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Volumn 6, Issue 4, 2006, Pages 421-438

Regulatable gene expression systems for gene therapy

Author keywords

Gene switch; Gene therapy; Spatial regulation; Temporal regulation; Transcriptional targeting

Indexed keywords

ADENOVIRUS VECTOR; ANTINEOPLASTIC AGENT; DOXYCYCLINE; EARLY GROWTH RESPONSE FACTOR 1; ECDYSTEROID; EPIDERMAL GROWTH FACTOR; FAS LIGAND; FK 506 BINDING PROTEIN; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; HUMAN GROWTH HORMONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; LIPOSOME; LUCIFERASE; MIFEPRISTONE; PROSTAGLANDIN; PROTEIN C FOS; PROTEIN C JUN; RAPAMYCIN; RECEPTOR; REPRESSOR PROTEIN; TACROLIMUS; TAMOXIFEN; TETRACYCLINE; THYMIDINE KINASE; TNFERADE; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 33746921625     PISSN: 15665232     EISSN: None     Source Type: Journal    
DOI: 10.2174/156652306777934829     Document Type: Review
Times cited : (52)

References (141)
  • 1
    • 0031833563 scopus 로고    scopus 로고
    • Mammalian target of rapamycin: Immunosuppressive drugs uncover a novel pathway of cytokine recepetor signaling
    • Abraham, R.T. (1998) Mammalian target of rapamycin: immunosuppressive drugs uncover a novel pathway of cytokine recepetor signaling. Curr. Opin. Immunol., 10: 330-336.
    • (1998) Curr. Opin. Immunol. , vol.10 , pp. 330-336
    • Abraham, R.T.1
  • 2
    • 0034266617 scopus 로고    scopus 로고
    • Ligand-dependent regulation of vascular endothelial growth factor and erythropoietin expression by a plasmid-based, autoinducible Gene-Switch system
    • Abruzzese, R.V., Godin, D., Mehta, V., Perrard, J.L., French, M., Nelson, W., Howell, G., Coleman, M., O'Malley, B.W., Nordstrom, J.L. (2000) Ligand-dependent regulation of vascular endothelial growth factor and erythropoietin expression by a plasmid-based, autoinducible Gene-Switch system. Mol. Ther., 2: 276-287.
    • (2000) Mol. Ther. , vol.2 , pp. 276-287
    • Abruzzese, R.V.1    Godin, D.2    Mehta, V.3    Perrard, J.L.4    French, M.5    Nelson, W.6    Howell, G.7    Coleman, M.8    O'Malley, B.W.9    Nordstrom, J.L.10
  • 3
    • 0036328505 scopus 로고    scopus 로고
    • Constitutive and regulated expression of processed insulin following in vivo hepatic gene transfer
    • Auricchio, A., Gao, G.P., Yu, Q.C., Raper, S., Rivera, V.M., Clackson, T., Wilson, J.M. (2002a) Constitutive and regulated expression of processed insulin following in vivo hepatic gene transfer. Gene Ther., 9: 963-971.
    • (2002) Gene Ther. , vol.9 , pp. 963-971
    • Auricchio, A.1    Gao, G.P.2    Yu, Q.C.3    Raper, S.4    Rivera, V.M.5    Clackson, T.6    Wilson, J.M.7
  • 5
    • 0038029933 scopus 로고    scopus 로고
    • "Blue heart": Characterization of a mifepristone-dependent system for conditional gene expression in genetically modified animals
    • Babij, P., Psaltis, G., Song, D., Kulik, J., Mollova, N., Abruzzese, R.V., Nordstrom, J.L. (2003) "Blue heart": characterization of a mifepristone-dependent system for conditional gene expression in genetically modified animals. Biochim. Biophys Acta, 1627: 15-25.
    • (2003) Biochim. Biophys Acta , vol.1627 , pp. 15-25
    • Babij, P.1    Psaltis, G.2    Song, D.3    Kulik, J.4    Mollova, N.5    Abruzzese, R.V.6    Nordstrom, J.L.7
  • 7
    • 30344473326 scopus 로고    scopus 로고
    • Efficient control of gene expression in the hematopoietic system using a single tet-on inducible lentiviral vector
    • Barde, I., Zanta-Boussif, M.A., Paisant, S., Leboeuf, M., Rameau, P., Delenda, C., Danos, O. (2006) Efficient control of gene expression in the hematopoietic system using a single tet-on inducible lentiviral vector. Mol. Ther., 13: 382-390.
    • (2006) Mol. Ther. , vol.13 , pp. 382-390
    • Barde, I.1    Zanta-Boussif, M.A.2    Paisant, S.3    Leboeuf, M.4    Rameau, P.5    Delenda, C.6    Danos, O.7
  • 8
    • 0030797223 scopus 로고    scopus 로고
    • Tetracycline-controlled transcription in eukaryotes: Novel transactivators with graded transactivation potential
    • Baron, U., Gossen, M., Bujard, H. (1997) Tetracycline-controlled transcription in eukaryotes: novel transactivators with graded transactivation potential. Nucleic Acids Res., 25: 2723-2729.
    • (1997) Nucleic Acids Res. , vol.25 , pp. 2723-2729
    • Baron, U.1    Gossen, M.2    Bujard, H.3
  • 9
    • 0033514374 scopus 로고    scopus 로고
    • Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes
    • Baron, U., Schnappinger, D., Helbl, V., Gossen, M., Hillen, W., Bujard, H. (1999) Generation of conditional mutants in higher eukaryotes by switching between the expression of two genes. Proc. Natl. Acad. Sci. USA, 96: 1013-1018.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 1013-1018
    • Baron, U.1    Schnappinger, D.2    Helbl, V.3    Gossen, M.4    Hillen, W.5    Bujard, H.6
  • 11
    • 8844219665 scopus 로고    scopus 로고
    • Tissue-specific targeting for cardiovascular gene transfer. Potential vectors and future challenges
    • Beck, C., Uramoto, H., Boren, J., Akyurek, L.M. (2004) Tissue-specific targeting for cardiovascular gene transfer. Potential vectors and future challenges. Curr. Gene Ther., 4: 457-467.
