-
2
-
-
0014754653
-
Biotransformation of ethylbenzene, styrene and alpha-methylstyrene in man
-
Bardodej Z., Bardodejova E. Biotransformation of ethylbenzene, styrene and alpha-methylstyrene in man. Am. Ind. Hyg. Assoc. J. 31:1970;206-209.
-
(1970)
Am. Ind. Hyg. Assoc. J.
, vol.31
, pp. 206-209
-
-
Bardodej, Z.1
Bardodejova, E.2
-
3
-
-
0037452421
-
The integration of data on physico-chemical properties, in vitro-derived toxicity data and physiologically based kinetic and dynamic as modelling a tool in hazard and risk assessment. A commentary
-
Blaauboer B.J. The integration of data on physico-chemical properties, in vitro-derived toxicity data and physiologically based kinetic and dynamic as modelling a tool in hazard and risk assessment. A commentary. Toxicol. Lett. 138:2003;161-171.
-
(2003)
Toxicol. Lett.
, vol.138
, pp. 161-171
-
-
Blaauboer, B.J.1
-
4
-
-
0345490845
-
Effect of methanol, ethanol, dimethyl sulfoxide, and acetonitrile on in vitro activities of cDNA expressed human cytochromes P-450
-
Busby W.F., Ackermann J.M., Crespi C.L. Effect of methanol, ethanol, dimethyl sulfoxide, and acetonitrile on in vitro activities of cDNA expressed human cytochromes P-450. Drug Metab. Dispos. 27:1999;246-249.
-
(1999)
Drug Metab. Dispos.
, vol.27
, pp. 246-249
-
-
Busby, W.F.1
Ackermann, J.M.2
Crespi, C.L.3
-
5
-
-
0842341740
-
Ethylbenzene
-
Claydon, G., Claydon, F. (Eds.). Wiley/Interscience, New York
-
Cavender, F., 1994. Ethylbenzene. In: Claydon, G., Claydon, F. (Eds.), Patty's Industrial Hygiene and Toxicology. Wiley/Interscience, New York, pp. 1342-1346.
-
(1994)
Patty's Industrial Hygiene and Toxicology
, pp. 1342-1346
-
-
Cavender, F.1
-
6
-
-
0031940804
-
Effect of common organic solvents on in vitro cytochrome P450-mediated metabolic activities in human liver microsomes
-
Chauret N., Gauthier A., Nicoll-Griffith D.A. Effect of common organic solvents on in vitro cytochrome P450-mediated metabolic activities in human liver microsomes. Drug Metab. Dispos. 26:1998;1-4.
-
(1998)
Drug Metab. Dispos.
, vol.26
, pp. 1-4
-
-
Chauret, N.1
Gauthier, A.2
Nicoll-Griffith, D.A.3
-
7
-
-
0034076405
-
Changes in microsomal activity in alcoholism and obesity
-
de la Maza M.P., Hirsch S., Petermann M., Suazo M., Ugarte G., Bunout D. Changes in microsomal activity in alcoholism and obesity. Alcohol. Clin. Exp. Res. 24:2000;605-610.
-
(2000)
Alcohol. Clin. Exp. Res.
, vol.24
, pp. 605-610
-
-
De La Maza, M.P.1
Hirsch, S.2
Petermann, M.3
Suazo, M.4
Ugarte, G.5
Bunout, D.6
-
8
-
-
0031962621
-
Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes
-
Eagling V.A., Tjia J.F., Back D.J. Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes. Br. J. Clin. Pharmacol. 45:1998;107-114.
-
(1998)
Br. J. Clin. Pharmacol.
, vol.45
, pp. 107-114
-
-
Eagling, V.A.1
Tjia, J.F.2
Back, D.J.3
-
9
-
-
0021740236
-
Urinary disposition of ethylbenzene and m-xylene in man following separate and combined exposure
-
Engstrom K., Riihimaki V., Laine A. Urinary disposition of ethylbenzene and m-xylene in man following separate and combined exposure. Int. Arch. Occup. Environ. Health. 54:1984;355-363.
-
(1984)
Int. Arch. Occup. Environ. Health
, vol.54
, pp. 355-363
-
-
Engstrom, K.1
Riihimaki, V.2
Laine, A.3
-
10
-
-
0033074472
-
Effects of disease on expression and regulation of CYPs
-
Farrell G. Effects of disease on expression and regulation of CYPs. Mol. Aspects Med. 20:1999;55-70.
-
(1999)
Mol. Aspects Med.
, vol.20
, pp. 55-70
-
-
Farrell, G.1
-
11
-
-
0022122253
-
An overview of environmental and toxicological aspects of aromatic hydrocarbons IV
-
Fishbein L. An overview of environmental and toxicological aspects of aromatic hydrocarbons IV. Ethylbenzene. Sci. Tot. Environ. 44:1985;269-287.
-
(1985)
Ethylbenzene. Sci. Tot. Environ.
