.4
Waring, A.J.5
Ganz, T.6
-
23
-
-
0035902605
-
Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) konckout mice
-
Nicolas G, Bennoun M, Devaux I, Beaumont C, Grandchamp B, Kahn A, Vaulont S. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) konckout mice. Proc Natl Acad Sci USA 2001;98:8780-5.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 8780-8785
-
-
Nicolas, G.1
Bennoun, M.2
Devaux, I.3
Beaumont, C.4
Grandchamp, B.5
Kahn, A.6
Vaulont, S.7
-
24
-
-
1642315903
-
Functional differences between hepcidin 1 and 2 in transgenic mice
-
Lou D-Q, Nicolas G, Lesbordes J-C, Viatte L, Grimber G, Szajnert M-F, Kahn A, Vaulont S. Functional differences between hepcidin 1 and 2 in transgenic mice. Blood 2004;103:2816-21.
-
(2004)
Blood
, vol.103
, pp. 2816-2821
-
-
Lou, D.-Q.1
Nicolas, G.2
Lesbordes, J.-C.3
Viatte, L.4
Grimber, G.5
Szajnert, M.-F.6
Kahn, A.7
Vaulont, S.8
-
25
-
-
0035902605
-
Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
-
Nicolas G, Bennoun M, Deyaux I, Beaumont C, Grandchamp B, Kahn A, Vaulont S. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci USA 2001;98:8780-5.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 8780-8785
-
-
Nicolas, G.1
Bennoun, M.2
Deyaux, I.3
Beaumont, C.4
Grandchamp, B.5
Kahn, A.6
Vaulont, S.7
-
26
-
-
33745752870
-
Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis
-
Lesbordes-Brion J-C, Viatte L, Bennoun M, Lou D-Q, Ramey G, Houbron C, Hamard G, Kahn A, Vaulont S. Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis. Blood 2006;108:1402-5.
-
(2006)
Blood
, vol.108
, pp. 1402-1405
-
-
Lesbordes-Brion, J.-C.1
Viatte, L.2
Bennoun, M.3
Lou, D.-Q.4
Ramey, G.5
Houbron, C.6
Hamard, G.7
Kahn, A.8
Vaulont, S.9
-
27
-
-
0037007064
-
Severe iron deficiency anemia in transgenic mice expressing liver hepcidin
-
Nicolas G, Bennoun M, Porteu A, Mativet S, Beaumont C, Grandchamp B, Sirito M, Sawadogo M, Kahn A, Vaulont S. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci USA 2002;99:4596-601.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 4596-4601
-
-
Nicolas, G.1
Bennoun, M.2
Porteu, A.3
Mativet, S.4
Beaumont, C.5
Grandchamp, B.6
Sirito, M.7
Sawadogo, M.8
Kahn, A.9
Vaulont, S.10
-
28
-
-
0036727925
-
Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats
-
Frazer DM, Wilkins SJ, Becker EM, Vulpe CD, McKie AT, Trinder D, Anderson GJ. Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology 2002;123:835-44.
-
(2002)
Gastroenterology
, vol.123
, pp. 835-844
-
-
Frazer, D.M.1
Wilkins, S.J.2
Becker, E.M.3
Vulpe, C.D.4
McKie, A.T.5
Trinder, D.6
Anderson, G.J.7
-
29
-
-
0036791486
-
The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia and inflammation
-
Nicolas G, Chauvet C, Viatte L, Danan JL, Bigard X, Devaux I, Beaumont C, Kahn A, Vaulont S. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia and inflammation. J Clin Invest 2002;110:1037-44.
-
(2002)
J Clin Invest
, vol.110
, pp. 1037-1044
-
-
Nicolas, G.1
Chauvet, C.2
Viatte, L.3
Danan, J.L.4
Bigard, X.5
Devaux, I.6
Beaumont, C.7
Kahn, A.8
Vaulont, S.9
-
30
-
-
0029842459
-
Oxygen sensing and molecular adaptation to hypoxia
-
Bunn HF, Poyton RO. Oxygen sensing and molecular adaptation to hypoxia. Physiol Rev 1996;76:839-66.
-
(1996)
Physiol Rev
, vol.76
, pp. 839-866
-
-
Bunn, H.F.1
Poyton, R.O.2
-
31
-
-
2342510407
-
Il-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
-
Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, Ganz T. Il-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 2004;113:1271-6.
