Involvement of MEK/ERK pathway in cephaloridine-induced injury in rat renal cortical slices

Toxicology Letters

Volumn 143, Issue 2, 2003, Pages 185-194

  Kohda, Yuka ^a   Hiramatsu, Jun ^a   Gemba, Munekazu ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

Cephaloridine; ERK; Kidney cortical slices; MEK; Nephrotoxicity; Reactive oxygen species

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CEFALORIDINE; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATTENUATION; CELL DAMAGE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; FRACTIONATION; KIDNEY CORTEX; LIPID PEROXIDATION; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; RAT; WESTERN BLOTTING;

EID: 0038732279     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(03)00174-7     Document Type: Article

References (50)

1. Alessi D.R., Cuenda A., Cohen P., Dudley D.T., Saltiel A.R. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase in vitro and in vivo. J. Biol. Chem. 270:1995;27489-27494.
2. Assefa Z., Vantieghem A., Deslercq W., Vandenheede J.R., Merlevede W., de Witte P., Agostinis P. The activation of the c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signaling pathways protects Hela cells from apoptosis following photodynamic therapy with hypericin. J. Biol. Chem. 274:1999;8788-8796.
3. 2 in vascular smooth muscle cells. Circ. Res. 77:1995;29-36.
4. Badger A.M., Bradbeer J.N., Votta B., Lee J.C., Adams J.l., Griswold D.E. Pharmacological profile of SB203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function. J. Phrmacol. Exp. Ther. 279:1996;1453-1461.
5. Ballif B.A., Blenis J. Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals. Cell Growth Differ. 12:2001;397-408.
6. Baud L., Ardaillou R. Reactive oxygen species. Am. J. Physiol. 25:1986;F765-776.
7. Bhat N.R., Zhang P. Hydrogen peroxide activation of multiple mitogen-activated protein kinases in an oligodendrocyte cell line: role of extracellular signal-regulated kinase in hydrogen peroxide-induced cell death. J. Neurochem. 72:1999;112-119.
8. Boulton T.G., Nye S.H., Robbins D.J., Ip N.Y., Radziejewska E., Morgenbesser S.D., Depinho R.A., Paneyotatas N., Cobb M.H., Yancogenbesser G.D. ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell. 65:1991;663-675.
9. Braza M. The nephrotoxicity of cephalosporins: an overview. J. Infect. Dis. 137:1978;S60-S73.
10. Buckley S., Driscoll B., Barsky K., Weinberg K., Anderson K., Warburton D. ERK activation protects against DNA damage and apoptosis in hyperoxic rat AEC2. Am. J. Physiol. 277:1999;L159-166.
11. Buege J.A., Aust S.D. Microsomal lipid peroxidation. Methods Enzymol. 52:1985;302-310.
12. Campos-Gonzalez R., Kindy M.S. Tyrosine phosphorylation of microtubule-associated protein kinase after transient ischemia in the gerbil brain. J. Neurochem. 59:1992;1955-1958.
13. Chatterjee P.K., Cuzzocrea S., Brown P.A., Zacharowski K., Stewart K.N., Motafilipe H., Thiemermann C. Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat. Kidney Int. 58:2000;658-673.
14. Chen Y.R., Tan T.H. Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin. Oncogene. 17:1998;173-178.
15. Cobb M.H., Goldsmith E.J. How MAP kinase are regulated. J. Biol. Chem. 270:1995;14843-14846.
16. Cojocel C., Hannemann J., Baumann K. Cephaloridine-induced lipid peroxidation initiated by reactive oxygen species as a possible mechanism of cephaloridine nephrotoxicity. Biochim. Biophys. Acta. 834:1985;402-410.
17. Davis R.J. The mitogen-activated protein kinase signal transduction pathway. J. Biol. Chem. 268:1993;14553-14556.
18. Derkinderen P., Enslen H., Girault J.A. The ERK/MAP kinases cascade in the nervous system. Neuroreport. 10:1999;R24-R34.
19. Diamond J.R. The role of reactive oxygen species in animal models of glomerular disease. Am. J. Kidney Dis. 19:1992;292-300.
20. Favata M.F., Horiuchi K.Y., Manos E.J., Daurelio A.J., Stradley D.A., Feester W.S., Van Dyk D.E., Pitts W.J., Earl R.A., Hobbs F. Identification of a novel inhibitor of mitogen-activated protein kinase. J. Biol. Chem. 273:1998;18623-18632.
21. Foord R.D. Cephaloridine, cephalothin and the kidney. J. Antimicrob. Chemother. Suppl. 1:1975;119-133.
22. Formisano P., Oriente F., Fiory F., Caruso M., Miele C., Maitan M.A., Andreozzi F., Vigliotta G., Condorelli G., Beguinot F. Insulin-activated protein kinase C β by phased Ras and stimulate mitogen-activated protein kinase activity and cell proliferation in muscle cells. Mol. Cell. Biol. 20:2000;6323-6333.
23. Gemba M., Tachibana A., Sugihara K., Hori M., Nakajima M. Inhibitory effect of lithium on p-aminohippurate transport in rat kidney cortex in vitro. Renal Physiol. 8:1985;179-188.
