Regulation and critical role of potassium homeostasis in apoptosis

Progress in Neurobiology

Volumn 70, Issue 4, 2003, Pages 363-386

  Yu, Shan Ping ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM); AMPHOTERICIN B; ANTIARRHYTHMIC AGENT; ANTIOXIDANT; BUMETANIDE; CALCIUM; CARBOPLATIN; CASPASE; CISPLATIN; CYTOCHROME C; DIAZOXIDE; ENDONUCLEASE; GLIBENCLAMIDE; ION; IONOTROPIC RECEPTOR; LEVOCROMAKALIM; PINACIDIL; POTASSIUM; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL STIMULATING AGENT; POTASSIUM ION; PROTEIN; PYRUVIC ACID; SODIUM ION; SUCCINIC ACID; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ACETYLCHOLINE RELEASE; ALZHEIMER DISEASE; APOPTOSIS; ATTENUATION; BRAIN ISCHEMIA; CALCIUM CELL LEVEL; CALCIUM DEPLETION; CALCIUM TRANSPORT; CANCER THERAPY; CARCINOGENESIS; CARDIOVASCULAR DISEASE; CELL DEATH; CELL LOSS; CELL MEMBRANE; CELL PROLIFERATION; CELL TYPE; CLINICAL TRIAL; CONCENTRATION (PARAMETERS); DEMYELINATING DISEASE; DEPOLARIZATION; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; ENZYME ACTIVATION; HEART ARRHYTHMIA; HEART ATRIUM FIBRILLATION; HEART MUSCLE ISCHEMIA; HEART VENTRICLE TACHYCARDIA; HOMEOSTASIS; HUMAN; HYBRID CELL; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MODULATION; MOLECULAR MECHANICS; MULTIPLE SCLEROSIS; MYASTHENIA GRAVIS; NONHUMAN; PERMEABILITY; POTASSIUM CELL LEVEL; POTASSIUM DEPLETION; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTECTION; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; REGULATORY MECHANISM; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SPINAL CORD INJURY; TREATMENT INDICATION;

EID: 0042829363     PISSN: 03010082     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-0082(03)00090-X     Document Type: Review

References (303)

1. Abdul M., Hoosein N. Expression and activity of potassium ion channels in human prostate cancer. Cancer Lett. 186:2002;99.
2. Abele A.E., Miller R.J. Potassium channel activators abolish excitotoxicity in cultured hippocampal pyramidal neurons. Neurosci. Lett. 115:1990;195-200.
3. Adams J.M., Cory S. Apoptosomes: engines for caspase activation. Curr. Opin. Cell Biol. 14:2002;715-720.
4. Akao M., Ohler A., O'Rourke B., Marban E. Mitochondrial ATP-sensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells. Circ. Res. 88:2001;1267-1275.
5. Albano J., Bhoola K.D., Kingsley G. The control of cyclic GMP by calcium, ionophore A23187, potassium and acetycholine in enzyme-secreting pancreatic slices. J. Physiol. (Lond.). 267:1977;35P-36P.
6. Allbritton N.L., Verret C.R., Wolley R.C., Eisen H.N. Calcium ion concentrations and DNA fragmentation in target cell destruction by murine cloned cytotoxic T lymphocytes. J. Exp. Med. 167:1988;514-527.
7. Anderson P. Kinase cascades regulating entry into apoptosis. Microbiol. Mol. Biol. Rev. 61:1997;33-46.
8. Ankarcrona M., Dypbukt J.M., Bonfoco E., Zhivotovsky B., Orrenius S., Lipton S.A., Nicotera P. Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron. 15:1995;961-973.
9. Antonsson B., Conti F., Ciavatta A., Montessuit S., Lewis S., Martinou I., Bernasconi L., Bernard A., Mermod J.J., Mazzei G., Maundrell K., Gambale F., Sadoul R., Martinou J.C. Inhibition of Bax channel-forming activity by Bcl-2. Science. 277:1997;370-372.
10. Anwyl R. Permeability of the post-synaptic membrane of an excitatory glutamate synapse to sodium and potassium. J. Physiol. (Lond.). 273:1977;367-388.
11. + contents of synaptosomes by ouabain. Nature. 252:1974;595-596.
12. Ascher P., Nowak L. The role of divalent cations in the N-methyl-D-aspartate responses of mouse central neurones in culture. J. Physiol. (Lond.). 399:1988;247-266.
13. Ascher P., Bregestovski P., Nowak L. N-Methyl-D-aspartate-activated channels of mouse central neurones in magnesium-free solutions. J. Physiol. (Lond.). 399:1988;207-226.
14. + channels. Proc. Natl. Acad. Sci. U.S.A. 95:1998;11703-11708.
15. Baczko I., Lepran I., Papp J.G. KATP channel modulators increase survival rate during coronary occlusion-reperfusion in anaesthetized rats. Eur. J. Pharmacol. 324:1997;77-83.
16. Bajgar R., Seetharaman S., Kowaltowski A.J., Garlid K.D., Paucek P. Identification and properties of a novel intracellular (mitochondrial) ATP-sensitive potassium channel in brain. J. Biol. Chem. 276:2001;33369-33374.
17. Balakirev M.Y., Zimmer G. Gradual changes in permeability of inner mitochondrial membrane precede the mitochondrial permeability transition. Arch. Biochem. Biophys. 356:1998;46-54.
18. Barbiero G., Duranti F., Bonelli G., Amenta J.S., Baccino F.M. Intracellular ionic variations in the apoptotic death of L cells by inhibitors of cell cycle progression. Exp. Cell Res. 217:1995;410-418.
19. + channels. J. Leukoc. Biol. 57:1995;851-855.
20. Bennett M.R., White W. The survival and development of cholinergic neurons in potassium-enriched media. Brain Res. 173:1979;549-553.
21. Benson R.S., Heer S., Dive C., Watson A.J. Characterization of cell volume loss in CEM-C7A cells during dexamethasone-induced apoptosis. Am. J. Physiol. 270:1996;C1190-C1203.
22. Bernardi P. Mitochondrial transport of cations: channels, exchangers, and permeability transition. Physiol. Rev. 79:1999;1127-1155.
23. Bernardi P., Vassanelli S., Veronese P., Colonna R., Szabo I., Zoratti M. Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations. J. Biol. Chem. 267:1992;2934-2939.
24. + in HeLa cells. FEBS Lett. 424:1998;221-224.
25. Blight A.R., Toombs J.P., Bauer M.S., Widmer W.R. The effects of 4-aminopyridine on neurological deficits in chronic cases of traumatic spinal cord injury in dogs: a phase I clinical trial. J. Neurotrauma. 8:1991;103-119.
26. Bock J., Szabo I., Jekle A., Gulbins E. Actinomycin D-induced apoptosis involves the potassium channel Kv1.3. Biochem. Biophys. Res. Commun. 295:2002;526-531.
27. Bortner C.D., Cidlowski J.A. A necessary role for cell shrinkage in apoptosis. Biochem. Pharmacol. 56:1998;1549-1559.
28. +, cell shrinkage, and mitochondrial membrane potential during lymphocyte apoptosis. J. Biol. Chem. 274:1999;21953-21962.
29. + efflux in the activation of apoptosis. J. Biol. Chem. 272:1997;32436-32442.
30. Bortner C.D., Gomez-Angelats M., Cidlowski J.A. Plasma membrane depolarization without repolarization is an early molecular event in anti-Fas-induced apoptosis. J. Biol. Chem. 276:2001;4304-4314.
