Multidrug transporters as drug targets

Current Drug Targets

Volumn 7, Issue 8, 2006, Pages 911-921

  Liang, X J ^a   Aszalos, A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cancer chemotherapy; Drug resistance; Drug drug interactions; Intentional and or unintentional targets; Multidrug transporters; P glycoprotein; Polypharmacy

Indexed keywords

ASTEMIZOLE; BEPRIDIL; BILIRUBIN; CHLORPROMAZINE; CLEMASTINE; CYCLOSPORIN A; CYTARABINE; DAUNORUBICIN; DEXTROPROPOXYPHENE; DIGOXIN; DOXORUBICIN; GLYCOPROTEIN P; LOPERAMIDE; METOCLOPRAMIDE; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; NIMODIPINE; PACLITAXEL; PIROXICAM; PROCHLORPERAZINE; QUINIDINE; TALINOLOL; TAMOXIFEN; TERFENADINE; TRIMETHOBENZAMIDE; TRIPROLIDINE; UNINDEXED DRUG; VALSPODAR; VERAPAMIL; VINBLASTINE;

ACUTE GRANULOCYTIC LEUKEMIA; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; BLOOD BRAIN BARRIER; BONE MARROW SUPPRESSION; BRADYCARDIA; CANCER CHEMOTHERAPY; CARDIOTOXICITY; CELL MEMBRANE; CEREBROSPINAL FLUID; CHOROID PLEXUS; CLINICAL TRIAL; DIZZINESS; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG DOSE REGIMEN; DRUG ELIMINATION; DRUG RECEPTOR BINDING; DRUG RESISTANCE; DRUG TARGETING; DRUG TRANSPORT; DYSMETRIA; GENE TARGETING; HUMAN; HYPERREFLEXIA; HYPOTENSION; INTESTINE; KIDNEY CARCINOMA; KIDNEY PARENCHYMA; LEUKOPENIA; LIVER; LUNG NON SMALL CELL CANCER; MOUTH MUCOSA; NUCLEOTIDE SEQUENCE; OVARY CARCINOMA; PHARMACODYNAMICS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SEMINIFEROUS TUBULE; SERTOLI CELL; T LYMPHOCYTE; TISSUE DISTRIBUTION; TREMOR;

ANIMALS; BIOLOGICAL TRANSPORT; DRUG DELIVERY SYSTEMS; HUMANS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PHARMACEUTICAL PREPARATIONS;

EID: 33747202180     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/138945006778019264     Document Type: Article

References (116)

1. Ambudkar, S.V.; Dey, S.; Hrycyna, C.A.; Ramachandra; M.; Pastan, I. and Gottesman, M.M. (1999) Annu. Rev. Pharmacol. Toxicol., 39, 361-398.
2. Gottesman, M.M. and Pastan, I. (1993) Annu. Rev. Biochem. 62, 385-427.
3. Thiebaut, F.; Tsuruo, T.; Hamada, H.; Gottesman, M.M. and Pastan, I. (1987) Proc. Natl. Acad. Sci., USA, 84 (21), 7735-7738.
4. Gottesman, M.M.; Fojo, T. and Bates, S.F. (2002) Nat. Rev. Cancer, 2 (1), 48-58.
5. Watkins, P.B. (1997) Adv. Drug Delivery Rev., 27 (2-3), 161-170.
6. Clifford, S.C.; Neal, D.E. and Lunec, J. (1996) Carcinogenesis, 17 (3), 601-604.
7. Abbot, N.J. and Romeo, I.A. (1996) Mol. Med. Today, 2 (3), 106-113.
8. Rao, V.V.; Dahlheimer, J.L.; Bardet, M.E.; Snyder, A.Z.; Finch, R.A.; Sartorelli, A.C. and Piwnica-Worms, D. (1999) Proc. Natl. Acad. Sci. USA, 96 (7), 3900-3905.