24. Goldstein R.S., Pasino D.A., Hewitt W.R., Hook J.B. Biochemical mechanisms of cephaloridine nephrotoxicity: time and concentration dependence of peroxidative injury. Toxicol. Appl. Pharmacol. 83:1986;261-270.
25. 2. J. Biol. Chem. 271:1996;4138-4142.
26. Han H., Wang H., Long H., Nattel S., Wang Z. Oxidative preconditioning and apoptosis in L-cells. Role of protein kinase B and mitogen-activated protein kinases. J. Biol. Chem. 276:2001;26357-26364.
27. Harper S.J., LoGrasso P. Signaling for survival and death in neurons: the role of stress-activated kinase, JNK and p38. Cell Signal. 13:2001;299-310.
28. Kawai Y., Gemba M. Amelioration by cAMP of cephaloridine-induced injury in the porcine kidney cell line LLC-PK1. Jpn. J. Pharmacol. 72:1996;67-70.
29. Kindy M.S. Inhibition of tyrosine phosphorylation prevents delayed neuronal death following cerebral ischemia. J. Cereb. Blood Flow Metab. 13:1993;372-377.
30. Koga S., Nakano M., Uehara K. Mechanism for the generation of superoxide anion and singlet oxygen during heme compound-catalyzed linoleic acid hydroperoxide decomposition. Arch. Biochem. Biophys. 289:1991;223-229.
31. Kohda Y., Gemba M. Modulation by cyclic AMP and phorbol myristate acetate of cephaloridine-induced injury in rat renal cortical slices. Jpn. J. Pharmacol. 85:2001;54-59.
32. Kohda Y., Gemba M. Enhancement of protein kinase C activity and chemiluminescence intensity in mitochondria isolated from the kidney cortex of rats treated with cephaloridine. Biochem. Pharmacol. 64:2002;543-549.
33. Marais R., Light Y., Mason C., Paterson H., Olson M.F., Marshall C.J. Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C. Science. 280:1998;109-112.
34. Morey M., Serras F., Baguna J., Hafen E., Corominas M. Modulation of the Ras/MAPK signaling pathway by the redox function of selenoproteins in Drosophila melanogaster. Dev. Biol. 238:2001;145-156.
35. Namura S., Iihara K., Takami S., Nagata I., Kikuchi H., Matsushita K., Moskowitz M.A., Bonventre J.V., Alessandrin A. Intravenous administration of MEK Inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia. Proc. Natl. Acad. Sci. USA. 98:2001;11569-11574.
36. Ono K., Han J. The p38 signal transduction pathway: activation and function. Cell Signal. 12:2000;1-13.
37. Petrache I., Choi M.E., Otterbein L.E., Chin B.Y., Mantel L.L., Horowitz S., Choi A.M.K. Mitogen-activated protein kinase pathway mediates hyperoxia-induced apoptosis in cultured macrophage cells. Am. J. Physiol. 277:1999;L589-595.
38. Rush G.F., Heim R.A., Ponsler G.D., Engelhardt J. Cephaloridine-induced renal pathological and biochemical changes in female rabbits and isolated proximal tubules in suspension. Toxicol. Pathol. 20:1992;155-168.
39. - generation and lipid peroxidation during the oxidation of a glycated polypeptide, glycated polylysine, in the presence of iron-ADP. Biochim. Biophys. Acta. 1043:1990;27-33.
40. Satoh T., Nakatsuka D., Watanabe Y., Nagata I., Kikuchi H., Namura S. Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons. Neurosci. Lett. 288:2000;163-166.
41. Segal R.A., Greenberg M.E. Intracellular signaling pathways activated by neurotrophic factors. Annu. Rev. Neurosci. 19:1996;463-489.
42. Seger R., Krebs E.G. The MAPK signaling cascade. FASEB J. 9:1995;726-735.
43. 2+-induced ERK activation mediated by reactive oxygen species causes cell death in differentiated PC12 cells. J. Neurochem. 78:2001;600-610.
44. Stanciu M., Wang Y., Kentor R., Burke N., Watkins S., Kress G., Reynolds I., Klann E., Angiolieri M.R., Johnson J.W. Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures. J. Biol. Chem. 275:2000;12200-12206.
45. Thrane E.V., Refsnes M., Thoresen G.H., Lag M., Schwarze P.E. Fluoride-induced apoptosis in epithelial lung cells involves activation of MAP kinases p38 and possibly JNK. Toxicol. Sci. 61:2001;83-91.
46. Tune B.M. Renal tubular transport and nephrotoxicity of β-lactam antibiotics: structure-activity relationships. Minor Electrolyte Metab. 20:1994;221-231.
47. Tune B.M., Hsu C.Y. Effects of nephrotoxic β-lactam antibiotics on the mitochondrial metabolism of monocarboxylic substrates. J. Pharmacol. Exp. Ther. 274:1995;194-199.
48. Tunn B.M., Fernholt M., Schwartz A. Mechanisms of cephaloridine transport in the kidney. J. Pharmacol. Exp. Ther. 191:1974;311-317.
49. Wang X., Martindale J.L., Holbrook N.J. Requirement for ERK activation in cisplatin-induced apoptosis. J. Biol. Chem. 275:2000;39435-39443.
50. Xial L., Pimentel D.R., Wang J., Sing K., Colucci W.S., Sawyer D.B. Role of reactive oxygen species and NAD (P) H oxidase in α (1)-adrenoceptor signaling in adult rat cardiac myocytes. Am. J. Physiol. Cell Physiol. 282:2002;C926-934.