Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: Exploration of potential mechanism associated with apoptosis

Journal of Pharmacology and Experimental Therapeutics

Volumn 304, Issue 1, 2003, Pages 172-178

  Wang, Xinkang ^a   Wang, Hugh ^a   Xu, Lin ^a   Rozanski, Dennis J ^a   Sugawara, Taku ^b   Chan, Pak H ^b   Trzaskos, James M ^a   Feuerstein, Giora Z ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 8; CYTOCHROME C; DNA FRAGMENT; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PROTEIN KINASE;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INFARCTION; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; DOSE RESPONSE; ENZYME INHIBITION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY; WESTERN BLOTTING;

AMINOACETONITRILE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BRAIN INFARCTION; BRAIN ISCHEMIA; CASPASE 3; CASPASES; CYTOCHROME C GROUP; DNA FRAGMENTATION; ENZYME INHIBITORS; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MAP KINASE KINASE 1; MICE; MICE, INBRED C57BL; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MUSCULOSKELETAL EQUILIBRIUM; NEUROPROTECTIVE AGENTS; PHOSPHORYLATION; PROTEASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; REPERFUSION INJURY;

EID: 0037216665     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.040246     Document Type: Article

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