Validation of bupropion hydroxylation as a selective marker of human cytochrome P450 2B6 catalytic activity

Drug Metabolism and Disposition

Volumn 28, Issue 10, 2000, Pages 1222-1230

  Faucette, Stephanie R ^a   Hawke, Roy L ^a   Lecluyse, Edward L ^a   Shord, Stacy S ^a   Yan, Bingfang ^b   Laethem, Ronald M ^c   Lindley, Celeste M ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF RHODE ISLAND   (United States)

^c GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMFEBUTAMONE; COMPLEMENTARY DNA; CYTOCHROME P450 2B6; CYTOCHROME P450 ISOENZYME; DIMETHYLNITROSAMINE DEMETHYLASE; MONOCLONAL ANTIBODY; S MEPHENYTOIN N DEMETHYLASE; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG HYDROXYLATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE COMPLEX; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; LIVER MICROSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; VALIDATION PROCESS;

ANIMALS; ANTIBODIES, MONOCLONAL; ARYL HYDROCARBON HYDROXYLASES; BIOLOGICAL MARKERS; BUPROPION; CATALYSIS; CELL LINE; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROXYLATION; ISOENZYMES; KINETICS; MICROSOMES, LIVER; OXIDOREDUCTASES, N-DEMETHYLATING; RECOMBINANT PROTEINS; REPRODUCIBILITY OF RESULTS;

EID: 0033810079     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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