-
1
-
-
0030595339
-
The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
-
LEMAITRE B, NICOLAS E, MICHAUT L, REICHHART JM, HOFFMANN JA: The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell (1996) 86:973-983.
-
(1996)
Cell
, vol.86
, pp. 973-983
-
-
Lemaitre, B.1
Nicolas, E.2
Michaut, L.3
Reichhart, J.M.4
Hoffmann, J.A.5
-
4
-
-
1542377424
-
A toll-like receptor that prevents infection by uropathogenic bacteria
-
ZHANG D, ZHANG G, HAYDEN MS et al.: A toll-like receptor that prevents infection by uropathogenic bacteria. Science (2004) 303:1522-1526.
-
(2004)
Science
, vol.303
, pp. 1522-1526
-
-
Zhang, D.1
Zhang, G.2
Hayden, M.S.3
-
5
-
-
20644450101
-
Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP 105
-
DIVANOVIC S, TROMPETTE A, ATABANI SF et al.: Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP 105. Nat. Immunol. (2005) 6:571-578.
-
(2005)
Nat. Immunol.
, vol.6
, pp. 571-578
-
-
Divanovic, S.1
Trompette, A.2
Atabani, S.F.3
-
6
-
-
0034886143
-
Toll-like receptors: Critical proteins linking innate and acquired immunity
-
AKIRA S, TAKEDA K, KAISHO T: Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol. (2001) 2:675-680.
-
(2001)
Nat. Immunol.
, vol.2
, pp. 675-680
-
-
Akira, S.1
Takeda, K.2
Kaisho, T.3
-
7
-
-
0142031430
-
Role of Toll-like receptors in pathogen recognition
-
JANSSENS S, BEYAERT R: Role of Toll-like receptors in pathogen recognition. Clin. Microbiol. Rev. (2003) 16:637-646.
-
(2003)
Clin. Microbiol. Rev.
, vol.16
, pp. 637-646
-
-
Janssens, S.1
Beyaert, R.2
-
8
-
-
0036318851
-
Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments
-
AHMAD-NEJAD P, HACKER H, RUTZ M et al.: Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur. J. Immunol. (2002) 32:1958-1968.
-
(2002)
Eur. J. Immunol.
, vol.32
, pp. 1958-1968
-
-
Ahmad-Nejad, P.1
Hacker, H.2
Rutz, M.3
-
9
-
-
1542317578
-
Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
-
HEIL F, HEMMI H, HOCHREIN H et al.: Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science (2004) 303:1526-1529.
-
(2004)
Science
, vol.303
, pp. 1526-1529
-
-
Heil, F.1
Hemmi, H.2
Hochrein, H.3
-
10
-
-
32944464648
-
Pathogen recognition and innate immunity
-
AKIRA S, UEMATSU S, TAKEUCHI O: Pathogen recognition and innate immunity. Cell (2006) 124:783-801.
-
(2006)
Cell
, vol.124
, pp. 783-801
-
-
Akira, S.1
Uematsu, S.2
Takeuchi, O.3
-
11
-
-
0035953543
-
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
-
HAYASHI F, SMITH KD, OZINSKY A et al.: The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature (2001) 410:1099-1103.
-
(2001)
Nature
, vol.410
, pp. 1099-1103
-
-
Hayashi, F.1
Smith, K.D.2
Ozinsky, A.3
-
12
-
-
0030831210
-
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
-
MEDZHITOV R, PRESTON-HURLBURT P, JANEWAY CA Jr: A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature (1997) 388:394-397.
-
(1997)
Nature
, vol.388
, pp. 394-397
-
-
Medzhitov, R.1
Preston-Hurlburt, P.2
Janeway Jr., C.A.3
-
13
-
-
0034619794
-
A Toll-like receptor recognizes bacterial DNA
-
HEMMI H, TAKEUCHI O, KAWAI T et al.: A Toll-like receptor recognizes bacterial DNA. Nature (2000) 408:740-745.
-
(2000)
Nature
, vol.408
, pp. 740-745
-
-
Hemmi, H.1
Takeuchi, O.2
Kawai, T.3
-
14
-
-
0037232254
-
Toll-like receptors and their function in innate and adaptive immunity
-
HEINE H, LIEN E: Toll-like receptors and their function in innate and adaptive immunity. Int. Arch. Allergy Immunol. (2003) 130:180-192.
-
(2003)
Int. Arch. Allergy Immunol.
, vol.130
, pp. 180-192
-
-
Heine, H.1
Lien, E.2
-
15
-
-
0036839577
-
Endogenous ligands of Toll-like receptors: Implications for regulating inflammatory and immune responses
-
BEG AA: Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses. Trends Immunol. (2002) 23:509-512.
-
(2002)
Trends Immunol.
, vol.23
, pp. 509-512
-
-
Beg, A.A.1
-
16
-
-
0035451118
-
Fibrinogen stimulates macrophage chemokine secretion through Toll-like receptor 4
-
SMILEY ST, KING JA, HANCOCK WW: Fibrinogen stimulates macrophage chemokine secretion through Toll-like receptor 4. J. Immunol. (2001) 167:2887-2894.
-
(2001)
J. Immunol.
, vol.167
, pp. 2887-2894
-
-
Smiley, S.T.1
King, J.A.2
Hancock, W.W.3
-
17
-
-
0036499004
-
Heat-shock proteins as activators of the innate immune system
-
WALLIN RP, LUNDQVIST A, MORE SH et al.: Heat-shock proteins as activators of the innate immune system. Trends Immunol. (2002) 23:130-135.
-
(2002)
Trends Immunol.
, vol.23
, pp. 130-135
-
-
Wallin, R.P.1
Lundqvist, A.2
More, S.H.3
-
18
-
-
0035895913
-
Role of TLR-2 in the activation of nuclear factor κB by oxidative stress in cardiac myocytes
-
FRANTZ S, KELLY RA, BOURCIER T: Role of TLR-2 in the activation of nuclear factor κB by oxidative stress in cardiac myocytes. J. Biol. Chem. (2001) 276:5197-5203.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 5197-5203
-
-
Frantz, S.1
Kelly, R.A.2
Bourcier, T.3
-
19
-
-
0037213692
-
Evolutionary clues to the functions of the Toll-like family as surveillance receptors
-
JOHNSON GB, BRUNN GJ, TANG AH, PLATT JL: Evolutionary clues to the functions of the Toll-like family as surveillance receptors. Trends Immunol. (2003) 24:19-24.
-
(2003)
Trends Immunol.
, vol.24
, pp. 19-24
-
-
Johnson, G.B.1
Brunn, G.J.2
Tang, A.H.3
Platt, J.L.4
-
20
-
-
0034757203
-
IC14, a CD14 specific monoclonal antibody, is a potential treatment for patients with severe sepsis
-
AXTELLE T, PRIBBLE J: IC14, a CD14 specific monoclonal antibody, is a potential treatment for patients with severe sepsis. J. Endotoxin. Res. (2001) 7:310-314.