-
(2004)
J Clin Invest
, vol.113
, pp. 1271-1276
-
-
Nemeth, E.1
Rivera, S.2
Gabayan, V.3
Keller, C.4
Taudorf, S.5
Pedersen, B.K.6
Ganz, T.7
-
32
-
-
13844307889
-
Regulation of hepcidin transcription by interleukin-1 and interleukin-6
-
Lee P, Peng H, Gelbart T, Wang L, Beutler E. Regulation of hepcidin transcription by interleukin-1 and interleukin-6. Proc Natl Acad Sci USA 2005;102:1906-10.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 1906-1910
-
-
Lee, P.1
Peng, H.2
Gelbart, T.3
Wang, L.4
Beutler, E.5
-
33
-
-
29144437865
-
Up-regulation of hepcidin by interleukin-1b in human hepatoma cell lines
-
Inamura J, Ikuta K, Jimbo J, Shido M, Torimoto Y, Kohgo Y. Up-regulation of hepcidin by interleukin-1b in human hepatoma cell lines. Hepatol Res 2005;33:198-205.
-
(2005)
Hepatol Res
, vol.33
, pp. 198-205
-
-
Inamura, J.1
Ikuta, K.2
Jimbo, J.3
Shido, M.4
Torimoto, Y.5
Kohgo, Y.6
-
34
-
-
14744278436
-
Anemia of chronic disease
-
Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med 2005;352:1011-23.
-
(2005)
N Engl J Med
, vol.352
, pp. 1011-1023
-
-
Weiss, G.1
Goodnough, L.T.2
-
35
-
-
2342421100
-
Hepcidin and its role in iron absorption
-
Robson KJ. Hepcidin and its role in iron absorption. Gut 2004;53:617-9.
-
(2004)
Gut
, vol.53
, pp. 617-619
-
-
Robson, K.J.1
-
36
-
-
0037174609
-
C/EBPα regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism
-
Courselaud B, Pigeon C, Inoue Y, et al. C/EBPα regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism. J Biol Chem 2002;277:41163-70.
-
(2002)
J Biol Chem
, vol.277
, pp. 41163-41170
-
-
Courselaud, B.1
Pigeon, C.2
Inoue, Y.3
-
37
-
-
10844258104
-
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
-
Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004;306:2090-3.
-
(2004)
Science
, vol.306
, pp. 2090-2093
-
-
Nemeth, E.1
Tuttle, M.S.2
Powelson, J.3
Vaughn, M.B.4
Donovan, A.5
Ward, D.M.6
Ganz, T.7
Kaplan, J.8
-
38
-
-
0034677467
-
Positional cloning of zebrafish ferroportin 1 identifies a conserved vertebrate iron exporter
-
Donovan A, Brownlie A, Zhou Y, et al. Positional cloning of zebrafish ferroportin 1 identifies a conserved vertebrate iron exporter. Nature 2000;403:776-81.
-
(2000)
Nature
, vol.403
, pp. 776-781
-
-
Donovan, A.1
Brownlie, A.2
Zhou, Y.3
-
39
-
-
20444416123
-
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
-
Donovan A, Lima CA, Pinkus JK, Pinkus GS, Zon LI, Robine S, Andrews NC. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab 2005;1:191-200.
-
(2005)
Cell Metab
, vol.1
, pp. 191-200
-
-
Donovan, A.1
Lima, C.A.2
Pinkus, J.K.3
Pinkus, G.S.4
Zon, L.I.5
Robine, S.6
Andrews, N.C.7
-
40
-
-
0034733635
-
A novel mammalian iron-regulated protein involved in intracellular iron metabolism
-
Abboud S, Haile DJ. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem 2000;275:19 906-12.
-
(2000)
J Biol Chem
, vol.275
, Issue.19
, pp. 906-912
-
-
Abboud, S.1
Haile, D.J.2
-
41
-
-
0034677467
-
Positional cloning of zebrafish ferroportin 1 identifies a conserved iron exporter
-
Donovan A, Brownlie A, Zhou Y, et al. Positional cloning of zebrafish ferroportin 1 identifies a conserved iron exporter. Nature 2000;403:776-81.