    • (2004) Curr. Gene Ther. , vol.4 , pp. 457-467
    • Beck, C.1    Uramoto, H.2    Boren, J.3    Akyurek, L.M.4
  • 12
    • 0024999067 scopus 로고
    • Activation of the heat shock transcription factor by hypoxia in mammalian cells
    • Benjamin, I.J., Kroger, B., Williams, R.S. (1990) Activation of the heat shock transcription factor by hypoxia in mammalian cells. Proc. Natl. Acad. Sci. USA, 87: 6263-6267.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 6263-6267
    • Benjamin, I.J.1    Kroger, B.2    Williams, R.S.3
  • 13
    • 16244386276 scopus 로고    scopus 로고
    • Cardiac-specific and ligand-inducible target gene expression in transgenic mice
    • Bo, J., Yu, W., Zhang, Y.M., Demayo, F.J., Wei, L. (2005) Cardiac-specific and ligand-inducible target gene expression in transgenic mice. J. Mol. Cell. Cardiol., 38: 685-691.
    • (2005) J. Mol. Cell. Cardiol. , vol.38 , pp. 685-691
    • Bo, J.1    Yu, W.2    Zhang, Y.M.3    Demayo, F.J.4    Wei, L.5
  • 17
    • 0034634857 scopus 로고    scopus 로고
    • Eradication of breast cancer xenografts by hyperthermic suicide gene therapy under the control of the heat shock protein promoter
    • Braiden, V., Ohtsuru, A., Kawashita, Y., Miki, F., Sawada, T., Ito, M., Cao, Y., Kaneda, Y., Koji, T., Yamashita, S. (2000) Eradication of breast cancer xenografts by hyperthermic suicide gene therapy under the control of the heat shock protein promoter. Hum. Gene Ther., 11: 2453-2463.
    • (2000) Hum. Gene Ther. , vol.11 , pp. 2453-2463
    • Braiden, V.1    Ohtsuru, A.2    Kawashita, Y.3    Miki, F.4    Sawada, T.5    Ito, M.6    Cao, Y.7    Kaneda, Y.8    Koji, T.9    Yamashita, S.10
  • 18
    • 0030774216 scopus 로고    scopus 로고
    • Pre-existing immunity to adenovirus does not prevent tumor regression following intratumoral administration of a vector expressing IL-12 but inhibits virus dissemination
    • Bramson, J.L., Hitt, M., Gauldie, J., Graham, F.L. (1997) Pre-existing immunity to adenovirus does not prevent tumor regression following intratumoral administration of a vector expressing IL-12 but inhibits virus dissemination. Gene Ther., 4: 1069-1076.
    • (1997) Gene Ther. , vol.4 , pp. 1069-1076
    • Bramson, J.L.1    Hitt, M.2    Gauldie, J.3    Graham, F.L.4
  • 20
    • 26844501322 scopus 로고    scopus 로고
    • Glucose transporter-2 (GLUT2) promoter mediated transgenic insulin production reduces hyperglycemia in diabetic mice
    • Burkhardt, B.R., Parker, M.J., Zhang, Y.C., Song, S., Wasserfall, C.H., Atkinson, M.A. (2005) Glucose transporter-2 (GLUT2) promoter mediated transgenic insulin production reduces hyperglycemia in diabetic mice. FEBS Lett., 579: 5759-5764.
    • (2005) FEBS Lett. , vol.579 , pp. 5759-5764
    • Burkhardt, B.R.1    Parker, M.J.2    Zhang, Y.C.3    Song, S.4    Wasserfall, C.H.5    Atkinson, M.A.6
  • 21
    • 0842346433 scopus 로고    scopus 로고
    • Activation of stress-responsive promoters by ionizing radiation for deployment in targeted gene therapy
    • Chastel, C., Jiricny, J., Jaussi, R. (2004) Activation of stress-responsive promoters by ionizing radiation for deployment in targeted gene therapy. DNA Repair, 3: 201-215.
    • (2004) DNA Repair , vol.3 , pp. 201-215
    • Chastel, C.1    Jiricny, J.2    Jaussi, R.3
  • 22
    • 0036169663 scopus 로고    scopus 로고
    • A system for small-molecule control of conditionally replication-competent adenoviral vectors
    • Chong, H., Ruchatz, A., Clackson, T., Rivera, V.M., Vile, R.G. (2002) A system for small-molecule control of conditionally replication-competent adenoviral vectors. Mol. Ther., 5: 195-203.
    • (2002) Mol. Ther. , vol.5 , pp. 195-203
    • Chong, H.1    Ruchatz, A.2    Clackson, T.3    Rivera, V.M.4    Vile, R.G.5
  • 23
    • 33645995134 scopus 로고    scopus 로고
    • Heat shock response: Lessons from mouse knockouts
    • Christians, E.S., Benjamin, I.J. (2006) Heat shock response: lessons from mouse knockouts. Handb. Exp. Pharmacol., 172: 139-152.
    • (2006) Handb. Exp. Pharmacol. , vol.172 , pp. 139-152
    • Christians, E.S.1    Benjamin, I.J.2
  • 25
    • 0036008098 scopus 로고    scopus 로고
    • Synthesis of calcineurin-resistant derivatives of FK506 and selection of compensatory receptors
    • Clemons, P.A., Gladstone, B.G., Seth, A., Chao, E.D., Foley, M.A., Schreiber, S.L. (2002) Synthesis of calcineurin-resistant derivatives of FK506 and selection of compensatory receptors. Chem. Biol., 9: 49-61.
    • (2002) Chem. Biol. , vol.9 , pp. 49-61
    • Clemons, P.A.1    Gladstone, B.G.2    Seth, A.3    Chao, E.D.4    Foley, M.A.5    Schreiber, S.L.6
  • 26
    • 0035876445 scopus 로고    scopus 로고
    • The lac operator-repressor system is functional in the mouse
    • Cronin, C.A., Gluba, W., Scrable, H. (2001) The lac operator-repressor system is functional in the mouse. Genes & Dev., 15: 1506-1517.
    • (2001) Genes & Dev. , vol.15 , pp. 1506-1517
    • Cronin, C.A.1    Gluba, W.2    Scrable, H.3
  • 27
    • 2442475398 scopus 로고    scopus 로고
    • Viral evolution as a tool to improve the tetracycline-regulated gene expression system
    • Das, A.T., Zhou, X., Vink, M., Klaver, B., Verhoef, K., Marzio, G., Berkhout, B. (2004) Viral evolution as a tool to improve the tetracycline-regulated gene expression system. J. Biol. Chem., 279: 18776-18782.
    • (2004) J. Biol. Chem. , vol.279 , pp. 18776-18782
    • Das, A.T.1    Zhou, X.2    Vink, M.3    Klaver, B.4    Verhoef, K.5    Marzio, G.6    Berkhout, B.7
  • 30
    • 0032600013 scopus 로고    scopus 로고
    • A tetracycline-controlled activation/repression system with increased potential for gene transfer into mammalian cells
    • Freundlieb, S., Schirra-Muller, C., Bujard, H. (1999) A tetracycline-controlled activation/repression system with increased potential for gene transfer into mammalian cells. J. Gene Med., 1: 4-12.
