The functional role of CYP2B6 in human drug metabolism: Substrates and inhibitors in vitro, in vivo and in silico

Current Drug Metabolism

Volumn 7, Issue 7, 2006, Pages 705-714

  Turpeinen, Miia ^a   Raunio, Hannu ^b   Pelkonen, Olavi ^a  

^a UNIVERSITY OF OULU   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Bupropion; Clopidogrel; CYP2B6; Thiotepa; Ticlopidine

Indexed keywords

AMFEBUTAMONE; ARTEMISININ; CLOPIDOGREL; CYCLOPHOSPHAMIDE; CYTOCHROME P450 2B6; DEXLOXIGLUMIDE; EFAVIRENZ; FENPROPOREX; FLUOXETINE; IFOSFAMIDE; KETAMINE; LIDOCAINE; LOPERAMIDE; MEPHENYTOIN; METHADONE; METHYLPHENOBARBITAL; NEVIRAPINE; PETHIDINE; PHENAZONE; PICLAMILAST; PROPOFOL; ROPIVACAINE; SELEGILINE; SERTRALINE; SEVOFLURANE; THIOTEPA; TICLOPIDINE; TRAMADOL; UNINDEXED DRUG; VERAPAMIL;

AREA UNDER THE CURVE; CANCER; COMPUTER MODEL; CONCENTRATION RESPONSE; DEFLUORINATION; DEMETHYLATION; DRUG ACTIVATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG COMPETITION; DRUG EFFICACY; DRUG ELIMINATION; DRUG HYDROXYLATION; DRUG INHIBITION; DRUG METABOLISM; DRUG SCREENING; ENZYME ACTIVITY; ENZYME SUBSTRATE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VITRO STUDY; IN VIVO STUDY; MALARIA; NONHUMAN; PARKINSON DISEASE; PHARMACOGENETICS; PREDICTION; PROTEIN FUNCTION; RELIABILITY; REVIEW; SEIZURE; SINGLE NUCLEOTIDE POLYMORPHISM; TOBACCO DEPENDENCE;

CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; HUMANS; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS;

EID: 33749453826     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920006778520633     Document Type: Review

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