메뉴 건너뛰기




Volumn 4, Issue 4, 2005, Pages 359-364

Achieving hypoxia-inducible gene expression in tumors

Author keywords

Gene therapy; Hypoxia; Hypoxia response element

Indexed keywords

1 AZIRIDINO 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL; 5 (1 AZIRIDINYL) 2,4 DINITROBENZAMIDE; BACTERIAL ENZYME; CYTOCHROME P450 REDUCTASE; CYTOSINE DEAMINASE; ERYTHROPOIETIN; FLUCYTOSINE; FLUOROURACIL; GANCICLOVIR; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HERPESVIRUS VECTOR; HYPOXIA INDUCIBLE FACTOR 1; NITROREDUCTASE; OXYGEN; PHOSPHOGLYCERATE KINASE; PRODRUG; RECOMBINANT ENZYME; RECOMBINANT ERYTHROPOIETIN; RECOMBINANT VASCULOTROPIN; VASCULOTROPIN;

EID: 25144436926     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (28)

References (36)
  • 1
    • 84966192535 scopus 로고
    • The histological structure of some human lung cancers and the possible implications for radiotherapy
    • Thomlinson RH, Gray LH. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer 1955; 9:539-49.
    • (1955) Br J Cancer , vol.9 , pp. 539-549
    • Thomlinson, R.H.1    Gray, L.H.2
  • 2
    • 0018760476 scopus 로고
    • Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation
    • Brown JM. Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation. Br J Radiol 1979; 52:650-6.
    • (1979) Br J Radiol , vol.52 , pp. 650-656
    • Brown, J.M.1
  • 5
    • 0038685423 scopus 로고    scopus 로고
    • Prodrugs for gene-directed enzyme-prodrug therapy (suicide gene therapy)
    • Denny WA. Prodrugs for gene-directed enzyme-prodrug therapy (suicide gene therapy). J Biomed Biotechnol 2003; 1:48-70.
    • (2003) J Biomed Biotechnol , vol.1 , pp. 48-70
    • Denny, W.A.1
  • 6
    • 4043082727 scopus 로고    scopus 로고
    • Gene-based therapy in prostate cancer
    • Foley R, Lawler M, Hollywood D. Gene-based therapy in prostate cancer. Lancet Oncol 2004; 5:469-79.
    • (2004) Lancet Oncol , vol.5 , pp. 469-479
    • Foley, R.1    Lawler, M.2    Hollywood, D.3
  • 8
    • 0031823016 scopus 로고    scopus 로고
    • The molecular basis of the hypoxia response pathway: Tumour hypoxia as a therapy target
    • Blancher C, Harris AL. The molecular basis of the hypoxia response pathway: Tumour hypoxia as a therapy target. Cancer Metastasis Rev 1998; 17:187-94.
    • (1998) Cancer Metastasis Rev , vol.17 , pp. 187-194
    • Blancher, C.1    Harris, A.L.2
  • 10
    • 0028095127 scopus 로고
    • Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin
    • Goldberg MA, Schneider TJ. Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin. J Biol Chem 1994; 269:4355-9.
    • (1994) J Biol Chem , vol.269 , pp. 4355-4359
    • Goldberg, M.A.1    Schneider, T.J.2
  • 11
    • 0028805375 scopus 로고
    • Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences
    • Ebert BL, Firth JD, Ratcliffe PJ. Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences. J Biol Chem 1995; 270:29083-9.
    • (1995) J Biol Chem , vol.270 , pp. 29083-29089
    • Ebert, B.L.1    Firth, J.D.2    Ratcliffe, P.J.3
  • 12
    • 0028359320 scopus 로고
    • Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: Similarities with the erythropoietin 3′ enhancer
    • USA
    • Firth JD, Ebert BL, Pugh CW, Ratcliffe PJ. Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: Similarities with the erythropoietin 3′ enhancer. Proc Natl Acad Sci USA 1994; 91:6496-500.
    • (1994) Proc Natl Acad Sci , vol.91 , pp. 6496-6500
    • Firth, J.D.1    Ebert, B.L.2    Pugh, C.W.3    Ratcliffe, P.J.4
  • 13
    • 0028219331 scopus 로고
    • Transcriptional regulation of gene expression: Mechanisms and pathophysiology
    • Semenza GL. Transcriptional regulation of gene expression: Mechanisms and pathophysiology. Hum Mutat 1994; 3:180-99.
    • (1994) Hum Mutat , vol.3 , pp. 180-199
    • Semenza, G.L.1
  • 14
    • 0037133736 scopus 로고    scopus 로고
    • Identification of an additional hypoxia responsive element in the glyceraldehyde-3-phosphate dehydrogenase gene promoter