31. Borzak S., Al-Khaled N., Douthat L., Steinberg M., Goldberg A.D. Intravenous clofilium for conversion of atrial fibrillation. Am. J. Cardiol. 79:1997;94-97.
32. Budd S.L., Lipton S.A. Signaling events in NMDA receptor-induced apoptosis in cerebrocortical cultures. Ann. N. Y. Acad. Sci. 893:1999;261-264.
33. Buhrle C.P., Sonnhof U. The ionic mechanism of the excitatory action of glutamate upon the membranes of motoneurones of the frog. Pflugers Arch. 396:1983;154-162.
34. Burnashev N., Schoepfer R., Monyer H., Ruppersberg J.P., Gunther W., Seeburg P.H., Sakmann B. Control by asparagine residues of calcium permeability and magnesium blockade in the NMDA receptor. Science. 257:1992;1415-1419.
35. Cahn F., Lubin M. Inhibition of elongation steps of protein synthesis at reduced potassium concentrations in reticulocytes and reticulocyte lysate. J. Biol. Chem. 253:1978;7798-7803.
36. Chang H., Ciani S., Kidokoro Y. Ion permeation properties of the glutamate receptor channel in cultured embryonic Drosophila myotubes. J. Physiol. (Lond.). 476:1994;1-16.
37. Chen G.Q., Cui C., Mayer M.L., Gouaux E. Functional characterization of a potassium-selective prokaryotic glutamate receptor. Nature. 402:1999;817-821.
38. Chien M.M., Zahradka K.E., Newell M.K., Freed J.H. Fas-induced B cell apoptosis requires an increase in free cytosolic magnesium as an early event. J. Biol. Chem. 274:1999;7059-7066.
39. + channel in malignant astrocytoma cell lines. J. Neurosci. Res. 48:1997;122-127.
40. Chiu S.Y., Wilson G.F. The role of potassium channels in Schwann cell proliferation in Wallerian degeneration of explant rabbit sciatic nerves. J. Physiol. (Lond.). 408:1989;199-222.
41. Choi D.W. Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. Trends Neurosci. 11:1988a;465-469.
42. Choi D.W. Glutamate neurotoxicity and diseases of the nervous system. Neuron. 1:1988b;623-634.
43. Choi D.W. Excitotoxic cell death. J. Neurobiol. 23:1992;1261-1276.
44. Choi D.W., Yu S.P., Wei L. Potassium channel blockers attenuate neuronal deaths induced by hypoxic insults in cortical culture and by transient focal ischemia in the rat. Soc. Neurosci. Abstr. 24:1998;1226.
45. Choi B.Y., Kim H.Y., Lee K.H., Cho Y.H., Kong G. Clofilium, a potassium channel blocker, induces apoptosis of human promyelocytic leukemia (HL-60) cells via Bcl-2-insensitive activation of caspase-3. Cancer Lett. 147:1999;85-93.
46. Chvatal A., Anderova M., Ziak D., Sykova E. Glial depolarization evokes a larger potassium accumulation around oligodendrocytes than around astrocytes in gray matter of rat spinal cord slices. J. Neurosci. Res. 56:1999;493-505.
47. + pump in skeletal muscle: quantification, regulation and functional significance. Acta Physiol. Scand. 156:1996;227-235.
48. Collins F., Schmidt M.F., Guthrie P.B., Kater S.B. Sustained increase in intracellular calcium promotes neuronal survival. J. Neurosci. 11:1991;2582-2587.
49. Colom L.V., Diaz M.E., Beers D.R., Neely A., Xie W.J., Appel S.H. Role of potassium channels in amyloid-induced cell death. J. Neurochem. 70:1998;1925-1934.
50. + channel expression in brain during experimental cancer cachexia. FEBS Lett. 536:2003;45-50.
51. Cone C.D. Jr., Cone C.M. Induction of mitosis in mature neurons in central nervous system by sustained depolarization. Science. 192:1976;155-158.
52. Cornelius F., Mahmmoud Y.A., Christensen H.R. Modulation of Na, K-ATPase by associated small transmembrane regulatory proteins and by lipids. J. Bioenerg. Biomembr. 33:2001;415-423.
53. Cowan A.I., Martin R.L. Ionic basis of membrane potential changes induced by anoxia in rat dorsal vagal motoneurones. J. Physiol. (Lond.). 455:1992;89-109.
54. Crompton M. The mitochondrial permeability transition pore and its role in cell death. Biochem. J. 341:1999;233-249.
55. Dallaporta B., Hirsch T., Susin S.A., Zamzami N., Larochette N., Brenner C., Marzo I., Kroemer G. Potassium leakage during the apoptotic degradation phase. J. Immunol. 160:1998;5605-5615.
56. Dallaporta B., Marchetti P., de Pablo M.A., Maisse C., Duc H.T., Metivier D., Zamzami N., Geuskens M., Kroemer G. Plasma membrane potential in thymocyte apoptosis. J. Immunol. 162:1999;6534-6542.
57. Daniels M., Brown D.R. High extracellular potassium protects against the toxicity of cytosine arabinoside but is not required for the survival of cerebellar granule cells in vitro. Mol. Cell. Neurosci. 19:2002;281-291.
58. Deckers C.L., Lyons A.B., Samuel K., Sanderson A., Maddy A.H. Alternative pathways of apoptosis induced by methylprednisolone and valinomycin analyzed by flow cytometry. Exp. Cell Res. 208:1993;362-370.
59. + channels in human T lymphocytes: a role in mitogenesis? Nature. 307:1984;465-468.
60. Dekin M.S. Permeability changes induced by L-glutamate at the crayfish neuromuscular junction. J. Physiol. (Lond.). 341:1983;105-125.
61. de Luca A., Weller M., Fontana A. TGF-beta-induced apoptosis of cerebellar granule neurons is prevented by depolarization. J. Neurosci. 16:1996;4174-4185.
62. Diem R., Meyer R., Weishaupt J.H., Bahr M. Reduction of potassium currents and phosphatidylinositol 3-kinase-dependent AKT phosphorylation by tumor necrosis factor-α rescues axotomized retinal ganglion cells from retrograde cell death in vivo. J. Neurosci. 21:2001;2058-2066.
63. DiPolo R., Beauge L. Regulation of Na-Ca exchange. An overview. Ann. N. Y. Acad. Sci. 639:1991;100-111.
64. + transport with a 53 kilodalton mitochondrial protein. Biochem. Biophys. Res. Commun. 153:1988;224-230.
65. Dobretsov M., Stimers J.R. Characterization of the Na/K pump current in N20.1 oligodendrocytes. Brain Res. 724:1996;103-111.
66. + channel protects the ischemic heart. Am. J. Physiol. Heart Circ. Physiol. 283:2002;H284-H295.
67. Du C., Hu R., Csernansky C.A., Hsu C.Y., Choi D.W. Very delayed infarction after mild focal cerebral ischemia: a role for apoptosis? J. Cereb. Blood Flow Metab. 16:1996;195-201.
68. Duff H.J., Mitchell L.B., Wyse D.G., Gillis A.M., Sheldon R.S. Mexiletine/quinidine combination therapy: electrophysiologic correlates of anti-arrhythmic efficacy. Clin. Invest. Med. 14:1991;476-483.