-
(2001)
J. Endotoxin. Res.
, vol.7
, pp. 310-314
-
-
Axtelle, T.1
Pribble, J.2
-
21
-
-
20444366947
-
Adaptor usage and Toll-like receptor signaling specificity
-
DUNNE A, O'NEILL LA: Adaptor usage and Toll-like receptor signaling specificity. FEBS Lett. (2005) 579:3330-3335.
-
(2005)
FEBS Lett.
, vol.579
, pp. 3330-3335
-
-
Dunne, A.1
O'neill, L.A.2
-
22
-
-
3142724031
-
Toll-like receptor signalling
-
AKIRA S, TAKEDA K: Toll-like receptor signalling. Nat. Rev. Immunol. (2004) 4:499-511.
-
(2004)
Nat. Rev. Immunol.
, vol.4
, pp. 499-511
-
-
Akira, S.1
Takeda, K.2
-
23
-
-
0043176281
-
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
-
YAMAMOTO M, SATO S, HEMMI H et al.: Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science (2003) 301:640-643.
-
(2003)
Science
, vol.301
, pp. 640-643
-
-
Yamamoto, M.1
Sato, S.2
Hemmi, H.3
-
24
-
-
0242624622
-
TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway
-
YAMAMOTO M, SATO S, HEMMI H et al.: TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway. Nat. Immunol. (2003) 4:1144-1150.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 1144-1150
-
-
Yamamoto, M.1
Sato, S.2
Hemmi, H.3
-
25
-
-
0042591216
-
TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling
-
BIN LH, XU LG, SHU HB: TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. J. Biol. Chem. (2003) 278:24526-24532.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 24526-24532
-
-
Bin, L.H.1
Xu, L.G.2
Shu, H.B.3
-
26
-
-
5444254408
-
Toll-like receptors in the pathogenesis of human disease
-
COOK DN, PISETSKY DS, SCHWARTZ DA: Toll-like receptors in the pathogenesis of human disease. Nat. Immunol. (2004) 5:975-979.
-
(2004)
Nat. Immunol.
, vol.5
, pp. 975-979
-
-
Cook, D.N.1
Pisetsky, D.S.2
Schwartz, D.A.3
-
27
-
-
5444262511
-
Toll-like receptor control of the adaptive immune responses
-
IWASAKI A, MEDZHITOV R: Toll-like receptor control of the adaptive immune responses. Nat. Immunol. (2004) 5:987-995.
-
(2004)
Nat. Immunol.
, vol.5
, pp. 987-995
-
-
Iwasaki, A.1
Medzhitov, R.2
-
28
-
-
0035524488
-
Toll-like receptors and innate immunity
-
MEDZHITOV R: Toll-like receptors and innate immunity. Nat. Rev. Immunol. (2001) 1:135-145.
-
(2001)
Nat. Rev. Immunol.
, vol.1
, pp. 135-145
-
-
Medzhitov, R.1
-
29
-
-
23944489407
-
Selected Toll-like receptor agonist combinations synergistically trigger a T helper Type 1-polarizing program in dendritic cells
-
NAPOLITANI G, RINALDI A, BERTONI F, SALLUSTO F, LANZAVECCHIA A: Selected Toll-like receptor agonist combinations synergistically trigger a T helper Type 1-polarizing program in dendritic cells. Nat. Immunol. (2005) 6:769-776.
-
(2005)
Nat. Immunol.
, vol.6
, pp. 769-776
-
-
Napolitani, G.1
Rinaldi, A.2
Bertoni, F.3
Sallusto, F.4
Lanzavecchia, A.5
-
30
-
-
0035371187
-
In vivo expression of proinflammatory mediators in the adult heart after endotoxin administration: The role of toll-like receptor-4
-
BAUMGARTEN G, KNUEFERMANN P, NOZAKI N et al.: In vivo expression of proinflammatory mediators in the adult heart after endotoxin administration: the role of toll-like receptor-4. J. Infect. Dis. (2001) 183:1617-1624.
-
(2001)
J. Infect. Dis.
, vol.183
, pp. 1617-1624
-
-
Baumgarten, G.1
Knuefermann, P.2
Nozaki, N.3
-
32
-
-
1642463859
-
Inflammatory mediators in chronic heart failure: An overview
-
ANKER SD, VON HAEHLING S: Inflammatory mediators in chronic heart failure: an overview. Heart (2004) 90:464-470.
-
(2004)
Heart
, vol.90
, pp. 464-470
-
-
Anker, S.D.1
Von Haehling, S.2
-
33
-
-
0346055157
-
The role of innate immune responses in the heart in health and disease
-
KNUEFERMANN P, VALLEJO J, MANN DL: The role of innate immune responses in the heart in health and disease. Trends Cardiovasc. Med. (2004) 14:1-7.
-
(2004)
Trends Cardiovasc. Med.
, vol.14
, pp. 1-7
-
-
Knuefermann, P.1
Vallejo, J.2
Mann, D.L.3
-
34
-
-
0035164253
-
Regulation of Toll-like receptors in human monocytes and dendritic cells
-
VISINTIN A, MAZZONI A, SPITZER JH et al.: Regulation of Toll-like receptors in human monocytes and dendritic cells. J. Immunol. (2001) 166:249-255.
-
(2001)
J. Immunol.
, vol.166
, pp. 249-255
-
-
Visintin, A.1
Mazzoni, A.2
Spitzer, J.H.3
-
35
-
-
0037080024
-
Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines
-
ZAREMBER KA, GODOWSKI PJ: Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J. Immunol. (2002) 168:554-561.
-
(2002)
J. Immunol.
, vol.168
, pp. 554-561
-
-
Zarember, K.A.1
Godowski, P.J.2
-
36
-
-
0034601057
-
The apoptotic signaling pathway activated by Toll-like receptor-2
-
ALIPRANTIS AO, YANG RB, WEISS DS, GODOWSKI P, ZYCHLINSKY A: The apoptotic signaling pathway activated by Toll-like receptor-2. EMBO J. (2000) 19:3325-3336.
-
(2000)
EMBO J.
, vol.19
, pp. 3325-3336
-
-
Aliprantis, A.O.1
Yang, R.B.2
Weiss, D.S.3
Godowski, P.4
Zychlinsky, A.5
-
37
-
-
0345599171
-
Toll-like receptor-2 modulates ventricular remodeling after myocardial infarction
-
SHISHIDO T, NOZAKI N, YAMAGUCHI S et al.: Toll-like receptor-2 modulates ventricular remodeling after myocardial infarction. Circulation (2003) 108:2905-2910.
-
(2003)
Circulation
, vol.108
, pp. 2905-2910
-
-
Shishido, T.1
Nozaki, N.2
Yamaguchi, S.3
-
38
-
-
8144229686
-
Modulation of doxorubicin-induced cardiac dysfunction in toll-like receptor-2-knockout mice
-
NOZAKI N, SHISHIDO T, TAKEISHI Y, KUBOTA I: Modulation of doxorubicin-induced cardiac dysfunction in toll-like receptor-2-knockout mice. Circulation (2004) 110:2869-2874.
