A death-promoting role for extracellular signal-regulated kinase

Journal of Pharmacology and Experimental Therapeutics

Volumn 319, Issue 3, 2006, Pages 991-997

  Zhuang, Shougang ^a   Schnellmann, Rick G ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CASPASE 3; CISPLATIN; CYTOCHROME C; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PROTEIN KINASE B; SL 327; UNCLASSIFIED DRUG;

APOPTOSIS; BRAIN INJURY; BRAIN ISCHEMIA; CELL DEATH; CELL TYPE; CYTOKINE RELEASE; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INACTIVATION; EPITHELIUM CELL; HUMAN; KIDNEY EPITHELIUM; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; TISSUE INJURY;

ANIMALS; APOPTOSIS; CELL DEATH; CELL SURVIVAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; SIGNAL TRANSDUCTION;

EID: 33751190327     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.107367     Document Type: Review

References (95)

1. Ahmed-Choudhury J, Williams KT, Young LS, Adams DH, and Afford SC (2006) CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2. Cell Signal 18:456-468.
2. Alessandrini A, Namura S, Moskowitz MA, and Bonventre JV (1999) MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia. Proc Natl Acad Sci USA 96:12866-12869.
3. Alessi DR, Cuenda A, Cohen P, Dudley DT, and Saltiel AR (1995) PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 270:27489-27494.
4. Alexia C, Fallot G, Lasfer M, Schweizer-Groyer G, and Groyer A (2004) An evaluation of the role of insulin-like growth factors (IGF) and of type-I IGF receptor signalling in hepatocarcinogenesis and in the resistance of hepatocarcinoma cells against drug-induced apoptosis. Biochem Pharmacol 68:1003-1015.
5. Amaravadi R and Thompson CB (2005) The survival kinases Akt and Pim as potential pharmacological targets. J Clin Investig 115:2618-2624.
6. Arany I, Megyesi JK, Kaneto H, Price PM, and Safirstein RL (2004) Cisplatin-induced cell death is EGFR/src/ERK signaling dependent in mouse proximal tubule cells. Am J Physiol 287:F543-F549.
7. Baines CP and Molkentin JD (2005) STRESS signaling pathways that modulate cardiac myocyte apoptosis. J Mol Cell Cardiol 38:47-62.
8. Barone FC and Feuerstein GZ (1999) Inflammatory mediators and stroke: new opportunities for novel therapeutics. J Cereb Blood Flow Metab 19:819-834.
9. Bhat NR and Zhang P (1999) Hydrogen peroxide activation of multiple mitogen-activated protein kinases in an oligodendrocyte cell line: role of extracellular signal-regulated kinase in hydrogen peroxide-induced cell death. J Neurochem 72:112-119.
10. Boatright KM and Salvesen GS (2003) Mechanisms of caspase activation. Curr Opin Cell Biol 15:725-731.
11. Bogoyevitch MA and Court NW (2004) Counting on mitogen-activated protein kinases-ERKs 3, 4, 5, 6, 7 and 8. Cell Signal 16:1345-1354.
12. Brown L and Benchimol S (2006) The involvement of MAPK signaling pathways in determining the cellular response to p53 activation: cell cycle arrest or apoptosis. J Biol Chem 281:3832-3840.
13. Cagnol S, Van Obberghen-Schilling E, and Chambard JC (2006) Prolonged activation of ERK1,2 induces FADD-independent caspase 8 activation and cell death. Apoptosis 11:337-346.
14. Cavanaugh JE, Ham J, Hetman M, Poser S, Yan C, and Xia Z (2001) Differential regulation of mitogen-activated protein kinases ERK1/2 and ERK5 by neurotrophins, neuronal activity, and cAMP in neurons. J Neurosci 21:434-443.
15. Chen J, Liu X, Mandel LJ, and Schnellmann RG (2001) Progressive disruption of the plasma membrane during renal proximal tubule cellular injury. Toxicol Appl Pharmacol 171:1-11.
16. Chen M, Bao W, Aizman R, Huang P, Aspevall O, Gustafsson LE, Ceccatelli S, and Celsi G (2004) Activation of extracellular signal-regulated kinase mediates apoptosis induced by uropathogenic Escherichia coli toxins via nitric oxide synthase: protective role of heme oxygenase-1. J Infect Dis 190:127-135.