    • Lu S, Gu X, Hoestje S, Epner DE. Identification of an additional hypoxia responsive element in the glyceraldehyde-3-phosphate dehydrogenase gene promoter. Biochim Biophys Acta 2002; 1574:152-6.
    • (2002) Biochim Biophys Acta , vol.1574 , pp. 152-156
    • Lu, S.1    Gu, X.2    Hoestje, S.3    Epner, D.E.4
  • 15
    • 0025972125 scopus 로고
    • Erythropoietin mRNA levels are governed by both the rate of gene transcription and posttranscriptional events
    • Goldberg MA, Gaut CC, Bunn HF. Erythropoietin mRNA levels are governed by both the rate of gene transcription and posttranscriptional events. Blood 1991; 77:271-7.
    • (1991) Blood , vol.77 , pp. 271-277
    • Goldberg, M.A.1    Gaut, C.C.2    Bunn, H.F.3
  • 16
    • 0026468180 scopus 로고
    • A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    • Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 1992; 12:5447-54.
    • (1992) Mol Cell Biol , vol.12 , pp. 5447-5454
    • Semenza, G.L.1    Wang, G.L.2
  • 17
    • 0028967752 scopus 로고
    • The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TF1
    • Galson DL, Tsuchiya T, Tendler DS, Huang LE, Ren Y, Ogura T, Bunn HF. The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TF1. Mol Cell Biol 1995; 15:2135-44.
    • (1995) Mol Cell Biol , vol.15 , pp. 2135-2144
    • Galson, D.L.1    Tsuchiya, T.2    Tendler, D.S.3    Huang, L.E.4    Ren, Y.5    Ogura, T.6    Bunn, H.F.7
  • 18
    • 0031742542 scopus 로고    scopus 로고
    • Enhancement of gene expression under hypoxic conditions using fragments of the human vascular endothelial growth factor and the erythropoietin genes
    • Shibata T, Akiyama N, Noda M, Sasai K, Hiraoka M. Enhancement of gene expression under hypoxic conditions using fragments of the human vascular endothelial growth factor and the erythropoietin genes. Int J Radiat Oncol Biol Phys 1998; 42:913-6.
    • (1998) Int J Radiat Oncol Biol Phys , vol.42 , pp. 913-916
    • Shibata, T.1    Akiyama, N.2    Noda, M.3    Sasai, K.4    Hiraoka, M.5
  • 19
    • 0033222349 scopus 로고    scopus 로고
    • Killing of brain tumor cells by hypoxia-responsive element mediated expression of BAX
    • Ruan H, Wang J, Hu L, Lin CS, Lamborn KR, Deen DF. Killing of brain tumor cells by hypoxia-responsive element mediated expression of BAX. Neoplasia 1999; 1:431-7.
    • (1999) Neoplasia , vol.1 , pp. 431-437
    • Ruan, H.1    Wang, J.2    Hu, L.3    Lin, C.S.4    Lamborn, K.R.5    Deen, D.F.6
  • 20
    • 0028359320 scopus 로고
    • Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: Similarities with the erythropoietin 3′ enhancer
    • USA
    • Firth JD, Ebert BL, Pugh CW, Ratcliffe PJ. Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: Similarities with the erythropoietin 3′ enhancer. Proc Natl Acad Sci USA 1994; 91:6496-500.
    • (1994) Proc Natl Acad Sci , vol.91 , pp. 6496-6500
    • Firth, J.D.1    Ebert, B.L.2    Pugh, C.W.3    Ratcliffe, P.J.4
  • 21
    • 0032866070 scopus 로고    scopus 로고
    • An adenoviral vector regulated by hypoxia for the treatment of ischaemic disease and cancer
    • Binley K, Iqball S, Kingsman A, Kingsman S, Naylor S. An adenoviral vector regulated by hypoxia for the treatment of ischaemic disease and cancer. Gene Ther 1999; 6:1721-7.
    • (1999) Gene Ther , vol.6 , pp. 1721-1727
    • Binley, K.1    Iqball, S.2    Kingsman, A.3    Kingsman, S.4    Naylor, S.5
  • 23
    • 0028843411 scopus 로고
    • Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents
    • Gleadle JM, Ebert BL, Firth JD, Ratcliffe PJ. Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents. Am J Physiol 1995; 268:C1362-8.
    • (1995) Am J Physiol , vol.268
    • Gleadle, J.M.1    Ebert, B.L.2    Firth, J.D.3    Ratcliffe, P.J.4
  • 25
    • 0034017489 scopus 로고    scopus 로고
    • Development of a hypoxia-responsive vector for tumor-specific gene therapy
    • Shibata T, Giaccia AJ, Brown JM. Development of a hypoxia-responsive vector for tumor-specific gene therapy. Gene Ther 2000; 7:493-8.