9. Klimechi, W.T.; Futscher, B.W.; Grogren, T.M. and Dalton, W.S. (1994) Blood, 83 (9), 2451-2458.
10. Johnston, R.W.; Ruefli, A.A. and Smyth, M.J. (2000) Trends Biochem. Sci., 25 (1), 1-6.
11. Westphal, K.; Weinbrenner, A.; Greissmann, T.; Stuhr, M.; Franke, G.; Zschiesche, M.; Oertel, R.; Terhaag, B.; Kroemer, H.K. and Siegmund, W. (2000) Clin. Pharmacol. Ther., 68 (1), 6-12.
12. Fromm, M.F.; Kim, R.B.; Stein, C.M.; Wilkinson, G.R. and Roden, D.M. (1999) Circulation, 99 (4), 552-554.
13. Drescher, S.; Glaeser, H.; Muldter, T.; Hitzl, M.; Eichelbaum, M. and Fromm, M.F. (2003) Clin. Pharmacol. Ther., 73 (3), 223-231.
14. Fojo, T. and Bates, S. (2003) Oncogene, 22 (47), 7512-7523
15. Sridhar, K.S.; Krishan, A.; Samy, T.S.A.; Sauerteig, A.; Wellham, L.L.; McPhee, G.; Duncan, R.C.; Anac, S.Y.; Ardalan, B. and Benedetto, P.W. (1993) Cancer Chemother. Pharmacol., 31 (6), 423-430.
16. Motzer, R.J.; Lyn, P.; Ficher, P.; Lianes, P.; Ngo, R.L.; Cordon-Cardo, C. and O'Brieb, J.P. (1995) J. Clin. Oncol., 13 (8), 1958-1965.
17. Agarwala, S.S.; Bahnson, R.R.; Wilson, J.W.; Sumowski, J. and Ernstoff, M.S. (1995) Am. J. Clin. Oncol., 18 (3), 211-215.
18. Trump, D.L.; Smith, D.C.; Ellis, P.G.; Rogers, M.P.; Schold, S.C.; Winer, E.P.; Panella, T.J.; Jordan, V.C. and Fine, R.L. (1992) J. Natl. Cancer Inst., 84 (23), 1811-1816.
19. Lum, B.L.; Kaubisch, S.; Fisher, G.A.; Brown, B.W. and Sikic, B.I. (2000) Cancer Chemother. Pharmacol., 45 (4), 305-311.
20. Chico, I.; Kang, M.H.; Bergan, R.; Abraham, J.; Bakke, S.; Meadows, B.; Rutt, A.; Robey, R.; Choyke, P.; Merino, M.; Goldspiel, B.; Smith, T.; Steinberg, S.; Figg, W.D.; Fojo, T. and Bates, S. (2001) J. Clin. Oncol. 19 (3), 832-842.
21. Sonneveld, P.; Burnett, A.; Vossebeld, P.; Ben-Am, M.; Rozenkranz, G.; Pfister, C.; Verhoef, G.; Dekker, A.; Ossenkoppele, G.; Ferrant, C.; Yin, L.; Gratwohl, A.; Kovacsovics, T.; Vellenga, E.; Capdeville, R. and Lowenberg, B. (2000) Hematol. J., 1 (6), 411-421.
22. Bakelandt, M.; Lehne, G.; Trope, C.G.; Szanto. I.: Pfeiffer, P.; Gustavsson, B. and Kristensen, G.B. (2001) J. Clin. Onco., 19 (12), 2983-2993.
23. Limtrakul, P.; Khantamat, O. and Pintha, K. (2004) Cancer Chemother. Pharmacol., 54 (6), 525-530.
24. Webster, L.; Linsenmeyer, M.; Millward, M.; Morton, C.; Bishop, J. and Woodcook, D. (1993) J. Natl. Cancer Inst., 85 (2), 1685-1690.
25. Ross, D.D.; Wooten, P.J.; Tong, Y.; Cornblatt, B.; Levy, C.; Sridhara, R.; Lee, E.J. and Schiffer, C.A. (1994) Blood, 83 (5), 1337-1347.
