Erk-dependent cytosolic phospholipase A2 activity is induced by CD95 ligand cross-linking in the mouse derived Sertoli cell line TM4 and is required to trigger apoptosis in CD95 bearing cells

Cell Death and Differentiation

Volumn 7, Issue 10, 2000, Pages 916-924

  Ulisse, S ^a   Cinque, B ^a   Silvano, G ^a   Rucci, N ^a   Biordi, L ^a   Cifone, M G ^a   D'Armiento, M ^b  

^a UNIVERSITY OF L'AQUILA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Apoptosis; CD95L; MAPK; PLA2; Reverse signalling

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; FAS LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; MONOCLONAL ANTIBODY; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL LINE; CONTROLLED STUDY; CROSS LINKING; CYTOSOL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; INCUBATION TIME; LEUKEMIA CELL LINE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SERTOLI CELL; SIGNAL TRANSDUCTION; SOLUBILITY; SUPERNATANT; T LYMPHOCYTE; WESTERN BLOTTING;

EID: 0033774228     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400716     Document Type: Article

References (62)

1. Fas and Fas ligand in embryos and adult mice: Ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turnover
2. Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity
3. Expression of Fas ligand by human cytorophoblasts: Implication in placentation and fetal survival
4. Gld/gld mice are unable to express a functional ligand for Fas
5. A specific intercellular pathway of apoptotic cell death is defective in the mature peripheral T cells of autoimmune lpr and gld mice
6. A role for CD95 ligand in preventing graft rejection
7. Constitutive Fas ligand gene transcription in Sertoli cells is regulated by SP1
8. The Fas death factor
9. The role of FasL-induced apoptosis in immune privilege
10. Human lung carcinomas express Fas ligand
11. The Fas counter attack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand
12. Generalized lymphoproliferation disease in mice, caused by a point mutation in the Fas ligand
13. A specific intercellular pathway of apoptotic cell death is defective in the mature peripheral T cells of autoimmune lpr and gld mice
14. The Fas system is a key regulator of germ cell apoptosis in the testis
15. The Fas system, a regulator of testicular germ cell apoptosis, is differentially up-regulated in Sertoli cell versus germ cell injury of the testis
16. An early and massive wave of germinal cell apoptosis is required for the development of functional spermatogenesis
17. A matter of death and life: The significance of germ cell death during spermatogenesis
18. Hormonal control of apoptotic cell death in the testis: Gonadotropins and androgens as testicular cell survival factors
19. Testicular degeneration in Bclw-deficient mice
20. The meiotic checkpoint monitoring synapsis eliminates spermatocytes via p53-independent apoptosis
21. Differences defined by bone marrow transplantation suggest that lpr and gld are mutations of genes encoding an interacting pair of molecules
22. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family
23. Downregulation of Fas ligand by shedding
24. The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen
25. Apoptotic signalling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase
26. FLICE is activated by association with the CD95 death-inducing signalling complex (DISC)
27. Multiple pathways originate at the CD95/APO-1 (CD95) receptor: Sequential involvement of phosphatidylcholine-specific phospholipase C and acid sphingomyelinase in the propagation of the apoptotic signal
28. Requirement of an ICE/CED-3 protease for CD95/APO-1-mediated apoptosis
29. Maximal proliferation of cytotoxic T lymphocytes requires reverse signalling through Fas ligand
30. The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death
31. Crosslinking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells
32. Reverse signalling via CD30 ligand
33. A casein kinase I motif present in the cytoplasmic domain of members of the tumor necrosis factor ligand family is implicated in ″reverse signalling″
34. TCR/CD3 coupling to Fas-based cytotoxicity
35. CD40 ligand-transduced costimulation of T cells in the development of helper function
36. Human monocytic cells contain high levels of intracellular Fas ligand: Rapid release following cellular activation
37. Degranulation plays on essential part in regulation cell surface expression of Fas ligand in T cells and natural killer cells
38. Phospholipase and phagocytosis: The role of phospholipid-derived second messengers in phagocytosis
39. 2
40. 2 is phosphorylated and activated by MAP kinase
41. 2
42. 2 are abrogated by an inhibitor of the p38 MAP kinase cascade in human neutrophils
43. 2 and the release of arachidonic acid in human neutrophils
44. 2
45. 2 is phosphorylated in collagen- And thrombin-stimulated human platelets independent of protein kinase C and mitogen-activated protein kinase
46. Identification of a ten-amino acid proline-rich SH3 binding site
47. Human Fas ligand: Gene structure, chromosomal localization and species specificity
48. Interaction of peptides derived from the Fas ligand with the Fyn-SH3 domain
49. The mitogen-activated protein kinase signal transduction pathway
50. Mitogen-activated protein kinases: Specific messages from ubiquitous messenger
51. Release of preformed Fas ligand in soluble form is the major factor for activation-induced death of jurkat T cells
52. Expression of the functional soluble form of human Fas ligand in activated lymphocytes
53. Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing
54. Fas ligand in human serum
55. Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity
56. Activated human T cells release bioactive Fas ligand and APO2 ligand in microvesicles
57. Thyroid hormone stimulates glucose transport and GLUT1 mRNA in rat Sertoli cells
58. Establishment and characterization of two distinct mouse testicular epithelial cell lines
59. Single step method of RNA isolation by guanidinium thiocyanate-phenol-chloroform extraction
60. NKR-P1A stimulation of arachidonate-generating enzymes in rat NK cells is associated with granule release and cytotoxic activity
61. Interleukin-2-activated rat natural killer cells express inducible nitric oxide synthase that contributes to cytotoxic function and interferon-γ production
62. A rapid method of total lipid extraction and purification