-
(2004)
Circulation
, vol.110
, pp. 2869-2874
-
-
Nozaki, N.1
Shishido, T.2
Takeishi, Y.3
Kubota, I.4
-
39
-
-
0033574415
-
Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction
-
CHOW JC, YOUNG DW, GOLENBOCK DT, CHRIST WJ, GUSOVSKY F: Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J. Biol. Chem. (1999) 274:10689-10692.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 10689-10692
-
-
Chow, J.C.1
Young, D.W.2
Golenbock, D.T.3
Christ, W.J.4
Gusovsky, F.5
-
40
-
-
0033120081
-
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
-
HOSHINO K, TAKEUCHI O, KAWAI T et al.: Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. (1999) 162:3749-3752.
-
(1999)
J. Immunol.
, vol.162
, pp. 3749-3752
-
-
Hoshino, K.1
Takeuchi, O.2
Kawai, T.3
-
41
-
-
0036086439
-
Escherichia coli LPS-induced IV dysfunction: Role of toll-like receptor-4 in the adult heart
-
NEMOTO S, VALLEJO JG, KNUEFERMANN P et al.: Escherichia coli LPS-induced IV dysfunction: role of toll-like receptor-4 in the adult heart. Am. J. Physiol. Heart Circ. Physiol. (2002) 282:H2316-H2323.
-
(2002)
Am. J. Physiol. Heart Circ. Physiol.
, vol.282
-
-
Nemoto, S.1
Vallejo, J.G.2
Knuefermann, P.3
-
42
-
-
0034084438
-
TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
-
ARBOUR NC, LORENZ E, SCHUTTE BC et al.: TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat. Genet. (2000) 25:187-191.
-
(2000)
Nat. Genet.
, vol.25
, pp. 187-191
-
-
Arbour, N.C.1
Lorenz, E.2
Schutte, B.C.3
-
43
-
-
2342457148
-
Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms
-
SALEH M, VAILLANCOURT JP, GRAHAM RK et al.: Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature (2004) 429:75-79.
-
(2004)
Nature
, vol.429
, pp. 75-79
-
-
Saleh, M.1
Vaillancourt, J.P.2
Graham, R.K.3
-
44
-
-
15544369643
-
Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease
-
SCHRODER NW, SCHUMANN RR: Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious disease. Lancet Infect. Dis. (2005) 5:156-164.
-
(2005)
Lancet Infect. Dis.
, vol.5
, pp. 156-164
-
-
Schroder, N.W.1
Schumann, R.R.2
-
45
-
-
27744459867
-
Polymorphisms of the Toll-like receptors and human disease
-
SCHWARTZ DA, COOK DN: Polymorphisms of the Toll-like receptors and human disease. Clin. Infect. Dis. (2005) 41(Suppl. 7):S403-S407.
-
(2005)
Clin. Infect. Dis.
, vol.41
, Issue.SUPPL. 7
-
-
Schwartz, D.A.1
Cook, D.N.2
-
46
-
-
0037130195
-
Toll-like receptor 4 polymorphisms and atherogenesis
-
KIECHL S, LORENZ E, REINDL M et al.: Toll-like receptor 4 polymorphisms and atherogenesis. N. Engl. J. Med. (2002) 347:185-192.
-
(2002)
N. Engl. J. Med.
, vol.347
, pp. 185-192
-
-
Kiechl, S.1
Lorenz, E.2
Reindl, M.3
-
47
-
-
0037334224
-
Effectiveness and costs of interventions to lower systolic blood pressure and cholesterol: A global and regional analysis on reduction of cardiovascular-disease risk
-
MURRAY CJ, LAUER JA, HUTUBESSY RC et al.: Effectiveness and costs of interventions to lower systolic blood pressure and cholesterol: a global and regional analysis on reduction of cardiovascular-disease risk. Lancet (2003) 361:717-725.
-
(2003)
Lancet
, vol.361
, pp. 717-725
-
-
Murray, C.J.1
Lauer, J.A.2
Hutubessy, R.C.3
-
48
-
-
0037180771
-
Inflammation in atherosclerosis
-
LIBBY P: Inflammation in atherosclerosis. Nature (2002) 420:868-874.
-
(2002)
Nature
, vol.420
, pp. 868-874
-
-
Libby, P.1
-
49
-
-
3242728901
-
Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways
-
BJORKBACKA H, KUNJATHOOR VV, MOORE KJ et al.: Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Nat. Med. (2004) 10:416-421.
-
(2004)
Nat. Med.
, vol.510
, pp. 416-421
-
-
Bjorkbacka, H.1
Kunjathoor, V.V.2
Moore, K.J.3
-
50
-
-
0036461415
-
Evidence for infectious agents in cardiovascular disease and atherosclerosis
-
LEINONEN M, SAIKKU P: Evidence for infectious agents in cardiovascular disease and atherosclerosis. Lancet Infect. Dis. (2002) 2:11-17.
-
(2002)
Lancet Infect. Dis.
, vol.2
, pp. 11-17
-
-
Leinonen, M.1
Saikku, P.2
-
51
-
-
4143101842
-
Toll-like receptor 4 functions intracellularly in human coronary artery endothelial cells: Roles of LBP and sCD14 in mediating LPS responses
-
DUNZENDORFER S, LEE HK, SOLDAU K, TOBIAS PS: Toll-like receptor 4 functions intracellularly in human coronary artery endothelial cells: roles of LBP and sCD14 in mediating LPS responses. FASEB J. (2004) 18:1117-1119.
-
(2004)
FASEB J.
, vol.18
, pp. 1117-1119
-
-
Dunzendorfer, S.1
Lee, H.K.2
Soldau, K.3
Tobias, P.S.4
-
52
-
-
1342278730
-
Association of the Toll-like receptor 4 gene Asp299Gly polymorphism with acute coronary events
-
AMEZIANE N, BEILLAT T, VERPILLAT P et al.: Association of the Toll-like receptor 4 gene Asp299Gly polymorphism with acute coronary events. Arterioscler. Thromb. Vasc. Biol. (2003) 23:e61-e64.
-
(2003)
Arterioscler. Thromb. Vasc. Biol.
, vol.23
-
-
Ameziane, N.1
Beillat, T.2
Verpillat, P.3
-
53
-
-
0038179661
-
Variants of toll-like receptor 4 modify the efficacy of statin therapy and the risk of cardiovascular events
-
BOEKHOLDT SM, AGEMA WR, PETERS RJ et al.: Variants of toll-like receptor 4 modify the efficacy of statin therapy and the risk of cardiovascular events. Circulation (2003) 107:2416-2421.
-
(2003)
Circulation
, vol.107
, pp. 2416-2421
-
-
Boekholdt, S.M.1
Agema, W.R.2
Peters, R.J.3
-
54
-
-
23044510864
-
Toll-like receptor 4 gene C119A but not Asp299Gly polymorphism is associated with ischemic stroke among ethnic Chinese in Taiwan
-
LIN YC, CHANG YM, YU JM et al.: Toll-like receptor 4 gene C119A but not Asp299Gly polymorphism is associated with ischemic stroke among ethnic Chinese in Taiwan. Atherosclerosis (2005) 180:305-309.