26. Hwang, M.; Ahn, C-H.; Pine, P.S.; Yin, J-J.; Hrycyna, C.A.; Liht, T. and Aszalos, A. (1996) Int. J. Cancer, 65 (3), 389-397.
27. Woodcock, D.M.; Linsenmeyer, M.E.; Chojnowski, G.; Krieger, A.B.; Nink, V.; Webster, L.K. and Sawyer, W.H. (1992) Br. J. Cancer, 66 (1), 62-68.
28. Callahan, R.; Stafford, A, and Epand, R.M. (1993) Biochem. Biophys. Acta, 1175 (3), 277-282.
29. Saeki, T.; Shimabuku, A.M.; Ueda, K. and Komano, T. (1992) Biochem. Biophys. Acta, 1107 (1), 105-110.
30. Wesolowska, O.; Hendrich, A.B.; Motohashi, N.; Kawase, M.; Dobryszycki, P.; Ozyhar, A. and Michalak, K. (2004) Biophys. Chem., 109 (3), 399-412.
31. Hendrich, A.B. and Michalak, K. (2003) Curr. Drug Targets, 4 (1), 23-30.
32. Aszalos, A. (2004) Arch. Pharm. Res., 27 (2), 127-135.
33. Raderer, M. and Scheithauer, W. (1993) Cancer, 72 (12), 3553-3563.
34. Robey, R.; Balle, S.; Stein, W.; Meadows, B.; Litma, T.; Patis, S.; Smith, T.; Fojo, T. and Bates, S. (1999) Blood, 93 (1), 306-314.
35. Hendrikse, N.H.; de Vries, E.G.; Eriks-Fluks, L.; van der Graaf, W.T.; Hospers, G.A.; Willemsen, A.T.; Vaalburg, W. and Franssen, E.J. (1999) Cancer Res., 59 (10), 2411-2416.
36. Chen, C.C.; Meados, B.; Regis, J.; Kalafsky, G.; Fojo, T.; Carrasquillo, J.A. and Bates, S.E. (1997) Clin. Cancer Res., 3 (4), 545-552.
37. Agrawal, M.; Abraham, J.; Balis, F.M.; Edgerly, M.; Stein, W.D.; Bates, S.; Fojo, T. and Chen, C.C. (2003) Clin. Cancer Res., 9 (2), 650-656.
38. Ibrahim, S.; Peggins, J.; Knapton, A.; Licht, T. and Aszalos, A. (2001) Anticancer Res., 21 (2A), 847-856.
39. Ibrahim, S.; Peggins, J.; Knapton, A.; Licht, T. and Aszalos, A. (2000) J. Pharmacol. Exp. Ther., 295 (3), 1276-1283.
40. Szabo, D.; Szabo, G.; Ocsovszki, I.; Aszalos, A and Molnar, J. (1999) Cancer Lett., 139 (1), 115-119.
41. Weiss, J.; Dormann, S.G.; Martin-Facklam, M.; Kerpen, C.J.; Ketabi-Kiyanvash, N. and Haefeli, W.E. (2003) J. Pharmacol. Exp. Ther., 305 (1), 197-204.
42. Westphal, K.; Weinbrenner, A.; Zschiesche, M.; Franke, G.; Knoke, M.; Oertel, R.; Fritz, P.; von Richter, O.; Warzok, R.; Hachenberg, T.; Kaufmann, H-M.; Schrenk, D.; Terhaag, B.; Kroemer, H.K. and Siegmund, W. (2000) Clin. Pharmacol. Ther., 68 (4), 345-355.
43. Durr, D.; Stieger, B.; Kullak-Ublick, G.A.; Rentsch, K.M.; Steinert, H.C.; Meier, P.J. and Fattinger, K. (2000) Clin. Pharmacol. Ther., 68 (6), 598-604.
