The orchestration of body iron intake: How and where do enterocytes receive their cues?

Blood Cells, Molecules, and Diseases

Volumn 30, Issue 3, 2003, Pages 288-297

  Frazer, David M ^a   Anderson, Gregory J ^a,b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; CD71 ANTIGEN; ERYTHROPOIETIN; FERRITIN; FERROPORTIN 1; HEPCIDIN; LIVER PROTEIN; PROTEIN DCYTB; PROTEIN DMT1; TRANSFERRIN; TRANSFERRIN RECEPTOR; TRANSFERRIN RECEPTOR 2; UNCLASSIFIED DRUG;

CELL MATURATION; DUODENUM; HOMEOSTASIS; HUMAN; INTESTINE ABSORPTION; INTESTINE CELL; INTESTINE CRYPT; INTESTINE EPITHELIUM; INTESTINE VILLUS; IRON ABSORPTION; IRON INTAKE; IRON TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RETICULOENDOTHELIAL SYSTEM; REVIEW;

EID: 0037962795     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1079-9796(03)00039-1     Document Type: Review

References (79)

1. McCance R.A., Widdowson E.M. Absorption and excretion of iron. Lancet. ii:1937;680-684.
2. Andrews N.C. Iron homeostasis insights from genetics and animal models . Nat. Rev. Genet. 1:2000;208-217.
3. Pietrangelo A. Physiology of iron transport and the hemochromatosis gene. Am. J. Physiol. 282:2002;G403-G414.
4. Anderson G.J., Vulpe C.D. Regulation of intestinal iron transport. Templeton D.M. Molecular and Cellular Iron Transport. 2002;559-595 Dekker, New York.
5. McKie A.T., Barrow D., Latunde-Dada G.O., Rolfs A., Sager G., Mudaly E., Mudaly M., Richardson C., Barlow D., Bomford A., Peters T.J., Raja K.B., Shirali S., Hediger M.A., Farzaneh F., Simpson R.J. An iron-regulated ferric reductase associated with the absorption of dietary iron. Science. 291:2001;1755-1759.
6. Fleming M.D., Trenor III C.C., Su M.A., Foernzler D., Beier D.R., Dietrich W.F., Andrews N.C. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat. Genet. 16:1997;383-386.
7. Gunshin H., Mackenzie B., Berger U.V., Gunshin Y., Romero M.F., Boron W.F., Nussberger S., Gollan J.L., Hediger M.A. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature. 388:1997;482-488.
8. Vulpe C.D., Kuo Y., Murphy T.L., Cowley L., Askwith C., Libina N., Gitschier J., Anderson G.J. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat. Genet. 21:1999;195-199.
9. Donovan A., Brownlie A., Zhou Y., Shepard J., Pratt S.J., Moynihan J., Paw B.H., Drejer A., Barut B., Zapata A., Law T.C., Brugnara C., Lux S.E., Pinkus G.S., Pinkus J.L., Kingsley P.D., Palis J., Fleming M.D., Andrews N.C., Zon L.I. Postional cloning of zebrafish ferroportinl identifies a conserved vertebrate iron exporter. Nature. 403:2000;776-781.
10. McKie A.T., Marciani P., Rolfs A., Brennan K., Wehr K., Barrow D., Miret S., Bomford A., Peters T.J., Farzaneh F., Hediger M.A., Hentze M.W., Simpson R.J. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol. Cell. 5:2000;299-309.
11. Abboud S., Haile D.J. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J. Biol. Chem. 275:2000;19906-19912.
12. Feder J.N., Gnirke A., Thomas W., Tsuchihashi Z., Ruddy D.A., Basava A., Dormishain F., Domingo R. Jr., Ellis M.C., Fullan A., Hinton L.M., Jones N.L., Kimmel B.E., Kronmal G.S., Lauer P., Lee V.K., Loeb D.B., Mapa F.A., McClelland E., Meyer N.C., Mintier G.A., Moeller N., Moore T., Morikang E., Prass C.E., Quintana L., Starnes S.M., Schatzman R.C., Brunke K.J., Drayna D.T., Risch N.J., Bacon B.R., Wolff R.K. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat. Genet. 13:1996;399-408.
13. Kawabata H., Yang R., Hirama T., Vuong P.T., Kawano S., Gombart A.F., Koeffler H.P. Molecular cloning of transferrin receptor 2 a new member of the transferrin receptor-like family . J. Biol. Chem. 274:1999;20826-20832.
14. Camaschella C., Roetto A., Cali A., De Gobbi M., Garozzo G., Carella M., Majorano N., Totaro A., Gasparini P. The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22. Nat. Genet. 25:2000;14-15.
