Hepcidin and its role in iron absorption

Gut

Volumn 53, Issue 5, 2004, Pages 617-619

  Robson, K J ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HEPCIDIN;

ANEMIA; GENETICS; HEALTH; HEMOCHROMATOSIS; HOMEOSTASIS; IRON ABSORPTION; IRON BALANCE; IRON METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SHORT SURVEY;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; HEMOCHROMATOSIS; HOMEOSTASIS; HUMANS; INTESTINAL ABSORPTION; IRON; MICE;

EID: 2342421100     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2003.027631     Document Type: Short Survey

References (27)

1. Fleming RE, Sly WS. Mechanisms of iron accumulation in hereditary hemochromatasis. Annu Rev Physiol 2002;64:663-80.
2. Knutson M, Wessling-Resnick M. Iron metabolism in the reticuloendothelial system. Crit Rev Biochem Mol Biol 2003;38:61-88.
3. Finch C. Regulators of iron balance in humans. Blood 1994;84:1697-702.
4. Krause A, Neitz S, Magert HJ, et al. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett 2000;480:147-50.
5. Park CH, Valare EV, Waring AJ, et al. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 2001;276:7896-910.
6. Pigeon C, Ilyin G, Courselaud B, et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 2001;276:7811-19.
7. Shike H, Lauth X, Westerman ME, et al. Boss hepcidin is a novel antimicrobial peptide induced by bacterial challenge. Eur J Biochem 2002;269:2232-7.
8. Nemeth E, Valore EV, Territa M, et al. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2003;101:2461-3.
9. Nicolas G, Bennoun M, Devaux I, et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci USA 2001;998:8780-5.
10. Nicolas G, Bennoun M, Porteu A, et al. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci USA 2002;99:4596-601.
11. Nicolas G, Chauvet C, Viatte L, et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia. J Clin Invest 2002;110:1037-44.
12. Weinstein DA, Roy CN, Fleming MD, et al. Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood 2002;100:3776-81.
13. Bridle KR, Frazer DM, Wilkins SJ, et al. Disrupted hepcidin regulation in HFE-associated haemochromotosis and the liver as a regulator of body iron homeostasis. Lancet 2003;361:669-73.
14. Gehrke SG, Kuloksiz H, Herrmann T, et al. Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron. Blood 2003;102:371-6.
15. Roetto A, Papanikoloau G, Politou M, et al. Mutant antimicrobial peptide hepcidin is associated with severe juvenile haemochromatosis. Nat Genet 2003;33:21-2.
16. Merryweather-Clarke AT, Cadet E, Bomford A, et al. Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis. Hum Mol Gen 2003;12:2241-7.
17. Nicolas G, Viatte L, Lou D-Q, et al. Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatasis. Nat Genet 2003;34:97-101.
18. Muckenthaler M, Roy CN, Custodio AO, et al. Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. Nat Genet 2003;34:102-7.
19. Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 2003;102:783-8.
20. Hunter HN, Fultan DB, Ganz T, et al. The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis. J Biol Chem 2002;277:37597-603.
21. Kulaksiz H, Gehrke SG, Janetzko A, et al. Pro-hepcidin: expression and cell specific localisation in the liver and its regulation in hereditary haemochromatasis, chronic renal insufficiency, and renal anaemia. Gut 2004;53:735-43.
22. Njajou OT, Vaessen N, Joosse M, et al. A mutation in SLC11A3 is associated with autosomal dominant hemochromatasis. Nat Genet 2001;28:213-14.
23. Montosi G, Donovan A, Totaro A, et al. Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene. J Clin Invest 2001;108:619-23.
24. Devalia V, Carter K, Walker AP, et al. Autosomal dominant reticulo-endothelial iron overload associated with a three base pair deletion in the ferroportin 1 gene (SLC11A3). Blood 2002;100:695-7.
25. Roetto A, Merryweather-Clarke AT, Doraio R, et al. A valine deletion in ferroportin 1: a common mutation in hemochromatosis type 4? Blood 2002;100:733-4.
26. Courselaud B, Pigeon C, Inoue Y, et al. C/EBPα regulates hepatic transcription of hepcidin, and antimicrobial peptide and regulator of iron metabolism. J Biol Chem 2002;277:41163-70.
27. Papanikolaou G, Samuels ME, Ludwig EH, et al. Mutations in HFE2 cause iron overload in chromosome Iq-linked juvenile hemochromatosis. Nat Genet 2004;36:77-82.