-
(2005)
Atherosclerosis
, vol.18
, pp. 305-309
-
-
Lin, Y.C.1
Chang, Y.M.2
Yu, J.M.3
-
55
-
-
0035910010
-
Toll-like receptor-4 is expressed by macrophages in routine and human lipid-rich atherosclerosic plaques and upregulated by oxidized LDL
-
XU XH, SHAH PK, FAURE E et al.: Toll-like receptor-4 is expressed by macrophages in routine and human lipid-rich atherosclerosic plaques and upregulated by oxidized LDL. Circulation (2001) 104:3103-3108.
-
(2001)
Circulation
, vol.104
, pp. 3103-3108
-
-
Xu, X.H.1
Shah, P.K.2
Faure, E.3
-
56
-
-
0037044401
-
In vivo evidence for a role of toll-like receptor 4 in the development of intimal lesions
-
VINK A, SCHONEVELD AH, VAN DER MEER JJ et al.: In vivo evidence for a role of toll-like receptor 4 in the development of intimal lesions. Circulation (2002) 106:1985-1990.
-
(2002)
Circulation
, vol.106
, pp. 1985-1990
-
-
Vink, A.1
Schoneveld, A.H.2
Van Der Meer, J.J.3
-
57
-
-
24944513945
-
Atherothrombosis and high-risk plaque: Part I: Evolving concepts
-
FUSTER V, MORENO PR, FAYAD ZA, CORTI R, BADIMON JJ: Atherothrombosis and high-risk plaque: part I: evolving concepts. J. Am. Coll. Cardiol. (2005) 46:937-954.
-
(2005)
J. Am. Coll. Cardiol.
, vol.46
, pp. 937-954
-
-
Fuster, V.1
Moreno, P.R.2
Fayad, Z.A.3
Corti, R.4
Badimon, J.J.5
-
58
-
-
9144224212
-
Toll-like receptor 4 is involved in outward arterial remodeling
-
HOLLESTELLE SC, DE VRIES MR, VAN KEULEN JK et al.: Toll-like receptor 4 is involved in outward arterial remodeling. Circulation (2004) 109:393-398.
-
(2004)
Circulation
, vol.109
, pp. 393-398
-
-
Hollestelle, S.C.1
De Vries, M.R.2
Van Keulen, J.K.3
-
59
-
-
19644390754
-
Expansion of circulating Toll-like receptor 4-positive monocytes in patients with acute coronary syndrome
-
METHE H, KIM JO, KOFLER S et al.: Expansion of circulating Toll-like receptor 4-positive monocytes in patients with acute coronary syndrome. Circulation (2005) 111:2654-2661.
-
(2005)
Circulation
, vol.111
, pp. 2654-2661
-
-
Methe, H.1
Kim, J.O.2
Kofler, S.3
-
60
-
-
33646116570
-
Activated toll-like receptor 4 in monocytes is associated with heart failure after acute myocardial infarction
-
SATOH M, SHIMODA Y, MAESAWA C et al.: Activated toll-like receptor 4 in monocytes is associated with heart failure after acute myocardial infarction. Int. J. Cardiol. (2006) 109(2):226-234.
-
(2006)
Int. J. Cardiol.
, vol.109
, Issue.2
, pp. 226-234
-
-
Satoh, M.1
Shimoda, Y.2
Maesawa, C.3
-
61
-
-
0037066041
-
Expression of toll-like receptors in human atherosclerotic lesions: A possible pathway for plaque activation
-
EDFELDT K, SWEDENBORG J, HANSSON GK, YAN ZQ: Expression of toll-like receptors in human atherosclerotic lesions: a possible pathway for plaque activation. Circulation (2002) 105:1158-1161.
-
(2002)
Circulation
, vol.105
, pp. 1158-1161
-
-
Edfeldt, K.1
Swedenborg, J.2
Hansson, G.K.3
Yan, Z.Q.4
-
62
-
-
27644568878
-
Modulation of atherosclerosis in mice by Toll-like receptor 2
-
MULLICK AE, TOBIAS PS, CURTISS LK: Modulation of atherosclerosis in mice by Toll-like receptor 2. J. Clin. Invest (2005) 115:3149-3156.
-
(2005)
J. Clin. Invest
, vol.115
, pp. 3149-3156
-
-
Mullick, A.E.1
Tobias, P.S.2
Curtiss, L.K.3
-
63
-
-
0035928838
-
Immunopathogenesis of atherosclerosis: Endotoxin accelerates atherosclerosis in rabbits on hypercholesterolemic diet
-
LEHR HA, SAGBAN TA, IHLING C et al.: Immunopathogenesis of atherosclerosis: endotoxin accelerates atherosclerosis in rabbits on hypercholesterolemic diet. Circulation (2001) 104:914-920.
-
(2001)
Circulation
, vol.104
, pp. 914-920
-
-
Lehr, H.A.1
Sagban, T.A.2
Ihling, C.3
-
64
-
-
0037396875
-
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
-
LEVY MM, FINK MP, MARSHALL JC et al.: 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med. (2003) 29:530-538.
-
(2003)
Intensive Care Med.
, vol.29
, pp. 530-538
-
-
Levy, M.M.1
Fink, M.P.2
Marshall, J.C.3
-
65
-
-
0018419540
-
Mechanisms of cardiodepression in endotoxin shock
-
LEFER AM: Mechanisms of cardiodepression in endotoxin shock. Circ. Shock Suppl. (1979) 1:1-8.
-
(1979)
Circ. Shock Suppl.
, vol.1
, pp. 1-8
-
-
Lefer, A.M.1
-
66
-
-
0023934409
-
Depressed left ventricular performance. Response to volume infusion in patients with sepsis and septic shock
-
OGNIBENE FP, PARKER MM, NATANSON C, SHELHAMER JH, PARRILLO JE: Depressed left ventricular performance. Response to volume infusion in patients with sepsis and septic shock. Chest (1988) 93:903-910.
-
(1988)
Chest
, vol.93
, pp. 903-910
-
-
Ognibene, F.P.1
Parker, M.M.2
Natanson, C.3
Shelhamer, J.H.4
Parrillo, J.E.5
-
67
-
-
0035800883
-
Chlamydia pneumoniae and chlamydial heat shock protein 60 stimulate proliferation of human vascular smooth muscle cells via toll-like receptor 4 and p44/p42 mitogen-activated protein kinase activation
-
SASU S, LAVERDA D, QURESHI N, GOLENBOCK DT, BEASLEY D: Chlamydia pneumoniae and chlamydial heat shock protein 60 stimulate proliferation of human vascular smooth muscle cells via toll-like receptor 4 and p44/ p42 mitogen-activated protein kinase activation. Circ. Res. (2001) 89:244-250.