    • (1999) J. Gene Med. , vol.1 , pp. 4-12
    • Freundlieb, S.1    Schirra-Muller, C.2    Bujard, H.3
  • 33
    • 1942458116 scopus 로고    scopus 로고
    • Novel macrolide-adjustable bidirectional expression modules for coordinated expression of two different transgenes in mice
    • Fux, C. Weber, W., Daoud-el Baba, M., Heinzen, C., Aubel, D., Fussenegger, M. (2003) Novel macrolide-adjustable bidirectional expression modules for coordinated expression of two different transgenes in mice. J. Gene Med., 5: 1067-1079.
    • (2003) J. Gene Med. , vol.5 , pp. 1067-1079
    • Fux, C.1    Weber, W.2    Daoud-el Baba, M.3    Heinzen, C.4    Aubel, D.5    Fussenegger, M.6
  • 35
    • 0036579880 scopus 로고    scopus 로고
    • Optimization and direct comparison of the dimerizer and reverse tet transcriptional control systems
    • Go, W.Y., Ho, S.N. (2002) Optimization and direct comparison of the dimerizer and reverse tet transcriptional control systems. J. Gene Med., 4: 258-270.
    • (2002) J. Gene Med. , vol.4 , pp. 258-270
    • Go, W.Y.1    Ho, S.N.2
  • 36
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • Gossen, M., Bujard, H. (1992) Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA, 89: 5547-5551.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 37
  • 38
    • 3042858567 scopus 로고    scopus 로고
    • Endogenous GATA factors bind the core sequence of the tetO and influence gene regulation with the tetracycline system
    • Gould, D.J., Chernajovsky, Y. (2004) Endogenous GATA factors bind the core sequence of the tetO and influence gene regulation with the tetracycline system. Mol. Ther., 10: 127-138.
    • (2004) Mol. Ther. , vol.10 , pp. 127-138
    • Gould, D.J.1    Chernajovsky, Y.2
  • 39
    • 31444439776 scopus 로고    scopus 로고
    • Hypoxia- and radiation-activated Cre/loxP "molecular switch" vectors for gene therapy of cancer
    • Greco, O., Joiner, M.C., Doleh, A., Powell, A.D., Hillman, G.G., Scott, S.D. (2006) Hypoxia- and radiation-activated Cre/loxP "molecular switch" vectors for gene therapy of cancer. Gene Ther., 13: 206-215.
    • (2006) Gene Ther. , vol.13 , pp. 206-215
    • Greco, O.1    Joiner, M.C.2    Doleh, A.3    Powell, A.D.4    Hillman, G.G.5    Scott, S.D.6
  • 42
    • 0012954146 scopus 로고
    • "Topics in Molecular & Structural Biology, in Protein-Nucleic Acid Interaction: Tet repressor- tet operator interaction"
    • Eds Saeger & Heinemann, MacMillan, London
    • Hillen, W., Wissman, A. (1989) "Topics in Molecular & Structural Biology, in Protein-Nucleic Acid Interaction: Tet repressor- tet operator interaction", Eds Saeger & Heinemann, MacMillan, London, 10: 143-162.
    • (1989) , vol.10 , pp. 143-162
    • Hillen, W.1    Wissman, A.2
  • 43
    • 0034137147 scopus 로고    scopus 로고
    • Adenovirus-mediated inducible gene expression in vivo by a hybrid ecdysone receptor
    • Hoppe, U.C., Marban, E., Johns, D.C. (2000) Adenovirus-mediated inducible gene expression in vivo by a hybrid ecdysone receptor. Mol. Ther., 1: 159-164.
    • (2000) Mol. Ther. , vol.1 , pp. 159-164
    • Hoppe, U.C.1    Marban, E.2    Johns, D.C.3
  • 46
    • 0038365487 scopus 로고    scopus 로고
    • Regulated expression of erythropoietin from an AAV vector safely improves the anemia of β-thalassemia in a mouse model
    • Johnston, J., Tazelaar, J., Rivera, V.M., Clackson, T., Gao, G.P., Wilson, J.M. (2003) Regulated expression of erythropoietin from an AAV vector safely improves the anemia of β-thalassemia in a mouse model. Mol. Ther., 7: 493-497.
    • (2003) Mol. Ther. , vol.7 , pp. 493-497
    • Johnston, J.1    Tazelaar, J.2    Rivera, V.M.3    Clackson, T.4    Gao, G.P.5    Wilson, J.M.6
  • 47
    • 33646010643 scopus 로고    scopus 로고
    • Chaperones in preventing protein denaturation in living cells and protecting against cellular stress
    • Kampinga, H.H. (2006) Chaperones in preventing protein denaturation in living cells and protecting against cellular stress. Handb. Exp. Pharmacol., 172: 1-42.
    • (2006) Handb. Exp. Pharmacol. , vol.172 , pp. 1-42
    • Kampinga, H.H.1
  • 48
    • 3042566947 scopus 로고    scopus 로고
    • Manipulation of gene expression by an ecdysone-inducible gene switch in tumor xenografts
    • Karns, L.R., Kisielewski, A., Gulding, K.M., Seraj, J.M., Theodorescu, D. (2001) Manipulation of gene expression by an ecdysone-inducible gene switch in tumor xenografts. BMC Biotechnol., 1: 11.
    • (2001) BMC Biotechnol. , vol.1 , pp. 11
    • Karns, L.R.1    Kisielewski, A.2    Gulding, K.M.3    Seraj, J.M.4    Theodorescu, D.5
  • 49
    • 25644434920 scopus 로고    scopus 로고
    • Inducible control of transgene expression with ecdysone receptor: Gene switches with high sensitivity, robust expression, and reduced size
    • Karzenowski, D., Potter, D.W., Padidam, M. (2005) Inducible control of transgene expression with ecdysone receptor: gene switches with high sensitivity, robust expression, and reduced size. Biotechniques, 39: 191-192.
    • (2005) Biotechniques , vol.39 , pp. 191-192
    • Karzenowski, D.1    Potter, D.W.2    Padidam, M.3
  • 51
    • 0037069431 scopus 로고    scopus 로고
    • A single point mutation in ecdysone receptor leads to increased ligand specificity: Implications for gene switch applications
    • Kumar, M.B., Fujimoto, T., Potter, D.W., Deng, Q., Palli, S.R. (2002) A single point mutation in ecdysone receptor leads to increased ligand specificity: implications for gene switch applications. Proc. Natl. Acad. Sci. USA, 99: 14710-14715.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 14710-14715
    • Kumar, M.B.1    Fujimoto, T.2    Potter, D.W.3    Deng, Q.4    Palli, S.R.5
  • 55
    • 25144469762 scopus 로고    scopus 로고
    • Cancer-specific gene therapy
    • Lo, H.W., Day, C.P., Hung, M.C. (2005) Cancer-specific gene therapy. Adv. Genet., 54: 235-255.