-
(2000)
Nature
, vol.403
, pp. 776-781
-
-
Donovan, A.1
Brownlie, A.2
Zhou, Y.3
-
42
-
-
20444464809
-
Ferroportin 1 is required for normal iron cycling in zebrafish
-
Fraenkel PG, Traver D, Donovan A, Zahrieh D, Zon LI. Ferroportin 1 is required for normal iron cycling in zebrafish. J Clin Invest 2005;115:1532-41.
-
(2005)
J Clin Invest
, vol.115
, pp. 1532-1541
-
-
Fraenkel, P.G.1
Traver, D.2
Donovan, A.3
Zahrieh, D.4
Zon, L.I.5
-
43
-
-
20844462571
-
In vitro functional analysis of human ferroportin (FPN) and hemochromatosis- associated FPN mutations
-
Schimanski LM, Drakesmith H, Merryweather-Clarke AT, et al. In vitro functional analysis of human ferroportin (FPN) and hemochromatosis- associated FPN mutations. Blood 2005;105:4096-102.
-
(2005)
Blood
, vol.105
, pp. 4096-4102
-
-
Schimanski, L.M.1
Drakesmith, H.2
Merryweather-Clarke, A.T.3
-
44
-
-
23044508432
-
Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin
-
Drakesmith H, Schimanski LM, Ormerod E, et al. Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin. Blood 2005;106:1092-7.
-
(2005)
Blood
, vol.106
, pp. 1092-1097
-
-
Drakesmith, H.1
Schimanski, L.M.2
Ormerod, E.3
-
45
-
-
21144435281
-
The molecular basis of ferroportin-linked hemochromatosis
-
De Domenico I, Ward DM, Nemeth E, Vaughn MB, Musci G, Ganz T, Kaplan J. The molecular basis of ferroportin-linked hemochromatosis. Proc Natl Acad Sci USA 2005;102:8955-60.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 8955-8960
-
-
De Domenico, I.1
Ward, D.M.2
Nemeth, E.3
Vaughn, M.B.4
Musci, G.5
Ganz, T.6
Kaplan, J.7
-
46
-
-
1442306702
-
Non-HFE hemochromatosis
-
Pietrangelo A. Non-HFE hemochromatosis. Hepatol 2004;39:21-9.
-
(2004)
Hepatol
, vol.39
, pp. 21-29
-
-
Pietrangelo, A.1
-
47
-
-
0018671415
-
Distribution of iron between the binding sites of transferrin in serum: Methods and results in normal human subjects
-
Leibman A, Aisen P. Distribution of iron between the binding sites of transferrin in serum: methods and results in normal human subjects. Blood 1979;53:1058-65.
-
(1979)
Blood
, vol.53
, pp. 1058-1065
-
-
Leibman, A.1
Aisen, P.2
-
48
-
-
0021265943
-
The effect of the iron saturation of transferrin on its binding and uptake by rabbit reticulocytes
-
Young SP, Bomford R, Williams R. The effect of the iron saturation of transferrin on its binding and uptake by rabbit reticulocytes. Biochem J 1984;219:505-10.
-
(1984)
Biochem J
, vol.219
, pp. 505-510
-
-
Young, S.P.1
Bomford, R.2
Williams, R.3
-
49
-
-
9344224529
-
A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
-
Feder JN, Gnirke A, Thomas W, et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 1996;13:399-408.
-
(1996)
Nat Genet
, vol.13
, pp. 399-408
-
-
Feder, J.N.1
Gnirke, A.2
Thomas, W.3
-
50
-
-
13144282684
-
The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding
-
Feder JN, Penny DM, Irrinki A, Lee VK, Lebron JA, Watson N, Tsuchihashi Z, Sigal E, Bjorkman PJ, Schatzman RC. The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc Natl Acad Sci USA 1998;95:1472-7.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 1472-1477
-
-
Feder, J.N.1
Penny, D.M.2
Irrinki, A.3
Lee, V.K.4
Lebron, J.A.5
Watson, N.6
Tsuchihashi, Z.7
Sigal, E.8
Bjorkman, P.J.9
Schatzman, R.C.10
-
51
-
-
0037460697
-
Disrupted hepcidin upregulation in HFE-associated hemochromatosis and the liver as a regulator of body iron homeostasis
-
Bridle KR, Frazer DM, Wilkins SJ, Dixon JL, Purdie DM, Crawford DHG, Subramaniam VN, Powell LW, Anderson GJ, Ramm GA. Disrupted hepcidin upregulation in HFE-associated hemochromatosis and the liver as a regulator of body iron homeostasis. Lancet 2003;361:669-73.
