Regression of hepatocellular carcinoma in vitro and in vivo by radiosensitizing suicide gene therapy under the inducible and spatial control of radiation

Human Gene Therapy

Volumn 10, Issue 9, 1999, Pages 1509-1519

  Kawashita, Yujo ^a   Ohtsuru, Akira ^a,c   Kaneda, Yasufumi ^b   Nagayama, Yuji ^a   Kawazoe, Yasushi ^a   Eguchi, Susumu ^a   Kuroda, Hiroaki ^a   Fujioka, Hikaru ^a   Ito, Masahiro ^a   Kanematsu, Takashi ^a   Yamashita, Shunichi ^a  

^a NAGASAKI UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^c NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GANCICLOVIR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER RADIOTHERAPY; CANCER REGRESSION; CONTROLLED STUDY; GENE ACTIVATION; GENE ACTIVITY; GENE EXPRESSION; GENE THERAPY; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; RADIOSENSITIZATION; SUICIDE GENE;

AGED; ANIMALS; ANTIVIRAL AGENTS; CARCINOMA, HEPATOCELLULAR; CELLS, CULTURED; COMBINED MODALITY THERAPY; DNA-BINDING PROTEINS; EARLY GROWTH RESPONSE PROTEIN 1; FEMALE; GANCICLOVIR; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE THERAPY; HUMANS; IMMEDIATE-EARLY PROTEINS; LAC OPERON; LIVER; LIVER NEOPLASMS; MALE; MICE; MICE, NUDE; MIDDLE AGED; PROMOTER REGIONS (GENETICS); RADIATION TOLERANCE; RNA, MESSENGER; SIMPLEXVIRUS; THYMIDINE KINASE; TRANSCRIPTION FACTORS; TUMOR CELLS, CULTURED;

ANIMALIA; MUS MUSCULUS;

EID: 2442745332     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430349950017842     Document Type: Article

References (50)

