Unexpected role of ceruloplasmin in intestinal iron absorption

Cell Metabolism

Volumn 2, Issue 5, 2005, Pages 309-319

  Cherukuri, Srujana ^a,b   Potla, Ramesh ^a,b   Sarkar, Joydeep ^a,c   Nurko, Saul ^a   Harris, Z Leah ^d   Fox, Paul L ^a,b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CLEVELAND STATE UNIVERSITY   (United States)

^c Case Western Reserve University   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CERULOPLASMIN; HEMOGLOBIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; BLEEDING; CONTROLLED STUDY; CONVALESCENCE; DUODENUM; ERYTHROCYTE; HEMOGLOBIN DETERMINATION; INTESTINE ABSORPTION; INTESTINE EPITHELIUM; IRON ABSORPTION; IRON METABOLISM; IRON TRANSPORT; LAMINA PROPRIA; LIVER; MOUSE; NONHUMAN; PHLEBOTOMY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TRANSPORT; REGULATORY MECHANISM; SPLEEN; STRESS; WILD TYPE;

ANIMALS; CATION TRANSPORT PROTEINS; CERULOPLASMIN; DUODENUM; ENTEROCYTES; HOMEOSTASIS; HUMANS; INTESTINAL ABSORPTION; IRON; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUCOUS MEMBRANE; RNA, MESSENGER; SPLEEN; STRESS; STRESS, PHYSIOLOGICAL; TIME FACTORS; TRANSFERRIN;

ANIMALIA; VERTEBRATA;

EID: 33645070287     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2005.10.003     Document Type: Article

References (37)