-
(2003)
Lancet
, vol.361
, pp. 669-673
-
-
Bridle, K.R.1
Frazer, D.M.2
Wilkins, S.J.3
Dixon, J.L.4
Purdie, D.M.5
Crawford, D.H.G.6
Subramaniam, V.N.7
Powell, L.W.8
Anderson, G.J.9
Ramm, G.A.10
-
52
-
-
0037509928
-
Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis
-
Muckenthaler M, Roy CN, Custodio AO, Minana B, deGraaf J, Montross LK, Andrews NC, Hentze MW. Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. Nat Genet 2003;34:102-7.
-
(2003)
Nat Genet
, vol.34
, pp. 102-107
-
-
Muckenthaler, M.1
Roy, C.N.2
Custodio, A.O.3
Minana, B.4
deGraaf, J.5
Montross, L.K.6
Andrews, N.C.7
Hentze, M.W.8
-
53
-
-
0037847496
-
Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis
-
Nicolas G, Viatte L, Lou D-Q, Bennoun M, Beaumont C, Kahn A, Andrews NC, Vaulont S. Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis. Nat Genet 2003;34:97-101.
-
(2003)
Nat Genet
, vol.34
, pp. 97-101
-
-
Nicolas, G.1
Viatte, L.2
Lou, D.-Q.3
Bennoun, M.4
Beaumont, C.5
Kahn, A.6
Andrews, N.C.7
Vaulont, S.8
-
54
-
-
33645525540
-
Chronic hepcidin induction causes hyposideremia and alters the pattern of cellular iron accumulation in hemochromatotic mice
-
Viatte L, Nicolas G, Lou D-Q, et al. Chronic hepcidin induction causes hyposideremia and alters the pattern of cellular iron accumulation in hemochromatotic mice. Blood 2006;107:2952-8.
-
(2006)
Blood
, vol.107
, pp. 2952-2958
-
-
Viatte, L.1
Nicolas, G.2
Lou, D.-Q.3
-
55
-
-
0035914480
-
Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites
-
West AP, Giannetti AM, Herr AB, Bennett MJ, Nangiana JS, Pierce JR, Weiner LP, Snow PM, Bjorkman PJ. Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites. J Mol Biol 2001;313:385-7.
-
(2001)
J Mol Biol
, vol.313
, pp. 385-387
-
-
West, A.P.1
Giannetti, A.M.2
Herr, A.B.3
Bennett, M.J.4
Nangiana, J.S.5
Pierce, J.R.6
Weiner, L.P.7
Snow, P.M.8
Bjorkman, P.J.9
-
56
-
-
10244255021
-
Regulation of transferrin receptor 2 protein levels by transferrin
-
Robb A, Wessling-Resnick M. Regulation of transferrin receptor 2 protein levels by transferrin. Blood 2004;104:4294-9.
-
(2004)
Blood
, vol.104
, pp. 4294-4299
-
-
Robb, A.1
Wessling-Resnick, M.2
-
57
-
-
13544250486
-
Hepcidin is decreased in TFR2 hemochromatosis
-
Nemeth E, Roetto A, Garozzo G, Ganz T, Camaschella C. Hepcidin is decreased in TFR2 hemochromatosis. Blood 2005;105:1803-6.
-
(2005)
Blood
, vol.105
, pp. 1803-1806
-
-
Nemeth, E.1
Roetto, A.2
Garozzo, G.3
Ganz, T.4
Camaschella, C.5
-
58
-
-
0034623930
-
Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE
-
West AP, Bennett MJ, Sellers VM, Andrews NC, Enns CA, Bjorkman PJ. Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE. J Biol Chem 2000;275:38 135-8.
-
(2000)
J Biol Chem
, vol.275
, Issue.38
, pp. 135-138
-
-
West, A.P.1
Bennett, M.J.2
Sellers, V.M.3
Andrews, N.C.4
Enns, C.A.5
Bjorkman, P.J.6
-
59
-
-
0032959574
-
Transferrin receptor is necessary for development of erythrocytes and nervous system
-
Levy JE, Jin O, Fujiwara Y, Kuo F, Andrews NC. Transferrin receptor is necessary for development of erythrocytes and nervous system. Nat Genet 1999;21:396-9.