, vol.44
, pp. 269-287
-
-
Fishbein, L.1
-
12
-
-
0030815178
-
Chlormethiazole inhibition of cytochrome P450 2E1 as assessed by chlorzoxazone hydroxylation in humans
-
Gebhardt A.C., Lucas D., Menez J.F., Seitz H.K. Chlormethiazole inhibition of cytochrome P450 2E1 as assessed by chlorzoxazone hydroxylation in humans. Hepatology. 26:1997;957-961.
-
(1997)
Hepatology
, vol.26
, pp. 957-961
-
-
Gebhardt, A.C.1
Lucas, D.2
Menez, J.F.3
Seitz, H.K.4
-
14
-
-
0026035519
-
Role of human cytochrome P-450 IIEI in the oxidation of many low molecular weight cancer suspects
-
Guengerich F.P., Kim D.H., Iwasaki M. Role of human cytochrome P-450 IIEI in the oxidation of many low molecular weight cancer suspects. Chem. Res. Toxicol. 4:1991;168-179.
-
(1991)
Chem. Res. Toxicol.
, vol.4
, pp. 168-179
-
-
Guengerich, F.P.1
Kim, D.H.2
Iwasaki, M.3
-
15
-
-
0036290174
-
The use of in vitro metabolic parameters and physiologically based pharmacokinetic (PBPK) modeling to explore the risk assessment of trichloroethylene
-
Hissink E.M., Bogaards J.J.P., Freidig A.P., Commandeur J.N.M., Vermeulen N.P.E., van Bladeren P.J. The use of in vitro metabolic parameters and physiologically based pharmacokinetic (PBPK) modeling to explore the risk assessment of trichloroethylene. Environ. Toxicol. Pharm. 11:2002;259-271.
-
(2002)
Environ. Toxicol. Pharm.
, vol.11
, pp. 259-271
-
-
Hissink, E.M.1
Bogaards, J.J.P.2
Freidig, A.P.3
Commandeur, J.N.M.4
Vermeulen, N.P.E.5
Van Bladeren, P.J.6
-
16
-
-
0028342648
-
Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance
-
Houston J.B. Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance. Biochem. Pharmacol. 47:1994;1469-1479.
-
(1994)
Biochem. Pharmacol.
, vol.47
, pp. 1469-1479
-
-
Houston, J.B.1
-
17
-
-
0026705603
-
Inducibility of human cytochromes P-450 primarily involved in the activation of chemical carcinogens
-
Kadlubar F.F., Guengerich F.P. Inducibility of human cytochromes P-450 primarily involved in the activation of chemical carcinogens. Chemosphere. 25:1992;201-204.
-
(1992)
Chemosphere
, vol.25
, pp. 201-204
-
-
Kadlubar, F.F.1
Guengerich, F.P.2
-
18
-
-
0027159323
-
Single-dose disulfiram inhibition of chlorzoxazone metabolism: A clinical probe for P450 2E1
-
Kharasch E.D., Thummel K.E., Mhyre J., Lillibridge J.H. Single-dose disulfiram inhibition of chlorzoxazone metabolism: a clinical probe for P450 2E1. Clin. Pharmacol. Ther. 53:1993;643-650.
-
(1993)
Clin. Pharmacol. Ther.
, vol.53
, pp. 643-650
-
-
Kharasch, E.D.1
Thummel, K.E.2
Mhyre, J.3
Lillibridge, J.H.4
-
19
-
-
0030878442
-
Cytochrome P450 isozymes responsible for the metabolism of toluene and styrene in human liver microsomes
-
Kim H., Wang R.S., Elovaara E., Raunio H., Pelkonen O., Aoyama T., Vainio H., Nakajima T. Cytochrome P450 isozymes responsible for the metabolism of toluene and styrene in human liver microsomes. Xenobiotica. 27:1997;657-665.
-
(1997)
Xenobiotica
, vol.27
, pp. 657-665
-
-
Kim, H.1
Wang, R.S.2
Elovaara, E.3
Raunio, H.4
Pelkonen, O.5
Aoyama, T.6
Vainio, H.7
Nakajima, T.8
-
20
-
-
0004041970
-
-
Lewis Publishers, Boca Raton, FL
-
Lauwerys, R.R., Hoet, P., 2001. Industrial Chemical Exposure: Guidelines for Biological Monitoring. Lewis Publishers, Boca Raton, FL.
-
(2001)
Industrial Chemical Exposure: Guidelines for Biological Monitoring
-
-
Lauwerys, R.R.1
Hoet, P.2
-
21
-
-
0037041195
-
Incorporating human interindividual biotransformation variance in health risk assessment
-
Lipscomb J.C., Kedderis G.L. Incorporating human interindividual biotransformation variance in health risk assessment. Sci. Tot. Environ. 288:2002;13-21.
-
(2002)
Sci. Tot. Environ.
, vol.288
, pp. 13-21
-
-
Lipscomb, J.C.1
Kedderis, G.L.2
-
22
-
-
0034874878
-
The effects of alcohol and diallyl sulphide on CYP2E1 activity in humans: A phenotyping study using chlorzoxazone
-
Loizou G.D., Cocker J. The effects of alcohol and diallyl sulphide on CYP2E1 activity in humans: a phenotyping study using chlorzoxazone. Hum. Exp. Toxicol. 20:2001;321-327.
