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Volumn 18, Issue 18, 1998, Pages 7296-7305

Regional selective neuronal degeneration after protein phosphatase inhibition in hippocampal slice cultures: Evidence for a MAP kinase-dependent mechanism

Author keywords

Apoptosis; CA3; Cytoskeleton; Electron microscopy; ERK1 2; Fluorescence microscopy; Genistein; H7; Image analysis; K 252a; KN 93; KN 04; KN 62; KN 92; KT5926; MAP kinase; MEK1 2; Naringin; Nonapoptotic cell death; Okadaic acid; P44 42 MAP kinase; PD98059; Propidium iodide; Staurosporine

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; K 252A; KT 5926; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE (CALCIUM,CALMODULIN) II; PROTEIN KINASE C;

EID: 0032530577     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-18-07296.1998     Document Type: Article
Times cited : (160)

References (27)
  • 1
    • 0028884033 scopus 로고
    • PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
    • Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR (1995) PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 270:27489-27494.
    • (1995) J Biol Chem , vol.270 , pp. 27489-27494
    • Alessi, D.R.1    Cuenda, A.2    Cohen, P.3    Dudley, D.T.4    Saltiel, A.R.5
  • 2
    • 0030574021 scopus 로고    scopus 로고
    • Calcineurin and mitochondrial function in glutamate-induced neuronal cell death
    • Ankarcrona M, Dypbukt JM.Orrenius S, Nicotera P (1996) Calcineurin and mitochondrial function in glutamate-induced neuronal cell death. FEES Lett 394:321-324.
    • (1996) FEES Lett , vol.394 , pp. 321-324
    • Ankarcrona, M.1    Dypbukt, J.M.2    Orrenius, S.3    Nicotera, P.4
  • 3
    • 0029066704 scopus 로고
    • Increased expression and subcellular translocation of the mitogen-activated protein kinase kinase and mitogen-activated protein kinase in Alzheimer's disease
    • Arendt T, Holzer M, Grossmann A, Zedlick D, Bruckner MK (1995) Increased expression and subcellular translocation of the mitogen-activated protein kinase kinase and mitogen-activated protein kinase in Alzheimer's disease. Neuroscience 68:5-18.
    • (1995) Neuroscience , vol.68 , pp. 5-18
    • Arendt, T.1    Holzer, M.2    Grossmann, A.3    Zedlick, D.4    Bruckner, M.K.5
  • 5
    • 0031007546 scopus 로고    scopus 로고
    • Regulated phosphorylation and dephosphorylation of tau protein: Effects on microtubule interaction, intracellular trafficking and neurodegeneration
    • Billingsley ML, Kincaid RL (1997) Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration. Biochem J 323: 577-591.
    • (1997) Biochem J , vol.323 , pp. 577-591
    • Billingsley, M.L.1    Kincaid, R.L.2
  • 6
    • 0026949225 scopus 로고
    • Evidence that MAP (mitogen-activated protein) kinase activation may be a necessary but not sufficient signal for a restricted subset of responses in IL-1-treated epidermoid cells
    • Bird TA, Schule HD, Delaney PB, Sims JE, Thoma B, Dower SK (1992) Evidence that MAP (mitogen-activated protein) kinase activation may be a necessary but not sufficient signal for a restricted subset of responses in IL-1-treated epidermoid cells. Cytokine 4:429-440.
    • (1992) Cytokine , vol.4 , pp. 429-440
    • Bird, T.A.1    Schule, H.D.2    Delaney, P.B.3    Sims, J.E.4    Thoma, B.5    Dower, S.K.6
  • 7
    • 0029077946 scopus 로고
    • Disruption of the cytokeratin cytoskeleton and inhibition of hepatocytic autophagy by okadaic acid
    • Blankson H, Holen I, Seglen PO (1995) Disruption of the cytokeratin cytoskeleton and inhibition of hepatocytic autophagy by okadaic acid. Exp Cell Res 218:522-530.