-
(2001)
Circ. Res.
, vol.89
, pp. 244-250
-
-
Sasu, S.1
Laverda, D.2
Qureshi, N.3
Golenbock, D.T.4
Beasley, D.5
-
68
-
-
2442695034
-
Drug intervention trials in sepsis: Divergent results
-
POLDERMAN KH, GIRBES AR: Drug intervention trials in sepsis: divergent results. Lancet (2004) 363:1721-1723.
-
(2004)
Lancet
, vol.363
, pp. 1721-1723
-
-
Polderman, K.H.1
Girbes, A.R.2
-
69
-
-
0034902654
-
Vascular cell adhesion molecule-1 expression is obligatory for endotoxin-induced myocardial neutrophil accumulation and contractile dysfunction
-
RAEBURN CD, CALKINS CM, ZIMMERMAN MA et al.: Vascular cell adhesion molecule-1 expression is obligatory for endotoxin-induced myocardial neutrophil accumulation and contractile dysfunction. Surgery (2001) 130:319-325.
-
(2001)
Surgery
, vol.130
, pp. 319-325
-
-
Raeburn, C.D.1
Calkins, C.M.2
Zimmerman, M.A.3
-
70
-
-
0028490597
-
Contractile dysfunction of ventricular myocytes isolated from endotoxemic guinea pigs
-
RUBIN LJ, KELLER RS, PARKER JL, ADAMS HR: Contractile dysfunction of ventricular myocytes isolated from endotoxemic guinea pigs. Shock (1994) 2:113-120.
-
(1994)
Shock
, vol.2
, pp. 113-120
-
-
Rubin, L.J.1
Keller, R.S.2
Parker, J.L.3
Adams, H.R.4
-
71
-
-
0036451206
-
TLR4 as the mammalian endotoxin sensor
-
BEUTLER B: TLR4 as the mammalian endotoxin sensor. Curr. Top. Microbiol. Immunol. (2002) 270:109-120.
-
(2002)
Curr. Top. Microbiol. Immunol.
, vol.270
, pp. 109-120
-
-
Beutler, B.1
-
72
-
-
0038466165
-
High frequency of polymorphism Arg753Gln of the Toll-like receptor-2 gene detected by a novel allele-specific PCR
-
SCHRODER NW, HERMANN C, HAMANN L et al.: High frequency of polymorphism Arg753Gln of the Toll-like receptor-2 gene detected by a novel allele-specific PCR. J. Mol. Med. (2003) 81:368-372.
-
(2003)
J. Mol. Med.
, vol.81
, pp. 368-372
-
-
Schroder, N.W.1
Hermann, C.2
Hamann, L.3
-
73
-
-
0037777811
-
Expression of Toll-like receptor 4 is associated with enteroviral replication in human myocarditis
-
SATOH M, NAKAMURA M, AKATSU T et al.: Expression of Toll-like receptor 4 is associated with enteroviral replication in human myocarditis. Clin. Sci. (Load.) (2003) 104:577-584.
-
(2003)
Clin. Sci. (Load.)
, vol.104
, pp. 577-584
-
-
Satoh, M.1
Nakamura, M.2
Akatsu, T.3
-
74
-
-
33644991938
-
MyD88 signaling controls autoimmune myocarditis induction
-
MARTY RR, DIRNHOFER S, MAUERMANN N et al.: MyD88 signaling controls autoimmune myocarditis induction. Circulation (2006) 113:258-265.
-
(2006)
Circulation
, vol.113
, pp. 258-265
-
-
Marty, R.R.1
Dirnhofer, S.2
Mauermann, N.3
-
75
-
-
22744457707
-
Human cardiac inflammatory responses triggered by Coxsackie B viruses are mainly Toll-like receptor (TLR) 8-dependent
-
TRIANTAFILOU K, ORTHOPOULOS G, VAKAKIS E et al.: Human cardiac inflammatory responses triggered by Coxsackie B viruses are mainly Toll-like receptor (TLR) 8-dependent. Cell Microbiol. (2005) 7:1117-1126.
-
(2005)
Cell Microbiol.
, vol.7
, pp. 1117-1126
-
-
Triantafilou, K.1
Orthopoulos, G.2
Vakakis, E.3
-
76
-
-
0034110023
-
Epidemiology, aetiology, and prognosis of heart failure
-
McMURRAY JJ, STEWART S: Epidemiology, aetiology, and prognosis of heart failure. Heart (2000) 83:596-602.
-
(2000)
Heart
, vol.83
, pp. 596-602
-
-
Mcmurray, J.J.1
Stewart, S.2
-
77
-
-
1642463859
-
Inflammatory mediators in chronic heart failure: An overview
-
ANKER SD, VON HAEHLING S: Inflammatory mediators in chronic heart failure: an overview. Heart (2004) 90:464-470.
-
(2004)
Heart
, vol.90
, pp. 464-470
-
-
Anker, S.D.1
Von Haehling, S.2
-
78
-
-
0032701642
-
Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium
-
FRANTZ S, KOBZIK L, KIM YD et al.: Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium. J. Clin. Invest. (1999) 104:271-280.
-
(1999)
J. Clin. Invest.
, vol.104
, pp. 271-280
-
-
Frantz, S.1
Kobzik, L.2
Kim, Y.D.3
-
79
-
-
0033614672
-
Endotoxin and immune activation in chronic heart failure: A prospective cohort study
-
NIEBAUER J, VOLK HD, KEMP M et al.: Endotoxin and immune activation in chronic heart failure: a prospective cohort study. Lancet (1999) 353:1838-1842.
-
(1999)
Lancet
, vol.353
, pp. 1838-1842
-
-
Niebauer, J.1
Volk, H.D.2
Kemp, M.3
-
80
-
-
0842285548
-
Increased toll-like receptor 4 in the myocardium of patients requiring left ventricular assist devices
-
BIRKS EJ, FELKIN LE, BANNER NR et al.: Increased toll-like receptor 4 in the myocardium of patients requiring left ventricular assist devices. J. Heart Lung Transplant. (2004) 23:228-235.
-
(2004)
J. Heart Lung Transplant.
, vol.23
, pp. 228-235
-
-
Birks, E.J.1
Felkin, L.E.2
Banner, N.R.3
-
81
-
-
0029871896
-
Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: A report from the Studies of Left Ventricular Dysfunction (SOLVD)
-
TORRE-AMIONE G, KAPADIA S, BENEDICT C et al.: Proinflammatory cytokine levels in patients with depressed left ventricular ejection fraction: a report from the Studies of Left Ventricular Dysfunction (SOLVD). J. Am. Coll. Cardiol. (1996) 27:1201-1206.
-
(1996)
J. Am. Coll. Cardiol.
, vol.27
, pp. 1201-1206
-
-
Torre-Amione, G.1
Kapadia, S.2
Benedict, C.3
-
82
-
-
0036954040
-
Antagonism of in vivo and ex vivo response to endotoxin by E5564, a synthetic lipid A analogue
-
ROSSIGNOL DP, LYNN M: Antagonism of in vivo and ex vivo response to endotoxin by E5564, a synthetic lipid A analogue. J. Endotoxin. Res. (2002) 8:483-488.
