Ring hydroxylation of [o-3H]methoxychlor as a probe for liver microsomal CYP2B activity: Potential for in vivo CYP2B assay

Analytical Biochemistry

Volumn 233, Issue 1, 1996, Pages 100-107

  Stresser, David M ^a   Dehal, Shangara S ^a   Kupfer, David ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHARCOAL; INSECTICIDES; METABOLITES; MONOCLONAL ANTIBODIES; RATS; BIOCHEMISTRY;

HYDROXYLASE ACTIVITY; LIVER MICROSOMES; MECHANISM-BASED; MONOCLONAL ANTIBODIES (MAB); ORGANIC METABOLITES; PARENT COMPOUNDS; PYRIDINE TREATMENT; URINARY EXCRETION; IN-VIVO;

HYDROXYLATION; CHEMISTRY;

16ALPHA CYANOPREGNENOLONE; 3 METHYLCHOLANTHRENE; BETA NAPHTHOFLAVONE; CHLORPHENOTANE; CLOFIBRATE; DEXAMETHASONE; LIVER ENZYME; METHOXYCHLOR; MONOCLONAL ANTIBODY; ORPHENADRINE; PHENOBARBITAL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRITIUM OXIDE; UNSPECIFIC MONOOXYGENASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; FEMALE; HYDROXYLATION; LIVER MICROSOME; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOMETRY; RAT;

ANIMALIA; TRITIUM;

EID: 0029671245     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1006/abio.1996.0013     Document Type: Article

References (26)

1. Nelson, D. R., Kamataki, T., Waxman, D. J., Guengerich, F. P., Estabrook, R. W., Feyereisen, R., Gonzalez, F. J., Coon, M. J., Gunsalus, I. C., Gotoh, O., Okuda, K., and Nebert, D. W. (1993) DNA Cell Biol. 12, 1-51.
2. Waxman, D. J. (1988) Biochem. Pharmacol. 37, 71-84.
3. Koop, D. R., Laethem, C. L., and Tierney, D. J. (1989) Drug Metab. Rev. 20, 541-551.
4. Burke, M. D., Thompson, S., Weaver, R. J., Wolf, C. R., and Mayer, R. T. (1994) Biochem. Pharmacol. 48, 923-936.
5. Rodrigues, A. D., Kukulka, M. J., Surber, B. W., Thomas, S. B., and Uchic, J. T. (1994) Anal. Biochem. 219, 309-320.
6. Liu, G., Gelboin, H. V., and Myers, M. J. (1991) Arch. Biochem. Biophys. 284, 400-406.
7. Watkins, P. B., Murray, S. A., Winkelman, L. G., Heuman, D. M., Wrighton, S. A., and Guzelian, P. S. (1989) J. Clin. Invest. 83, 688-697.
8. Peter, R., Bocker, R., Beaune, P. H., Iwaski, M., Guengerich, F. P., and Yang, C. S. (1990) Chem. Res. Toxicol. 3, 565-573.
9. Kupfer, D., Bulger, W. H., and Theoharides, A. D. (1990) Chem. Res. Toxicol. 3, 8-16.
10. Dehal, S. S., and Kupfer, D. (1994) Drug Metab. Dispos. 22, 937-946.
11. Mitscher, L. A., Gollapudi, S. R., Drake, S., and Oburn, D. S. (1985) Phytochemistry 24, 1481-1484.
12. Burstein, S. H., and Kupfer, D. (1971) Ann. NY Acad. Sci. 191, 61-67.
13. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951) J. Biol. Chem. 193, 265-275.
14. Stauffer, C. E. (1975) Anal. Biochem. 69, 646-648.
15. Kamath, S. A., Kummerow, F. A., and Narayan, K. A. (1971) FEBS Lett. 17, 90-92.
16. Kupfer, D., and Levin, E. (1972) Biochem. Biophys. Res. Commun. 47, 611-618.
17. Kupfer, D., Miranda, G. K., and Bulger, W. H. (1981) Anal. Biochem. 116, 27-34.
18. Guroff, G., Daly, J. W., Jerina, D. M., Renson, J., Witkop, B., and Udenfriend, S. (1967) Science 157, 1524-1530.
19. Reidy, G. F., Mehta, I., and Murray, M. (1989) Mol. Pharmacol. 35, 736-743.
20. Waxman, D. J., and Azaroff, L. (1992) Biochem. J. 281, 577-592.
21. Gibson, G. G., Norton, T. C., and Tarburini, P. P. (1982) Biochem. J. 203, 161-168.
22. Kim, S. G., Williams, D. E., Schuetz, E. G., Guzelian, P. S., and Novak, R. F. (1988) J. Pharmacol. Exp. Ther. 246, 1175-1182.
23. Yamazoe, Y., Shimada, M., Murayama, N., and Kato, R. (1987) J. Biol. Chem. 262, 7423-7428.
24. Namkung, M. J., Yang, H. L., Hulla, J. E., and Juchau, M. R. (1988) Mol. Pharmacol. 34, 628-637.
25. Bulger, W. H., Muticelli, R. M., and Kupfer, D. (1978) Biochem. Pharmacol. 27, 2417-2423.
26. Ousterhout, J., Struck, R. F., and Nelson, J. A. (1981) Biochem. Pharmacol. 30, 2869-2871.