1. BARBA, D., HARDIN, J., SADELAIN, M., and GAGE, F. H. (1994). Development of antitumor immunity following thymidine kinase-mediated killing of experimental brain tumors. Proc. Natl. Acad. Sci. U.S.A. 91, 4348-4352.
2. BERRY, M. N., and FRIEND, D. S. (1969). High-yield preparation of isolated rat liver parenchymal cells: A biochemical and fine structural study. J. Cell. Biol. 43, 506-520.
3. CARUSO, M., PANIS, Y., GAGANDEEP, S., HOUSSIN, D., SALZMANN, J., and KLATZMANN, D. (1993). Regression of established macroscopic liver metastases after in situ transduction of a suicide gene. Proc. Natl. Acad. Sci. U.S.A. 90, 7024-7028.
4. CHEN, S., SHINE, H. D., GOODMAN, J. C., GROSSMAN, R. G., and WOO, S. L. C. (1994). Gene therapy for brain tumors: Regression of experimental tumors by adenovirus-mediated gene transfer in vivo. Proc. Natl. Acad. Sci. U.S.A. 91, 3054-3057.
5. CHENG, X., and ILIAKIS, G. (195). Effect of ionizing radiation on the expression of chloramphenicol acetyltransferase gene under the control of commonly used constitutive or inducible promoters. Int. J. Radiat. Biol. 67, 261-267.
6. COLOMBO, M. (1992). Hepatocellular carcinoma. J. Hepatol. 15, 225-236.
7. CULVER, K. W., RAM, Z., WALLBRIDGE, S., ISHII, H., OLDFIELD, E. H., and BLAESE, R. M. (1992). In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science 256, 1550-1552.
8. DATTA, R., RUBIN, E., SUKHATME, V., QURESHI, S., HALLAHAN, D., WEICHSELBAUM, R., R., and KUFE, D. W. (1992). Ionizing radiation activates transcription of the EGR1 gene via CArG elements. Proc. Natl. Acad. Sci. U.S.A. 89, 10149-10153.
9. FREEMAN, S. M., ABBOUD, C. N., WHARENBY, K. A., PACKMAN, C. H., KOEPLIN, D. S., MOOLTEN, F. L., and ABRAHAM, G. N. (1993). The "bystander effect"; tumor repression when a fraction of the tumor mass is genetically modified. Cancer Res. 53, 5274-5283.
10. GROVER, B. A., ADAMSON, E., and MERCOLA, D. (1994). Transformation-specific pattern of phosphorylation of c-Jun, Jun-B, Jun-D and Egr-1 in v-sis transformed cells. Carcinogenesis 15, 1667-1674.
11. HALLAHAN, D. E., MAUCERI, H. J., SEUNG, L. P., DUNPHY, E. J., WAYNE, J. D., HANNA, N. N., TOLEDANO, A., HELLMAN, S., KUFE, D. W., and WEICHSELBAUM, R. R. (1995). Spatial and temporal control of gene therapy using ionizing radiation. Nature Med. 1, 786-791.
12. HIRANO, T., FUJIMOTO, J., UEKI, T., YAMAMOTO, H., IWASAKI, T., MORISHITA, R., SAWA, Y., KANEDA, Y., TAKAHASHI, H., and OKAMOTO, E. (1998). Persistent gene expression in rat liver in vivo by repetitive transfections using HVJ-liposome. Gene Ther. 5, 459-464.
13. HWANG, H. C., SMYTHE, W. R., ELSHAMI, A. A., KUCHARCZUK, J. C., AMIN, K. M., WILLIAMS, J. P., LITZKY, L. A., KAISER, L. R., and ALBELDA, S. M. (1995). Gene therapy using adenovirus carrying the herpes simplex-thymidine kinase gene to treat in vivo models of human malignant mesothelioma and lung cancer. Am. J. Respir. Cell Mol. Biol. 13, 7-16.
14. IDO, A., NAKATA, K., KATO, Y., NAKAO, K., MURATA, K., FUJITA, M., ISHII, N., TAMAOKI, T., SHIKU, H., and NAGATAKI, S. (1995). Gene therapy for hepatoma cells using a retrovirus vector carrying herpes simplex virus thymidine kinase gene under the control of human α-fetoprotein gene promoter. Cancer Res. 55, 3105-3109.
15. JOKI, T., NAKAMURA, M., and OHNO, T. (1995). Activation of the radiosensitive EGR-1 promoter induces expression of the herpes simplex virus thymidine kinase gene and sensitivity of human glioma cells to ganciclovir. Hum. Gene Ther. 6, 1507-1513.
16. KANAI, F., SHIRATORI, Y., YOSHIDA, Y., WAKIMOTO, H., HAMADA, H., KANEGAE, Y., SAITO, I.., NAKABAYASHI, H., TAMAOKI, T., LAN, K.-H., KATO, N., SHIINA, S., and OMATA, M. (1996). Gene therapy for α-fetoprotein-producing human hepatoma cells by adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene. Hepatology 23, 1359-1368.