17. Clausen F, Lundqvist H, Ekmark S, Lewen A, Ebendal T, and Hillered L (2004) Oxygen free radical-dependent activation of extracellular signal-regulated kinase mediates apoptosis-like cell death after traumatic brain injury. J Neurotrauma 21:1168-1182.
18. Columbano A (1995) Cell death: current difficulties in discriminating apoptosis from necrosis in the context of pathological processes in vivo. J Cell Biochem 58:181-190.
19. de Bernardo S, Canals S, Casarejos MJ, Solano RM, Menendez J, and Mena MA (2004) Role of extracellular signal-regulated protein kinase in neuronal cell death induced by glutathione depletion in neuron/glia mesencephalic cultures. J Neurochem 91:667-682.
20. Degli Esposti M and Dive C (2003) Mitochondrial membrane permeabilisation by Bax/Bak. Biochem Biophys Res Commun 304:455-461.
21. di Mari JF, Davis R, and Safirstein RL (1999) MAPK activation determines renal epithelial cell survival during oxidative injury. Am J Physiol 277:F195-F203.
22. Dong J, Ramachandiran S, Tikoo K, Jia Z, Lau SS, and Monks TJ (2004) EGFR-independent activation of p38 MAPK and EGFR-dependent activation of ERK1/2 are required for ROS-induced renal cell death. Am J Physiol 287:F1049-F1058.
23. Downward J (1998) Ras signalling and apoptosis. Curr Opin Genet Dev 8:49-54.
24. Emsley HC and Tyrrell PJ (2002) Inflammation and infection in clinical stroke. J Cereb Blood Flow Metab 22:1399-1419.
25. English JM, Vanderbilt CA, Xu S, Marcus S, and Cobb MH (1995) Isolation of MEK5 and differential expression of alternatively spliced forms. J Biol Chem 270:28897-28902.
26. Fadeel B and Orrenius S (2005) Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease. J Intern Med 258:479-517.
27. Favata MF, Horiuchi KY, Manos EJ, Daulerio AJ, Stradley DA, Feeser WS, Van Dyk DE, Pitts WJ, Earl RA, Hobbs F, et al. (1998) Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 273:18623-18632.
28. Garrington TP and Johnson GL (1999) Organization and regulation of mitogen-activated protein kinase signaling pathways. Curr Opin Cell Biol 11:211-218.
29. Goillot E, Raingeaud J, Ranger A, Tepper RI, Davis RJ, Harlow E, and Sanchez I (1997) Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway. Proc Natl Acad Sci USA 94:3302-3307.
30. Gomez-Santos C, Ferrer I, Reiriz J, Vinals F, Barrachina M, and Ambrosio S (2002) MPP+ increases alpha-synuclein expression and ERK/MAP-kinase phosphorylation in human neuroblastoma SH-SY5Y cells. Brain Res 935:32-39.
31. ras/extracellular regulated kinase in neuronal ischemic preconditioning. Proc Natl Acad Sci USA 97:436-441.
32. 2+ signaling and calpains mediate renal cell death. Cell Death Differ 9:734-741.
33. Irving EA, Barone FC, Reith AD, Hadingham SJ, and Parsons AA (2000) Differential activation of MAPK/ERK and p38/SAPK in neurones and glia following focal cerebral ischaemia in the rat. Brain Res Mol Brain Res 77:65-75.
34. Ishikawa Y and Kitamura M (2000) Anti-apoptotic effect of quercetin: intervention in the JNK- and ERK-mediated apoptotic pathways. Kidney Int 58:1078-1087.
35. Jo SK, Cho WY, Sung SA, Kim HK, and Won NH (2005) MEK inhibitor, U0126, attenuates cisplatin-induced renal injury by decreasing inflammation and apoptosis. Kidney Int 67:458-466.
36. Kamakura S, Moriguchi T, and Nishida E (1999) Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus. J Biol Chem 274:26563-26571.
37. Kim GS, Hong JS, Kim SW, Koh JM, An CS, Choi JY, and Cheng SL (2003) Leptin induces apoptosis via ERK/cPLA2/cytochrome c pathway in human bone marrow stromal cells. J Biol Chem 278:21920-21929.
