메뉴 건너뛰기




Volumn 2, Issue 3, 1996, Pages 106-113

Transporting therapeutics across the blood-brain barrier

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; DRUG CARRIER; GLYCOPROTEIN P; LIPID;

EID: 0030099527     PISSN: 13574310     EISSN: None     Source Type: Journal    
DOI: 10.1016/1357-4310(96)88720-X     Document Type: Review
Times cited : (424)

References (41)
  • 1
    • 0025804884 scopus 로고
    • Drug metabolizing enzymes in the brain and cerebral microvessels
    • Minn, A. et al. (1991) Drug metabolizing enzymes in the brain and cerebral microvessels, Brain Res. Rev. 16, 65-82
    • (1991) Brain Res. Rev. , vol.16 , pp. 65-82
    • Minn, A.1
  • 2
    • 0023108382 scopus 로고
    • Astrocytes induce blood-brain barrier properties in endothelial cells
    • Janzer, R.C. and Raff, M.C. (1987) Astrocytes induce blood-brain barrier properties in endothelial cells, Nature 325, 253-257
    • (1987) Nature , vol.325 , pp. 253-257
    • Janzer, R.C.1    Raff, M.C.2
  • 3
    • 0028246186 scopus 로고
    • Modulation of tight junction structure in blood-brain barrier endothelial cells
    • Wolburg, H. et al. (1994) Modulation of tight junction structure in blood-brain barrier endothelial cells, J. Cell Sci. 107, 1347-1357
    • (1994) J. Cell Sci. , vol.107 , pp. 1347-1357
    • Wolburg, H.1
  • 4
    • 0002870158 scopus 로고
    • Drug entry into the brain and its pharmacological manipulation
    • (Bradbury, M.W.B., ed.), Springer-Verlag
    • Greig, N.H. (1992) Drug entry into the brain and its pharmacological manipulation, in The Physiology and Pharmacology of the Blood-brain Barrier (Bradbury, M.W.B., ed.), pp. 487-523, Springer-Verlag
    • (1992) The Physiology and Pharmacology of the Blood-brain Barrier , pp. 487-523
    • Greig, N.H.1
  • 5
    • 0028158735 scopus 로고
    • A method to determine the ability of drugs to diffuse through the blood-brain barrier
    • Seelig, A., Gottschlich, R. and Devant, R.M. (1994) A method to determine the ability of drugs to diffuse through the blood-brain barrier, Proc. Natl Acad. Sci. USA 91, 68-72
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 68-72
    • Seelig, A.1    Gottschlich, R.2    Devant, R.M.3
  • 6
    • 0028108085 scopus 로고
    • Factors that influence the distribution of solutes between blood and brain
    • Abraham, M., Chadha, H.S. and Mitchell, R.C. (1994) Factors that influence the distribution of solutes between blood and brain, J. Pharm. Sci. 83, 1257-1268
    • (1994) J. Pharm. Sci. , vol.83 , pp. 1257-1268
    • Abraham, M.1    Chadha, H.S.2    Mitchell, R.C.3
  • 7
    • 0001658070 scopus 로고
    • Drug delivery to the brain by blood-brain barrier: Circumvention and drug modification
    • (Neuwelt, E.A., ed.), Plenum
    • Greig, N.H. (1989) Drug delivery to the brain by blood-brain barrier: circumvention and drug modification, in Implications of the Blood-brain Barrier and its Manipulation. Vol. 1 (Neuwelt, E.A., ed.), pp. 311-367, Plenum
    • (1989) Implications of the Blood-brain Barrier and Its Manipulation , vol.1 , pp. 311-367
    • Greig, N.H.1
  • 8
    • 0017757318 scopus 로고
    • The blood-brain barrier
    • (Bito, L.Z., Davson, H. and Fenstermacher, J.D., eds). Academic Press
    • Oldendorf, W.H. (1977) The blood-brain barrier, in The Ocular and Cerebrospinal Fluids (Bito, L.Z., Davson, H. and Fenstermacher, J.D., eds). pp. 177-190, Academic Press
    • (1977) The Ocular and Cerebrospinal Fluids , pp. 177-190
    • Oldendorf, W.H.1
  • 9
    • 0028457099 scopus 로고
    • Evaluation of an estradiol chemical delivery system (CDS) designed to provide enhanced and sustained hormone levels in the brain
    • Estes, K.S., Brewster, M.E. and Bodor, N. (1994) Evaluation of an estradiol chemical delivery system (CDS) designed to provide enhanced and sustained hormone levels in the brain. Adv. Drug Deliv. Rev. 14, 167-175
    • (1994) Adv. Drug Deliv. Rev. , vol.14 , pp. 167-175
    • Estes, K.S.1    Brewster, M.E.2    Bodor, N.3
  • 10
    • 0028942269 scopus 로고