15. Nicolas G., Bennoun M., Devaux I., Beaumont C., Grandchamp B., Kahn A., Vaulont S. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc. Natl. Acad. Sci. USA. 98:2001;8780-8785.
16. Pigeon C., Ilyin G., Courselaud B., Leroyer P., Turlin B., Brissot P., Loréal O. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J. Biol. Chem. 276:2001;7811-7819.
17. Frazer D.M., Vulpe C.D., McKie A.T., Wilkins S.J., Trinder D., Cleghorn G.J., Anderson G.J. Cloning and gastrointestinal expression of rat hephaestin relationship to other iron transport proteins . Am. J. Physiol. 281:2001;G931-G939.
18. D.M. Frazer, S.J. Wilkins, E.M. Becker, T.L. Murphy, C.D. Vulpe, A.T. McKie, G.J. Anderson, A rapid decrease in the expression of DMT1 and Dcytb but not Ireg1 or hephaestin explains the mucosal block phenomenon of iron absorption, Gut 52 (2003) 340-346.
19. Frazer D.M., Anderson G.J. Intestinal iron transport and its regulation. Hematology. 6:2001;193-203.
20. Conrad M.E., Weintraub L.R., Crosby W.H. The role of the intestine in iron kinetics. J. Clin. Invest. 43:1964;963-974.
21. Charlton R.W., Jacobs P., Bothwell T.H. The role of the intestinal mucosa in iron absorption. J. Clin. Invest. 44:1965;543-554.
22. Hahn P.F., Bale W.F., Ross J.F., Balfour W.M., Whipple G.H. Radioactive iron absorption by gastro-intestinal tract influence of anemia, anoxia, and antecedent feeding distribution in growing dogs . J. Exp. Med. 78:1943;169-188.
23. Weintraub L.R., Conrad M.E., Crosby W.H. The significance of iron turnover in the control of iron absorption. Blood. 24:1964;19-24.
24. Cortell S., Conrad M.E. Effect of endotoxin on iron absorption. Am. J. Physiol. 213:1967;43-47.
25. Finch C.A., Huebers H., Eng M., Miller L. Effect of transfused reticulocytes on iron exchange. Blood. 59:1982;364-369.
26. Walters G.O., Miller F.M., Worwood M. Serum ferritin concentration and iron stores in normal subjects. J. Clin. Pathol. 26:1973;770-772.
27. Peschle C., Jori G.P., Marone G., Condorelli M. Independence of iron absorption from the rate of eyrthropoiesis. Blood. 44:1974;353-358.
28. Nicolas G., Bennoun M., Porteu A., Mativet S., Beaumont C., Grandchamp B., Sirito M., Sawadogo M., Kahn A., Vaulont S. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc. Natl. Acad. Sci. USA. 99:2002;4596-4601.
29. Nicolas G., Chauvet C., Viatte L., Danan J.L., Bigard X., Devaux I., Beaumont C., Kahn A., Vaulont S. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J. Clin. Invest. 110:2002;1037-1044.
30. Roetto A., Papanikolaou G., Politou M., Alberti F., Girelli D., Christakis J., Loukopoulos D., Camaschella C. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat. Genet. 33:2003;21-22.
31. Frazer D.M., Wilkins S.J., Becker E.M., Vulpe C.D., McKie A.T., Trinder D., Anderson G.J. Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology. 123:2002;835-844.
32. Fleming R.E., Sly W.S. Hepcidin a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease . Proc. Natl. Acad. Sci. USA. 98:2001;8160-8162.
33. Finch C.A., Huebers H.A., Cazzola M., Gaetano B., Bellotti V. Storage Iron. Albertini A., Arosio P., Chiancone E., Drysdale J. Ferritins and Isoferritins as Biochemical Markers. 1984;Elsevier, Amsterdam.
34. Cavill I., Worwood M., Jacobs A. Internal regulation of iron absorption. Nature. 256:1975;328-329.
35. Roetto A., Totaro A., Piperno A., Piga A., Longo F., Garozzo G., Cali A., De Gobbi M., Gasparini P., Camaschella C. New mutations inactivating transferrin receptor 2 in hemochromatosis type 3. Blood. 97:2001;2555-2560.
36. Fleming R.E., Ahmann J.R., Migas M.C., Waheed A., Koeffler H.P., Kawabata H., Britton R.S., Bacon B.R., Sly W.S. Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis. Proc. Natl. Acad. Sci. USA. 99:2002;10653-10658.
37. K.R. Bridle, D.M. Frazer, S.J. Wilkins, J.L. Dixon, D.M. Purdie, D.H.G. Crawford, V.N. Subramaniam, L.W. Powell, G.J. Anderson, G.A. Ramm, Disrupted hepcidin upregulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homeostasis, Lancet 361 (2003) 669-673.
