Involvement of activation of NADPH oxidase and extracellular signal-regulated kinase (ERK) in renal cell injury induced by zinc

Journal of Toxicological Sciences

Volumn 30, Issue 2, 2005, Pages 135-144

  Matsunaga, Yoshiko ^a   Kawai, Yoshiko ^a   Kohda, Yuka ^a   Gemba, Munekazu ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

ERK; NADPH oxidase; Nephrotoxicity; Oxidative stress; Renal epithelial cell; Zinc injury

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ANTIOXIDANT; DIPHENYLIODONIUM SALT; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N,N' DIPHENYL 1,4 PHENYLENEDIAMINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; ZINC;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOSOLIC FRACTION; DRUG INHIBITION; ENZYME ACTIVATION; KIDNEY EPITHELIUM; KIDNEY INJURY; KIDNEY PROXIMAL TUBULE; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PROTEIN PHOSPHORYLATION; SWINE;

ANIMALIA; SUS SCROFA;

EID: 20444427653     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.30.135     Document Type: Article

References (34)

1. Berg, J.M. and Shi, Y. (1996): The galvanization of biology: A growing appreciation for the roles of zinc. Science, 271, 1081-1085.
2. Brenner, A.J. and Harris, E.D. (1995): A quantitative test for copper using bicinchoninic acid. Anal. Biochem., 226, 80-84.
3. Celis, J.E. and Gromov, P. (2000): High-resolution two-dimensional gel electrophoresis and protein indentification using western blotting and ECL detection. EXS., 88, 55-67.
4. Choi, D.W. and Koh, J.Y. (1998): Zinc and brain injury. Annu. Rev. Neurosci., 21, 347-375.
5. Cui, X.L. and Douglas, J.G. (1997): Arachidonic acid activates c-jun N-terminal kinase through NADPH oxidase in rabbit proximal tubular epithelial cells. Proc. Natl. Acad. Sci. U.S.A., 94, 3771-3776.
6. Derkinderen, P., Enslen, H. and Girault, J.A. (1999): The ERK/MAP-kinases cascade in the nervous system. Neuroreport, 10, R24-34.
7. Gad, S. and Weil, C.W. (1986): Statistics and experimental design for toxicologists. The Telford Press Inc., New Jersey, U.S.A., 86, 18.
8. Goering, P.L., Morgan, D.L. and Ali, S.F. (2002): Effects of mercury vapor inhalation on reactive oxygen species and antioxidant enzymes in rat brain and kidney are minimal. J. Appl. Toxicol., 22, 167-172.
9. Grummt, F., Weinmann-Dorsch, C., Schneider-Schaulies, J. and Lux, A. (1986): Zinc as a second messenger of mitogenic induction. Effects on diadenosine tetraphosphate (Ap4A) and DNA synthesis. Exp. Cell Res., 163, 191-200.
10. 2+ signaling via NADPH oxidase and diacylglycerol-sensitive protein kinase C isozymes in mesangial cells. J. Biol. Chem., 278, 33951-33962.
11. 2+ entry produces oxidative neuronal necrosis in cortical cell cultures. Eur. J. Neurosci., 11, 327-334.
12. Kim, Y.H., Kim, E.Y., Gwag, B.J., Sohn, S. and Koh, J.Y. (1999): Zinc-induced cortical neuronal death with features apoptosis and necrosis: Mediation by free radicals. Neuroscience, 89, 175-182.
13. Kim, Y.H. and Koh, J.Y. (2002): The role of NADPH oxidase and neuronal nitric oxide synthase in zinc-induced poly (ADP-ribose) polymerase activation and cell death in cortical culture. Exp. Neurol., 177, 407-418.
14. Kohda, Y., Hiramatsu, J. and Gemba, M. (2003): Involvement of MEK/ERK pathway in cephaloridine-induced injury in rat renal cortical slices. Toxicol. Lett., 143, 185-194.
15. Liu, S.X., Athar, M., Lippai, I., Waldren, C. and Hei, T.K. (2001): Induction of oxyradicals by arsenic: Implication for mechanism of genotoxicity. Proc. Natl. Acad. Sci. U.S.A., 98, 1643-1648.