    • (2005) Adv. Genet. , vol.54 , pp. 235-255
    • Lo, H.W.1    Day, C.P.2    Hung, M.C.3
  • 57
    • 0011625753 scopus 로고    scopus 로고
    • Development of regulated lentiviral vectors
    • Luce, M.J., Reiser, J. (2002) Development of regulated lentiviral vectors. Mol. Ther., 5: S32.
    • (2002) Mol. Ther. , vol.5
    • Luce, M.J.1    Reiser, J.2
  • 58
    • 9644266818 scopus 로고    scopus 로고
    • Induction and reversal of cardiac phenotype of human hypertrophic cardiomyopathy mutation cardiac troponin T-Q92 in switch on-switch off bigenic mice
    • Lutucuta, S., Tsybouleva, N., Ishiyama, M., Defreitas, G., Wei, L., Carabello, B., Marian, A.J. (2004) Induction and reversal of cardiac phenotype of human hypertrophic cardiomyopathy mutation cardiac troponin T-Q92 in switch on-switch off bigenic mice. J. Am. Coll. Cardiol., 44: 2221-2230.
    • (2004) J. Am. Coll. Cardiol. , vol.44 , pp. 2221-2230
    • Lutucuta, S.1    Tsybouleva, N.2    Ishiyama, M.3    Defreitas, G.4    Wei, L.5    Carabello, B.6    Marian, A.J.7
  • 59
    • 0031441285 scopus 로고    scopus 로고
    • Pharmacologic control of a humanized gene therapy system implanted into nude mice
    • Magari, S.R., Rivera, V.M., Iuliucci, J.D., Gilman, M., Cerasoli, F. Jr. (1997) Pharmacologic control of a humanized gene therapy system implanted into nude mice. J. Clin. Invest., 100: 2865-2872.
    • (1997) J. Clin. Invest. , vol.100 , pp. 2865-2872
    • Magari, S.R.1    Rivera, V.M.2    Iuliucci, J.D.3    Gilman, M.4    Cerasoli Jr., F.5
  • 60
    • 0032126019 scopus 로고    scopus 로고
    • Transgene expression in malignant glioma using a replication-defective adenoviral vector containing the EGR-1 promoter: Activation by ionizing radiation or uptake of radioactive iododeoxyuridine
    • Manome, Y., Kunieda, T., Wen, P.Y., Koga, T., Kufe, D.W., Ohno, T. (1998) Transgene expression in malignant glioma using a replication-defective adenoviral vector containing the EGR-1 promoter: activation by ionizing radiation or uptake of radioactive iododeoxyuridine. Hum. Gene Ther., 9: 1409-1417.
    • (1998) Hum. Gene Ther. , vol.9 , pp. 1409-1417
    • Manome, Y.1    Kunieda, T.2    Wen, P.Y.3    Koga, T.4    Kufe, D.W.5    Ohno, T.6
  • 62
    • 28644442724 scopus 로고    scopus 로고
    • Comparison of single regulated lentiviral vectors with rtTA expression driven by an autoregulatory loop or a constitutive promoter
    • Markusic, D., Oude-Elferink, R., Das, A.T., Berkhout, B., Seppen, J. (2005) Comparison of single regulated lentiviral vectors with rtTA expression driven by an autoregulatory loop or a constitutive promoter. Nucleic Acids Res., 33: e63.
    • (2005) Nucleic Acids Res. , vol.33
    • Markusic, D.1    Oude-Elferink, R.2    Das, A.T.3    Berkhout, B.4    Seppen, J.5
  • 64
    • 0031908236 scopus 로고    scopus 로고
    • Tumour therapy in mice using adenovirus vectors expressing human TNFa
    • Marr, R.A., Hitt, M., Muller, W.J., Gauldie, J., Graham, F.L. (1998) Tumour therapy in mice using adenovirus vectors expressing human TNFa. Int. J. Oncol., 12: 509-515.
    • (1998) Int. J. Oncol. , vol.12 , pp. 509-515
    • Marr, R.A.1    Hitt, M.2    Muller, W.J.3    Gauldie, J.4    Graham, F.L.5
  • 65
    • 0033190968 scopus 로고    scopus 로고
    • A p75 tumor necrosis factor receptor-specific mutant of murine tumor necrosis factor alpha expressed from an adenovirus vector induces an antitumor response with reduced toxicity
    • Marr, R.A., Hitt, M., Gauldie, J., Muller, W.J., Graham, F.L. (1999) A p75 tumor necrosis factor receptor-specific mutant of murine tumor necrosis factor alpha expressed from an adenovirus vector induces an antitumor response with reduced toxicity. Cancer Gene Ther., 6: 465-474.
    • (1999) Cancer Gene Ther. , vol.6 , pp. 465-474
    • Marr, R.A.1    Hitt, M.2    Gauldie, J.3    Muller, W.J.4    Graham, F.L.5
  • 67
    • 0029777311 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha (TNF alpha) gene therapy targeted by ionizing radiation selectively damages tumor vasculature
    • Mauceri, H.J., Hanna, N.N., Wayne, J.D., Hallahan, D.E., Hellman, S., Weichselbaum, R.R. (1996) Tumor necrosis factor alpha (TNF alpha) gene therapy targeted by ionizing radiation selectively damages tumor vasculature. Cancer Res., 56: 4311-4314.
    • (1996) Cancer Res. , vol.56 , pp. 4311-4314
    • Mauceri, H.J.1    Hanna, N.N.2    Wayne, J.D.3    Hallahan, D.E.4    Hellman, S.5    Weichselbaum, R.R.6
  • 69
    • 1542646349 scopus 로고    scopus 로고
    • Cancer-specific viruses and the development of ONYX-015
    • McCormick, F. (2003) Cancer-specific viruses and the development of ONYX-015. Cancer Biol. Ther., 2: S157-160.
    • (2003) Cancer Biol. Ther. , vol.2
    • McCormick, F.1
  • 70
    • 0023687765 scopus 로고
    • Ischemia induces changes in the level of mRNAs coding for stress protein 71 and creatine kinase M
    • Mehta, H.B., Popovich, B.K., Dillmann, W.H. (1988) Ischemia induces changes in the level of mRNAs coding for stress protein 71 and creatine kinase M. Circ. Res., 63: 512-517.