44. Hennesey, M.; Kelleher, D.; Spiers, J.P.; Barry, M.; Kavanagh, P.; Back, D.; Mulcahy, F. and Feely, J. (2002) Brit. J. Clin. Pharmacol., 53 (1), 75-83.
45. Herbert, M.F. and Lam, A.Y. (1999) Ann. Pharmacother., 33 (6), 680-682.
46. Stockley, I.H. (1999) A Source Book of Adverse Interactions, Their Mechanisms, Clinical Importance and Management, Pharmaceutical Press, London.
47. Yu, D.K. (1999) J. Clin. Pharmacol., 39 (12), 1203-1211.
48. Wandel, C.; Kim, R.B.; Kajiji, S.; Guengerich, F.P.; Wikinson, G.R. and Wood, A.J.J. (1999) Cancer Res., 59 (16), 3944-3948.
49. Cole, S.P.; Bhardwaj, G.; Gelach, J.H.; Mackie, J.E.; Grant, C.E.; Almquist, K.C.; Stewart, A.J.; Kurz, E.U.; Duncan, A.M. and Deeley, R.G. (1992) Science, 258 (5088), 1650-1654.
50. Slovak, M.L.; Ho, J.P.; Bhardwaj, G.; Kurz, E.U.; Deeley, R.G. and Cole, S.P. (1993) Cancer Res., 53 (14), 3221-3225.
51. Paul, S.; Belinsky, M.G.; Shen, H. and Kruh, G.D. (1996) Biochemistry, 35 (42), 13647-13655.
52. Büchler, M.; König, J.; Brom, M.; Kartenbeck, J.; Spring, H.; Horie, T. and Keppler, D. (1996) J. Biol. Chem., 271 (25), 15091-15098
53. Cole, S.P.C. and Deeley, R.G. (1993) Science, 260, 879.
54. Taniguchi, K.; Wada, M.; Kohno, K.; Nakamura, T.; Kawabe, T.; Kawakami, M.; Kagotani, K.; Okumura, K.; Akiyama, S. and Kuwano, M. (1996) Cancer Res., 56 (18), 4124-4129.
55. Rosenberg, M.F.; Mao, Q.; Holzenburg, A.; Ford, R.C,; Deeley, R.G. and Cole, S.P. (2001) J. Biol. Chem., 276 (19), 16076-16082.
56. Zhu, Q.; Sun, H. and Center, M.S. (1997) Oncol. Res., 9 (5), 229-236.
57. Ma, L.; Krishnamachary, N. and Center, M.S. (1995) Biochemistry, 34 (10), 3338-3343.
58. Fernandez, S.B.; Hollo, Z.; Kern, A.; Bakos, E.; Fischer, P.A.; Borst, P. and Evers R. (2002) J. Biol. Chem., 277 (34), 31048-31055.
59. Bakos, E.; Hegedus, T.; Hollo, Z.; Welker, E.; Tusnady, G.E.; Zaman, G.J.; Flens, M.J.; Varadi, A. and Sarkadi, B. (1996) J. Biol. Chem., 271 (21), 12322-12326.
60. Borst, P.; Evers, R.; Kool, M. and Wijnholds, J. (2000) J. Natl. Cancer Inst., 92 (16), 1295-1302.
61. Paulusma, C.C.; Bosma, P.J.; Zaman, G.J.R.; Bakker, C.T.M.; Otter, M.; Scheffer, G.L.; Scheper, R.J.; Borst, P. and Oude Elferink, R.P.J. (1996) Science, 271 (5252), 1126-1128.
62. Ito, K.; Suzuki, H.; Hirohashi, T.; Kume, K.; Shimizu, T. and Sugiyama, Y. (1997) Am. J. Physiol., 272 (1 Pt 1), G16-G22.
63. de Bittencourt, Junior, P.I.; Senna, S.M.; Vidor, A.C.; Miyasaka, C.K.; Curi, R. and Williams, J.F. (1998) Biochem. Mol. Biol. Int., 45 (6), 1243-1254.