38. Townsend A., Drakesmith H. Role of HFE in iron metabolism, hereditary haemochromatosis, anaemia of chronic disease, and secondary iron overload. Lancet. 359:2002;786-790.
39. Crawford D., Hubscher S., Stuart K., McCaughan G., Gane E., Angus P., Jeffrey G., Kerlin P., Powell L., Fletcher L., Elias E. Hereditary hemochromatosis and liver transplantation implications for patient survival, graft function and the pathogenesis of hereditary hemochromatosis . Hepatology. 36:2002;194A.
40. Fleming R.E., Migas M.C., Holden C.C., Waheed A., Britton R.S., Tomatsu S., Bacon B.R., Sly W.S. Transferrin receptor 2 continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis . Proc. Natl. Acad. Sci. USA. 97:2000;2214-2219.
41. Parkkila S., Waheed A., Britton R.S., Feder J.N., Tsuchihashi Z., Schatzman R.C., Bacon B.R., Sly W.S. Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract. Proc. Natl. Acad. Sci. USA. 94:1997;2534-2539.
42. Bastin J.M., Jones M., O'Callaghan C.A., Schimanski L., Mason D.Y., Townsend A.R.M. Kupffer cell staining by an HFE-specific monoclonal antibody implications for hereditary haemochromatosis . Br. J. Haematol. 103:1998;931-941.
43. Leibman A., Aisen P. Distribution of iron between the binding sites of transferrin in serum methods and results in normal human subjects . Blood. 53:1979;1058-1065.
44. Huebers H.A., Josephson B., Huebers E., Csiba E., Finch C.A. Occupancy of the iron binding sites of human transferrin. Proc. Natl. Acad. Sci. USA. 81:1984;4326-4330.
45. Young S.P., Bomford A., Williams R. The effect of the iron saturation oftransferrin on its binding and uptake by rabbit reticulocytes. Biochem. J. 219:1984;505-510.
46. Huebers H., Csiba E., Huebers E., Finch C.A. Molecular advantage of diferric transferrin in delivering iron to reticulocytes a comparative study . Proc. Soc. Exp. Biol. Med. 179:1985;222-226.
47. Cazzola M., Huebers H.A., Sayers M.H., MacPhail A.P., Eng M., Finch C.A. Transferrin saturation, plasma iron turnover, and transferrin uptake in normal humans. Blood. 66:1985;935-939.
48. Parkkila S., Waheed A., Britton R.S., Bacon B.R., Zhou X.Y., Tomatsu S., Fleming R.E., Sly W.S. Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis. Proc. Natl. Acad. Sci. USA. 94:1997;13198-13202.
49. Waheed A., Parkkila S., Saarnio J., Fleming R.E., Zhou X.Y., Tomatsu S., Britton R.S., Bacon B.R., Sly W.S. Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum. Proc. Natl. Acad. Sci. USA. 96:1999;1579-1584.
50. West A.P., Giannetti A.M., Herr A.B., Bennett M.J., Nangiana J.S., Pierce J.R., Weiner L.P., Snow P.M., Bjorkman P.J. Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites. J. Mol. Biol. 313:2001;385-387.
51. Huebers H.A., Finch C.A. The physiology of transferrin and transferrin receptors. Physiol. Rev. 67:1987;520-582.
52. Ward J.H., Kushner J.P., Kaplan J. Regulation of HeLa cell transferrin receptors. J. Biol. Chem. 257:1982;10317-10323.
53. Mattia E., Rao K., Shapiro D.S., Sussman H.H., Klausner R.D. Biosynthetic regulation of the human transferrin receptor by desferrioxamine in K562 cells. J. Biol. Chem. 259:1984;2689-2692.
54. Morton A.G., Tavill A.S. The role of iron in the regulation of hepatic transferrin synthesis. Br. J. Haematol. 36:1977;383-394.
55. Han O., Fleet J.C., Wood R.J. Reciprocal regulation of HFE and Nramp2 gene expression by iron in human intestinal cells. J. Nutr. 129:1999;98-104.
56. Byrnes V., Ryan E., O'Keane C., Crowe J. Immunohistochemistry of the Hfe protein in patients with hereditary hemochromatosis, iron deficiency anemia, and normal controls. Blood Cells Mol. Dis. 26:2000;2-8.
57. West A.P., Bennett M.J., Sellers V.M., Andrews N.C., Enns C.A., Bjorkman P.J. Comparisons of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE. J. Biol. Chem. 275:2000;38135-38138.