    • (1988) Circ. Res. , vol.63 , pp. 512-517
    • Mehta, H.B.1    Popovich, B.K.2    Dillmann, W.H.3
  • 73
    • 27944453080 scopus 로고    scopus 로고
    • In vivo transduction of HIV-1-derived lentiviral particles engineered for macrolide-adjustable transgene expression
    • Mitta, B., Weber, C.C., Fussenegger, M. (2005) In vivo transduction of HIV-1-derived lentiviral particles engineered for macrolide-adjustable transgene expression. J. Gene Med., 7: 1400-1408.
    • (2005) J. Gene Med. , vol.7 , pp. 1400-1408
    • Mitta, B.1    Weber, C.C.2    Fussenegger, M.3
  • 74
    • 0041381205 scopus 로고    scopus 로고
    • Tight positive regulation of transgene expression by a single adenovirus vector containing the rtTA and tTS expression cassettes in separate genome regions
    • Mizuguchi, H., Xu, Z.L., Sakurai, F., Mayumi, T., Hayakawa, T. (2003) Tight positive regulation of transgene expression by a single adenovirus vector containing the rtTA and tTS expression cassettes in separate genome regions. Hum. Gene Ther., 14: 1265-1277.
    • (2003) Hum. Gene Ther. , vol.14 , pp. 1265-1277
    • Mizuguchi, H.1    Xu, Z.L.2    Sakurai, F.3    Mayumi, T.4    Hayakawa, T.5
  • 75
    • 0031772471 scopus 로고    scopus 로고
    • Heat shock proteins and the inflammatory response
    • Moseley, P.L. (1998) Heat shock proteins and the inflammatory response. Ann. N.Y. Acad. Sci., 856: 206-213.
    • (1998) Ann. N.Y. Acad. Sci. , vol.856 , pp. 206-213
    • Moseley, P.L.1
  • 76
    • 33645959208 scopus 로고    scopus 로고
    • Heat shock proteins in immunity
    • Multhoff, G. (2006) Heat shock proteins in immunity. Handb. Exp. Pharmacol., 172: 279-304.
    • (2006) Handb. Exp. Pharmacol. , vol.172 , pp. 279-304
    • Multhoff, G.1
  • 79
    • 0029865151 scopus 로고    scopus 로고
    • Ecdysone-inducible gene expression in mammalian cells and transgenic mice
    • No, D., Yao, T.P., Evans, R.M. (1996) Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proc. Natl. Acad. Sci. USA, 93: 3346-3351.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 3346-3351
    • No, D.1    Yao, T.P.2    Evans, R.M.3
  • 80
    • 0036811515 scopus 로고    scopus 로고
    • Antiprogestin-controllable transgene regulation in vivo
    • Nordstrom, J.L. (2002) Antiprogestin-controllable transgene regulation in vivo. Curr. Opin. Biotechnol., 13: 453-458.
    • (2002) Curr. Opin. Biotechnol. , vol.13 , pp. 453-458
    • Nordstrom, J.L.1
  • 81
    • 30844448402 scopus 로고    scopus 로고
    • Agonists of an ecdysone-inducible mammalian expression system inhibit Fas Ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO
    • Oehme, I., Bosser, S., Zornig, M. (2006) Agonists of an ecdysone-inducible mammalian expression system inhibit Fas Ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO. Cell Death Differ., 13: 189-201.
    • (2006) Cell Death Differ. , vol.13 , pp. 189-201
    • Oehme, I.1    Bosser, S.2    Zornig, M.3
  • 83
    • 0037352451 scopus 로고    scopus 로고
    • Improved ecdysone receptor-based inducible gene regulation system
    • Palli, S.R., Kapitskaya, M.Z., Kumar, M.B., Cress D.E. (2003) Improved ecdysone receptor-based inducible gene regulation system. Eur. J. Biochem., 270: 1308-1315.
    • (2003) Eur. J. Biochem. , vol.270 , pp. 1308-1315
    • Palli, S.R.1    Kapitskaya, M.Z.2    Kumar, M.B.3    Cress, D.E.4
  • 84
    • 28244499555 scopus 로고    scopus 로고
    • The influence of heterodimer partner ultraspiracle/retinoid X receptor on the function of ecdysone receptor
    • Palli, S.R., Kapitskaya, M.Z., Potter, D.W. (2005) The influence of heterodimer partner ultraspiracle/retinoid X receptor on the function of ecdysone receptor. FEBS J., 272: 5979-5990.
    • (2005) FEBS J. , vol.272 , pp. 5979-5990
    • Palli, S.R.1    Kapitskaya, M.Z.2    Potter, D.W.3
  • 86
    • 0034700090 scopus 로고    scopus 로고
    • Delivery of a stringent, dimerizer-regulated gene expression system in a single retroviral vector
    • Pollock, R., Issner, R., Zoller, K., Nateson, S., Rivera, V.M., Clackson, T. (2000) Delivery of a stringent, dimerizer-regulated gene expression system in a single retroviral vector. Proc. Natl. Acad. Sci. USA, 97: 13221-13226.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 13221-13226
    • Pollock, R.1    Issner, R.2    Zoller, K.3    Nateson, S.4    Rivera, V.M.5    Clackson, T.6
  • 87
  • 88
    • 0028948325 scopus 로고
    • Structure-based design of transcription factors
    • Pomerantz, J.L., Sharp, P.A., Pabo, C.O. (1995) Structure-based design of transcription factors. Science, 267: 93-96.
    • (1995) Science , vol.267 , pp. 93-96
    • Pomerantz, J.L.1    Sharp, P.A.2    Pabo, C.O.3
  • 89
    • 0034159971 scopus 로고    scopus 로고
    • The tetracycline-responsive promoter contains functional interferon-inducible response elements
    • Rang, A., Will, H. (2000) The tetracycline-responsive promoter contains functional interferon-inducible response elements. Nucleic Acids Res., 28: 1120-1125.
    • (2000) Nucleic Acids Res. , vol.28 , pp. 1120-1125
    • Rang, A.1    Will, H.2
  • 92
    • 13544262341 scopus 로고    scopus 로고
    • Long-term pharmacologically regulated expression of erythropoietin in primates following AAV-mediated gene transfer
    • Rivera, V.M., Gao, G.P., Grant, R.L., Schnell, M.A., Zoltick, P.W., Rozamus, L.W., Clackson, T., Wilson, J.M. (2005) Long-term pharmacologically regulated expression of erythropoietin in primates following AAV-mediated gene transfer. Blood, 105: 1424-1430.