69. Duggan P.F. An enzyme system requiring magnesium, calcium and potassium ions. Proc. R. Ir. Acad. B. 77:1977;449-455.
70. Duke R.C., Witter R.Z., Nash P.B., Young J.D., Ojcius D.M. Cytolysis mediated by ionophores and pore-forming agents: role of intracellular calcium in apoptosis. FASEB J. 8:1994;237-246.
71. + pump by tetraethylammonium. Biochim. Biophys. Acta. 1372:1998;289-300.
72. Edwards G., Weston A.H. Pharmacology of the potassium channel openers. Cardiovasc. Drugs Ther. 9(Suppl. 2):1995;185-193.
73. Eggleston T.L.V., Krebs H. The role of glutamic acid in the transport of potassium in brain and retina. J. Physiol. (Lond.). 47:1950;139-149.
74. Eliseev R.A., Salter J.D., Gunter K.K., Gunter T.E. Bcl-2 and tBid proteins counter-regulate mitochondrial potassium transport. Biochim. Biophys. Acta. 1604:2003;1-5.
75. Elliott J.I., Higgins C.F. IKCa1 activity is required for cell shrinkage, phosphatidylserine translocation and death in T lymphocyte apoptosis. EMBO Rep. 4:2003;189-194.
76. + channel activity and enhances survival in vascular smooth muscle cells. Am. J. Physiol. Cell Physiol. 281:2001;C157-C165.
77. Enokido Y., Hatanaka H. Apoptotic cell death occurs in hippocampal neurons cultured in a high oxygen atmosphere. Neuroscience. 57:1993;965-972.
78. Evan G., Harrington E., Fanidi A., Land H., Amati B., Bennett M. Integrated control of cell proliferation and cell death by the c-myc oncogene. Philos. Trans. R. Soc. Lond. B Biol. Sci. 345:1994;269-275.
79. + channels to cell stress through mediation of phosphoinositides as examined by photoirradiation. J. Physiol. (Lond.). 529:2000;707-721.
80. Farkas D.L., Wei M.D., Febbroriello P., Carson J.H., Loew L.M. Simultaneous imaging of cell and mitochondrial membrane potentials. Biophys. J. 56:1989;1053-1069.
81. Feldenberg L.R., Thevananther S., del Rio M., de Leon M., Devarajan P. Partial ATP depletion induces Fas- and caspase-mediated apoptosis in MDCK cells. Am. J. Physiol. 276:1999;F837-F846.
82. Fernandez-Segura E., Canizares F.J., Cubero M.A., Warley A., Campos A. Changes in elemental content during apoptotic cell death studied by electron probe X-ray microanalysis. Exp. Cell Res. 253:1999;454-462.
83. Ferrari G., Greene L.A. Proliferative inhibition by dominant-negative Ras rescues naive and neuronally differentiated PC12 cells from apoptotic death. EMBO J. 13:1994;5922-5928.
84. Fischer E.H. Cell signaling by protein tyrosine phosphorylation. Adv. Enzyme Regul. 39:1999;359-369.
85. Forbes R.A., Steenbergen C., Murphy E. Diazoxide-induced cardioprotection requires signaling through a redox-sensitive mechanism. Circ. Res. 88:2001;802-809.
86. + channel blockers reduce microglia-induced neurotoxicity). Soc. Neurosci. Abstr. 17:2002;892.
87. Franklin J.L., Johnson E.M. Jr. Suppression of programmed neuronal death by sustained elevation of cytoplasmic calcium. Trends Neurosci. 15:1992;501-508.
88. Fujita H., Takizawa S., Nanri K., Matsushima K., Ogawa S., Shinohara Y. Potassium channel opener reduces extracellular glutamate concentration in rat focal cerebral ischemia. Brain Res. Bull. 43:1997;365-368.
89. Furlong I.J., Lopez Mediavilla C., Ascaso R., Lopez Rivas A., Collins M.K. Induction of apoptosis by valinomycin: mitochondrial permeability transition causes intracellular acidification. Cell Death Differ. 5:1998;214-221.
90. + channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein. Nature. 379:1996;74-78.
91. Gallagher J.D., Fay M.J., North W.G., McCann F.V. Ionic signals in T47D human breast cancer cells. Cell Signal. 8:1996;279-284.
92. Gallo V., Kingsbury A., Balazs R., Jorgensen O.S. The role of depolarization in the survival and differentiation of cerebellar granule cells in culture. J. Neurosci. 7:1987;2203-2213.
93. Gantner F., Uhlig S., Wendel A. Quinine inhibits release of tumor necrosis factor, apoptosis, necrosis and mortality in a murine model of septic liver failure. Eur. J. Pharmacol. 294:1995;353-355.
94. Garlid K.D., Paucek P. The mitochondrial potassium cycle. IUBMB Life. 52:2001;153-158.
95. Garlid K.D., Paucek P., Yarov-Yarovoy V., Sun X., Schindler P.A. The mitochondrial KATP channel as a receptor for potassium channel openers. J. Biol. Chem. 271:1996;8796-8799.
96. Gary D.S., Mattson M.P. Integrin signaling via the PI3-kinase-Akt pathway increases neuronal resistance to glutamate-induced apoptosis. J. Neurochem. 76:2001;1485-1496.
97. Ghosh S., Standen N.B., Galinanes M. Evidence for mitochondrial K ATP channels as effectors of human myocardial preconditioning. Cardiovasc. Res. 45:2000;934-940.
98. Gloor S.M. Relevance of Na, K-ATPase to local extracellular potassium homeostasis and modulation of synaptic transmission. FEBS Lett. 412:1997;1-4.
99. Goldberg, M.P., 2002. Stroke Trials Directory. Internet Stroke Center at Washington University ( http://www.stroketrials.org ). Web page for BMS-204352: http://www.strokecenter.org/trials/InterventionDetail.asp?therapyName=ints/ intPage53.htm, accessed on 24 April 2002.
100. + and cell shrinkage. A role for PKC upstream of caspases. J. Biol. Chem. 275:2000;19609-19619.
101. + channel openers protect hippocampal neurons against oxidative injury and amyloid beta-peptide toxicity. Brain Res. 706:1996;328-332.
102. Greene H.L., Graham E.L., Werner J.A., Sears G.K., Gross B.W., Gorham J.P., Kudenchuk P.J., Trobaugh G.B. Toxic and therapeutic effects of amiodarone in the treatment of cardiac arrhythmias. J. Am. Coll. Cardiol. 2:1983;1114-1128.
103. Gribkoff V.K., Starrett J.E. Jr., Dworetzky S.I., Hewawasam P., Boissard C.G., Cook D.A., Frantz S.W., Heman K., Hibbard J.R., Huston K., Johnson G., Krishnan B.S., Kinney G.G., Lombardo L.A., Meanwell N.A., Molinoff P.B., Myers R.A., Moon S.L., Ortiz A., Pajor L., Pieschl R.L., Post-Munson D.J., Signor L.J., Srinivas N., Taber M.T., Thalody G., Trojnacki J.T., Wiener H., Yeleswaram K., Yeola S.W. Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels. Nat. Med. 7:2001;471-477.
104. + channels and myocardial preconditioning. Circ. Res. 84:1999;973-979.
105. Grover G.J. Pharmacology of ATP-sensitive potassium channel (KATP) openers in models of myocardial ischemia and reperfusion. Can J. Physiol. Pharmacol. 75:1997;309-315.
106. Grover G.J., Garlid K.D. ATP-sensitive potassium channels: a review of their cardioprotective pharmacology. J. Mol. Cell. Cardiol. 32:2000;677-695.