-
(1999)
Nat Genet
, vol.21
, pp. 396-399
-
-
Levy, J.E.1
Jin, O.2
Fujiwara, Y.3
Kuo, F.4
Andrews, N.C.5
-
60
-
-
0034623930
-
Comparison of the interaction of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE
-
West AP, Bennett MJ, Sellers VM, Andrews NC, Enns CA, Bjorkman PJ. Comparison of the interaction of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE. J Biol Chem 2000;275:38 135-8.
-
(2000)
J Biol Chem
, vol.275
, Issue.38
, pp. 135-138
-
-
West, A.P.1
Bennett, M.J.2
Sellers, V.M.3
Andrews, N.C.4
Enns, C.A.5
Bjorkman, P.J.6
-
61
-
-
1642395635
-
Expression pattern of the repulsive guidance molecules RGM A, B and C during mouse development
-
Oldekamp J, Kramer N, Alvarez-Bolado G, Skutella T. Expression pattern of the repulsive guidance molecules RGM A, B and C during mouse development. Gene Expr Patterns 2004;4:283-8.
-
(2004)
Gene Expr Patterns
, vol.4
, pp. 283-288
-
-
Oldekamp, J.1
Kramer, N.2
Alvarez-Bolado, G.3
Skutella, T.4
-
62
-
-
27144459908
-
Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin
-
Lin L, Goldberg YP, Ganz T. Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin. Blood 2005;106:2884-9.
-
(2005)
Blood
, vol.106
, pp. 2884-2889
-
-
Lin, L.1
Goldberg, Y.P.2
Ganz, T.3
-
63
-
-
9144252017
-
Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis
-
Papanikolaou G, Samuels ME, Ludwig EH, et al. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet 2004;36:77-82.
-
(2004)
Nat Genet
, vol.36
, pp. 77-82
-
-
Papanikolaou, G.1
Samuels, M.E.2
Ludwig, E.H.3
-
64
-
-
0031002910
-
Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract
-
Parkkila S, Waheed A, Britton RS, Feder JN, Tsuchicashi Z, Schatzman RC, Bacon RB, Sly WS. Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract. Proc Natl Acad Sci USA 1997;94:2534-9.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 2534-2539
-
-
Parkkila, S.1
Waheed, A.2
Britton, R.S.3
Feder, J.N.4
Tsuchicashi, Z.5
Schatzman, R.C.6
Bacon, R.B.7
Sly, W.S.8
-
67
-
-
0030959086
-
Regulation of intestinal non-haem iron absorption
-
Lombard M, Chua E, O'Toole P. Regulation of intestinal non-haem iron absorption. Gut 1997;40:435-9.
-
(1997)
Gut
, vol.40
, pp. 435-439
-
-
Lombard, M.1
Chua, E.2
O'Toole, P.3
-
68
-
-
33644792074
-
Iron Imports. III. Transfer of iron from the mucosa into circulation
-
Wessling-Resnick M. Iron Imports. III. Transfer of iron from the mucosa into circulation. Am J Physiol Gastrointest Liver Physiol 2006;290:1-6.
-
(2006)
Am J Physiol Gastrointest Liver Physiol
, vol.290
, pp. 1-6
-
-
Wessling-Resnick, M.1
-
69
-
-
4644301624
-
Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis
-
Frazer DM, Inglis HR, Wilkins SJ, Millard KN, Steele TM, McLaren GD, McKie AT, Vulpe CD, Anderson GJ. Delayed hepcidin response explains the lag period in iron absorption following a stimulus to increase erythropoiesis. Gut 2004;53:1509-15.
-
(2004)
Gut
, vol.53
, pp. 1509-1515
-
-
Frazer, D.M.1
Inglis, H.R.2
Wilkins, S.J.3
Millard, K.N.4
Steele, T.M.5
McLaren, G.D.6
McKie, A.T.7
Vulpe, C.D.8
Anderson, G.J.9
-
70
-
-
0037962795
-
The orchestration of body iron intake: How and where do enterocytes receive their cues?
-
Frazer DM, Anderson GJ. The orchestration of body iron intake: how and where do enterocytes receive their cues? Blood Cells Molec Dis 2003;30:288-97.