    • (1995) Exp Cell Res , vol.218 , pp. 522-530
    • Blankson, H.1    Holen, I.2    Seglen, P.O.3
  • 8
    • 0029925968 scopus 로고    scopus 로고
    • Site-specific regulation of Alzheimer-like tau phosphorylation in living neurons
    • Burack MA, Halpain S (1996) Site-specific regulation of Alzheimer-like tau phosphorylation in living neurons. Neuroscience 72:167-184.
    • (1996) Neuroscience , vol.72 , pp. 167-184
    • Burack, M.A.1    Halpain, S.2
  • 9
    • 0000591486 scopus 로고    scopus 로고
    • Protective action of isoquinolinesulfonamides in in vitro models of neuronal apoptosis
    • Cagnoli CM, Atabay C, Manev H (1996a) Protective action of isoquinolinesulfonamides in in vitro models of neuronal apoptosis. Life Sci 58:L295-L301.
    • (1996) Life Sci , vol.58
    • Cagnoli, C.M.1    Atabay, C.2    Manev, H.3
  • 10
    • 0030093869 scopus 로고    scopus 로고
    • Apoptosis induced in neuronal cultures by either the phosphatase inhibitor okadaic acid or the kinase inhibitor staurosporine is attenuated by isoquinolinesulfonamides H-7, H-8, and H-9
    • Cagnoli CM, K harlamov E, Atabay C, Uz T, Manev H (1996b) Apoptosis induced in neuronal cultures by either the phosphatase inhibitor okadaic acid or the kinase inhibitor staurosporine is attenuated by isoquinolinesulfonamides H-7, H-8, and H-9. J Mol Neurosci 7:65-76.
    • (1996) J Mol Neurosci , vol.7 , pp. 65-76
    • Cagnoli, C.M.1    Kharlamov, E.2    Atabay, C.3    Uz, T.4    Manev, H.5
  • 11
    • 0026730122 scopus 로고
    • Tyrosine phosphorylation of microtubule-associated protein kinase after transient ischemia in the gerbil brain
    • Campos-Gonzalez R, Kindy MS (1992) Tyrosine phosphorylation of microtubule-associated protein kinase after transient ischemia in the gerbil brain. J Neurochem 59:1955-1958.
    • (1992) J Neurochem , vol.59 , pp. 1955-1958
    • Campos-Gonzalez, R.1    Kindy, M.S.2
  • 12
    • 0026761765 scopus 로고
    • Pathological phosphorylation causes neuronal death: Effect of okadaic acid in primary culture of cerebellar granule cells
    • Candeo P, Favaron M, Lengyel I, Manev RM, Rimland JM, Manev H (1992) Pathological phosphorylation causes neuronal death: effect of okadaic acid in primary culture of cerebellar granule cells. J Neurochem 59:1558-1561.
    • (1992) J Neurochem , vol.59 , pp. 1558-1561
    • Candeo, P.1    Favaron, M.2    Lengyel, I.3    Manev, R.M.4    Rimland, J.M.5    Manev, H.6
  • 13
    • 0027437604 scopus 로고
    • Time course of the translocation and inhibition of protein kinase C during complete cerebral ischemia in the rat
    • Cardell M, Wieloch T (1993) Time course of the translocation and inhibition of protein kinase C during complete cerebral ischemia in the rat. J Neurochem 61:1308-1314.
    • (1993) J Neurochem , vol.61 , pp. 1308-1314
    • Cardell, M.1    Wieloch, T.2
  • 14
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME (1997) Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231-241.
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6    Greenberg, M.E.7
  • 15
    • 0030297475 scopus 로고    scopus 로고
    • Differential sensitivity of normal and H-ras oncogene-transformed rat kidney epithelial cells to okadaic acid-induced apoptosis
    • Davis MA, Chang SH, Trump BF (1996) Differential sensitivity of normal and H-ras oncogene-transformed rat kidney epithelial cells to okadaic acid-induced apoptosis. Toxicol Appl Pharmacol 141:93-101.
    • (1996) Toxicol Appl Pharmacol , vol.141 , pp. 93-101
    • Davis, M.A.1    Chang, S.H.2    Trump, B.F.3
  • 16
    • 0029761702 scopus 로고    scopus 로고
    • Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: The potential for multiplex signalling
    • Denhardt DT (1996) Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signalling. Biochem J 318:729-747.
    • (1996) Biochem J , vol.318 , pp. 729-747
    • Denhardt, D.T.1
  • 19
    • 0030602178 scopus 로고    scopus 로고
    • Inhibition of protein phosphatases induces IGF-1-blocked neurotrophin-insensitive neuronal apoptosis
    • Fernández-Sánchez MT, García-Rodríguez A, Díaz-Trelles R, Novelli A (1996) Inhibition of protein phosphatases induces IGF-1-blocked neurotrophin-insensitive neuronal apoptosis. FEES Lett 398:106-112.
    • (1996) FEES Lett , vol.398 , pp. 106-112
    • Fernández-Sánchez, M.T.1    García-Rodríguez, A.2    Díaz-Trelles, R.3    Novelli, A.4
  • 20
    • 0030879686 scopus 로고    scopus 로고
    • Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar Aβ
    • Ferreira A, Lu Q, Orecchio L, Kosik KS (1997) Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar Aβ. Mol Cell Neurosci 9:220-234.
    • (1997) Mol Cell Neurosci , vol.9 , pp. 220-234
    • Ferreira, A.1    Lu, Q.2    Orecchio, L.3    Kosik, K.S.4
  • 21
    • 0023795276 scopus 로고
    • Organotypic cultures of neural tissue
    • Gähwiler BH (1988) Organotypic cultures of neural tissue. Trends Neurosci 11:484-489.
    • (1988) Trends Neurosci , vol.11 , pp. 484-489
    • Gähwiler, B.H.1
  • 22
    • 0028917372 scopus 로고
    • Nitric oxide signaling in the central nervous system
    • Garthwaite J, Boulton CL (1995) Nitric oxide signaling in the central nervous system. Annu Rev Physiol 57:683-706.
    • (1995) Annu Rev Physiol , vol.57 , pp. 683-706
    • Garthwaite, J.1    Boulton, C.L.2
  • 23
    • 85062139768 scopus 로고
    • Tau phosphorylation in brain slices: Pharmacological evidence for convergent effects of protein phosphatases on tau and mitogen-activated protein kinase
    • Garver TD, Oyler GA, Harris KA, Polavarapu R, Damuni Z, Lehman RA, Billingsley ML (1995) Tau phosphorylation in brain slices: pharmacological evidence for convergent effects of protein phosphatases on tau and mitogen-activated protein kinase. Mol Pharmacol 47:745-756.
    • (1995) Mol Pharmacol , vol.47 , pp. 745-756
    • Garver, T.D.1    Oyler, G.A.2    Harris, K.A.3    Polavarapu, R.4    Damuni, Z.5    Lehman, R.A.6    Billingsley, M.L.7
  • 24
    • 0029874980 scopus 로고    scopus 로고
    • Microtubule assembly competence analysis of freshly-biopsied human tau, dephosphorylated tau, and Alzheimer tau
    • Garver TD, Lehman RA, Billingsley ML (1996) Microtubule assembly competence analysis of freshly-biopsied human tau, dephosphorylated tau, and Alzheimer tau. J Neurosci Res 44:12-20.
    • (1996) J Neurosci Res , vol.44 , pp. 12-20
    • Garver, T.D.1    Lehman, R.A.2    Billingsley, M.L.3
  • 26
    • 0028957045 scopus 로고
    • Protection by naringin and some other flavonoids of hepatocytic autophagy and endocytosis against inhibition by okadaic acid
    • Gordon PB, Holen I, Seglen PO (1995) Protection by naringin and some other flavonoids of hepatocytic autophagy and endocytosis against inhibition by okadaic acid. J Biol Chem 270:5830-5838.
    • (1995) J Biol Chem , vol.270 , pp. 5830-5838
    • Gordon, P.B.1    Holen, I.2    Seglen, P.O.3
  • 27
    • 0029018851 scopus 로고
    • Secreted beta-APP stimulates MAP kinase and phosphorylation of tau in neurons
    • Greenberg SM, Kosik KS (1995) Secreted beta-APP stimulates MAP kinase and phosphorylation of tau in neurons. Neurobiol Aging 16:403-407.
    • (1995) Neurobiol Aging , vol.16 , pp. 403-407
    • Greenberg, S.M.1    Kosik, K.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.