    • (2000) Gene Ther , vol.7 , pp. 493-498
    • Shibata, T.1    Giaccia, A.J.2    Brown, J.M.3
  • 26
    • 0031742542 scopus 로고    scopus 로고
    • Enhancement of gene expression under hypoxic conditions using fragments of the human vascular endothelial growth factor and the erythropoietin genes
    • Shibata T, Akiyama N, Noda M, Sasai K, Hiraoka M. Enhancement of gene expression under hypoxic conditions using fragments of the human vascular endothelial growth factor and the erythropoietin genes. Int J Radiat Oncol Biol Phys 1998; 42:913-6.
    • (1998) Int J Radiat Oncol Biol Phys , vol.42 , pp. 913-916
    • Shibata, T.1    Akiyama, N.2    Noda, M.3    Sasai, K.4    Hiraoka, M.5
  • 27
    • 0036145795 scopus 로고    scopus 로고
    • Hypoxia-inducible regulation of a prodrug-activating enzyme for tumor-specific gene therapy
    • Shibata T, Giaccia AJ, Brown JM. Hypoxia-inducible regulation of a prodrug-activating enzyme for tumor-specific gene therapy. Neoplasia 2002; 4:40-8.
    • (2002) Neoplasia , vol.4 , pp. 40-48
    • Shibata, T.1    Giaccia, A.J.2    Brown, J.M.3
  • 28
    • 0030460724 scopus 로고    scopus 로고
    • Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
    • Semenza GL, Jiang BH, Leung SW, Passantino R, Concordet JP, Maire P, Giallongo A. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J Biol Chem 1996; 271:32529-37.
    • (1996) J Biol Chem , vol.271 , pp. 32529-32537
    • Semenza, G.L.1    Jiang, B.H.2    Leung, S.W.3    Passantino, R.4    Concordet, J.P.5    Maire, P.6    Giallongo, A.7
  • 29
    • 0032741858 scopus 로고    scopus 로고
    • Identification of an oxygen responsive enhancer element in the glyceraldehyde-3-phosphate dehydrogenase gene
    • Graven KK, Yu Q, Pan D, Roncarati JS, Farber HW. Identification of an oxygen responsive enhancer element in the glyceraldehyde-3-phosphate dehydrogenase gene. Biochim Biophys Acta 1999; 1447:208-18.
    • (1999) Biochim Biophys Acta , vol.1447 , pp. 208-218
    • Graven, K.K.1    Yu, Q.2    Pan, D.3    Roncarati, J.S.4    Farber, H.W.5
  • 30
    • 0034880629 scopus 로고    scopus 로고
    • A hypoxia-regulated adeno-associated virus vector for cancer-specific gene therapy
    • Ruan H, Su H, Hu L, Lamborn KR, Kan YW, Deen DF. A hypoxia-regulated adeno-associated virus vector for cancer-specific gene therapy. Neoplasia 2001; 3:255-63.
    • (2001) Neoplasia , vol.3 , pp. 255-263
    • Ruan, H.1    Su, H.2    Hu, L.3    Lamborn, K.R.4    Kan, Y.W.5    Deen, D.F.6
  • 33
    • 0034213449 scopus 로고    scopus 로고
    • Therapeutic efficacy of the suicide gene driven by the promoter of vascular endothelial growth factor gene against hypoxic tumor cells
    • Koshikawa N, Takenaga K, Tagawa M, Sakiyama S. Therapeutic efficacy of the suicide gene driven by the promoter of vascular endothelial growth factor gene against hypoxic tumor cells. Cancer Res 2000; 60:2936-41.
    • (2000) Cancer Res , vol.60 , pp. 2936-2941
    • Koshikawa, N.1    Takenaga, K.2    Tagawa, M.3    Sakiyama, S.4
  • 35
    • 0002182753 scopus 로고    scopus 로고
    • Hypoxia-inducible expression of BAX: Application in tumour-targeted gene therapy
    • Ruan H, Hu L, Wang J, Ozawa T. Hypoxia-inducible expression of BAX: Application in tumour-targeted gene therapy Neurosurg. Focus 2000; 8(4).
    • (2000) Neurosurg. Focus , vol.8 , Issue.4
    • Ruan, H.1    Hu, L.2    Wang, J.3    Ozawa, T.4
  • 36
    • 0035008659 scopus 로고    scopus 로고
    • Evaluation of a new dual-specificity promoter for selective induction of apoptosis in breast cancer cells
    • Hernandez-Alcoceba R, Pihalja M, Nunez G, Clarke MF. Evaluation of a new dual-specificity promoter for selective induction of apoptosis in breast cancer cells. Cancer Gene Ther 2001; 8:298-307.
    • (2001) Cancer Gene Ther , vol.8 , pp. 298-307
    • Hernandez-Alcoceba, R.1    Pihalja, M.2    Nunez, G.3    Clarke, M.F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.