38. Kim R, Emi M, Tanabe K, Murakami S, Uchida Y, and Arihiro K (2006) Regulation and interplay of apoptotic and non-apoptotic cell death. J Pathol 208:319-326.
39. Kim YK, Kim HJ, Kwon CH, Kim JH, Woo JS, Jung JS, and Kim JM (2005) Role of ERK activation in cisplatin-induced apoptosis in OK renal epithelial cells. J Appl Toxicol 25:374-382.
40. Kohda Y, Hiramatsu J, and Gemba M (2003) Involvement of MEK/ERK pathway in cephaloridine-induced injury in rat renal cortical slices. Toxicol Lett 143:185-194.
41. Kohda Y, Kawai Y, Iwamoto N, Matsunaga Y, Aiga H, Awaya A, and Gemba M (2005) Serum thymic factor, FTS, attenuates cisplatin nephrotoxicity by suppressing cisplatin-induced ERK activation. Biochem Pharmacol 70:1408-1416.
42. Kulich SM and Chu CT (2001) Sustained extracellular signal-regulated kinase activation by 6-hydroxydopamine: implications for Parkinson's disease. J Neurochem 77:1058-1066.
43. Kyosseva SV (2004) Mitogen-activated protein kinase signaling. Int Rev Neurobiol 59:201-220.
44. Lee JS, Kim SY, Kwon CH, and Kim YK (2005) EGFR-dependent ERK activation triggers hydrogen peroxide-induced apoptosis in OK renal epithelial cells. Arch Toxicol 80:337-346.
45. Lee SR and Lo EH (2003) Interactions between p38 mitogen-activated protein kinase and caspase-3 in cerebral endothelial cell death after hypoxia-reoxygenation. Stroke 34:2704-2709.
46. Lesuisse C and Martin LJ (2002) Immature and mature cortical neurons engage different apoptotic mechanisms involving caspase-3 and the mitogen-activated protein kinase pathway. J Cereb Blood Flow Metab 22:935-950.
47. Leu JI, Dumont P, Hafey M, Murphy ME, and George DL (2004) Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat Cell Biol 6:443-450.
48. Li DW, Liu JP, Mao YW, Xiang H, Wang J, Ma WY, Dong Z, Pike HM, Brown RE, and Reed JC (2005) Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activation. Mol Biol Cell 16:4437-4453.
49. Li H, Zhu H, Xu CJ, and Yuan J (1998) Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94:491-501.
50. Liu X, Van Vleet T, and Schnellmann RG (2004) The role of calpain in oncotic cell death. Annu Rev Pharmacol Toxicol 44:349-370.
51. Magnuson NS, Beck T, Vahidi H, Hahn H, Smola U, and Rapp UR (1994) The Raf-1 serine/threonine protein kinase. Semin Cancer Biol 5:247-253.
52. Majno G and Joris I (1995) Apoptosis, oncosis, and necrosis. An overview of cell death. Am J Pathol 146:3-15.
53. Matsunaga Y, Kawai Y, Kohda Y, and Gemba M (2005) Involvement of activation of NADPH oxidase and extracellular signal-regulated kinase (ERK) in renal cell injury induced by zinc. J Toxicol Sci 30:135-144.
54. Medina MG, Ledesma MD, Dominguez JE, Medina M, Zafra D, Alameda F, Dotti CG, and Navarro P (2005) Tissue plasminogen activator mediates amyloid-induced neurotoxicity via Erk1/2 activation. EMBO (Eur Mol Biol Organ) J 24:1706-1716.
55. Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P, and Moll UM (2003) p53 has a direct apoptogenic role at the mitochondria. Mol Cell 11:577-590.
56. Miyajima A, Nakashima J, Yoshioka K, Tachibana M, Tazaki H, and Murai M (1997) Role of reactive oxygen species in cis-dichlorodiammineplatinum-induced cytotoxicity on bladder cancer cells. Br J Cancer 76:206-210.
57. Moll UM, Wolff S, Speidel D, and Deppert W (2005) Transcription- independent pro-apoptotic functions of p53. Curr Opin Cell Biol 17:631-636.
58. Mori T, Wang X, Jung JC, Sumii T, Singhal AB, Fini ME, Dixon CE, Alessandrini A, and Lo EH (2002) Mitogen-activated protein kinase inhibition in traumatic brain injury: in vitro and in vivo effects. J Cereb Blood Flow Metab 22:444-452.