    • Synthesis and pharmacological properties of 2-[S-acetylthiorphan]-1,3-diacylaminopropan-2-ol derivatives as chimeric lipid drug carriers containing an enkephalinase inhibitor
    • Lambert, D.M. et al. (1994) Synthesis and pharmacological properties of 2-[S-acetylthiorphan]-1,3-diacylaminopropan-2-ol derivatives as chimeric lipid drug carriers containing an enkephalinase inhibitor, Pharm. Res. 12, 187-191
    • (1994) Pharm. Res. , vol.12 , pp. 187-191
    • Lambert, D.M.1
  • 11
    • 0025782641 scopus 로고
    • Stereoselective transport of baclofen across the blood-brain barrier in rats as determined by the unit impulse response methodology
    • van Bree, J.B.M.M. et al. (1991) Stereoselective transport of baclofen across the blood-brain barrier in rats as determined by the unit impulse response methodology, Pharm. Res. 8, 259-262
    • (1991) Pharm. Res. , vol.8 , pp. 259-262
    • Van Bree, J.B.M.M.1
  • 12
    • 0027723017 scopus 로고
    • Gabapentin anticonvulsant action in rats: Disequilibrium with peak drug concentrations in plasma and brain microdialysate
    • Welty, D.F. et al. (1993) Gabapentin anticonvulsant action in rats: disequilibrium with peak drug concentrations in plasma and brain microdialysate, Epilepsy Res. 16, 175-181
    • (1993) Epilepsy Res. , vol.16 , pp. 175-181
    • Welty, D.F.1
  • 13
    • 0026708467 scopus 로고
    • Rapid high-affinity transport of a chemotherapeutic amino acid across the blood-brain barrier
    • Takada, Y. et al. (1992) Rapid high-affinity transport of a chemotherapeutic amino acid across the blood-brain barrier, Cancer Res. 52, 2191-2196
    • (1992) Cancer Res. , vol.52 , pp. 2191-2196
    • Takada, Y.1
  • 14
    • 0027007977 scopus 로고
    • Drug delivery to the brain: Barrier modification and drug modification methodologies
    • Rapoport, S.I. (1992) Drug delivery to the brain: barrier modification and drug modification methodologies, NIDA Res. Monogr. 120, 121-137
    • (1992) NIDA Res. Monogr. , vol.120 , pp. 121-137
    • Rapoport, S.I.1
  • 15
  • 16
    • 0027769788 scopus 로고
    • Distributional transport kinetics of zidovudine between plasma and brain extracellular fluid/cerebrospinal fluid in the rabbit: Investigation of the inhibitory effect of probenecid utilizing microdialysis
    • Wong, S.L., van Bell, K. and Sawchuk, R.J. (1993) Distributional transport kinetics of zidovudine between plasma and brain extracellular fluid/cerebrospinal fluid in the rabbit: investigation of the inhibitory effect of probenecid utilizing microdialysis, J. Pharmacol. Exp. Ther. 264, 899-909
    • (1993) J. Pharmacol. Exp. Ther. , vol.264 , pp. 899-909
    • Wong, S.L.1    Van Bell, K.2    Sawchuk, R.J.3
  • 17
    • 0025063494 scopus 로고
    • Zidovudine with probenecid
    • Duckworth, A.S. et al. (1990) Zidovudine with probenecid, Lancet 336, 441
    • (1990) Lancet , vol.336 , pp. 441
    • Duckworth, A.S.1
  • 18
    • 0027768971 scopus 로고
    • Microdialysis study of zidovudine (AZT) transport in rat brain
    • Dykstra, K.H. et al. (1993) Microdialysis study of zidovudine (AZT) transport in rat brain, J. Pharmacol. Exp. Ther. 267, 1227-1236
    • (1993) J. Pharmacol. Exp. Ther. , vol.267 , pp. 1227-1236
    • Dykstra, K.H.1
  • 19
    • 0027218689 scopus 로고
    • Biochemistry of multidrug resistance mediated by the multidrug transporter
    • Gottesman, M.M. and Pastan, I. (1993) Biochemistry of multidrug resistance mediated by the multidrug transporter, Annu. Rev. Biochem. 62, 385-427
    • (1993) Annu. Rev. Biochem. , vol.62 , pp. 385-427
    • Gottesman, M.M.1    Pastan, I.2
  • 20
    • 0027365896 scopus 로고
    • Modulation of vinblastine resistance with cyclosporine: A Phase I study
    • Samuels, B.L. et al. (1993) Modulation of vinblastine resistance with cyclosporine: a Phase I study, J. Clin. Pharmacol. Ther. 54, 421-429
    • (1993) J. Clin. Pharmacol. Ther. , vol.54 , pp. 421-429
    • Samuels, B.L.1
  • 21
    • 0028941366 scopus 로고
    • Comparative study on reversal efficacy of SDZ PSC833, cyclosporin a and verapamil on multidrug resistance in vitro and in vivo