1. S. Abboud D.J. Haile A novel mammalian iron-regulated protein involved in intracellular iron metabolism J. Biol. Chem. 275 2000 19906-19912
2. R.S. Ajioka J.E. Levy N.C. Andrews J.P. Kushner Regulation of iron absorption in Hfe mutant mice Blood 100 2002 1465-1469
3. A.R. Aldred A. Grimes G. Schreiber J.F. Mercer Rat ceruloplasmin. Molecular cloning and gene expression in liver, choroid plexus, yolk sac, placenta, and testis J. Biol. Chem. 262 1987 2875-2878
4. R.M. Bannerman R.G. Cooper Sex-linked anemia: A hypochromic anemia of mice Science 151 1966 581-582
5. H. Chen Z.K. Attieh T. Su B.A. Syed H. Gao R.M. Alaeddine T.C. Fox J. Usta C.E. Naylor R.W. Evans et. al. Hephaestin is a ferroxidase that maintains partial activity in sex-linked anemia mice Blood 103 2004 3933-3939
6. H. Chen T. Su Z.K. Attieh T.C. Fox A.T. McKie G.J. Anderson C.D. Vulpe Systemic regulation of Hephaestin and Ireg1 revealed in studies of genetic and nutritional iron deficiency Blood 102 2003 1893-1899
7. S. Cherukuri N.A. Tripoulas S. Nurko P.L. Fox Anemia and impaired stress-induced erythropoiesis in aceruloplasminemic mice Blood Cells Mol. Dis. 33 2004 346-355
8. J.E. Dennis D.M. Gay R.E. Welsch Algorithm 573. NL2SOL - An adaptive nonlinear least-squares algorithm ACM Trans. Math. Softw. 7 1981 369-383
9. L. Dini M. Carbonaro G. Musci L. Calabrese The interaction of ceruloplasmin with Kupffer cells Eur. J. Cell Biol. 52 1990 207-212
10. A. Donovan A. Brownlie Y. Zhou J. Shepard S.J. Pratt J. Moynihan B.H. Paw A. Drejer B. Barut A. Zapata et. al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter Nature 403 2000 776-781
11. A. Donovan C.A. Lima J.L. Pinkus G.S. Pinkus L.I. Zon S. Robine N.C. Andrews The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis Cell Metab. 1 2005 191-200
12. F. Dupic S. Fruchon M. Bensaid O. Loreal P. Brissot N. Borot M.P. Roth H. Coppin Duodenal mRNA expression of iron related genes in response to iron loading and iron deficiency in four strains of mice Gut 51 2002 648-653
13. M.D. Fleming C.C. Trenor M.A. Su D. Foernzler D.R. Beier W.F. Dietrich N.C. Andrews Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene Nat. Genet. 16 1997 383-386
14. R.E. Fleming J.D. Gitlin Primary structure of rat ceruloplasmin and analysis of tissue-specific gene expression during development J. Biol. Chem. 265 1990 7701-7707
15. D.M. Frazer C.D. Vulpe A.T. McKie S.J. Wilkins D. Trinder G.J. Cleghorn G.J. Anderson Cloning and gastrointestinal expression of rat hephaestin: relationship to other iron transport proteins Am. J. Physiol. 281 2001 G931-G939
16. H. Gunshin B. Mackenzie U.V. Berger Y. Gunshin M.F. Romero W.F. Boron S. Nussberger J.L. Gollan M.A. Hediger Cloning and characterization of a mammalian proton-coupled metal-ion transporter Nature 388 1997 482-488
17. H. Gunshin C.N. Starr C. Direnzo M.D. Fleming J. Jin E.L. Greer V.M. Sellers S.M. Galica N.C. Andrews Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice Blood 106 2005 2879-2883
18. P. Hahn Y. Qian T. Dentchev L. Chen J. Beard Z.L. Harris J.L. Dunaief Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration Proc. Natl. Acad. Sci. USA 101 2004 13850-13855
19. Z.L. Harris S.R. Davis-Kaplan J.D. Gitlin J. Kaplan A fungal multicopper oxidase restores iron homeostasis in aceruloplasminemia Blood 103 2004 4672-4673
20. Z.L. Harris A.P. Durley T.K. Man J.D. Gitlin Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux Proc. Natl. Acad. Sci. USA 96 1999 10812-10817
21. N.E. Hellman M. Schaefer S. Gehrke P. Stegen W.J. Hoffman J.D. Gitlin W. Stremmel Hepatic iron overload in aceruloplasminaemia Gut 47 2000 858-860
22. M.W. Hentze M.U. Muckenthaler N.C. Andrews Balancing acts: Molecular control of mammalian iron metabolism Cell 117 2004 285-297
23. 2+, ceruloplasmin, and phosphate Arch. Biochem. Biophys. 295 1992 302-308
24. L.W.J. Klomp Z.S. Farhangrazi L.L. Dugan J.D. Gitlin Ceruloplasmin gene expression in the murine central nervous system J. Clin. Invest. 98 1996 207-215
25. Y.M. Kuo T. Su H. Chen Z. Attieh B.A. Syed A.T. McKie G.J. Anderson J. Gitschier C.D. Vulpe Mislocalisation of hephaestin, a multicopper ferroxidase involved in basolateral intestinal iron transport, in the sex linked anaemia mouse Gut 53 2004 201-206
26. P.J. Lockhart J.F. Mercer Cloning and expression analysis of the sheep ceruloplasmin cDNA Gene 236 1999 251-257
27. A.T. McKie D. Barrow G.O. Latunde-Dada A. Rolfs G. Sager E. Mudaly M. Mudaly C. Richardson D. Barlow A. Bomford et. al. An iron-regulated ferric reductase associated with the absorption of dietary iron Science 291 2001 1755-1759
28. A.T. McKie P. Marciani A. Rolfs K. Brennan K. Wehr D. Barrow S. Miret A. Bomford T.J. Peters F. Farzaneh et. al. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation Mol. Cell 5 2000 299-309
29. E. Nemeth M.S. Tuttle J. Powelson M.B. Vaughn A. Donovan D.M. Ward T. Ganz J. Kaplan Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization Science 306 2004 2090-2093
30. S. Osaki D.A. Johnson Mobilization of liver iron by ferroxidase (ceruloplasmin) J. Biol. Chem. 244 1969 5757-5765
31. S. Osaki D.A. Johnson E. Frieden The possible significance of the ferrous oxidase activity of ceruloplasmin in normal human serum J. Biol. Chem. 241 1966 2746-2751
32. B.N. Patel R.J. Dunn S.Y. Jeong Q. Zhu J.P. Julien S. David Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury J. Neurosci. 22 2002 6578-6586
33. J. Sarkar V. Seshadri N.A. Tripoulas M.E. Ketterer P.L. Fox Role of ceruloplasmin in macrophage iron efflux during hypoxia J. Biol. Chem. 278 2003 44018-44024
34. M. Tavassoli T. Kishimoto M. Kataoka Liver endothelium mediates the hepatocyte's uptake of ceruloplasmin J. Cell Biol. 102 1986 1298-1303
35. Torrance, J.D., and Bothwell, T.H., eds. (1980). Tissue iron stores (New York, Churchill Livingstone).
36. C.D. Vulpe Y.M. Kuo T.L. Murphy L. Cowley C. Askwith N. Libina J. Gitschier G.J. Anderson Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse Nat. Genet. 21 1999 195-199
37. K. Yamamoto K. Yoshida Y. Miyagoe A. Ishikawa K. Hanaoka S. Nomoto K. Kaneko S. Ikeda S. Takeda Quantitative evaluation of expression of iron-metabolism genes in ceruloplasmin-deficient mice Biochim. Biophys. Acta 1588 2002 195-202