    • (2005) Blood , vol.105 , pp. 1424-1430
    • Rivera, V.M.1    Gao, G.P.2    Grant, R.L.3    Schnell, M.A.4    Zoltick, P.W.5    Rozamus, L.W.6    Clackson, T.7    Wilson, J.M.8
  • 93
    • 0036196566 scopus 로고    scopus 로고
    • Resistance to tetracycline, macrolide-lincosamide-streptogramin, trimethoprim and sulfonamide drug classes
    • Roberts, M. (2002) Resistance to tetracycline, macrolide-lincosamide-streptogramin, trimethoprim and sulfonamide drug classes. Mol. Biotechnol., 20: 261-284.
    • (2002) Mol. Biotechnol. , vol.20 , pp. 261-284
    • Roberts, M.1
  • 94
    • 11844304311 scopus 로고    scopus 로고
    • Spatial and temporal control of expression of therapeutic genes using heat shock protein promoters
    • Rome, C., Couillaud, Moonen, C.T.W. (2005). Spatial and temporal control of expression of therapeutic genes using heat shock protein promoters. Methods, 35: 188-198.
    • (2005) Methods , vol.35 , pp. 188-198
    • Rome, C.1    Couillaud2    Moonen, C.T.W.3
  • 95
    • 0036853029 scopus 로고    scopus 로고
    • Long-term and tight control of gene expression in mouse skeletal muscle by a new hybrid human transcription factor
    • Roscilli, G., Rinaudo, C.D., Cimino, M., Sporeno, E., Lamartina, S., Ciliberto, G., Toniatti, C. (2002) Long-term and tight control of gene expression in mouse skeletal muscle by a new hybrid human transcription factor. Mol. Ther., 6: 653-663.
    • (2002) Mol. Ther. , vol.6 , pp. 653-663
    • Roscilli, G.1    Rinaudo, C.D.2    Cimino, M.3    Sporeno, E.4    Lamartina, S.5    Ciliberto, G.6    Toniatti, C.7
  • 96
    • 15944404602 scopus 로고    scopus 로고
    • New complex Ad vectors incorporating both rtTA and tTS deliver tightly regulated transgene expression both in vitro and in vivo
    • Rubinchik, S., Woraratanadharm, J., Yu, H., Dong, J.Y. (2005) New complex Ad vectors incorporating both rtTA and tTS deliver tightly regulated transgene expression both in vitro and in vivo. Gene Ther., 12: 504-511.
    • (2005) Gene Ther. , vol.12 , pp. 504-511
    • Rubinchik, S.1    Woraratanadharm, J.2    Yu, H.3    Dong, J.Y.4
  • 97
    • 3042642186 scopus 로고    scopus 로고
    • Visualization of the dynamics of gene expression in the living mouse
    • Ryan, A., Scrable, H. (2004) Visualization of the dynamics of gene expression in the living mouse. Mol. Imaging, 3: 33-42.
    • (2004) Mol. Imaging , vol.3 , pp. 33-42
    • Ryan, A.1    Scrable, H.2
  • 99
    • 15444343874 scopus 로고    scopus 로고
    • Differential heat shock protein induction by acetaminophen and a nonhepatotoxic regioisomer, 3′-hydroxyacetanilide, in mouse liver
    • Salminen, W.F., Jr, Voellmy, R., Roberts, S.M. (1997) Differential heat shock protein induction by acetaminophen and a nonhepatotoxic regioisomer, 3′-hydroxyacetanilide, in mouse liver. J. Pharmacol. Exp. Ther., 282: 1533-1540.
    • (1997) J. Pharmacol. Exp. Ther. , vol.282 , pp. 1533-1540
    • Salminen Jr., W.F.1    Voellmy, R.2    Roberts, S.M.3
  • 101
    • 0037051129 scopus 로고    scopus 로고
    • Mifepristone: Bioavailability, pharmacokinetics, and use-effectiveness
    • Sarkar, N.N. (2002) Mifepristone: bioavailability, pharmacokinetics, and use-effectiveness. Eur. J. Obstet. Gynecol. Reprod. Biol., 101: 113-120.
    • (2002) Eur. J. Obstet. Gynecol. Reprod. Biol. , vol.101 , pp. 113-120
    • Sarkar, N.N.1
  • 102
    • 33645976879 scopus 로고    scopus 로고
    • Protein aggregation as a cause for disease
    • Scheibel, T., Buchner, J. (2006) Protein aggregation as a cause for disease. Handb. Exp. Pharmacol., 172: 199-219.
    • (2006) Handb. Exp. Pharmacol. , vol.172 , pp. 199-219
    • Scheibel, T.1    Buchner, J.2
  • 103
    • 0023688079 scopus 로고
    • Cis-acting elements involved in the regulated expresion of a human hsp70 gene
    • Schiller, P., Amin, J., Ananthan, J., Brown, M.E., Scott, W.A., Voellmy, R. (1988) Cis-acting elements involved in the regulated expresion of a human hsp70 gene. J. Mol. Biol., 203: 97-105.
    • (1988) J. Mol. Biol. , vol.203 , pp. 97-105
    • Schiller, P.1    Amin, J.2    Ananthan, J.3    Brown, M.E.4    Scott, W.A.5    Voellmy, R.6
  • 108
    • 0036090701 scopus 로고    scopus 로고
    • Hsp70 and Hsp90 expression in leucocytes after exercise in moderately trained humans
    • Shastry, S., Toft, D.O., Joyner, M.J. (2002) Hsp70 and Hsp90 expression in leucocytes after exercise in moderately trained humans. Acta Physiol. Scand., 175: 138-146.
    • (2002) Acta Physiol. Scand. , vol.175 , pp. 138-146
    • Shastry, S.1    Toft, D.O.2    Joyner, M.J.3
  • 109
    • 0036209678 scopus 로고    scopus 로고
    • Spatial and temporal control of transgene expression through ultrasound-mediated induction of the heat shock protein 70B promoter in vivo
    • Smith, R.C., Machluf, M., Bromley, P., Atala, A., Walsh, K. (2002) Spatial and temporal control of transgene expression through ultrasound-mediated induction of the heat shock protein 70B promoter in vivo. Hum. Gene Ther., 13: 697-706.