64. Flens, M.J.; Zaman, G.J.R.; van der Valk, P.; Izquierdo, M.A.; Schroeiers, A.B.; Scheffer, G.L.; van der Groep, P.; de Haas, M.; Meijer, C.J.L.M.; and Scheper, R.J. (1996) Am. J. Pathol., 148 (4), 1237-1247.
65. Wijnholds, J.; Evers, R.; Leusden, M.R.; Mol, C.A.; Zaman, G.J.R.; Mayer, U.; Beijnen, J.; Van der Valk, P.; Krimpenfort, P. and Borst, P. (1997) Nat. Med., 3 (1), 1275-1279.
66. Evers, R.; Zaman, G.J.R.; van Deemter, L.; Jansen, H.; Calafat, J.; Oomen, L.C.J.M.; Oude Elferink, R.P.J.; Borst, P. and Schinkel, A.H. (1996) J. Clin. Invest., 97 (5), 1211-1218.
67. Wijnholds, J.; Scheffer, G.L.; Van der Valk, M.; Van derValk, P.; Beijnen, J.H.; Scheper, R.J. and Borst, P. (1998) J. Exp. Med., 188 (5), 797-808.
68. Wijnholds, J.; deLange, E.C.; Scheffer, G.L.; van den Berg, D.J.; Mol, C.A.; van der Valk, M.; Schinkel, A.H.; Scheper, R.J.; Breimer, D.D. and Borst, P. (2000) J. Clin. Invest., 105 (3), 279-285.
69. Liang, X.J.; Shen, D.W.; Garfield, S. and Gottesman, M.M. (2003) Cancer Res., 63 (18), 5909-5916.
70. Van Aubel, R.A.; Hartog, A.; Bindels, R.J.; Van Os, C.H. and Russel, F.G. (2000) Eur. J. Pharmacol., 400 (2-3), 195-198.
71. Masereeuw, R.; Terlouw, S.A.; van Aubel, R.A.; Russel, F.G.; Miller, D.S. (2000) Mol. Pharmacol., 57 (1), 59-67.
72. Robbiani, D.F.; Finch, R.A.; Jager, D.; Muller, W.A.; Sartorelli, A.C. and Randolph, G.J. (2000) Cell, 103 (5), 757-768.
73. Schultz, M.J.; Wijnholds, J.; Peppelenbosch, M.P.; Vervoordeldonk, M.J.; Speelman, P.; van Deventer, S.J.; Borst, P. and van der Poll, T. (2001) J. Immunol., 166 (6), 4059-4064.
74. Lorico, A.; Rappa, G.; Finch, R.A.; Yang, D.; Flavell, R.A. and Sartorelli, A.C. (1997) Cancer Res., 57 (23), 5238-5242.
75. Rao, V.V.; Dahlheimer, J.L.; Bardgett, M.E.; Snyder, A.Z.; Finch, R.A.; Sartorelli, A.C. and Piwnica-Worms, D. (1999) Proc. Natl. Acad. Sci. USA, 96 (7), 3900-3905.
76. Wada, M.; Toh, S.; Taniguchi, K.; Nakamura, T.; Uchiumi, T.; Kohno, K.; Yoshida, I.; Kimura, A.; Sakisaka, S.; Adachi, Y. and Kuwano, M. (1998) Hum. Mol. Genet., 7 (2), 203-207.
77. Paulusma, C.C.; Kool, M,; Bosma, P.J.; Scheffer, G.L.; ter Borg, F.; Scheper, R.J.; Tytgat, G.N.; Borst, P.; Baas, F. and Oude Elferink, R.P. (1997) Hepatology, 25 (6), 1539-1542.
78. Leier, I.; Jedlitschky, G.; Buchholz, U.; Center, M.; Cole, S.P.; Deeley, R.G. and Keppler, D. (1996) Biochem. J., 314 (Pt2), 433-437.
