Inhibition of cytochromes P450 by antifungal imidazole derivatives

Drug Metabolism and Disposition

Volumn 30, Issue 3, 2002, Pages 314-318

  Zhang, Wenjiang ^b   Ramamoorthy, Yamini ^b   Kilicarslan, Tansel ^b   Nolte, Helma ^b   Tyndale, Rachel F ^a,b,d   Sellers, Edward M ^a,b,c,d  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHOXY 4 TRIFLUOROMETHYLCOUMARIN; ANTIFUNGAL AGENT; CHLORZOXAZONE; CLOTRIMAZOLE; COUMARIN ANTICOAGULANT; COUMARIN DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; DEXTROMETHORPHAN; DICLOFENAC; FLUCONAZOLE; IMIDAZOLE DERIVATIVE; KETOCONAZOLE; MICONAZOLE; OMEPRAZOLE; PHENACETIN; SULCONAZOLE; TIOCONAZOLE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DEMETHYLATION; DRUG HYDROXYLATION; DRUG PROTEIN BINDING; ENZYME INHIBITION; HUMAN; HUMAN CELL; LIVER MICROSOME; LYMPHOBLAST; MICROSOME; MOLECULAR INTERACTION; PRIORITY JOURNAL; REACTION ANALYSIS;

ANIMALS; ANTIFUNGAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DNA, COMPLEMENTARY; DRUG INTERACTIONS; HUMANS; IMIDAZOLES; ISOENZYMES; MICROSOMES, LIVER; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TUMOR CELLS, CULTURED;

EID: 0036176695     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.30.3.314     Document Type: Article

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