    • Watanabe, T. et al. (1995) Comparative study on reversal efficacy of SDZ PSC833, cyclosporin A and verapamil on multidrug resistance in vitro and in vivo, Acta Oncol. 34, 235-241
    • (1995) Acta Oncol. , vol.34 , pp. 235-241
    • Watanabe, T.1
  • 22
    • 0028062850 scopus 로고
    • Insulin fragments as a carrier for peptide delivery across the blood-brain barrier
    • Fukuta, M. et al. (1994) Insulin fragments as a carrier for peptide delivery across the blood-brain barrier, Pharm. Res. 11, 1681-1688
    • (1994) Pharm. Res. , vol.11 , pp. 1681-1688
    • Fukuta, M.1
  • 23
    • 0027955868 scopus 로고
    • NGF and anti-transferrin receptor antibody conjugate: Short and long-term effects on survival of cholinergic neurons in intraocular septal transplants
    • Granholm, A.C. et al. (1994) NGF and anti-transferrin receptor antibody conjugate: short and long-term effects on survival of cholinergic neurons in intraocular septal transplants, J. Pharmacol. Exp. Ther. 268, 448-459
    • (1994) J. Pharmacol. Exp. Ther. , vol.268 , pp. 448-459
    • Granholm, A.C.1
  • 24
    • 0027536084 scopus 로고
    • Pharmacologic effects in vivo in brain by vector-mediated peptide drug delivery
    • Bickel, U. et al. (1993) Pharmacologic effects in vivo in brain by vector-mediated peptide drug delivery, Proc. Natl Acad. Sci. USA 90, 2618-2622
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 2618-2622
    • Bickel, U.1
  • 25
    • 0028915964 scopus 로고
    • Transferrin-antibody fusion proteins are effective in brain targeting
    • Shin, S-U. et al. (1995) Transferrin-antibody fusion proteins are effective in brain targeting, Proc. Natl Acad. Sci. USA 92, 2820-2824
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 2820-2824
    • Shin, S.-U.1
  • 26
    • 0028000934 scopus 로고
    • Brain delivery of biotin bound to a conjugate of neutral avidin and cationized human albumin
    • Kang, Y-S. and Pardridge, W.M. (1994) Brain delivery of biotin bound to a conjugate of neutral avidin and cationized human albumin, Pharm. Res. 11, 1257-1264
    • (1994) Pharm. Res. , vol.11 , pp. 1257-1264
    • Kang, Y.-S.1    Pardridge, W.M.2
  • 27
    • 0028500927 scopus 로고
    • Complete inactivation of target mRNA by biotinylated antisense oligodeoxynucleotide-avidin conjugates
    • Boado, R. and Pardridge, W.M. (1994) Complete inactivation of target mRNA by biotinylated antisense oligodeoxynucleotide-avidin conjugates, Bioconjug. Chem. 5, 406-410
    • (1994) Bioconjug. Chem. , vol.5 , pp. 406-410
    • Boado, R.1    Pardridge, W.M.2
  • 28
    • 0000136690 scopus 로고
    • Experimental manipulation of the blood-brain and blood-retinal barriers
    • (Bradbury, M.W.B., ed.), Springer-Verlag
    • Greenwood, J. (1992) Experimental manipulation of the blood-brain and blood-retinal barriers, in The Physiology and Pharmacology of the Blood-brain Barrier (Bradbury, M.W.B., ed.), pp. 459-486, Springer-Verlag
    • (1992) The Physiology and Pharmacology of the Blood-brain Barrier , pp. 459-486
    • Greenwood, J.1
  • 30
    • 0028364840 scopus 로고
    • Therapeutic dilemma of disseminated CNS germinoma and the potential of increased platinum-based chemotherapy delivery with osmotic blood-brain barrier disruption, Pediatr
    • Neuwelt, E.A. et al. (1994) Therapeutic dilemma of disseminated CNS germinoma and the potential of increased platinum-based chemotherapy delivery with osmotic blood-brain barrier disruption, Pediatr. Neurosurg. 21, 16-22
    • (1994) Neurosurg. , vol.21 , pp. 16-22
    • Neuwelt, E.A.1
  • 31
    • 0028910695 scopus 로고
    • Gene expression from recombinant viral vectors in the central nervous system after blood-brain barrier disruption
    • Doran, S.E. et al. (1995) Gene expression from recombinant viral vectors in the central nervous system after blood-brain barrier disruption, Neurosurgery 36, 965-970
    • (1995) Neurosurgery , vol.36 , pp. 965-970
    • Doran, S.E.1
  • 32
    • 0028344580 scopus 로고