17. KANAI, F., KAWAKAMI, T., HAMADA, H., SADATA, A., YOSHIDA, Y., WAKIMOTO, H., TANAKA, T., OHASHI, M., LAN, K.-H., KATO, N., SHIRATORI, Y., and OMATA, M. (1998). Adenovirus-mediated transduction of Escherichia coli uracil phosphoribosyltransferase gene sensitizes cancer cells to low concentrations of 5-fluorouracil. Cancer Res. 58, 1946-1951.
18. KANEDA, Y. (1994). Virus (Sendai virus envelopes)-mediated gene transfer. In. Cell Biology: A Laboratory Handbook, Vol. III. J. E. Celis, ed. (Academic Press, San Diego, CA) pp. 50-57.
19. KANEKO, S., HALLENBECK, P., KOTANI, T., NAKABAYASHI, H., McGARRITY, G., TAMAOKI, T., ANDERSON, W. F., and CHIANG, Y. L. (1995). Adenovirus-mediated gene therapy of hepatocellular carcinoma using cancer-specific gene expression. Cancer Res. 55, 5283-5287.
20. KATO, K., NAKANISHI, M., KANEDA, Y., UCHIDA, T., and OKADA, Y. (1991). Expression of hepatitis B virus surface antigen in adult rat liver. J. Biol. Chem. 266, 3361-3364.
21. KIESER, A., SEITZ, T., ADLER, H. S., COFFER, R., KREMMER, E., CRESPO, P., GUTKIND, J. S., HENDERSON, D. W., MUSHINSKI, J. F., KOLCH, W., and MISCHAK, H. (1996). Protein kinase C-zeta reverts v-raf transformation of NIH-3T3 cells. Genbs Dev. 10, 1455-1466.
22. KIM, J. H., KIM S. H., BROWN, S. L., and FREYTAG, S. O. (1994). Selective enhancement by an antiviral agent of the radiation-induced cell killing of human glioma cells transduced with HSV-tk gene. Cancer Res. 54, 6053-6056.
23. LAN, K. H., KANAI, F., SHIRATORI, Y., OHASHI, M., TANAKA, T., OKUDAIRA, T., YOSHIDA, Y., HAMADA, H., and OMATA, M. (1997). In vivo gene expression and therapy mediated by adenoviral vectors for human carcinoembrionic antigen-producing gastric carcinoma. Cancer Res. 57, 4279-4284.
24. LIN, Y. L., CHEN, H. C., YEH, S. F., and CHOU, C. K. (1995). Differential pathways of insulin action upon the hepatitis B surface antigen gene expression and cell proliferation in human hepatoma cells. Endocrinology 136, 2922-2927.
25. MAHESWARAN, S., PARK, S., BERNARD, A., MORRIS, J. F., RAUSCHER, F., HILL, D. E., and HABER, D. A. (1993). Physical and functional interaction between WT1 and p53 proteins. Proc. Natl. Acad. Sci. U.S.A. 90, 5100-5104.
26. MANOME, Y., KUNIEDA, T., WEN, P. Y., KOGA, T., KUFE, D. W., and OHNO, T. (1998). Transgene expression in malignant glioma using a replication-defective adenoviral vector containing the Egr-1 promoter: Activation by ionizing radiation or uptake of radioactive iododeoxyuridine. Hum. Gene Ther. 9, 1409-1417.
27. MATSUMOTO, K., SHIBATA, H., FUJISAWA, J. I., INOUE, H., HAKURA, A., TSUKAHARA, T., and FUJII, M. (1997). Human T-cell leukemia virus type 1 Tax protein transforms rat fibroblasts via two distinct pathways. J. Virol. 71, 4445-4451.
28. MOOLTEN, F. L. (1986). Tumor chemosensitivity conferred by inserted herpes simplex thymidine kinase genes: Paradigm for a prospective cancer control study. Cancer Res. 46, 5276-5281.
29. MOOLTEN, F. L. (1994). Drug sensitivity ("suicide") genes for selective cancer chemotherapy. Cancer Gen Ther. 1, 279-287.
30. MOOLTEN, F. L., and WELLS, J. M. (1990). Curability of tumors bearing herpes thymidine kinase genes transferred by retrovirus vectors. J. Natl. Cancer Inst. 82, 297-300.
31. MORISHITA, R., GIBBONS, G. H., KANEDA, Y., OGIHARA, T., and DZAU, V. J. (1993). Novel and effective gene transfer technique for study of vascular renin angiotensin system. J. Clin. Invest. 91, 2580-2585.
32. NISHIHARA, E., NAGAYAMA, Y., MAWATARI, F., TANAKA, K., NAMBA, H., NIWA, M., and YAMASHITA, S. (1997). Retrovirus-mediated herpes simplex virus thymidine kinase gene transduction renders human thyroid carcinoma cell lines sensitive to ganciclovir and radiation in vitro and in vivo. Endocrinology 138, 4577-4583.