    • (2002) Hum. Gene Ther. , vol.13 , pp. 697-706
    • Smith, R.C.1    Machluf, M.2    Bromley, P.3    Atala, A.4    Walsh, K.5
  • 110
    • 9244261579 scopus 로고    scopus 로고
    • Adeno-associated viral vector delivers cardiac-specific and hypoxia-inducible VEGF expression in ischemic mouse hearts
    • Su, H., Joho, S., Huang, Y., Barcena, A., Arakawa-Hoyt, J., Grossman, W., Kan, Y.W. (2004) Adeno-associated viral vector delivers cardiac-specific and hypoxia-inducible VEGF expression in ischemic mouse hearts. Proc. Natl. Acad. Sci. USA, 101: 16280-16285.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 16280-16285
    • Su, H.1    Joho, S.2    Huang, Y.3    Barcena, A.4    Arakawa-Hoyt, J.5    Grossman, W.6    Kan, Y.W.7
  • 111
    • 0032493446 scopus 로고    scopus 로고
    • High level transactivation by a modified Bombyx ecdysone receptor in mammalian cells without exogenous retinoid X receptor
    • Suhr, S.T., Gil, E.B., Senut, M.C., Gage, F.H. (1998) High level transactivation by a modified Bombyx ecdysone receptor in mammalian cells without exogenous retinoid X receptor. Proc. Natl. Acad. Sci. USA, 95: 7999-8004.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 7999-8004
    • Suhr, S.T.1    Gil, E.B.2    Senut, M.C.3    Gage, F.H.4
  • 112
    • 0027340093 scopus 로고
    • Heterodimerization of the Drosophila ecdysone receptor with retinoid X receptor and ultraspiracle
    • Thomas, H.E., Stunnenberg, H.G., Stewart, A.F. (1993) Heterodimerization of the Drosophila ecdysone receptor with retinoid X receptor and ultraspiracle. Nature, 362: 471-475.
    • (1993) Nature , vol.362 , pp. 471-475
    • Thomas, H.E.1    Stunnenberg, H.G.2    Stewart, A.F.3
  • 113
    • 1942537842 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: Transcription regulatory systems
    • Toniatti, C., Bujard, H., Cortese, R., Ciliberto, G. (2004) Gene therapy progress and prospects: transcription regulatory systems. Gene Ther., 11: 649-657.
    • (2004) Gene Ther. , vol.11 , pp. 649-657
    • Toniatti, C.1    Bujard, H.2    Cortese, R.3    Ciliberto, G.4
  • 114
    • 0034608802 scopus 로고    scopus 로고
    • Exploring the sequence space for tetracycline-dependent transcriptional activators: Novel mutations yield expanded range and sensitivity
    • Urlinger, S., Baron, U., Thellmann, M., Hasan, M.T., Bujard, H., Hillen, W. (2000) Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity. Proc. Natl. Acad. Sci. USA, 97: 7963-7968.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 7963-7968
    • Urlinger, S.1    Baron, U.2    Thellmann, M.3    Hasan, M.T.4    Bujard, H.5    Hillen, W.6
  • 115
    • 0026653659 scopus 로고
    • The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor
    • Vegeto E., Allan G.F., Schrader, W.T., Tsai, M.J., McDonnell, D.P., O'Malley, B.W. (1992) The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor. Cell, 69: 703-713.
    • (1992) Cell , vol.69 , pp. 703-713
    • Vegeto, E.1    Allan, G.F.2    Schrader, W.T.3    Tsai, M.J.4    McDonnell, D.P.5    O'Malley, B.W.6
  • 116
    • 0034153335 scopus 로고    scopus 로고
    • Control of transgene expression using local hyperthermia in combination with a heat-sensive promoter
    • Vekris, A., Maurange, C., Moonen, C., Mazurier, F., De Verneuil, H., Canioni, P., Voisin, P. (2000) Control of transgene expression using local hyperthermia in combination with a heat-sensive promoter. J. Gene Med., 2: 89-96.
    • (2000) J. Gene Med. , vol.2 , pp. 89-96
    • Vekris, A.1    Maurange, C.2    Moonen, C.3    Mazurier, F.4    De Verneuil, H.5    Canioni, P.6    Voisin, P.7
  • 117
    • 0029980260 scopus 로고    scopus 로고
    • Heat shock protein 72/73 in normal and diseased kidneys
    • Venkataseshan, V.S., Marquet, E. (1996) Heat shock protein 72/73 in normal and diseased kidneys. Nephron, 73: 442-449.
    • (1996) Nephron , vol.73 , pp. 442-449
    • Venkataseshan, V.S.1    Marquet, E.2
  • 118
    • 22644434444 scopus 로고    scopus 로고
    • Novel gene switches for targeted and timed expression of proteins of interest
    • Vilaboa, N., Fenna, M., Munson, J., Roberts, S.M., Voellmy, R. (2005) Novel gene switches for targeted and timed expression of proteins of interest. Mol. Ther., 12: 290-298.
    • (2005) Mol. Ther. , vol.12 , pp. 290-298
    • Vilaboa, N.1    Fenna, M.2    Munson, J.3    Roberts, S.M.4    Voellmy, R.5
  • 119
    • 0000769573 scopus 로고
    • Isolation and functional analysis of a human 70,000 dalton heat shock protein gene segment
    • Voellmy, R., Ahmed, A., Schiller, P., Bromley, P., Rungger, D. (1985) Isolation and functional analysis of a human 70,000 dalton heat shock protein gene segment. Proc. Natl. Acad. Sci. USA, 82: 4949-4953.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 4949-4953
    • Voellmy, R.1    Ahmed, A.2    Schiller, P.3    Bromley, P.4    Rungger, D.5
  • 120
    • 33646004634 scopus 로고    scopus 로고
    • Feedback regulation of the heat shock response
    • Voellmy, R. (2006) Feedback regulation of the heat shock response. Handb. Exp. Pharmacol., 172: 43-68.
    • (2006) Handb. Exp. Pharmacol. , vol.172 , pp. 43-68
    • Voellmy, R.1
  • 122
    • 0031001166 scopus 로고    scopus 로고
    • Positive and negative regulation of gene expression in eukaryotic cells with an inducible transcriptional regulator
    • Wang, Y., Xu, J., Pierson, T., O'Malley, B.W., Tsai, S.Y. (1997a) Positive and negative regulation of gene expression in eukaryotic cells with an inducible transcriptional regulator. Gene Ther., 4: 432-441.
    • (1997) Gene Ther. , vol.4 , pp. 432-441
    • Wang, Y.1    Xu, J.2    Pierson, T.3    O'Malley, B.W.4    Tsai, S.Y.5
  • 123
    • 0030965628 scopus 로고    scopus 로고
    • Ligand-inducible and liver-specific target gene expression in transgenic mice
    • Wang, Y., DeMayo, F.J., Tsai, S.Y., O'Malley, B.W. (1997b) Ligand-inducible and liver-specific target gene expression in transgenic mice. Nat. Biotechnol., 15: 239-243.