107. Guatteo E., Federici M., Siniscalchi A., Knopfel T., Mercuri N.B., Bernardi G. Whole cell patch-clamp recordings of rat midbrain dopaminergic neurons isolate a sulphonylurea- and ATP-sensitive component of potassium currents activated by hypoxia. J. Neurophysiol. 79:1998;1239-1245.
108. Guizouarn H., Motais R., Garcia-Romeu F., Borgese F. Cell volume regulation: the role of taurine loss in maintaining membrane potential and cell pH. J. Physiol. (Lond.). 523:2000;147-154.
109. 2 deprivation in central neurons. Kidney Int. 51:1997;467-472.
110. Halter J.A., Blight A.R., Donovan W.H., Calvillo O. Intrathecal administration of 4-aminopyridine in chronic spinal injured patients. Spinal Cord. 38:2000;728-732.
111. Hansebout R.R., Blight A.R., Fawcett S., Reddy K. 4-Aminopyridine in chronic spinal cord injury: a controlled, double-blind, crossover study in eight patients. J. Neurotrauma. 10:1993;1-18.
112. Harvey A.M.H. Excitatory acidic amino acids and the cation content and sodium ion flux of isolated tissues from the brain. Biochem. J. 108:1968;269-274.
113. Hayes K.C., Blight A.R., Potter P.J., Allatt R.D., Hsieh J.T., Wolfe D.L., Lam S., Hamilton J.T. Preclinical trial of 4-aminopyridine in patients with chronic spinal cord injury. Paraplegia. 31:1993;216-224.
114. Hengartner M.O., Ellis R.E., Horvitz H.R. Caenorhabditis elegans gene ced-9 protects cells from programmed cell death. Nature. 356:1992;494-499.
115. Hertz L. Autonomic control of neuronal-astrocytic interactions, regulating metabolic activities, and ion fluxes in the CNS. Brain Res. Bull. 29:1992;303-313.
116. + currents via a Ras- and Raf-1-dependent pathway in cultured oligodendrocytes. J. Neurosci. 18:1998;8712-8719.
117. Hirsch T., Marchetti P., Susin S.A., Dallaporta B., Zamzami N., Marzo I., Geuskens M., Kroemer G. The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death. Oncogene. 15:1997;1573-1581.
118. Hollmann M., Heinemann S. Cloned glutamate receptors. Annu. Rev. Neurosci. 17:1994;31-108.
119. Holmes T.C., Berman K., Swartz J.E., Dagan D., Levitan I.B. Expression of voltage-gated potassium channels decreases cellular protein tyrosine phosphorylation. J. Neurosci. 17:1997;8964-8974.
120. Houzen H., Kikuchi S., Kanno M., Shinpo K., Tashiro K. Tumor necrosis factor enhancement of transient outward potassium currents in cultured rat cortical neurons. J. Neurosci. Res. 50:1997;990-999.
121. Huang H., Gao T.M., Gong L., Zhuang Z., Li X. Potassium channel blocker TEA prevents CA1 hippocampal injury following transient forebrain ischemia in adult rats. Neurosci. Lett. 305:2001;83-86.
122. Hughes F.M. Jr., Cidlowski J.A. Potassium is a critical regulator of apoptotic enzymes in vitro and in vivo. Adv. Enzyme Regul. 39:1999;157-171.
123. + suppresses the activation of apoptosis in lymphocytes. J. Biol. Chem. 272:1997;30567-30576.
124. + current mediated by NMDA receptor channel in mouse cortical neurons. Soc. Neurosci. Abstr. 26:2000;2147.
125. Ichinose M., Yonemochi H., Sato T., Saikawa T. Diazoxide triggers cardioprotection against apoptosis induced by oxidative stress. Am. J. Physiol. Heart Circ. Physiol. 284:2003a;H2235-H2241.
126. + current in cortical neurons. J. Physiol., in press.
127. Iino M., Ozawa S., Tsuzuki K. Permeation of calcium through excitatory amino acid receptor channels in cultured rat hippocampal neurones. J. Physiol. (Lond.). 424:1990;151-165.
128. Inai Y., Yabuki M., Kanno T., Akiyama J., Yasuda T., Utsumi K. Valinomycin induces apoptosis of ascites hepatoma cells (AH-130) in relation to mitochondrial membrane potential. Cell Struct. Funct. 22:1997;555-563.
129. + channel in the mitochondrial inner membrane. Nature. 352:1991;244-247.
130. + ions in determining apoptosis and extent of suppression afforded by bcl-2 during hybridoma cell culture. Apoptosis. 4:1999;335-355.
131. Itoh T., Seki N., Suzuki S., Ito S., Kajikuri J., Kuriyama H. Membrane hyperpolarization inhibits agonist-induced synthesis of inositol 1,4,5-trisphosphate in rabbit mesenteric artery. J. Physiol. (Lond.). 451:1992;307-328.
132. Jacobson M.D., Evan G.I. Apoptosis. Breaking the ICE. Curr. Biol. 4:1994;337-340.
133. Jacotot E., Costantini P., Laboureau E., Zamzami N., Susin S.A., Kroemer G. Mitochondrial membrane permeabilization during the apoptotic process. Ann. N. Y. Acad. Sci. 887:1999;18-30.
134. - channel activity in rat cortical astrocytes. Brain Res. 746:1997;85-97.
135. Jan L.Y., Jan Y.N. L-Glutamate as an excitatory transmitter at the Drosophila larval neuromuscular junction. J. Physiol. (Lond.). 262:1976;215-236.
136. Jan L.Y., Jan Y.N. Cloned potassium channels from eukaryotes and prokaryotes. Annu. Rev. Neurosci. 20:1997;91-123.
137. + current in central neurons. Brain Res. 614:1993;352-356.
138. Johnson E.M. Jr., Koike T., Franklin J. A "calcium set-point hypothesis" of neuronal dependence on neurotrophic factor. Exp. Neurol. 115:1992;163-166.
139. Johnson E.M. Jr., Greenlund L.J., Akins P.T., Hsu C.Y. Neuronal apoptosis: current understanding of molecular mechanisms and potential role in ischemic brain injury. J. Neurotrauma. 12:1995;843-852.
140. Johnston A.R., Fraser J.R., Jeffrey M., MacLeod N. Alterations in potassium currents may trigger neurodegeneration in murine scrapie. Exp. Neurol. 151:1998;326-333.
141. Jonas D., Walev I., Berger T., Liebetrau M., Palmer M., Bhakdi S. Novel path to apoptosis: small transmembrane pores created by staphylococcal alpha-toxin in T lymphocytes evoke internucleosomal DNA degradation. Infect. Immun. 62:1994;1304-1312.
142. Jones R.E., Heron J.R., Foster D.H., Snelgar R.S., Mason R.J. Effects of 4-aminopyridine in patients with multiple sclerosis. J. Neurol. Sci. 60:1983;353-362.
143. Jurkowitz-Alexander M.S., Altschuld R.A., Hohl C.M., Johnson J.D., McDonald J.S., Simmons T.D., Horrocks L.A. Cell swelling, blebbing, and death are dependent on ATP depletion and independent of calcium during chemical hypoxia in a glial cell line (ROC-1). J. Neurochem. 59:1992;344-352.