-
(2002)
J. Endotoxin. Res.
, vol.8
, pp. 483-488
-
-
Rossignol, D.P.1
Lynn, M.2
-
83
-
-
3142742677
-
Safety, pharmacokinetics, pharmacodynamics, and plasma lipoprotein distribution of eritoran (E5564) during continuous intravenous infusion into healthy volunteers
-
ROSSIGNOL DP, WASAN KM, CHOO E et al.: Safety, pharmacokinetics, pharmacodynamics, and plasma lipoprotein distribution of eritoran (E5564) during continuous intravenous infusion into healthy volunteers. Antimicrob. Agents Chemother. (2004) 48:3233-3240.
-
(2004)
Antimicrob. Agents Chemother.
, vol.48
, pp. 3233-3240
-
-
Rossignol, D.P.1
Wasan, K.M.2
Choo, E.3
-
84
-
-
0037442501
-
Blocking of responses to endotoxin by E5564 in healthy volunteers with experimental endotoxemia
-
LYNN M, ROSSIGNOL DP, WHEELER JL et al.: Blocking of responses to endotoxin by E5564 in healthy volunteers with experimental endotoxemia. J. Infect. Dis. (2003) 187:631-639.
-
(2003)
J. Infect. Dis.
, vol.187
, pp. 631-639
-
-
Lynn, M.1
Rossignol, D.P.2
Wheeler, J.L.3
-
85
-
-
9144257824
-
Extended in vivo pharmacodynamic activity of E5564 in normal volunteers with experimental endotoxemia
-
LYNN M, WONG YN, WHEELER JL et al.: Extended in vivo pharmacodynamic activity of E5564 in normal volunteers with experimental endotoxemia. J. Pharmacol. Exp. Ther. (2004) 308:175-181.
-
(2004)
J. Pharmacol. Exp. Ther.
, vol.308
, pp. 175-181
-
-
Lynn, M.1
Wong, Y.N.2
Wheeler, J.L.3
-
86
-
-
0042925330
-
Association of the endotoxin antagonist E5564 with high-density lipoproteins in vitro: Dependence on low-density and triglyceride-rich lipoprotein concentrations
-
WASAN KM, SIVAK O, COTE RA et al.: Association of the endotoxin antagonist E5564 with high-density lipoproteins in vitro: dependence on low-density and triglyceride-rich lipoprotein concentrations. Antimicrob. Agents Chemother. (2003) 47:2796-2803.
-
(2003)
Antimicrob. Agents Chemother.
, vol.47
, pp. 2796-2803
-
-
Wasan, K.M.1
Sivak, O.2
Cote, R.A.3
-
87
-
-
28544447821
-
Discovery of novel and potent small-molecule inhibitors of NO and cytokine production as antisepsis agents: Synthesis and biological activity of alkyl 6-(N-substituted sulfamoyl)cyclohex-1-ene-1-carboxylate
-
YAMADA M, ICHIKAWA T, II M et al.: Discovery of novel and potent small-molecule inhibitors of NO and cytokine production as antisepsis agents: synthesis and biological activity of alkyl 6-(N-substituted sulfamoyl)cyclohex-1-ene-1-carboxylate. J. Med. Chem. (2005) 48:7457-7467.
-
(2005)
J. Med. Chem.
, vol.48
, pp. 7457-7467
-
-
Yamada, M.1
Ichikawa II, T.M.2
-
88
-
-
20244369887
-
Synthetic toll-like receptor 4 agonists stimulate innate resistance to infectious challenge
-
CLUFF CW, BALDRIDGE JR, STOVER AG et al.: Synthetic toll-like receptor 4 agonists stimulate innate resistance to infectious challenge. Infect. Immun. (2005) 73:3044-3052.
-
(2005)
Infect. Immun.
, vol.73
, pp. 3044-3052
-
-
Cluff, C.W.1
Baldridge, J.R.2
Stover, A.G.3
-
89
-
-
18244364622
-
A novel class of endotoxin receptor agonists with simplified structure, toll-like receptor 4-dependent immunostimulatory action, and adjuvant activity
-
HAWKINS LD, ISHIZAKA ST, McGUINNESS P et al.: A novel class of endotoxin receptor agonists with simplified structure, toll-like receptor 4-dependent immunostimulatory action, and adjuvant activity. J. Pharmacol. Exp. Ther. (2002) 300:655-661.
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.300
, pp. 655-661
-
-
Hawkins, L.D.1
Ishizaka, S.T.2
Mcguinness, P.3
-
90
-
-
0035877718
-
Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2
-
DA SILVA CJ, SOLDAU K, CHRISTEN U, TOBIAS PS, ULEVITCH RJ: Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2. J. Biol. Chem. (2001) 276:21129-21135.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 21129-21135
-
-
Da Silva, C.J.1
Soldau, K.2
Christen, U.3
Tobias, P.S.4
Ulevitch, R.J.5
-
91
-
-
0032541661
-
Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
-
YANG RB, MARK MR, GRAY A et al.: Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature (1998) 395:284-288.
-
(1998)
Nature
, vol.395
, pp. 284-288
-
-
Yang, R.B.1
Mark, M.R.2
Gray, A.3
-
92
-
-
0035284868
-
IC14, an anti-CD14 antibody, inhibits endotoxin-mediated symptoms and inflammatory responses in humans
-
VERBON A, DEKKERS PE, TEN HOVE T et al.: IC14, an anti-CD14 antibody, inhibits endotoxin-mediated symptoms and inflammatory responses in humans. J. Immunol. (2001) 166:3599-3605.
-
(2001)
J. Immunol.
, vol.166
, pp. 3599-3605
-
-
Verbon, A.1
Dekkers, P.E.2
Ten Hove, T.3
-
93
-
-
33746806508
-
The anti-CD14 antibody IC14 suppresses ex vivo endotoxin stimulated tumor necrosis factor-α in patients with chronic heart failure
-
GENTH-ZOTZ S, VON HAEHLING S, BOLGER AP et al.: The anti-CD14 antibody IC14 suppresses ex vivo endotoxin stimulated tumor necrosis factor-α in patients with chronic heart failure. Eur. J. Heart Fail. (2005).
-
(2005)
Eur. J. Heart Fail.
-
-
Genth-Zotz, S.1
Von Haehling, S.2
Bolger, A.P.3
-
94
-
-
2442565752
-
CD14 receptor occupancy in severe sepsis: Results of a Phase I clinical trial with a recombinant chimeric CD14 monoclonal antibody (IC14)
-
REINHART K, GLUCK T, LIGTENBERG J et al.: CD14 receptor occupancy in severe sepsis: results of a Phase I clinical trial with a recombinant chimeric CD14 monoclonal antibody (IC14). Crit. Care Med. (2004) 32:1100-1108.
-
(2004)
Crit. Care Med.