    • Delivery of virus-sized iron oxide particles to rodent CNS neurons
    • Neuwelt, E.A. et al. (1994) Delivery of virus-sized iron oxide particles to rodent CNS neurons, Neurosurgery 34, 777-784
    • (1994) Neurosurgery , vol.34 , pp. 777-784
    • Neuwelt, E.A.1
  • 33
    • 0027991897 scopus 로고
    • Intracarotid infusion of bradykinin selectively increases blood-tumor permeability in 9L and C6 brain tumors
    • Nomura, T., Inamura, T. and Black, K.L. (1994) Intracarotid infusion of bradykinin selectively increases blood-tumor permeability in 9L and C6 brain tumors, Brain Res. 659, 62-66
    • (1994) Brain Res. , vol.659 , pp. 62-66
    • Nomura, T.1    Inamura, T.2    Black, K.L.3
  • 34
    • 0025301993 scopus 로고
    • Selective opening of the blood-tumour barrier by intracarotid infusion of leukotriene C4
    • Black, K.L. et al. (1990) Selective opening of the blood-tumour barrier by intracarotid infusion of leukotriene C4, J. Neurosurg. 72, 912-916
    • (1990) J. Neurosurg. , vol.72 , pp. 912-916
    • Black, K.L.1
  • 35
    • 0027394947 scopus 로고
    • Treatment of leptomeningeal metastasis with intraventricular administration of depot cytarabine (DTC 101). A Phase I study
    • Chamberlain, M.C. et al. (1993) Treatment of leptomeningeal metastasis with intraventricular administration of depot cytarabine (DTC 101). A Phase I study, Arch. Neurol. 50, 261-264
    • (1993) Arch. Neurol. , vol.50 , pp. 261-264
    • Chamberlain, M.C.1
  • 36
    • 85013515042 scopus 로고
    • Interstitial drug delivery to the central nervous system using controlled release polymers: Chemotherapy for brain tumours
    • Tamargo, R.J., Langer, R. and Brem, H. (1994) Interstitial drug delivery to the central nervous system using controlled release polymers: chemotherapy for brain tumours, Methods Neurosci. 21, 135-149
    • (1994) Methods Neurosci. , vol.21 , pp. 135-149
    • Tamargo, R.J.1    Langer, R.2    Brem, H.3
  • 37
    • 0029001712 scopus 로고
    • Convection-enhanced distribution of large molecules in gray matter during interstitial drug infusion
    • Lieberman, D.M. et al. (1994) Convection-enhanced distribution of large molecules in gray matter during interstitial drug infusion, J. Neurosurg. 82, 1021-1029
    • (1994) J. Neurosurg. , vol.82 , pp. 1021-1029
    • Lieberman, D.M.1
  • 38
    • 0027350398 scopus 로고
    • Tissue implants in treatment of parkinsonian syndromes in animals and implications for use of tissue implants in humans
    • Kopin, I.J. et al. (1993) Tissue implants in treatment of parkinsonian syndromes in animals and implications for use of tissue implants in humans, Adv. Neurol. 60, 707-714
    • (1993) Adv. Neurol. , vol.60 , pp. 707-714
    • Kopin, I.J.1
  • 39
    • 0027957150 scopus 로고
    • Vascularization and microvascular permeability in solid versus cell-suspension embryonic neural grafts
    • Leigh, K., Elisevich, K. and Rogers, K.A. (1994) Vascularization and microvascular permeability in solid versus cell-suspension embryonic neural grafts, J. Neurosurg. 81, 272-283
    • (1994) J. Neurosurg. , vol.81 , pp. 272-283
    • Leigh, K.1    Elisevich, K.2    Rogers, K.A.3
  • 40
    • 0028124751 scopus 로고
    • Gene therapy for the treatment of recurrent pediatric malignant astrocytomas with in vivo tumour transduction with the herpes simplex thymidine kinase/ganciclovir system, Hum
    • Raffel, C. et al. (1994) Gene therapy for the treatment of recurrent pediatric malignant astrocytomas with in vivo tumour transduction with the herpes simplex thymidine kinase/ganciclovir system, Hum. Gene Ther. 5, 863-890
    • (1994) Gene Ther. , vol.5 , pp. 863-890
    • Raffel, C.1
  • 41
    • 0028125042 scopus 로고
    • Endothelial cell implantation and survival within experimental gliomas
    • Lal, B. et al. (1994) Endothelial cell implantation and survival within experimental gliomas, Proc. Natl Acad. Sci. USA 91, 9695-9699
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 9695-9699
    • Lal, B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.