Transgene expression in malignant glioma using a replication-defective adenoviral vector containing the Egr-1 promoter: Activation by ionizing radiation or uptake of radioactive iododeoxyuridine

Human Gene Therapy

Volumn 9, Issue 10, 1998, Pages 1409-1417

  Manome, Yoshinobu ^a   Kunieda, Takehiko ^a   Wen, Patrick Y ^b   Koga, Tomohiko ^c   Kufe, Donald W ^d   Ohno, Tsuneya ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c Chiba Social Insurance Hospital   (Japan)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; IDOXURIDINE; IODINE 125;

ADENOVIRUS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN TUMOR; CLONING VECTOR; CONTROLLED STUDY; EARLY RESPONSE GENE; GENE ACTIVATION; GENE THERAPY; GLIOBLASTOMA; HUMAN; HUMAN CELL; IONIZING RADIATION; IRRADIATION; MALE; NONHUMAN; PROMOTER REGION; RAT; REPORTER GENE; TRANSCRIPTION REGULATION; TRANSGENE;

EID: 0032126019     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1998.9.10-1409     Document Type: Article

References (10)

1. ANDERSON, W.F. (1992). Human gene therapy. Science 256, 808-813.
2. BARKER, M., HOSHINO, T., GURCAY, O., WILSON, C.B., NIELSEN, S.L., DOWNIE, R., and ELIASON, J. (1973). Development of an animal brain tumor model and its response to therapy with 1,3-bis(2-chloroethyl)-1-nitrosourea. Cancer Res. 35, 976-986.
3. CHEN, S.-H., SHINE, H.D., GOODMAN, J.C., GROSSMAN, R.G., and WOO, S.L. (1994). Gene therapy for brain tumor: Regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proc. Natl. Acad. Sci. U.S.A. 91, 3054-3057.
4. CHIRGWIN, J.M., PRZBYLA, A.E., MACDONALD, R.J., and RUTTER, W.J. (1979). Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18, 5294-5299.
5. CULVER, K.W., RAM, Z., WALBRIDGE, S., ISHII, H., OLDFIELD, E.H., and B. LEASE, R.M. (1992). In vivo gene transfer with retroviral-vector producer cells for treatment of experimental brain tumors. Science 256, 1550-1552.
6. CUSACK, J.C., SPITZ, F.R., NGUYEN, D., ZHANG, W.W., CRISTIANO, R.J., and ROTH, J.A. (1996). High levels of gene transduction in human lung tumors following intralesional injection of recombinant adenovirus. Cancer Gene Ther. 3, 245-249.
7. DACHS, G.U., PATTERSON, A.V., FIRTH, J.D., RATCLIFFE, P.J., TOWNSEND, K.M., STRATFORD, I.J., and HARRIS, A.L. (1997). Targeting gene expression to hypoxic tumor cells. Nature Med. 3, 515-520.
8. DATTA, R., RUBIN, E., SUKHATME, V., QURESHI, S., HALLAHAN, D., WEICHSELBAUM, R.R., and KUFE, D.W. (1992). Ionizing radiation activates transcription of the EGR1 gene via CArG elements. Proc. Natl. Acad. Sci. U.S.A. 89, 10149-10153.
9. DATTA, R., TANEJA, N., SUKHATME, V.P., QURESHI, S.A., WEICHSELBAUM, R., and KUFE, D.W. (1993). Reactive oxygen intermediates target CC(A/T)6GG sequences to mediate activation of the early growth response 1 transcription factor gene by ionizing radiation. Proc. Natl. Acad. Sci. U.S.A. 90, 2419-2422.
10. DELORT, J.P., and CAPECCHI, M.R. (1996). TAXI/UAS: A molecular switch to control expression of genes in vivo. Hum. Gene Ther. 7, 809-820.