Neogenin mediates the action of repulsive guidance molecule

Nature Cell Biology

Volumn 6, Issue 8, 2004, Pages 756-762

  Rajagopalan, Srikanth ^a   Deitinghoff, Lutz ^b   Davis, Denise ^a   Conrad, Sabine ^c   Skutella, Thomas ^c   Chedotal, Alain ^d   Mueller, Bernhard K ^b   Strittmatter, Stephen M ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ABBOTT GMBH AND CO KG   (Germany)

^c Tissue Engineering Division   (Germany)

^d Groupe Enzymologie Moléculaire et Fonctionnelle   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CELL SURFACE PROTEIN; GLYCOSYLPHOSPHATIDYLINOSITOL; NEOGENIN; NETRIN; PROTEIN ANTIBODY; PROTEIN RGM; RECEPTOR PROTEIN; REPULSIVE GUIDANCE MOLECULE; UNCLASSIFIED DRUG; AVIAN PROTEIN; HYBRID PROTEIN; MEMBRANE PROTEIN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CHICKEN; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MOLECULAR CLONING; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RETINA NERVE CELL; SPINAL GANGLION; ANIMAL; CELL LINE; CELL STRAIN COS1; CERCOPITHECUS; CHEMISTRY; CHICK EMBRYO; CYTOLOGY; GENETICS; KIDNEY; METABOLISM; ORGAN CULTURE TECHNIQUE; PROTEIN TERTIARY STRUCTURE; RAT; RETINA;

ANIMALIA; GALLUS GALLUS;

ANIMALS; AVIAN PROTEINS; BINDING SITES; CELL LINE; CERCOPITHECUS AETHIOPS; CHICK EMBRYO; COS CELLS; GANGLIA, SPINAL; HUMANS; KIDNEY; MEMBRANE PROTEINS; ORGAN CULTURE TECHNIQUES; PROTEIN STRUCTURE, TERTIARY; RATS; RECOMBINANT FUSION PROTEINS; RETINA;

EID: 4143124603     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1156     Document Type: Article

References (27)

1. Monnier, P. P. et al. RGM is a repulsive guidance molecule for retinal axons. Nature 419, 392-395 (2002).
2. Niederkofler, V., Salie, R., Sigrist, M. & Arber, S. Repulsive guidance molecule (RGM) gene function is required for neural tube closure but not retinal topography in the mouse visual system. J. Neurosci. 24, 808-818 (2004).
3. Tessier-Lavigne, M. & Goodman, C. S. The molecular biology of axon guidance. Science 274, 1123-1133 (1996).
4. Yu, T. W. & Bargmann, C. I. Dynamic regulation of axon guidance. Nature Neurosci. 4 (Suppl.), 1169-1176 (2001).
5. Wang, H., Copeland, N. G, Gilbert, D. J., Jenkins, N. A. & Tessier-Lavigne, M. Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptors. J. Neurosci. 19, 4938-4947 (1999).
6. Keeling, S. L., Gad, J. M. & Cooper, H. M. Mouse Neogenin, a DCC-like molecule, has four splice variants and is expressed widely in the adult mouse and during embryogenesis. Oncogene 15, 691-700 (1997).
7. Stein, E., Zou, Y., Poo, M. & Tessier-Lavigne, M. Binding of DCC by netrin-1 to mediate axon guidance independent of adenosine A2B receptor activation. Science 291, 1976-1982 (2001).
8. Keino-Masu, K. et al. Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. Cell 87, 175-185 (1996).
9. Fazeli, A. et al. Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. Nature 386, 796-804 (1997).
10. Srinivasan, K., Strickland, P., Valdes, A., Shin, G. C. & Hinck, L. Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis. Dev. Cell 4, 371-382 (2003).
11. Hong, K. et al. A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion. Cell 97, 927-941 (1999).
12. Geisbrecht, B. V., Dowd, K. A., Barfield, R. W., Longo, P. A. & Leahy, D. J. Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin. J. Biol. Chem. 278, 32561-32568 (2003).
13. Gad, J. M., Keeling, S. L., Shu, T., Richards, L. J. & Cooper, H. M. The spatial and temporal expression patterns of netrin receptors, DCC and neogenin, in the developing mouse retina. Exp. Eye Res. 70, 711-722 (2000).
14. Vielmetter, J., Kayyem, J. F., Roman, J. M. & Dreyer, W. J. Neogenin, an avian cell surface protein expressed during terminal neuronal differentiation, is closely related to the human tumor suppressor molecule deleted in colorectal cancer. J. Cell Biol. 127, 2009-2020 (1994).
15. Sheppard, A. M., Konopka, M. & Jeffrey, P. L. Thy-1 expression in the retinotectal system of the chick. Brain Res. 471, 49-60 (1988).
16. Sheppard, A. M., Konopka, M., Robinson, S. R., Morgan, I. G. & Jeffrey, P. L. Thy-1 antigen is specific to ganglion cells in chicks. Neurosci. Lett. 123, 87-90 (1991).
17. Walter, J., Henke-Fahle, S. & Bonhoeffer, F. Avoidance of posterior tectal membranes by temporal retinal axons. Development 101, 909-913 (1987).
18. Walter, J., Kern-Veits, B., Huf, J., Stolze, B. & Bonhoeffer, F. Recognition of position-specific properties of tectal cell membranes by retinal axons in vitro. Development 101, 685-696 (1987).
19. Feldheim, D. A. et al. Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping. Neuron 25, 563-574 (2000).
20. Muller, B. K., Jay, D. G. & Bonhoeffer, F. Chromophore-assisted laser inactivation of a repulsive axonal guidance molecule. Curr. Biol. 6, 1497-1502 (1996).
21. Ming, G. L. et al. cAMP-dependent growth cone guidance by netrin-1. Neuron 19, 1225-1235 (1997).
22. Fournier, A. E., GrandPre, T. & Strittmatter, S. M. Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature 409, 341-346 (2001).
23. Nakamura, F., Tanaka, M., Takahashi, T., Kalb, R. G. & Strittmatter, S. M. Neuropilin-1 extracellular domains mediate semaphorin D/III-induced growth cone collapse. Neuron 21, 1093-1100 (1998).
24. Liu, B. P., Fournier, A., GrandPre, T. & Strittmatter, S. M. Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor. Science 297, 1190-1193 (2002).
25. Hornberger, M. R. et al. Modulation of EphA receptor function by coexpressed ephrinA ligands on retinal ganglion cell axons. Neuron 22, 731-742 (1999).
26. Vielmetter, J., Stolze, B., Bonhoeffer, F. & Stuermer, C. A. In vitro assay to test differential substrate affinities of growing axons and migratory cells. Exp. Brain Res. 81, 283-287 (1990).
27. Brinks, H. et al. The repulsive guidance molecule RGMa is involved in the formation of aferrent connections in the dentate gyrus. J. Neurosci. 24, 3862-3869 (2004).