16. Lobner, D., Gottron, F., Ying, H., Tian, M. and Dugan, L.L. (1997): Zinc-induced neuronal apoptosis or necrosis in cortical cell culture. Soc. Neurosci. Abstr., 23, 2255.
17. Mahadev, K., Zilbering, A., Zhu, L. and Goldstein, B.J. (2001): Insulin-stimulated hydrogen peroxide reversibly inhibits protein-tyrosine phosphatase 1b in vivo and enhances the early insulin action cascade. J. Biol. Chem., 276, 21938-21942.
18. Manev, H., Kharlamov, E., Uz, T., Mason, R.P. and Cagnoli, C.M. (1997): Characterization of zinc-induced neuronal death in primary cultures of rat cerebellar granule cells.Exp.Neurol., 146, 171-178.
19. McCabe, M.J.Jr., Jiang, S.A. and Orrenius, S. (1993): Chelation of intracellular zinc triggers apoptosis in mature thymocytes. Lab. Invest., 69, 101-110.
20. Midwinter, R.G., Vissers, M.C. and Winterbourn, C.C. (2001): Hypochlorous acid stimulation of the mitogen-activated protein kinase pathway enhances cell survival. Arch. Biochem. Biophys., 394, 13-20.
21. Noh, K.M. and Koh, J.Y. (2000): Induction and activation by zinc of NADPH oxidase in cultured cortical neurons and astrocytes. J. Neurosci., 20, RC111.
22. Petrie, L., Chesters, J.K. and Franklin, M. (1991): Inhibition of myoblast differentiation by lack of zinc. Biochem. J., 276, 109-111.
23. Powner, D.J., Hodgkin, M.N. and Wakelam, M.J. (2002): Antigen-stimulated activation of phospholipase D1b by Rac1, ARF6, and PKCalpha in RBL-2H3 cells. Mol. Biol. Cell, 13, 1252-1262.
24. Ramachandiran, S., Huang, Q., Dong, J., Lau, S.S. and Monks, T.J. (2002): Mitogen-activated protein kinases contribute to reactive oxygen species-induced cell death in renal proximal tubule epithelial cells. Chem. Res. Toxicol., 15, 1635-1642.
25. Ryu, R., Shin, Y., Choi, J.W., Min, W., Ryu, H., Choi, C.R. and Ko, H. (2002): Depletion of intracellular glutathione mediates zinc-induced cell death in rat primary astrocytes. Exp. Brain Res., 143, 257-263.
26. Schmidt, C. and Beyersmann, D. (1999): Transient peaks in zinc and metallothionein levels during differentiation of 3T3L1 cells. Arch. Biochem. Biophys., 364, 91-98.
27. 2+-induced ERK activation mediated by reactive oxygen species causes cell death in differentiated PC12 cells. J. Neurochem., 78, 600-610.
28. Sinha, D., Bannergee, S., Schwartz, J.H., Lieberthal, W. and Levine, J.S. (2003): Inhibition of ligand-independent ERK1/2 activity in kidney proximal tubular cells deprived of soluble survival factors upregulates Akt and prevents apoptosis. J. Biol. Chem., 279, 10962-10972.
29. Sunderman, F.W. Jr. (1995): The influence of zinc on apoptosis. Ann. Clin. Lab. Sci., 25, 134-142.
30. Thevenod, F. (2003): Nephrotoxicity and the proximal tubule. Insights from cadmium. Nephron Physiol., 93, 87-93.
31. Ubezio, P. and Civoli, F. (1994): Flow cytometric detection of hydrogen peroxide production induced by doxorubicin in cancer cells. Free Radic. Biol. Med., 16, 509-516.
32. Vallee, B.L. and Falchuk, K.H. (1993): The biochemical basis of zinc physiology. Physiol. Rev., 73, 79-118.
33. West, N., Guzik, T., Black, E. and Channon, K. (2001): Enhanced superoxide production in experimental venous bypass graft intimal hyperplasia: Role of NAD (P) H oxidase. Arterioscler. Thromb. Vasc. Biol., 21, 189-194.
34. Zoja, C., Donadelli, R., Colleoni, S., Figliuzzi, M., Bonazzola, S., Morigi, M. and Remuzzi, G. (1998): Protein overload stimulates RANTES production by proximal tubular cells depending on NF-kappa B activation. Kidney Int., 53, 1608-1615.