144. Kawasaki H., Morooka T., Shimohama S., Kimura J., Hirano T., Gotoh Y., Nishida E. Activation and involvement of p38 mitogen-activated protein kinase in glutamate-induced apoptosis in rat cerebellar granule cells. J. Biol. Chem. 272:1997;18518-18521.
145. Kerr J.F., Wyllie A.H., Currie A.R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer. 26:1972;239-257.
146. Kim Y.H., Kim E.Y., Gwag B.J., Sohn S., Koh J.Y. Zinc-induced cortical neuronal death with features of apoptosis and necrosis: mediation by free radicals. Neuroscience. 89:1999;175-182.
147. + channel blocker, in HepG2 human hepatoblastoma cells. Pharmacology. 60:2000;74-81.
148. Kitamura K., Kamouchi M. K channel openers activate different K channels in vascular smooth muscle cells. Cardiovasc. Drugs Ther. 7(Suppl. 3):1993;539-546.
149. + channel expression and cell proliferation are regulated by intracellular sodium and membrane depolarization in oligodendrocyte progenitor cells. J. Neurosci. 17:1997;2669-2682.
150. Koh J.Y., Gwag B.J., Lobner D., Choi D.W. Potentiated necrosis of cultured cortical neurons by neurotrophins. Science. 268:1995;573-575.
151. 2+ determine nerve growth factor dependence of sympathetic ganglion cells. Proc. Natl. Acad. Sci. U.S.A. 86:1989;6421-6425.
152. + and ATP levels during ricin-induced apoptosis through the specific ribosomal inactivation results in the cytolysis of U937 cells. J. Biochem. (Tokyo). 128:2000;463-470.
153. Kopia G.A., Eller B.T., Patterson E., Shea M J., Lucchesi B.R. Antiarrhythmic and electrophysiologic actions of clofilium in experimental canine models. Eur. J. Pharmacol. 116:1985;49-61.
154. Kovac L., Bohmerova E., Butko P. Ionophores and intact cells. I. Valinomycin and nigericin act preferentially on mitochondria and not on the plasma membrane of Saccharomyces cerevisiae. Biochim. Biophys. Acta. 721:1982;341-348.
155. + channel of heart mitochondria. Am. J. Physiol. Heart Circ. Physiol. 280:2001;H649-H657.
156. + channels induces apoptosis in vascular smooth muscle cells. Am. J. Physiol. Cell Physiol. 280:2001;C970-C979.
157. + channels in pulmonary vascular smooth muscle cells. Am. J. Physiol. Heart Circ. Physiol. 282:2002;H184-H193.
158. Kroemer G., Reed J.C. Mitochondrial control of cell death. Nat. Med. 6:2000;513-519.
159. Kroemer G., Petit P., Zamzami N., Vayssiere J.L., Mignotte B. The biochemistry of programmed cell death. FASEB J. 9:1995;1277-1287.
160. + ATPase activity: a common pathway in central nervous system disorders. J. Assoc. Phys. India. 50:2002;400-406.
161. Latta M., Kunstle G., Leist M., Wendel A. Metabolic depletion of ATP by fructose inversely controls CD95- and tumor necrosis factor receptor 1-mediated hepatic apoptosis. J. Exp. Med. 191:2000;1975-1985.
162. Lauritzen I., De Weille J.R., Lazdunski M. The potassium channel opener (-)-cromakalim prevents glutamate-induced cell death in hippocampal neurons. J. Neurochem. 69:1997;1570-1579.
163. Lavretsky E.P., Jarvik L.F. A group of potassium-channel blockers-acetylcholine releasers: new potentials for Alzheimer disease? A review. J. Clin. Psychopharmacol. 12:1992;110-118.
164. Ledbetter M.L., Lubin M. Control of protein synthesis in human fibroblasts by intracellular potassium. Exp. Cell Res. 105:1977;223-236.
165. Lesort M., Esclaire F., Yardin C., Hugon J. NMDA induces apoptosis and necrosis in neuronal cultures. Increased APP immunoreactivity is linked to apoptotic cells. Neurosci. Lett. 221:1997;213-216.
166. Li H., Yuan J. Deciphering the pathways of life and death. Curr. Opin. Cell Biol. 11:1999;261-266.
167. +-cotransport activity in erythrocytes of normal male subjects studied on two occasions Methods Find. Exp. Clin. Pharmacol. 8:1986;525-533.
168. Liu Y., Sato T., O'Rourke B., Marban E. Mitochondrial ATP-dependent potassium channels: novel effectors of cardioprotection? Circulation. 97:1998;2463-2469.
169. Liu Y., Sato T., Seharaseyon J., Szewczyk A., O'Rourke B., Marban E. Mitochondrial ATP-dependent potassium channels. Viable candidate effectors of ischemic preconditioning. Ann. N. Y. Acad. Sci. 874:1999;27-37.
170. Lopina O.D. Interaction of Na, K-ATPase catalytic subunit with cellular proteins and other endogenous regulators. Biochemistry (Mosc.). 66:2001;1122-1131.
171. Lubin M. Intracellular potassium and macromolecular synthesis in mammalian cells. Nature. 213:1967;451-453.
172. MacDermott A.B., Mayer M.L., Westbrook G.L., Smith S.J., Barker J.L. NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones. Nature. 321:1986;519-522.
173. Maeno E., Ishizaki Y., Kanaseki T., Hazama A., Okada Y. Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis. Proc. Natl. Acad. Sci. U.S.A. 97:2000;9487-9492.
174. Majno G., Joris I. Apoptosis, oncosis, and necrosis. An overview of cell death. Am. J. Pathol. 146:1995;3-15.
175. + channel currents in mammalian cells. Neurobiol. Dis. 4:1998;398-409.
176. Manikkam M., Li Y., Mitchell B.M., Mason D.E., Freeman L.C. Potassium channel antagonists influence porcine granulosa cell proliferation, differentiation, and apoptosis. Biol. Reprod. 67:2002;88-98.
177. +-adenosine triphosphatase. Endocrinology. 142:2001;5059-5068.
178. Marchetti P., Susin S.A., Decaudin D., Gamen S., Castedo M., Hirsch T., Zamzami N., Naval J., Senik A., Kroemer G. Apoptosis-associated derangement of mitochondrial function in cells lacking mitochondrial DNA. Cancer Res. 56:1996;2033-2038.
179. + flux. J. Antimicrob. Chemother. 48:2001a;781-786.
180. Marklund L., Henriksson R., Grankvist K. Cisplatin-induced apoptosis of mesothelioma cells is affected by potassium ion flux modulator amphotericin B and bumetanide. Int. J. Cancer. 93:2001;577-583.
181. Matthews G., Wickelgren W.O. Glutamate and synaptic excitation of reticulospinal neurones of lamprey. J. Physiol. (Lond.). 293:1979;417-433.
182. Mayer M.L., Westbrook G.L. The physiology of excitatory amino acids in the vertebrate central nervous system. Prog. Neurobiol. 28:1987a;197-276.
183. Mayer M.L., Westbrook G.L. Permeation and block of N-methyl-D-aspartic acid receptor channels by divalent cations in mouse cultured central neurones. J. Physiol. (Lond.). 394:1987;501-527.
184. McCabe R.D., Young D.B. Potassium inhibits cultured vascular smooth muscle cell proliferation. Am. J. Hypertens. 7:1994;346-350.
185. McCarthy J.V., Cotter T.G. Cell shrinkage and apoptosis: a role for potassium and sodium ion efflux. Cell Death Differ. 4:1997;756-770.