33. OHGUCHI, S., NAKATSUKASA, H., HIGASHI, T., ASHIDA, K., NOUSO, K., ISHIZAKI, M., HINO, N., KOBAYASHI, Y., UEMATSU, S., and TSUJI, T. (1998). Expression of α-fetoprotein and albumin genes in human hepatocellular carcinomas: Limitations in the application of the genes for targeting human hepatocellular carcinoma in gene therapy. Hepatology 27, 599-607.
34. OHTSURU, A., NAGATAKI, S., KOJI, T., and TAMAOKI, T. (1988). Analysis of α-fetoprotein gene expression in hepatocellular carcinoma and liver cirrhosis by in situ hybridization. Cancer 62, 1105-1112.
35. O'MALLEY, B. W., JR., CHEN, S. H., SCHWARTZ, M. R., and WOO, S. L. (1995). Adenovirus-mediated gene therapy for human head and neck squamous cell cancer in a nude mouse model. Cancer Res. 55, 1080-1085.
36. RAM, Z., WALBRIDGE, S., OSHIRO, E. M., VIOLA, J. J., CHIANG, Y., MUELLER, S. N., BLAESE, R. M., and OLDFIELD, E. H. Intrathecal gene therapy for malignant leptomeningeal neoplasia (1994). Cancer Res. 54, 2141-2145.
37. RAVOET, C., BLEIBERG, H., and GERARD, B. (1993). Non-surgical treatment of hepatocarcinoma. J. Surg. Oncol. (Suppl. 3), 104-111.
38. SAEKI, Y., MATSUMOTO, N., NAKANO, Y., MORI, M., AWAI, K., and KANEDA, Y. (1997). Development and characterization of cationic liposomes conjugated with HVJ (Sendai virus): Reciprocal effect of cationic lipid for in vitro and in vivo gene transfer. Hum. Gene Ther. 8, 2133-2141.
39. SAMBRANO, G. R., and STEINBERG, D. (1995). Recognition of oxidatively damaged and apoptotic cells by an oxidized low density lipoprotein receptor on mouse peritoneal macrophages: Role of membrane phosphatidylserine. Proc. Natl. Acad. Sci. U.S.A. 92, 1396-1400.
40. SAVILL, J., FADOK, V., HENSON, P., and HASLETT, C. (1993). Phagocyte recognition of cells undergoing apoptosis. Immunol. Today 4, 131-136.
41. SEUNG, L. P., MAUCERI, H. J., BECKETT, M. A., HALLAHAN, D. E., HELLMAN, S., and WEICHSELBAUM, R. R. (1995). Genetic radiotherapy overcomes tumor resistance to cytotoxic agents. Cancer Res. 55, 5561-5565.
42. SU, H., CHANG, J. C., XU, S. M., and KAN, Y. W. (1996). Selective killing of AFP-positive hepatocellular carcinoma cells by adeno-associated virus thymidine kinase Gene. Hum. Gene Ther. 7, 463-470.
43. SUKHATME, V. P., CAO, X. M., CHANG, L. C., TASI, M. C., STAMENKOVICH, D., FERREIRA, P. C., COHEN, D. R., EDWARDS, S. A., SHOWS, T. B., and CURRAN, T. (1988). A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization. Cell 53, 37-43.
44. SULLIVAN, D. E., DASH, S., DU, H., HIRAMATSU, N., AYDIN, F., KOLLS, J., BLANCHARD, J., BASKIN, G., and GERBER, M. A. (1997). Liver-directed gene transfer in non-human primates. Hum. Gene Ther. 8, 1195-1206.
45. TAKAHASHI, T., NAMIKI, Y., and OHNO, T. (1997). Induction of the suicide HSV-TK gene by activation of the Egr-1 promoter with radioisotopes. Hum. Gene Ther. 8, 827-833.
46. TSUKAZAKI, T., OHTSURU, A., NAMBA, H., ODA, J., MOTOMURA, K., OSAKI, M., KIRIYAMA, T., IWASAKI, K., and YAMASHITA, S. (1996). Parathyroid hormone-related protein (PTHrP) action in rat articular chondrocytes: Comparison of PTH (1-34), PTHrP (1-34), PTHrP (1-141), PTHrP (100-114) and antigens oligonucleotides against PTHrP. J. Endocrinol. 150, 359-368.
47. VENOOK, A. (1994). Treatment of hepatocellular carcinoma: Too many options? J. Clin. Oncol. 12, 1323-1334.
48. WEICHSELBAUM, R. R., HALLAHAN, D. E., BECKETT, M. A., MAUCERI, H. J., LEE, H., SUKHATME, V. P., and KUFE, D. W. (1994). Gene therapy targeted by radiation preferentially radiosensitizes tumor cells. Cancer Res. 54, 4266-4269.
49. WILLS, K. N., HUANG, W. M., HARRIS, M. P., MACHEMER, T., MANEVAL, D. C., and GREGORY, R. J. (1995). Gene therapy for hepatocellular carcinoma: Chemosensitivity conferred by adenovirus-mediated transfer of the HSV-1 thymidine kinase gene. Cancer Gene Ther. 2, 191-197.
50. WU, J. K., CANO, W. G., MEYLAERTS, S. A., QI, P., VRIONIS, F., and CHERINGTON, V. (1994). Bystander tumoricidal effect in the treatment of experimental brain tumors. Neurosurgery 35, 1094-1102.