58. Deaglio S., Capobianco A., Cali A., Bellora F., Alberti F., Righi L., Sapino A., Camaschella C., Malavasi F. Structural, functional, and tissue distribution analysis of human transferrin receptor-2 by murine monoclonal antibodies and a polyclonal antiserum. Blood. 100:2002;3782-3789.
59. McLaren G.D., Nathanson M.H., Jacobs A., Trevett D., Thomson W. Regulation of intestinal iron absorption and mucosal iron kinetics in hereditary hemochromatosis. J. Lab. Clin. Med. 117:1991;390-401.
60. Ajioka R.S., Levy J.E., Andrews N.C., Kushner J.P. Regulation of iron absorption in Hfe mutant mice. Blood. 100:2002;1465-1469.
61. Camaschella C. Juvenile haemochromatosis. Baillières Clin. Gastroenterol. 12:1998;227-235.
62. Bainton D.F., Finch C.A. The diagnosis of iron deficiency anemia. Am. J. Med. 37:1964;62-70.
63. Intragumtornchai T., Huebers H.A., Eng M., Finch C.A. In vivo transferrin-iron receptor relationships in erythron of rats. Am. J. Physiol. 255:1988;R326-R331.
64. Pootrakul P., Wattanasaree J., Anuwatanakulchai M.S., Wasi P. Increased red blood cell protoporphyrin in thalassemia a result of relative iron deficiency . Am. J. Clin. Pathol. 82:1984;289-293.
65. Cazzola M., Pootrakul P., Bergamaschi G., Huebers H.A., Eng M., Finch C.A. Adequacy of iron supply for erythropoiesis in vivo observations in humans . J. Lab. Clin. Med. 110:1987;734-739.
66. Erlandson M.E., Waldon B., Stern G., Hilgartner M.W., Wehman J., Smith C.H. Studies on congenital hemolytic syndromes. IV. Gastrointestinal absorption of iron. Blood. 19:1962;359-378.
67. Fessas P., Loukopoulos D. The b thalassaemias. Clin. Haematol. 3:1974;411-435.
68. Pippard M.J., Weatherall D.J. Iron absorption in non-transfused iron loading anaemias prediction of risk for iron loading, and response to iron chelation treatment, in b thalassaemia intermedia and congenital siderblastic anaemias . Haematologia. 17:1984;407-414.
69. Cazzola M., Beguin Y., Bergamaschi G., Guarnone R., Cerani P., Barella S., Cao A., Galanello R. Soluble transferrin receptor as a potential determinant of iron loading in congenital anaemias due to ineffective erythropoiesis. Br. J. Haematol. 106:1999;752-755.
70. Van Wyck D.B., Tancer M.E., Popp R.A. Iron homeostasis in b-thalassemic mice. Blood. 70:1987;1462-1465.
71. Goya N., Miyazaki S., Kodate S., Ushio B. A family of congenital atransferrinemia. Blood. 40:1972;239-245.
72. Hamill R.L., Woods J.C., Cook B.A. Congenital atransferrinemia a case report and review of the literature . Am. J. Clin. Pathol. 96:1991;215-218.
73. Beutler E., Gelbart T., Lee P., Trevino R., Fernandez M.A., Fairbanks V.F. Molecular characterization of a case of atransferrinemia. Blood. 96:2000;4071-4074.
74. Weinstein D.A., Roy C.N., Fleming M.D., Loda M.F., Wolfsdorf J.I., Andrews N.C. Inappropriate expression of hepcidin is associated with iron refractory anemia implications for the anemia of chronic disease . Blood. 100:2002;3776-3781.
75. Raja K.B., Pountney D.J., Simpson R.J., Peters T.J. Importance of anemia andtransferrin levels in the regulation of intestinal iron absorption in hypotransferrinemic mice. Blood. 94:1999;3185-3192.
76. Levy J.E., Jin O., Fujiwara Y., Kuo F., Andrews N.C. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nat. Genet. 21:1999;396-399.
77. Levy J.E., Montross L.K., Andrews N.C. Genes that modify the hemochromatosis phenotype in mice. J. Clin. Invest. 105:2000;1209-1216.
78. Chaudhary P.M., Ferguson C., Nguyen V., Nguyen O., Massa H.F., Eby M., Jasmin A., Trask B.J., Hood L., Nelson P.S. Cloning and characterization of two Toll/interleukin-1 receptor-like genes TIL3 and TIL4 evidence for a multi-gene receptor family in humans . Blood. 91:1998;4020-4027.
79. Rhee S.H., Hwang D. Murine TOLL-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NFkB and expression of the inducible cyclooxygenase. J. Biol. Chem. 275:2000;34035-34040.