186. 2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells. Cancer Res. 60:2000;3807-3812.
187. McLaughlin B., Pal S., Tran M.P., Parsons A.A., Barone F.C., Erhardt J.A., Aizenman E. p38 activation is required upstream of potassium current enhancement and caspase cleavage in thiol oxidant-induced neuronal apoptosis. J. Neurosci. 21:2001;3303-3311.
188. Menasche P., Kevelaitis E., Mouas C., Grousset C., Piwnica A., Bloch G. Preconditioning with potassium channel openers. A new concept for enhancing cardioplegic protection? J. Thorac. Cardiovasc. Surg. 110:1995;1606-1613.
189. Minn A.J., Velez P., Schendel S.L., Liang H., Muchmore S.W., Fesik S.W., Fill M., Thompson C.B. Bcl-x(L) forms an ion channel in synthetic lipid membranes. Nature. 385:1997;353-357.
190. 2+ channels in inspiratory brainstem neurones: intracellular signalling pathways and metabotropic glutamate receptors. Brain Res. 869:2000;166-177.
191. Mizumura T., Nithipatikom K., Gross G.J. Bimakalim, an ATP-sensitive potassium channel opener, mimics the effects of ischemic preconditioning to reduce infarct size, adenosine release, and neutrophil function in dogs. Circulation. 92:1995;1236-1245.
192. Monaghan D.T., Bridges R.J., Cotman C.W. The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system. Annu. Rev. Pharmacol. Toxicol. 29:1989;365-402.
193. Montague J.W., Bortner C.D., Hughes F.M. Jr., Cidlowski J.A. A necessary role for reduced intracellular potassium during the DNA degradation phase of apoptosis. Steroids. 64:1999;563-569.
194. Muchmore S.W., Sattler M., Liang H., Meadows R.P., Harlan J.E., Yoon H.S., Nettesheim D., Chang B.S., Thompson C.B., Wong S.L., Ng S.L., Fesik S.W. X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature. 381:1996;335-341.
195. Murphy K.P., Greenfield S.A. ATP-sensitive potassium channels counteract anoxia in neurones of the substantia nigra. Exp. Brain Res. 84:1991;355-358.
196. Murray N.M., Newsom-Davis J. Treatment with oral 4-aminopyridine in disorders of neuromuscular transmission. Neurology. 31:1981;265-271.
197. Nadeau H., McKinney S., Anderson D.J., Lester H.A. ROMK1 (Kir1.1) causes apoptosis and chronic silencing of hippocampal neurons. J. Neurophysiol. 84:2000;1062-1075.
198. Nagy P., Panyi G., Jenei A., Bene L., Gaspar R. Jr., Matko J., Damjanovich S. Ion-channel activities regulate transmembrane signaling in thymocyte apoptosis and T-cell activation. Immunol. Lett. 44:1995;91-95.
199. Nakajima W., Ishida A., Lange M.S., Gabrielson K.L., Wilson M.A., Martin L.J., Blue M.E., Johnston M.V. Apoptosis has a prolonged role in the neurodegeneration after hypoxic ischemia in the newborn rat. J. Neurosci. 20:2000;7994-8004.
200. Niethammer M., Kim E., Sheng M. Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases. J. Neurosci. 16:1996;2157-2163.
201. Nietsch H.H., Roe M.W., Fiekers J.F., Moore A.L., Lidofsky S.D. Activation of potassium and chloride channels by tumor necrosis factor alpha. Role in liver cell death. J. Biol. Chem. 275:2000;20556-20561.
202. Nilius B., Wohlrab W. Potassium channels and regulation of proliferation of human melanoma cells. J. Physiol. (Lond.). 445:1992;537-548.
203. + concentrations on the growth and development of ciliary ganglion neurons in cell culture. Dev. Biol. 87:1981;301-307.
204. Nord L.D., Stolfi R.L., Alfieri A.A., Netto G., Reuter V., Sternberg S.S., Colofiore J.R., Koutcher J.A., Martin D.S. Apoptosis induced in advanced CD8F1-murine mammary tumors by the combination of PALA, MMPR and 6AN precedes tumor regression and is preceded by ATP depletion. Cancer Chemother. Pharmacol. 40:1997;376-387.
205. Norman D.J., Feng L., Cheng S.S., Gubbay J., Chan E., Heintz N. The lurcher gene induces apoptotic death in cerebellar Purkinje cells. Development. 121:1995;1183-1193.
206. + channels reduces hydroxyl radicals in the rat myocardium. Arch. Biochem. Biophys. 378:2000;195-200.
207. Ojcius D.M., Zychlinsky A., Zheng L.M., Young J.D. Ionophore-induced apoptosis: role of DNA fragmentation and calcium fluxes. Exp. Cell Res. 197:1991;43-49.
208. Okada Y., Maeno E. Apoptosis, cell volume regulation and volume-regulatory chloride channels. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 130:2001;377-383.
209. Olej B., dos Santos N.F., Leal L., Rumjanek V.M. Ouabain induces apoptosis on PHA-activated lymphocytes. Biosci. Rep. 18:1998;1-7.
210. Olney J.W. Excitotoxicity: an overview. Can. Dis. Wkly. Rep. 16(Suppl. 1E):1990;47-57.
211. O'Reilly N., Xia Z., Fiander H., Tauskela J., Small D.L. Disparity between ionic mediators of volume regulation and apoptosis in N1E 115 mouse neuroblastoma cells. Brain Res. 943:2002;245-256.
212. Ozawa S., Nakamura T., Yuzaki M. Cation permeability change caused by L-glutamate in cultured rat hippocampal neurons. Brain Res. 443:1988;85-94.
213. Pal S.K., Du S., Hartnett K.A., Levitan E.S., Aizenman E. Involvement of the potassium channel subunit Kv2.1 in oxidative stress mediated cell death. Soc. Neurosci. Abstr. 12:2002;493.
214. Pappone P.A., Ortiz-Miranda S.I. Blockers of voltage-gated K channels inhibit proliferation of cultured brown fat cells. Am. J. Physiol. 264:1993;C1014-C1019.
215. Patel T., Bronk S.F., Gores G.J. Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in rat hepatocytes. J. Clin. Invest. 94:1994;2183-2192.
216. + channel from rat liver and beef heart mitochondria. J. Biol. Chem. 267:1992;26062-26069.
217. Paulson R.F., Bernstein A. Receptor tyrosine kinases and the regulation of hematopoiesis. Semin. Immunol. 7:1995;267-277.
218. +-ATPase activity mediated by protein kinase C isoforms. J. Bioenerg. Biomembr. 33:2001;439-447.
219. Pena C.L., Pendergast M., Pilar G. Selective membrane channels involved in developmental neuronal death. Soc. Neurosci. Abstr. 9:2002;631.
220. Penning L.C., Denecker G., Vercammen D., Declercq W., Schipper R.G., Vandenabeele P. A role for potassium in TNF-induced apoptosis and gene-induction in human and rodent tumour cell lines. Cytokine. 12:2000;747-750.
221. 2+ dynamic changes and thapsigargin-induced apoptosis in human cancer MCF7 cells. Mol. Cell. Biochem. 229:2002;163-171.
222. Perez G.I., Maravei D.V., Trbovich A.M., Cidlowski J.A., Tilly J.L., Hughes F.M. Jr. Identification of potassium-dependent and -independent components of the apoptotic machinery in mouse ovarian germ cells and granulosa cells. Biol. Reprod. 63:2000;1358-1369.