, vol.32
, pp. 1100-1108
-
-
Reinhart, K.1
Gluck, T.2
Ligtenberg, J.3
-
95
-
-
12344306187
-
Toll-like receptor 6-independent signaling by diacylated lipopeptides
-
BUWITT-BECKMANN U, HEINE H, WIESMULLER KH et al.: Toll-like receptor 6-independent signaling by diacylated lipopeptides. Eur. J. Immunol. (2005) 35:282-289.
-
(2005)
Eur. J. Immunol.
, vol.35
, pp. 282-289
-
-
Buwitt-Beckmann, U.1
Heine, H.2
Wiesmuller, K.H.3
-
96
-
-
15544381195
-
Future prospects of anticytokine therapy in chronic heart failure
-
VON HAEHLING S, ANKER SD: Future prospects of anticytokine therapy in chronic heart failure. Expert. Opin. Investig. Drugs (2005) 14:163-176.
-
(2005)
Expert. Opin. Investig. Drugs
, vol.14
, pp. 163-176
-
-
Von Haehling, S.1
Anker, S.D.2
-
97
-
-
0037235770
-
Statins and the role of nitric oxide in chronic heart failure
-
VON HAEHLING S, ANKER SD, BASSENGE E: Statins and the role of nitric oxide in chronic heart failure. Heart Fail. Rev. (2003) 8:99-106.
-
(2003)
Heart Fail. Rev.
, vol.8
, pp. 99-106
-
-
Von Haehling, S.1
Anker, S.D.2
Bassenge, E.3
-
98
-
-
11344279659
-
C-reactive protein levels and outcomes after statin therapy
-
RIDKER PM, CANNON CP, MORROW D et al.: C-reactive protein levels and outcomes after statin therapy. N. Engl. J. Med. (2005) 352:20-28.
-
(2005)
N. Engl. J. Med.
, vol.352
, pp. 20-28
-
-
Ridker, P.M.1
Cannon, C.P.2
Morrow, D.3
-
99
-
-
0041431121
-
Short-term statin therapy improves cardiac function and symptoms in patients with idiopathic dilated cardiomyopathy
-
NODE K, FUJITA M, KITAKAZE M, HORI M, LIAO JK: Short-term statin therapy improves cardiac function and symptoms in patients with idiopathic dilated cardiomyopathy. Circulation (2003) 108:839-843.
-
(2003)
Circulation
, vol.108
, pp. 839-843
-
-
Node, K.1
Fujita, M.2
Kitakaze, M.3
Hori, M.4
Liao, J.K.5
-
100
-
-
33746822766
-
HMG-CoA reductase inhibition reduces high peripheral blood monocyte Toll-like receptor 4 expression in patients with heart failure
-
(abstract)
-
FOLDES G, VON HAEHLING S, OKONKO DO, JANKOWSKA EA, POOLE-WILSON PA, ANKER SD. HMG-CoA reductase inhibition reduces high peripheral blood monocyte Toll-like receptor 4 expression in patients with heart failure (abstract). Circulation (2005) 112:II-638.
-
(2005)
Circulation
, vol.112
-
-
Foldes, G.1
Von Haehling, S.2
Okonko, D.O.3
Jankowska, E.A.4
Poole-Wilson, P.A.5
Anker, S.D.6
-
101
-
-
0034948339
-
Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site
-
WEITZ-SCHMIDT G, WELZENBACH K, BRINKMANN V et al.: Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nat. Med. (2001) 7:687-692.
-
(2001)
Nat. Med.
, vol.7
, pp. 687-692
-
-
Weitz-Schmidt, G.1
Welzenbach, K.2
Brinkmann, V.3
-
103
-
-
33746837908
-
NF-κB activating proteins as radioprotectants: Derivatives of flagellin from Salmonella protect mice from hematopoietic and gastrointestinal radiation syndromes
-
BURDELYA LG, DIDONATO J, KRIVOKRYSENKO VI, GUROVA KV, KOGAN Y, KOMAROV PG, GUDKOV AV: NF-κB activating proteins as radioprotectants: derivatives of flagellin from Salmonella protect mice from hematopoietic and gastrointestinal radiation syndromes. International Workshop in Space Radiation Research (2004).
-
(2004)
International Workshop in Space Radiation Research
-
-
Burdelya, L.G.1
Didonato, J.2
Krivokrysenko, V.I.3
Gurova, K.V.4
Kogan, Y.5
Komarov, P.G.6
Gudkov, A.V.7
-
104
-
-
33746798343
-
The effect of a Toll Receptor-7 agonist (S28690) on the immunogenicity of chronic lymphocytic leukemia cells
-
HICKS L, SHI Y, MENA J, HAMMOND C, TOMIC Y, TOMAI YA, MILLER RL, SPANER DE: The effect of a Toll Receptor-7 agonist (S28690) on the immunogenicity of chronic lymphocytic leukemia cells. Blood (2006) 104:11.
-
(2006)
Blood
, vol.104
, pp. 11
-
-
Hicks, L.1
Shi, Y.2
Mena, J.3
Hammond, C.4
Tomic, Y.5
Tomai, Y.A.6
Miller, R.L.7
Spaner, D.E.8
-
105
-
-
24144448068
-
Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection
-
HORSMANS Y, BERG T, DESAGER JP et al.: Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection. Hepatology (2005) 42:724-731.
-
(2005)
Hepatology
, vol.42
, pp. 724-731
-
-
Horsmans, Y.1
Berg, T.2
Desager, J.P.3
-
106
-
-
0029099053
-
Cytokine induction by the immunomodulators imiquimod and S-27609
-
TESTERMAN TL, GERSTER JF, IMBERTSON LM et al.: Cytokine induction by the immunomodulators imiquimod and S-27609. J. Leukoc. Biol. (1995) 58:365-372.
-
(1995)
J. Leukoc. Biol.
, vol.58
, pp. 365-372
-
-
Testerman, T.L.1
Gerster, J.F.2
Imbertson, L.M.3
-
107
-
-
0344443213
-
Randomized, single-blind, placebo-controlled study of topical application of the immune response modulator resiquimod in healthy adults
-
SAUDER DN, SMITH MH, SENTA-McMILLIAN T, SORIA I, MENG TC: Randomized, single-blind, placebo-controlled study of topical application of the immune response modulator resiquimod in healthy adults. Antimicrob. Agents Chemother. (2003) 47:3846-3852.
-
(2003)
Antimicrob. Agents Chemother.
, vol.47
, pp. 3846-3852
-
-
Sauder, D.N.1
Smith, M.H.2
Senta-Mcmillian, T.3
Soria, I.4
Meng, T.C.5
-
108
-
-
0035879830
-
Application of a topical immune response modifier, resiquimod gel, to modify the recurrence rate of recurrent genital herpes: A pilot study
-
SPRUANCE SL, TYRING SK, SMITH MH, MENG TC: Application of a topical immune response modifier, resiquimod gel, to modify the recurrence rate of recurrent genital herpes: a pilot study. J. Infect. Dis. (2001) 184:196-200.
