Oxygen and hydrogen isotope effects in an active site tyrosine to phenylalanine mutant of peptidylglycine α-hydroxylating monooxygenase: Mechanistic implications

Biochemistry

Volumn 42, Issue 7, 2003, Pages 1813-1819

  Francisco, Wilson A ^a,c   Blackburn, Ninian J ^b   Klinman, Judith P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c ARIZONA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CATALYSIS; CHEMICAL BONDS; CRYSTALLOGRAPHY; HYDROGEN; HYDROXYLATION; ISOTOPES; OXYGEN; QUANTUM THEORY; REACTION KINETICS;

REDUCTIVE ACTIVATION;

ENZYMES;

ENZYME; GLYCINE; HYDROGEN; OXYGEN; PHENETHYLAMINE DERIVATIVE; PHENYLALANINE; TYROSINE;

ARTICLE; CATALYSIS; CHEMICAL BOND; CRYSTALLOGRAPHY; ENZYME MECHANISM; HYDROXYLATION; KINETICS; PRIORITY JOURNAL; QUANTUM MECHANICS; REACTION ANALYSIS;

AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CATALYSIS; CELL LINE; DEUTERIUM; DOPAMINE BETA-HYDROXYLASE; HIPPURATES; HUMANS; HYDROXYLATION; KINETICS; MIXED FUNCTION OXYGENASES; MULTIENZYME COMPLEXES; OXYGEN ISOTOPES; PHENYLALANINE; TYROSINE;

EID: 0345270446     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi020592t     Document Type: Article

References (27)

1. Kulathila, R., Merkler, K. A., and Merkler, D. J. (1999) Nat. Prod. Rep. 16, 145-154.
2. Prigge, S. T., Mains, R. E., Eipper, B. A., and Amzel, L. M. (2000) Cell. Mol. Life Sci. 57, 1236-1259.
3. Southan, C., and Kruse, L. I. (1989) FEBS Lett. 255, 116-120.
4. Eipper, B. A., Quon, A. S. W., Mains, R. E., Boswell, J. S., and Blackburn, N. J. (1995) Biochemistry 34, 2857-2865.
5. Ahn, N., and Klinman, J. P. (1983) Biochemistry 22, 3096-3106.
6. Fitzpatrick, P. F., and Villafranca, J. J. (1987) Arch. Biochem. Biophys. 257, 231-250.
7. Bradbury, A. F., Mistry, J., Roos, B. A., and Smyth, D. G. (1990) Eur. J. Biochem. 189, 363-368.
8. Katopodis, A. G., and May, S. W. (1990) Biochemistry 29, 4541-4548.
9. Zabriskie, T. M., Cheng, H. M., and Vederas, J. C. (1992) J. Am. Chem. Soc. 114, 2270-2272.
10. Miller, S. M., and Klinman, J. P. (1985) Biochemistry 24, 2114-2127.
11. Tian, G. C., Berry, J. A., and Klinman, J. P. (1994) Biochemistry 33, 226-234.
12. Prigge, S. T., Kolhekar, A. S., Eipper, B. A., Mains, R. E., and Amzel, L. M. (1997) Science 278, 1300-1305.
13. Prigge, S. T., Kolhekar, A. S., Eipper, B. A., Mains, R. E., and Amzel, L. M. (1999) Nat. Struct. Biol. 6, 976-983.
14. Jaron, S., and Blackburn, N. J. (1999) J. Inorg. Biochem. 74, 180-180.
15. Dewolf, W. E., Carr, S. A., Varrichio, A., Goodhart, P. J., Mentzer, M. A., Roberts, G. D., Southan, C., Dolle, R. E., and Kruse, L. I. (1988) Biochemistry 27, 9093-9101.
16. Farrington, G. K., Kumar, A., and Villafranca, J. J. (1990) J. Biol. Chem. 265, 1036-1040.
17. Kolhekar, A. S., Keutmann, H. T., Mains, R. E., Quon, A. S. W., and Eipper, B. A. (1997) Biochemistry 36, 10901-10909.
18. Francisco, W. A., Merkler, D. J., Blackburn, N. J., and Klinman, J. P. (1998) Biochemistry 37, 8244-8252.
19. Miller, S. M., and Klinman, J. P. (1983) Biochemistry 22, 3091-3096.
20. Francisco, W. A., Knapp, M. J., Blackburn, N. J., and Klinman, J. P. (2002) J. Am. Chem. Soc. 124, 8194-8195.
21. Cleland, W. W. (1979) Methods Enzymol. 63, 103-138.
22. Northrop, D. B. (1975) Biochemistry 14, 2644-2651.
23. Tian, G. C., and Klinman, J. P. (1993) J. Am. Chem. Soc. 115, 8891-8897.
24. Klinman, J. P., Humphries, H., and Voet, J. G. (1980) J. Biol. Chem. 255, 1648-1651.
25. Cook, P. F., and Cleland, W. W. (1981) Biochemistry 20, 1790-1796.
26. Knapp, M. J., Rickert, K., and Klinman, J. P. (2002) J. Am. Chem. Soc. 124, 3865-3874.
27. Mendenhall, W. (1983) Introduction to Probability and Statistics, 6th ed., Duxbury, Boston, MA.