79. Loe, D.W.; Almquist, K.C.; Cole, S.P.C. and Deeley, R.G. (1996) J. Biol. Chem., 271 (16), 9683-9689.
80. Loe, D.W.; Almquist, K.C.; Deeley, R.G. and Cole, S.P.C. (1996) J. Biol. Chem., 271 (16), 9675-9682.
81. Müller, M.; Meijer, C.J.L.M.; Borst, P.; Scheper, R.J.; Mulder, N.H.; de Vries, E.G. and Jansen, P.L.M. (1994) Proc. Natl. Acad. Sci. USA, 91 (26), 13033-13037.
82. Jedlitschky, G.; Leier, I.; Buchholz, U.; Barnouin, K.; Kurz, G. and Keppler, D. (1996) Cancer Res., 56 (5), 988-994.
83. Loe, D.W.; Stewart, R.K.; Massey, T.E.; Deeley, R.G. and Cole, S.P. (1997) Mol. Pharmacol., 51(6), 1034-1041.
84. Ito, K.; Oleschuk, C.J.; Westlake, C.; Vasa, M.Z.; Deeley, R.G. and Cole, S.P. (2001) J. Biol. Chem., 276 (41), 38108-38114.
85. Masereeuw, R.; Moons, M.M.; Toomey, B.H.; Russel, F.G. and Miller, D.S. (1999) J. Pharmacol. Exp. Ther., 289 (2), 1104-1111.
86. Cui, Y.; Konig, J.; Buchholz, J.K.; Spring, H.; Leier, I. and Keppler, D. (1999) Mol. Pharmacol., 55 (5), 929-937.
87. Kawabe, T.; Chen, Z.S.; Wada, M.; Uchiumi, T.; Ono, M.; Akiyama, S. and Kuwano, M. (1999) FEBS Lett., 456 (2), 327-331.
88. Paulusma, C.C.; van Geer, M.A.; Evers, R.; Heijn, M.; Ottenhoff, R.; Borst, P. and Oude Elferink, R.P. (1999) Biochem. J., 338 (Pt 2), 393-401.
89. Roelofsen, H.; Soroka, C.J.; Keppler, D. and Boyer, J.L. (1998) J. Cell Sci., 111 (Pt 8), 1137-1145.
90. Mirski, S.E.L.; Gerlach, J.H. and Cole. S.P.C. (1987), Cancer Res., 47 (10), 2594-2598.
91. Almquist, K.C.; Loe, D.W.; Hipfner, D.R.; Mackie, J.E.; Cole, S.P. and Deeley, R.G. (1995) Cancer Res., 55 (1), 102-110.
92. Chang, X.B.; Hou, Y.X. and Riordan, J.R. (1997) J. Biol. Chem. 272 (49), 30962-30968.
93. Stewart, A.J.; Canitrot, Y.; Baracchini, E.; Dean, N.M.; Deeley, R.G. and Cole, S.P. (1996) Biochem. Pharmacol., 51 (4), 461-469.
94. Zeng, H.; Chen, Z.S.; Belinsky, M.G.; Rea, P.A. and Kruh, G.D. (2001) Cancer Res., 61(19), 7225-7232.
95. O'Brien, M.; Kruh, G.D. and Tew, K.D. (2000) J. Pharmacol. Exp. Ther., 294 (2), 480-487.
96. Koike, K.; Kawabe, T.; Tanaka, T.; Toh, S.; Uchiumi, T.; Wada, M.; Akiyama, S.; Ono, M. and Kuwano, M. (1997) Cancer Res., 57 (24), 5475-5479.
97. Loe, D.W.; Deeley, R.G. and Cole, S.P.C. (1998) Cancer Res., 58 (22), 5130-5136.
98. Van Aubel, R.A.; Koenderink, J.B.; Peters, J.G.; Van Os, C.H. and Russel, F.G. (1999) Mol. Pharmacol., 56 (4), 714-719.