-
(2003)
Blood Cells Molec Dis
, vol.30
, pp. 288-297
-
-
Frazer, D.M.1
Anderson, G.J.2
-
72
-
-
0345695547
-
Occupancy of the iron binding sites of human transferrin
-
Huebers HA, Josephson B, Huebers E, Csiba E, Finch CA. Occupancy of the iron binding sites of human transferrin. Proc Natl Acad Sci USA 1984;81:4326-30.
-
(1984)
Proc Natl Acad Sci USA
, vol.81
, pp. 4326-4330
-
-
Huebers, H.A.1
Josephson, B.2
Huebers, E.3
Csiba, E.4
Finch, C.A.5
-
73
-
-
0034007995
-
Transferrin receptor 2: Continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis
-
Flemming RE, Migas MC, Holden CC, Waheed A, Britton RS, Tomatsu S, Bacon BR, Sly WS. Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis. Proc Natl Acad Sci USA 2000;97:2214-19.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 2214-2219
-
-
Flemming, R.E.1
Migas, M.C.2
Holden, C.C.3
Waheed, A.4
Britton, R.S.5
Tomatsu, S.6
Bacon, B.R.7
Sly, W.S.8
-
74
-
-
10244265904
-
Diferric transferrin regulates transferrin receptor 2 protein stability
-
Johnson MB, Enns CE. Diferric transferrin regulates transferrin receptor 2 protein stability. Blood 2004;104:4287-93.
-
(2004)
Blood
, vol.104
, pp. 4287-4293
-
-
Johnson, M.B.1
Enns, C.E.2
-
75
-
-
14944345916
-
Juvenile hemochromatosis associated with pathogenic mutations of adult hemochromatosis genes
-
Pietrangelo A, Caleffi A, Henrion J, Ferrara F, Corradini E, Kulaksiz H, Stremmel W, Andreone P, Garuti C. Juvenile hemochromatosis associated with pathogenic mutations of adult hemochromatosis genes. Gastroenterol 2005;128:470-9.
-
(2005)
Gastroenterol
, vol.128
, pp. 470-479
-
-
Pietrangelo, A.1
Caleffi, A.2
Henrion, J.3
Ferrara, F.4
Corradini, E.5
Kulaksiz, H.6
Stremmel, W.7
Andreone, P.8
Garuti, C.9
-
76
-
-
27144459908
-
Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin
-
Lin L, Goldberg P, Ganz T. Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin. Blood 2005;106:2884-9.
-
(2005)
Blood
, vol.106
, pp. 2884-2889
-
-
Lin, L.1
Goldberg, P.2
Ganz, T.3
-
77
-
-
20244375259
-
DRAGON, a bone morphogenetic protein co-receptor
-
Samad TA, Rebbapragada A, Bell E, et al. DRAGON, a bone morphogenetic protein co-receptor. J Biol Chem 2005;280:14 122-9.
-
(2005)
J Biol Chem
, vol.280
, Issue.14
, pp. 122-129
-
-
Samad, T.A.1
Rebbapragada, A.2
Bell, E.3
-
78
-
-
23844456919
-
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor
-
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY. Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor. J Biol Chem 2005;280:29 820-7.
-
(2005)
J Biol Chem
, vol.280
, Issue.29
, pp. 820-827
-
-
Babitt, J.L.1
Zhang, Y.2
Samad, T.A.3
Xia, Y.4
Tang, J.5
Campagna, J.A.6
Schneyer, A.L.7
Woolf, C.J.8
Lin, H.Y.9
-
79
-
-
0037250476
-
Consequences of knocking out BMP signaling in the mouse
-
Zhao GQ. Consequences of knocking out BMP signaling in the mouse. Genesis 2003;35:43-56.
-
(2003)
Genesis
, vol.35
, pp. 43-56
-
-
Zhao, G.Q.1
-
80
-
-
0038682002
-
Mechanisms of TGF-beta signaling from cell membrane to the nucleus
-
Shi Y, Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003;113:685-700.
-
(2003)
Cell
, vol.113
, pp. 685-700
-
-
Shi, Y.1
Massague, J.2
-
81
-
-
33646370235
-
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
-
Babitt JL, Huang FW, Wrighting DM, et al. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet 2006;38:531-9.
-
(2006)
Nat Genet
, vol.38
, pp. 531-539
-
-
Babitt, J.L.1
Huang, F.W.2
Wrighting, D.M.3
-
82
-
-
33644876815
-
A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
-
Wang R-H, Li C, Xu X, et al. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab 2005;2:1-11.