223. Perregaux D., Gabel C.A. Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity. J. Biol. Chem. 269:1994;15195-15203.
224. Platia E.V., Reid P.R. Dose-ranging studies of clofilium, an antiarrhythmic quaternary ammonium. Clin. Pharmacol. Ther. 35:1984;193-202.
225. Portera-Cailliau C., Price D.L., Martin L.J. Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum. J. Comp. Neurol. 378:1997;70-87.
226. Potter P.J., Hayes K.C., Hsieh J.T., Delaney G.A., Segal J.L. Sustained improvements in neurological function in spinal cord injured patients treated with oral 4-aminopyridine: three cases. Spinal Cord. 36:1998;147-155.
227. Qin Z.H., Wang Y., Chase T.N. Stimulation of N-methyl-D-aspartate receptors induces apoptosis in rat brain. Brain Res. 725:1996;166-176.
228. + channels? Trends Pharmacol. Sci. 14:1993;332-337.
229. Que F.G., Gores G.J., LaRusso N.F. Development and initial application of an in vitro model of apoptosis in rodent cholangiocytes. Am. J. Physiol. 272:1997;G106-G115.
230. Quidt, F.N., 1994. Recording sodium and potassium currents from neuroblastoma cells. In: Ion Channels of Excitable Cells. Academic Press, San Diego, pp. 3-20.
231. Raff M.C., Barres B.A., Burne J.F., Coles H.S., Ishizaki Y., Jacobson M.D. Programmed cell death and the control of cell survival: lessons from the nervous system. Science. 262:1993;695-700.
232. Rajapakse N., Shimizu K., Kis B., Snipes J., Lacza Z., Busija D. Activation of mitochondrial ATP-sensitive potassium channels prevents neuronal cell death after ischemia in neonatal rats. Neurosci. Lett. 327:2002;208-212.
233. + channel currents in primary cultures of rat cerebellar granule and cortical neurones. J. Neurochem. 79:2001;699-712.
234. Reeves W.B., Shah S.V. Activation of potassium channels contributes to hypoxic injury in proximal tubules. J. Clin. Invest. 94:1994;2289-2294.
235. Repp H., Nieper H., Draheim H.J., Koschinski A., Muller H., Dreyer F. Infectious bursal disease virus changes the potassium current properties of chicken embryo fibroblasts. Virology. 246:1998;362-369.
236. Ribera A.B., Spitzer N.C. Developmental regulation of potassium channels and the impact on neuronal differentiation. Ion Channels. 3:1992;1-38.
237. +)-activated ATPase. Enzymatic and transport properties. Biochim. Biophys. Acta. 549:1979;145-176.
238. Rose C.R., Ransom B.R. Intracellular sodium homeostasis in rat hippocampal astrocytes. J. Physiol. (Lond.). 491:1996;291-305.
239. Rothman S.M., Olney J.W. Glutamate and the pathophysiology of hypoxic-ischemic brain damage. Ann. Neurol. 19:1986;105-111.
240. + channel block-induced mammalian neuroblastoma cell swelling: a possible mechanism to influence proliferation. J. Physiol. (Lond.). 510:1998;93-102.
241. Sattler R., Tymianski M. Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death. Mol. Neurobiol. 24:2001;107-129.
242. + channel-blocking agents on T lymphocyte proliferation and lymphokine production are "nonspecific" J. Immunol. 139:1987;3224-3230.
243. Schlesinger P.H., Gross A., Yin X.M., Yamamoto K., Saito M., Waksman G., Korsmeyer S.J. Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2. Proc. Natl. Acad. Sci. U.S.A. 94:1997;11357-11362.
244. Schmidt T.A., Kjeldsen K. Myocardial K homeostasis in ischemia - importance of Na, K-ATPase. Basic Res. Cardiol. 92(Suppl. 2):1997;57-59.
245. 2+ permeability. Biophys. J. 74:1998;1790-1974.
246. Schwarcz R., Meldrum B. Excitatory aminoacid antagonists provide a therapeutic approach to neurological disorders. Lancet. 2:1985;140-143.
247. Scorrano L., Petronilli V., Bernardi P. On the voltage dependence of the mitochondrial permeability transition pore. A critical appraisal. J. Biol. Chem. 272:1997;12295-12299.
248. Scott B.S., Fisher K.C. Potassium concentration and number of neurons in cultures of dissociated ganglia. Exp. Neurol. 27:1970;16-22.
249. Segal J.L., Brunnemann S.R. 4-Aminopyridine improves pulmonary function in quadriplegic humans with longstanding spinal cord injury. Pharmacotherapy. 17:1997;415-423.
250. Smith-Maxwell C.J., Eatock R.A., Begenisich T. Induction of K-channel expression in a neuroblastoma cell line. J. Neurobiol. 22:1991;327-341.
251. Sonnhof U., Grafe P., Krumnikl J., Linder M., Schindler L. Inhibitory postsynaptic actions of taurine, GABA and other amino acids on motoneurons of the isolated frog spinal cord. Brain Res. 100:1975;327-341.
252. + loss. Am. J. Physiol. 258:1990;F732-F740.
253. Sunderman F.W. Jr. The influence of zinc on apoptosis. Ann. Clin. Lab Sci. 25:1995;134-142.
254. Szucs A., Stefano G.B., Hughes T.K., Rozsa K.S. Modulation of voltage-activated ion currents on identified neurons of Helix pomatia L. by interleukin-1. Cell. Mol. Neurobiol. 12:1992;429-438.
255. Takaba H., Nagao T., Yao H., Kitazono T., Ibayashi S., Fujishima M. An ATP-sensitive potassium channel activator reduces infarct volume in focal cerebral ischemia in rats. Am. J. Physiol. 273:1997;R583-R586.
256. Takashi E., Ashraf M. Pathologic assessment of myocardial cell necrosis and apoptosis after ischemia and reperfusion with molecular and morphological markers. J. Mol. Cell. Cardiol. 32:2000;209-224.
257. Targ E.F., Kocsis J.D. 4-Aminopyridine leads to restoration of conduction in demyelinated rat sciatic nerve. Brain Res. 328:1985;358-361.
258. Teichberg V.I., Goldberg O., Luini A. The stimulation of ion fluxes in brain slices by glutamate and other excitatory amino acids. Mol. Cell. Biochem. 39:1981;281-295.
259. Tenneti L., D'Emilia D.M., Troy C.M., Lipton S.A. Role of caspases in N-methyl-D-aspartate-induced apoptosis in cerebrocortical neurons. J. Neurochem. 71:1998;946-959.
260. Thompson C.B. Apoptosis in the pathogenesis and treatment of disease. Science. 267:1995;1456-1462.
261. + inhibits death-receptor- and chemical-mediated apoptosis prior to caspase activation and cytochrome c release. Biochem. J. 357:2001;137-145.
262. Tikhonov D.B., Zhorov B.S., Magazanik L.G. Intersegment hydrogen bonds as possible structural determinants of the N/Q/R site in glutamate receptors. Biophys. J. 77:1999;1914-1926.
263. Trimarchi J.R., Liu L., Smith P.J., Keefe D.L. Apoptosis recruits two-pore domain potassium channels used for homeostatic volume regulation. Am. J. Physiol. Cell Physiol. 282:2002;C588-C594.