    • (1997) Nat. Biotechnol. , vol.15 , pp. 239-243
    • Wang, Y.1    DeMayo, F.J.2    Tsai, S.Y.3    O'Malley, B.W.4
  • 124
    • 0038489121 scopus 로고    scopus 로고
    • Single HSV-amplicon vector mediates drug-induced gene expression via dimerizer system
    • Wang, S., Petravicz, J., Breakefield, X.O. (2003) Single HSV-amplicon vector mediates drug-induced gene expression via dimerizer system. Mol. Ther., 7: 790-800.
    • (2003) Mol. Ther. , vol.7 , pp. 790-800
    • Wang, S.1    Petravicz, J.2    Breakefield, X.O.3
  • 127
    • 0042964105 scopus 로고    scopus 로고
    • Novel promoter/transactivator configurations for macroloide- and streptogramin-responsive transgene expression in mammalian cells
    • Weber, W., Kramer, B.P., Fux, C., Keller, B., Fussenegger, M. (2002b) Novel promoter/transactivator configurations for macroloide- and streptogramin-responsive transgene expression in mammalian cells. J. Gene Med., 4: 676-686.
    • (2002) J. Gene Med. , vol.4 , pp. 676-686
    • Weber, W.1    Kramer, B.P.2    Fux, C.3    Keller, B.4    Fussenegger, M.5
  • 129
    • 0036845222 scopus 로고    scopus 로고
    • Radiation-induced tumor necrosis factor-expression: Clinical application of physical and transcriptional targeting of gene therapy
    • Weichselbaum, R.R., Kufe, D.W., Hellman, S., Rasmussen, H.S., King, C.R., Fischer, P.H., Mauceri, H.J. (2002). Radiation-induced tumor necrosis factor-expression: clinical application of physical and transcriptional targeting of gene therapy. Lancet Oncol., 3: 665-671.
    • (2002) Lancet Oncol. , vol.3 , pp. 665-671
    • Weichselbaum, R.R.1    Kufe, D.W.2    Hellman, S.3    Rasmussen, H.S.4    King, C.R.5    Fischer, P.H.6    Mauceri, H.J.7
  • 130
    • 33645971638 scopus 로고    scopus 로고
    • The role of chaperones in Parkinson's disease and prion diseases
    • Winklhofer, K.F., Tatzelt, J. (2006) The role of chaperones in Parkinson's disease and prion diseases. Handb. Exp. Pharmacol., 172: 221-258.
    • (2006) Handb. Exp. Pharmacol. , vol.172 , pp. 221-258
    • Winklhofer, K.F.1    Tatzelt, J.2
  • 131
    • 0033911027 scopus 로고    scopus 로고
    • Modification of vascular tone using inos under the control of aradiation-inducible promoter
    • Worthington, J., Robson, T., Murray, M., O'Rourke, M. Keilty, G., Hirst, D.G. (2000) Modification of vascular tone using inos under the control of aradiation-inducible promoter. Gene Ther., 7: 1126-1131.
    • (2000) Gene Ther. , vol.7 , pp. 1126-1131
    • Worthington, J.1    Robson, T.2    Murray, M.3    O'Rourke, M.4    Keilty, G.5    Hirst, D.G.6
  • 132
    • 0034843646 scopus 로고    scopus 로고
    • Bicistronic expression of ecdysone-inducible receptors in mammalian cells
    • Wyborski, D.L., Bauer, J.C., Vaillancourt, P. (2001) Bicistronic expression of ecdysone-inducible receptors in mammalian cells. Biotechniques, 31: 618-20.
    • (2001) Biotechniques , vol.31 , pp. 618-620
    • Wyborski, D.L.1    Bauer, J.C.2    Vaillancourt, P.3
  • 134
    • 0038324327 scopus 로고    scopus 로고
    • Regulated gene expression from adenovirus vectors: A systematic comparison of various inducible systems
    • Xu, Z.L., Mizuguchi, H., Mayumi, T., Hayakawa, T. (2003) Regulated gene expression from adenovirus vectors: a systematic comparison of various inducible systems. Gene, 309: 145-151.
    • (2003) Gene , vol.309 , pp. 145-151
    • Xu, Z.L.1    Mizuguchi, H.2    Mayumi, T.3    Hayakawa, T.4
  • 135
    • 2942746207 scopus 로고    scopus 로고
    • Regulation of transgene expression in muscles by ultrasound-mediated hyperthermia
    • Xu, L., Zhao, Y., Zhang, Q., Li, Y., Xu, Y. (2004) Regulation of transgene expression in muscles by ultrasound-mediated hyperthermia. Gene Ther., 11: 894-900.
    • (2004) Gene Ther. , vol.11 , pp. 894-900
    • Xu, L.1    Zhao, Y.2    Zhang, Q.3    Li, Y.4    Xu, Y.5
  • 136
    • 0026646635 scopus 로고
    • Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation
    • Yao, T.P., Segraves, W.A., Oro, A.E., McKeown, M., Evans, R.M. (1992) Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation. Cell, 71: 63-72.
    • (1992) Cell , vol.71 , pp. 63-72
    • Yao, T.P.1    Segraves, W.A.2    Oro, A.E.3    McKeown, M.4    Evans, R.M.5
  • 140
    • 0035816681 scopus 로고    scopus 로고
    • Use of the tetracycline-controlled transcriptional silencer (tTS) to eliminate transgene leak in inducible overexpression transgenic mice
    • Zhu, Z., Ma, B., Homer, R.J., Zheng, T., Elias, J.A. (2001) Use of the tetracycline-controlled transcriptional silencer (tTS) to eliminate transgene leak in inducible overexpression transgenic mice. J. Biol. Chem., 276: 25222-25229.
    • (2001) J. Biol. Chem. , vol.276 , pp. 25222-25229
    • Zhu, Z.1    Ma, B.2    Homer, R.J.3    Zheng, T.4    Elias, J.A.5
  • 141
    • 0031868230 scopus 로고    scopus 로고
    • Correlation between glutathione oxidation and trimerization of heat shock factor 1, an early step in the stress induction of the Hsp response
    • Zou, J., Salminen, W.F., Roberts, S.M., Voellmy, R. (1998) Correlation between glutathione oxidation and trimerization of heat shock factor 1, an early step in the stress induction of the Hsp response. Cell Stress & Chaperones, 3: 130-141.
    • (1998) Cell Stress & Chaperones , vol.3 , pp. 130-141
    • Zou, J.1    Salminen, W.F.2    Roberts, S.M.3    Voellmy, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.