59. Namura S, Iihara K, Takami S, Nagata I, Kikuchi H, Matsushita K, Moskowitz MA, Bonventre JV, and Alessandrini A (2001) Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia. Proc Natl Acad Sci USA 98:11569-11574.
60. + transport, and cisplatin-induced apoptosis in renal cells. J Biol Chem 277:43377-43388.
61. Park BG, Yoo CI, Kim HT, Kwon CH, and Kim YK (2005) Role of mitogen-activated protein kinases in hydrogen peroxide-induced cell death in osteoblastic cells. Toxicology 215:115-125.
62. Park KM, Chen A, and Bonventre JV (2001) Prevention of kidney ischemia/reperfusion-induced functional injury and JNK, p38, and MAPK kinase activation by remote ischemic pretreatment. J Biol Chem 276:11870-11876.
63. Pavlovic D, Andersen NA, Mandrup-Poulsen T, and Eizirik DL (2000) Activation of extracellular signal-regulated kinase (ERK)1/2 contributes to cytokine-induced apoptosis in purified rat pancreatic beta-cells. Eur Cytokine Netw 11:267-274.
64. Persons DL, Yazlovitskaya EM, and Pelling JC (2000) Effect of extracellular signal-regulated kinase on p53 accumulation in response to cisplatin. J Biol Chem 275:35778-35785.
65. Petros AM, Gunasekera A, Xu N, Olejniczak ET, and Fesik SW (2004) Defining the p53 DNA-binding domain/Bcl-xL-binding interface using NMR. FEBS Lett 559:171-174.
66. Peyssonnaux C and Eychene A (2001) The Raf/MEK/ERK pathway: new concepts of activation. Biol Cell 93:53-62.
67. Pi X, Yan C, and Berk BC (2004) Big mitogen-activated protein kinase (BMK1)/ERK5 protects endothelial cells from apoptosis. Circ Res 94:362-369.
68. Ramachandiran S, Huang Q, Dong J, Lau SS, and Monks TJ (2002) Mitogen-activated protein kinases contribute to reactive oxygen species-induced cell death in renal proximal tubule epithelial cells. Chem Res Toxicol 15:1635-1642.
69. Rennefahrt U, Janakiraman M, Ollinger R, and Troppmair J (2005) Stress kinase signaling in cancer: fact or fiction? Cancer Lett 217:1-9.
70. Roux PP and Blenis J (2004) ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev 68:320-344.
71. Runden E, Seglen PO, Haug FM, Ottersen OP, Wieloch T, Shamloo M, and Laake JH (1998) Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: evidence for a MAP kinase-dependent mechanism. J Neurosci 18:7296-7305.
72. Sasada T, Iwata S, Sato N, Kitaoka Y, Hirota K, Nakamura K, Nishiyama A, Taniguchi Y, Takabayashi A, and Yodoi J (1996) Redox control of resistance to cis-diamminedichloroplatinum (II) (CDDP): protective effect of human thioredoxin against CDDP-induced cytotoxicity. J Clin Investig 97:2268-2276.
73. Sinha D, Bannergee S, Schwartz JH, Lieberthal W, and Levine JS (2004) Inhibition of ligand-independent ERK1/2 activity in kidney proximal tubular cells deprived of soluble survival factors up-regulates Akt and prevents apoptosis. J Biol Chem 279:10962-10972.
74. Slevin M, Krupinski J, Slowik A, Rubio F, Szczudlik A, and Gaffney J (2000) Activation of MAP kinase (ERK-1/ERK-2), tyrosine kinase and VEGF in the human brain following acute ischaemic stroke. Neuroreport 11:2759-2764.
75. Strniskova M, Barancik M, and Ravingerova T (2002) Mitogen-activated protein kinases and their role in regulation of cellular processes. Gen Physiol Biophys 21:231-255.
76. Sturla LM, Cowan CW, Guenther L, Castellino RC, Kim JY, and Pomeroy SL (2005) A novel role for extracellular signal-regulated kinase 5 and myocyte enhancer factor 2 in medulloblastoma cell death. Cancer Res 65:5683-5689.
77. Subramaniam S, Strelau J, and Unsicker K (2003) Growth differentiation factor-15 prevents low potassium-induced cell death of cerebellar granule neurons by differential regulation of Akt and ERK pathways. J Biol Chem 278:8904-8912.