99. Loe, D.W.; Deeley, R.G. and Cole, S.P. (1996) Eur. J. Cancer, 32A (6), 945-957.
100. Evers, R.; de Haas, M.; Sparidans, R.; Beijnen, J.; Wielinga, PR.; Lankelma, J. and Borst, P. (2000) Br. J. Cancer, 83 (3), 375-383.
101. Binyamin, L.; Assaraf, Y.G.; Haus-Cohen, M.; Stark, M. and Reiter, Y. (2004) Int. J. Cancer, 110 (6), 882-890.
102. Richardson, J.H.; Sodroski, J.G.; Waldmann, T.A. and Marasco, W.A. (1995) Proc. Natl. Acad. Sci. USA, 92 (8), 3137-3141.
103. Jannot, C.B.; Beerli, R.R.; Mason, S.; Gullick, W.J. and Hynes, N.E. (1996) Oncogene, 13 (2), 275-282.
104. Cattaneo, A. and Biocca, S. (1999) Trends Biotechnol., 17 (3), 115-121
105. Materna, V.; Liedert, B.; Thomale, J. and Lage, H. (2005) Int. J. Cancer, 115 (3), 393-402.
106. Chen, Z.S.; Aoki, S.; Komatsu, M.; Ueda, K.; Sumizawa, T.; Furukawa, T.; Okumura, H.; Ren, X.Q.; Belinsky, M.G.; Lee, K.; Kruh, G.D.; Kobayashi, M. and Akiyama, S. (2001) Int. J. Cancer, 93 (1), 107-113.
107. Marbeuf-Gueye, C.; Salerno, M.; Quidu, P. and Garnier-Suillerot, A. (2000) Eur. J. Pharmacol., 391 (3), 207-216.
108. Zaman, G.J.; Lankelma, J.; van Tellingen, O.; Beijnen, J.; Dekker, H.; Paulusma, C.; Oude Elferink, R.P.; Baas, F. and Borst, P. (1995) Proc. Natl. Acad. Sci. USA, 92 (17), 7690-7694.
109. Burg, D.; Wielinga, P.; Zelcer, N.; Saeki, T.; Mulder, G.J. and Borst, P. (2002) Mol. Pharmacol., 62 (5), 1160-1166.
110. Norman, B.H.; Gruber, J.M.; Hollinshead, S.P.; Wilson, J.W.; Starling, J.J.; Law, K.L.; Self, T.D.; Tabas, L.B.; Williams, D.C.; Paul, D.C.; Wagner, M.M. and Dantzig, A.H. (2002) Bioorg. Med. Chem. Lett., 2512 (6), 883-886.
111. Bakos, E.; Evers, R.; Calenda, G.; Tusnady, G.E.; Szakacs, G.; Varadi, A. and Sarkadi, B. (2000) J. Cell Sci., 113 (Pt 24), 4451-4461.
112. Ishikawa, T. and Sies, H. (1989) In Glutathione: Chemical Biochemical and Medical Aspects, Part B, (Dolphin, B., Avramovic, O. and Poulson, R., Eds.), John Wiley, New York, pp. 85-109.
113. Wang, E.J. and Johnson, W.W. (2003) Chemotherapy, 49 (6), 303-308.
114. Wortelboer, H.M.; Usta, M.; van der Velde, A.E.; Boersma, M.G.; Spenkelink, B.; van Zanden, J.J.; Rietjens, I.M.; van Bladeren, P.J. and Cnubben, N.H. (2003) Chem. Res. Toxicol., 16 (12), 1642-1651.
115. Trauner, M., Arrese, M., Soroka, C.J.; Ananthanarayanan, M.; Koeppel, T.A.; Schlosser, S.F.; Suchy, F.J.; Keppler, D. and Boyer, J.L. (1997) Gastroenterology, 113 (1), 255-264.
116. Pleban, K. and Ecker, G.F. (2005) Mini Rev. Med. Chem., 5 (2), 153-163.