-
(2001)
Hum. Exp. Toxicol.
, vol.20
, pp. 321-327
-
-
Loizou, G.D.1
Cocker, J.2
-
23
-
-
17744385960
-
In vitro human tissue models in risk assessment: Report of a consensus-building workshop
-
MacGregor J.T., Collins J.M., Sugiyama Y., Tyson C.A., Dean J., Smith L., Andersen M., Curren R.D., Houston J.B., Kadlubar F.F., Kedderis G.L., Krishnan K., Li A.P., Parchment R.E., Thummel K., Tomaszewski J.E., Ulrich R., Vickers A.E.M., Wrighton S.A. In vitro human tissue models in risk assessment: report of a consensus-building workshop. Toxicol. Sci. 59:2001;17-36.
-
(2001)
Toxicol. Sci.
, vol.59
, pp. 17-36
-
-
MacGregor, J.T.1
Collins, J.M.2
Sugiyama, Y.3
Tyson, C.A.4
Dean, J.5
Smith, L.6
Andersen, M.7
Curren, R.D.8
Houston, J.B.9
Kadlubar, F.F.10
Kedderis, G.L.11
Krishnan, K.12
Li, A.P.13
Parchment, R.E.14
Thummel, K.15
Tomaszewski, J.E.16
Ulrich, R.17
Vickers, A.E.M.18
Wrighton, S.A.19
-
24
-
-
0027988797
-
Styrene metabolism by cDNA-expressed human hepatic and pulmonary cytochromes P450
-
Nakajima T., Elovaara E., Gonzalez F.J., Gelboin H.V., Raunio H., Pelkonen O., Vainio H., Aoyama T. Styrene metabolism by cDNA-expressed human hepatic and pulmonary cytochromes P450. Chem. Res. Toxicol. 7:1994;891-896.
-
(1994)
Chem. Res. Toxicol.
, vol.7
, pp. 891-896
-
-
Nakajima, T.1
Elovaara, E.2
Gonzalez, F.J.3
Gelboin, H.V.4
Raunio, H.5
Pelkonen, O.6
Vainio, H.7
Aoyama, T.8
-
25
-
-
0028858960
-
Evaluation of specificities in the in vitro metabolism of therapeutic agents by human liver microsomes
-
Newton D.J., Wang R.W., Lu A.Y.H. Evaluation of specificities in the in vitro metabolism of therapeutic agents by human liver microsomes. Drug Metab. Dispos. 23:1995;154-157.
-
(1995)
Drug Metab. Dispos.
, vol.23
, pp. 154-157
-
-
Newton, D.J.1
Wang, R.W.2
Lu, A.Y.H.3
-
26
-
-
0034013033
-
Assessment of specificity of eight chamical inhibitors using cDNA expressed cytochromes P450
-
Sai Y., Dai Y., Yang T.J., Krausz K.W., Gonzalez F.W., Gelboin H.V., Shous M. Assessment of specificity of eight chamical inhibitors using cDNA expressed cytochromes P450. Xenobiotica. 30:2000;327-343.
-
(2000)
Xenobiotica
, vol.30
, pp. 327-343
-
-
Sai, Y.1
Dai, Y.2
Yang, T.J.3
Krausz, K.W.4
Gonzalez, F.W.5
Gelboin, H.V.6
Shous, M.7
-
27
-
-
0029875883
-
Human cytochrome P450 isoform specificity in the regioselective metabolism of toluene and o-, m- and p-xylene
-
Tassaneeyakul W., Birkett D.J., Edwards J.W., Veronese M.E., Tassaneeyakul W., Tukey R.H., Miners J.O. Human cytochrome P450 isoform specificity in the regioselective metabolism of toluene and o-, m- and p-xylene. J. Pharmacol. Exp. Ther. 276:1996;101-108.
-
(1996)
J. Pharmacol. Exp. Ther.
, vol.276
, pp. 101-108
-
-
Tassaneeyakul, W.1
Birkett, D.J.2
Edwards, J.W.3
Veronese, M.E.4
Tassaneeyakul, W.5
Tukey, R.H.6
Miners, J.O.7
-
28
-
-
0033674502
-
Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: Ratios of accessory proteins as sources of discrepancies between the approaches
-
Venkatakrishnan K., von Moltke L.L., Court M.H., Harmatz J.S., Crespi C.L., Greenblatt D.J. Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: ratios of accessory proteins as sources of discrepancies between the approaches. Drug Metab. Dispos. 28:2000;1493-1504.
-
(2000)
Drug Metab. Dispos.
, vol.28
, pp. 1493-1504
-
-
Venkatakrishnan, K.1
Von Moltke, L.L.2
Court, M.H.3
Harmatz, J.S.4
Crespi, C.L.5
Greenblatt, D.J.6
-
29
-
-
0012153583
-
-
Ethylbenzene, World Health Organisation, Geneva
-
WHO, 1996. Environmental Health Criteria 186. Ethylbenzene, World Health Organisation, Geneva.
-
(1996)
Environmental Health Criteria 186
-
-
|