78. Subramaniam S, Zirrgiebel U, von Bohlen Und Halbach O, Strelau J, Laliberte C, Kaplan DR, and Unsicker K (2004) ERK activation promotes neuronal degeneration predominantly through plasma membrane damage and independently of caspase-3. J Cell Biol 165:357-369.
79. Sugino T, Nozaki K, Takagi Y, Hattori I, Hashimoto N, Moriguchi T, and Nishida E (2000) Activation of mitogen-activated protein kinases after transient forebrain ischemia in gerbil hippocampus. J Neurosci 20:4506-4514.
80. Suzaki Y, Yoshizumi M, Kagami S, Koyama AH, Taketani Y, Houchi H, Tsuchiya K, Takeda E, and Tamaki T (2002) Hydrogen peroxide stimulates c-Src-mediated big mitogen-activated protein kinase 1 (BMK1) and the MEF2C signaling pathway in PC12 cells: potential role in cell survival following oxidative insults. J Biol Chem 277:9614-9621.
81. Tikoo K, Lau SS, and Monks TJ (2001) Histone H3 phosphorylation is coupled to poly-(ADP-ribosylation) during reactive oxygen species-induced cell death in renal proximal tubular epithelial cells. Mol Pharmacol 60:394-402.
82. Ulisse S, Cinque B, Silvano G, Rucci N, Biordi L, Cifone MG, and D'Armiento M (2000) Erk-dependent cytosolic phospholipase A2 activity is induced by CD95 ligand cross-linking in the mouse derived Sertoli cell line TM4 and is required to trigger apoptosis in CD95 bearing cells. Cell Death Differ 7:916-924.
83. Vossler MR, Yao H, York RD, Pan MG, Rim CS, and Stork PJ (1997) cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway. Cell 89:73-82.
84. Wang X, Martindale JL, and Holbrook NJ (2000) Requirement for ERK activation in cisplatin-induced apoptosis. J Biol Chem 275:39435-39443.
85. Wang X, Wang H, Xu L, Rozanski DJ, Sugawara T, Chan PH, Trzaskos JM, and Feuerstein GZ (2003) Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis. J Pharmacol Exp Ther 304:172-178.
86. Wang ZQ, Chen XC, Yang GY, and Zhou LF (2004a) U0126 prevents ERK pathway phosphorylation and interleukin-1beta mRNA production after cerebral ischemia. Chin Med Sci J 19:270-275.
87. Wang ZQ, Wu DC, Huang FP, and Yang GY (2004b) Inhibition of MEK/ERK 1/2 pathway reduces pro-inflammatory cytokine interleukin-1 expression in focal cerebral ischemia. Brain Res 996:55-66.
88. Woessmann W, Chen X, and Borkhardt A (2002) Ras-mediated activation of ERK by cisplatin induces cell death independently of p53 in osteosarcoma and neuroblastoma cell lines. Cancer Chemother Pharmacol 50:397-404.
89. Wong JK, Le HH, Zsarnovszky A, and Belcher SM (2003) Estrogens and ICI182,780 (Faslodex) modulate mitosis and cell death in immature cerebellar neurons via rapid activation of p44/p42 mitogen-activated protein kinase. J Neurosci 23:4984-4995.
90. Wu Z, Wu LJ, Tashiro S, Onodera S, and Ikejima T (2005) Phosphorylated extracellular signal-regulated kinase up-regulated p53 expression in shikonin-induced HeLa cell apoptosis. Chin Med J (Engl) 118:671-677.
91. Yang JY, Michod D, Walicki J, and Widmann C (2004) Surviving the kiss of death. Biochem Pharmacol 68:1027-1031.
92. Yoon S and Seger R (2006) The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions. Growth Factors 24:21-44.
93. Yu SP (2003) Regulation and critical role of potassium homeostasis in apoptosis. Prog Neurobiol 70:363-386.
94. Yu SP, Canzoniero LM, and Choi DW (2001) Ion homeostasis and apoptosis. Curr Opin Cell Biol 13:405-411.
95. Zhou G, Bao ZQ, and Dixon JE (1995) Components of a new human protein kinase signal transduction pathway. J Biol Chem 270:12665-12669.