264. Tsuzuki K., Mochizuki S., Iino M., Mori H., Mishina M., Ozawa S. Ion permeation properties of the cloned mouse epsilon 2/zeta 1 NMDA receptor channel. Brain Res. Mol. Brain Res. 26:1994;37-46.
265. Ucker D.S. Death by suicide: one way to go in mammalian cellular development? New Biol. 3:1991;103-109.
266. van Diemen H.A., Polman C.H., van Dongen T.M., van Loenen A.C., Nauta J.J., Taphoorn M.J., van Walbeek H.K., Koetsier J.C. The effect of 4-aminopyridine on clinical signs in multiple sclerosis: a randomized, placebo-controlled, double-blind, cross-over study. Ann. Neurol. 32:1992;123-130.
267. van Lookeren Campagne M., Lucassen P.J., Vermeulen J.P., Balazs R. NMDA and kainate induce internucleosomal DNA cleavage associated with both apoptotic and necrotic cell death in the neonatal rat brain. Eur. J. Neurosci. 7:1995;1627-1640.
268. Verheye-Dua F.A., Bohm L. Influence of apoptosis on the enhancement of radiotoxicity by ouabain. Strahlenther. Onkol. 176:2000;186-191.
269. Walev I., Reske K., Palmer M., Valeva A., Bhakdi S. Potassium-inhibited processing of IL-1 beta in human monocytes. EMBO J. 14:1995;1607-1614.
270. Walev I., Klein J., Husmann M., Valeva A., Strauch S., Wirtz H., Weichel O., Bhakdi S. Potassium regulates IL-1 beta processing via calcium-independent phospholipase A2. J. Immunol. 164:2000;5120-5124.
271. +-ATPase in cortical neurons. Soc. Neurosci. Abstr. 8:2002;446.
272. + channel activity associated with human myeloblastic ML-1 cell proliferation. Am. J. Physiol. 273:1997;C1657-C1665.
273. + channel mediates apoptosis of myeloblastic leukemia cells. J. Biol. Chem. 274:1999;3678-3685.
274. Wang X., Xiao A.Y., Ichinose T., Yu S.P. Effects of tetraethylammonium analogues on apoptosis and membrane currents in cultured cortical neurons. J. Pharmacol. Exp. Ther. 295:2000;524-530.
275. + channel, a regulator of tumor cell apoptosis and proliferation. Cancer Res. 62:2002;4843-4848.
276. +-ATPase and induction of hybrid death by 4-aminopyridine in cultured cortical neurons. J. Pharmacol. Exp. Ther. 305:2003a;502-506.
277. +-ATPase activity as a mechanism of neuronal death mediated by concurrent ATP deficiency and oxidant stress. J. Cell Sci. 116:2003b;2099-2110.
278. Warny M., Kelly C.P. Monocytic cell necrosis is mediated by potassium depletion and caspase-like proteases. Am. J. Physiol. 276:1999;C717-C724.
279. Watkins J.C., Evans R.H. Excitatory amino acid transmitters. Annu. Rev. Pharmacol. Toxicol. 21:1981;165-204.
280. Waxman S.G. Aminopyridines and the treatment of spinal cord injury. J. Neurotrauma. 10:1993;19-24.
281. Wei L., Yu S.P., Gottron F., Snider J., Zipfel G.J., Choi D.W. Potassium channel blockers attenuate hypoxia- and ischemia-induced neuronal death in vitro and in vivo. Stroke. 34:2003;1281-1286.
282. Wesseling H., Agoston S., Van Dam G.B., Pasma J., DeWit D.J., Havinga H. Effects of 4-aminopyridine in elderly patients with Alzheimer's disease. N. Engl. J. Med. 310:1984;988-989.
283. + efflux and apoptosis induced by the potassium channel modulatory protein KChAP/PIAS3beta in prostate cancer cells. J. Biol. Chem. 277:2002;17852-17862.
284. Wo Z.G., Oswald R.E. Unraveling the modular design of glutamate-gated ion channels. Trends Neurosci. 18:1995;161-168.
285. Wood M.W., VanDongen H.M., VanDongen A.M. Structural conservation of ion conduction pathways in K channels and glutamate receptors. Proc. Natl. Acad. Sci. U.S.A. 92:1995;4882-4886.
286. Xia S., Lampe P.A., Deshmukh M., Yang A., Brown B.S., Rothman S.M., Johnson E.M. Jr., Yu S.P. Multiple channel interactions explain the protection of sympathetic neurons from apoptosis induced by nerve growth factor deprivation. J. Neurosci. 22:2002;114-122.
287. + efflux in apoptosis induced by AMPA and kainate in mouse cortical neurons. Neuroscience. 108:2001;61-67.
288. +-ATPase and induction of hybrid death in cultured cortical neurons. Soc. Neurosci. Abstr. 10:2002a;701.
289. +-ATPase synergistically aggravates ceramide- and β-amyloid-induced apoptosis in cortical neurons. Brain Res. 955:2002b;253-259.
290. Xiao A.Y., Wei L., Xia S., Rothman S., Yu S.P. Ionic mechanism of ouabain-induced concurrent apoptosis and necrosis in individual cultured cortical neurons. J. Neurosci. 22:2002c;1350-1362.
291. Xuan C.X., Xu Z.C. Potassium currents in CA1 neurons of rat hippocampus increase shortly after transient cerebral ischemia. Neurosci. Lett. 281:2000;5-8.
292. +-ATPase in cultured cortical neurons. Soc. Neurosci. Abstr. 11:2002a;701.
293. Yang N.C., Jeng K.C., Ho W.M., Hu M.L. ATP depletion is an important factor in DHEA-induced growth inhibition and apoptosis in BV-2 cells. Life Sci. 70:2002b;1979-1988.
294. Yonish-Rouach E., Grunwald D., Wilder S., Kimchi A., May E., Lawrence J.J., May P., Oren M. p53-mediated cell death: relationship to cell cycle control. Mol. Cell. Biol. 13:1993;1415-1423.
295. 2+-dependent endonuclease (AN34) from etoposide-treated human leukemia HL-60 cells undergoing apoptosis. Cancer Res. 58:1998;2576-2582.
296. + channels contributes of neuronal death. In: Alzheimer's Disease and Related Disorders. Wiley, New York, pp. 371-382.
297. Yu S.P., Choi D.W. Ions, cell volume, and apoptosis. Proc. Natl. Acad. Sci. U.S.A. 97:2000;9360-9362.
298. Yu S.P., Ichinose T. The potassium current mediated by NMDA receptor channels in cortical neurons. Soc. Neurosci. Abstr. 25:1999;1485.
299. Yu S.P., Yeh C.H., Sensi S.L., Gwag B.J., Canzoniero L.M., Farhangrazi Z.S., Ying H.S., Tian M., Dugan L.L., Choi D.W. Mediation of neuronal apoptosis by enhancement of outward potassium current. Science. 278:1997;114-117.
300. Yu S.P., Farhangrazi Z.S., Ying H.S., Yeh C.H., Choi D.W. Enhancement of outward potassium current may participate in β-amyloid peptide-induced cortical neuronal death. Neurobiol. Dis. 5:1998;81-88.
301. + efflux and neuronal apoptosis. Science. 284:1999a;336-339.
302. + current in ceramide-induced caspase activation and apoptosis in cultured cortical neurons. J. Neurochem. 73:1999b;933-941.
303. Yu S.P., Canzoniero L.M., Choi D.W. Ion homeostasis and apoptosis. Curr. Opin. Cell Biol. 13:2001;405-411.