-
(2005)
Cell Metab
, vol.2
, pp. 1-11
-
-
Wang, R.-H.1
Li, C.2
Xu, X.3
-
83
-
-
33745898241
-
Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (TfR2), and Il-6
-
Truksa J, Peng H, Lee P, Beutler E. Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (TfR2), and Il-6. Proc Natl Acad Sci USA 2006;103: 10289-93.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 10289-10293
-
-
Truksa, J.1
Peng, H.2
Lee, P.3
Beutler, E.4
-
84
-
-
26644471267
-
Interaction of homojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells
-
Zhang A-S, West AP, Wyman AE, Bjorkman PJ, Enns CA. Interaction of homojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells. J Biol Chem 2005;280:33 885-94.
-
(2005)
J Biol Chem
, vol.280
, Issue.33
, pp. 885-894
-
-
Zhang, A.-S.1
West, A.P.2
Wyman, A.E.3
Bjorkman, P.J.4
Enns, C.A.5
-
85
-
-
4143080506
-
RGM and its receptor neogenin regulates neuronal survival
-
Matsunaga E, Tauszig-Delamasure S, Monnier PP, Mueller BK, Strittmatter SM, Mehlen P, Chedotal A. RGM and its receptor neogenin regulates neuronal survival. Nat Cell Biol 2004;6:749-55.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 749-755
-
-
Matsunaga, E.1
Tauszig-Delamasure, S.2
Monnier, P.P.3
Mueller, B.K.4
Strittmatter, S.M.5
Mehlen, P.6
Chedotal, A.7
-
86
-
-
4143124603
-
Neogenin mediates the action of repulsive guidance molecule
-
Rajagopalan S, Deitinghoff L, Davis D, Conrad S, Skutella T, Chedotal A, Mueller BK, Strittmatter SM. Neogenin mediates the action of repulsive guidance molecule. Nat. Cell Biol 2004;6:756-62.
-
(2004)
Nat. Cell Biol
, vol.6
, pp. 756-762
-
-
Rajagopalan, S.1
Deitinghoff, L.2
Davis, D.3
Conrad, S.4
Skutella, T.5
Chedotal, A.6
Mueller, B.K.7
Strittmatter, S.M.8
-
87
-
-
1842715573
-
The netrin receptor neogenin is required for neural tube formation and somitogenesis
-
Mawdseley DJ, Cooper HM, Hogan BM, Cody SH, Lieschke GJ, Heath JK. The netrin receptor neogenin is required for neural tube formation and somitogenesis. Dev Biol 2004;269:302-15.
-
(2004)
Dev Biol
, vol.269
, pp. 302-315
-
-
Mawdseley, D.J.1
Cooper, H.M.2
Hogan, B.M.3
Cody, S.H.4
Lieschke, G.J.5
Heath, J.K.6
-
88
-
-
0742322861
-
Repulsive guidance molecule (RGM) gene function is required for neural tube closure but not retinal topography in the mouse visual system
-
Niederkofler V, Salie R, Sigrist M, Arber S. Repulsive guidance molecule (RGM) gene function is required for neural tube closure but not retinal topography in the mouse visual system. J Neurosci 2004;24:808-18.
-
(2004)
J Neurosci
, vol.24
, pp. 808-818
-
-
Niederkofler, V.1
Salie, R.2
Sigrist, M.3
Arber, S.4
-
89
-
-
24744458603
-
Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs
-
Rivera S, Nemeth E, Gabayan V, Lopez MA, Farshidi D, Ganz T. Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs. Blood 2005;106:2196-9.
-
(2005)
Blood
, vol.106
, pp. 2196-2199
-
-
Rivera, S.1
Nemeth, E.2
Gabayan, V.3
Lopez, M.A.4
Farshidi, D.5
Ganz, T.6
-
90
-
-
0037198693
-
A component of innate immunity prevents bacterial biofilm development
-
Singh PK, Parsek MR, Greenberg EP, Welsh MJ. A component of innate immunity prevents bacterial biofilm development. Nature 2002;417:552-5.
-
(2002)
Nature
, vol.417
, pp. 552-555
-
-
Singh, P.K.1
Parsek, M.R.2
Greenberg, E.P.3
Welsh, M.J.4
|