-
(2001)
J. Infect. Dis.
, vol.184
, pp. 196-200
-
-
Spruance, S.L.1
Tyring, S.K.2
Smith, M.H.3
Meng, T.C.4
-
109
-
-
1842631153
-
Immunotherapeutic uses of CpG oligodeoxynucleotides
-
KLINMAN DM: Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat. Rev. Immunol. (2004) 4:249-258.
-
(2004)
Nat. Rev. Immunol.
, vol.4
, pp. 249-258
-
-
Klinman, D.M.1
-
110
-
-
11144282529
-
Role of Toll-like receptors in antisense and siRNA
-
AGRAWAL S, KANDIMALLA ER: Role of Toll-like receptors in antisense and siRNA. Nat. Biotechnol. (2004) 22:1533-1537.
-
(2004)
Nat. Biotechnol.
, vol.22
, pp. 1533-1537
-
-
Agrawal, S.1
Kandimalla, E.R.2
-
111
-
-
7944219649
-
Immunotherapeutic utility of stimulatory and suppressive oligodeoxynucleoddes
-
ISHII KJ, GURSEL I, GURSEL M, KLINMAN DM: Immunotherapeutic utility of stimulatory and suppressive oligodeoxynucleoddes. Curr. Opin. Mol. Ther. (2004) 6:166-174.
-
(2004)
Curr. Opin. Mol. Ther.
, vol.6
, pp. 166-174
-
-
Ishii, K.J.1
Gursel, I.2
Gursel, M.3
Klinman, D.M.4
-
112
-
-
0036219195
-
CpG motifs in bacterial DNA and their immune effects
-
KRIEG AM: CpG motifs in bacterial DNA and their immune effects. Ann. Rev. Immunol. (2002) 20:709-760.
-
(2002)
Ann. Rev. Immunol.
, vol.20
, pp. 709-760
-
-
Krieg, A.M.1
-
113
-
-
0036090792
-
Medicinal chemistry. and therapeutic potential of CpG DNA
-
AGRAWAL S, KANDIMALLA ER: Medicinal chemistry and therapeutic potential of CpG DNA. Trends Mol. Med. (2002) 8:114-121.
-
(2002)
Trends Mol. Med.
, vol.8
, pp. 114-121
-
-
Agrawal, S.1
Kandimalla, E.R.2
-
114
-
-
0035997957
-
Towards optimal design of second-generation immunomodulatory oligonucleotides
-
KANDIMALLA ER, YU D, AGRAWAL S: Towards optimal design of second-generation immunomodulatory oligonucleotides. Curr. Opin. Mol. Ther. (2002) 4:122-129.
-
(2002)
Curr. Opin. Mol. Ther.
, vol.4
, pp. 122-129
-
-
Kandimalla, E.R.1
Yu, D.2
Agrawal, S.3
-
115
-
-
7444242674
-
H1-like innate immunity in normal volunteers following subcutaneous but not intravenous administration of CPG 7909, a synthetic B-class CpG oligodeoxynucleotide TLR9 agonist
-
H1-like innate immunity in normal volunteers following subcutaneous but not intravenous administration of CPG 7909, a synthetic B-class CpG oligodeoxynucleotide TLR9 agonist. J. Immunother. (2004) 27:460-471.
-
(2004)
J. Immunother.
, vol.27
, pp. 460-471
-
-
Krieg, A.M.1
Efler, S.M.2
Wittpoth, M.3
Al Adhami, M.J.4
Davis, H.L.5
-
117
-
-
1242329059
-
Novel immunomodulatory oligonucleotides prevent development of allergic airway inflammation and airway hyperresponsiveness in asthma
-
AGRAWAL DK, EDWAN J, KANDIMALLA ER et al.: Novel immunomodulatory oligonucleotides prevent development of allergic airway inflammation and airway hyperresponsiveness in asthma. Int. Immunopharmacol. (2004) 4:127-138.
-
(2004)
Int. Immunopharmacol.
, vol.4
, pp. 127-138
-
-
Agrawal, D.K.1
Edwan, J.2
Kandimalla, E.R.3
-
118
-
-
20344404730
-
Progress in drug development of immunostimulatory CpG oligodeoxynucleotide ligands for TLR9
-
VOLLMER J: Progress in drug development of immunostimulatory CpG oligodeoxynucleotide ligands for TLR9. Expert Opin. Biol. Ther. (2005) 5:673-682.
-
(2005)
Expert Opin. Biol. Ther.
, vol.5
, pp. 673-682
-
-
Vollmer, J.1
-
119
-
-
3142690381
-
Taking a Toll on human disease: Toll-like receptor 4 agonists as vaccine adjuvants and monotherapeutic agents
-
BALDRIDGE JR, McGOWAN P, EVANS JT et al.: Taking a Toll on human disease: Toll-like receptor 4 agonists as vaccine adjuvants and monotherapeutic agents. Expert Opin. Biol. Ther. (2004) 4:1129-1138.
-
(2004)
Expert Opin. Biol. Ther.
, vol.4
, pp. 1129-1138
-
-
Baldridge, J.R.1
Mcgowan, P.2
Evans, J.T.3
-
120
-
-
0142185281
-
Technology evaluation: CpG-7909, Coley
-
PAUL S: Technology evaluation: CpG-7909, Coley. Curr. Opin. Mol. Ther. (2003) 5:553-559.
-
(2003)
Curr. Opin. Mol. Ther.
, vol.5
, pp. 553-559
-
-
Paul, S.1
-
121
-
-
0842343142
-
Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration
-
HEIKENWALDER M, POLYMENIDOU M, JUNT T et al.: Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration. Nat. Med. (2004) 10:187-192.
-
(2004)
Nat. Med.
, vol.10
, pp. 187-192
-
-
Heikenwalder, M.1
Polymenidou, M.2
Junt, T.3
-
122
-
-
23344433384
-
Technology evaluation: HYB-2055, Hybridon
-
SWITAJ T, LASEK W: Technology evaluation: HYB-2055, Hybridon. Curr. Opin. Mol. Ther. (2005) 7:376-383.
-
(2005)
Curr. Opin. Mol. Ther.
, vol.7
, pp. 376-383
-
-
Switaj, T.1
Lasek, W.2
-
123
-
-
0347951007
-
The use of Toll-like receptor-7 agonist in the treatment of basal cell carcinoma: An overview
-
STOCKFLETH E, TREFZER U, GARCIA-BARTELS C et al.: The use of Toll-like receptor-7 agonist in the treatment of basal cell carcinoma: an overview. Br. J. Dermatol. (2003) 149(Suppl. 66):53-56.
-
(2003)
Br. J. Dermatol.
, vol.149
, Issue.SUPPL. 66
, pp. 53-56
-
-
Stockfleth, E.1
Trefzer, U.2
Garcia-Bartels, C.3
-
125
-
-
8644221278
-
Evidence for a role of toll-like receptor 4 in development of chronic allograft rejection after cardiac transplantation
-
METHE H, ZIMMER E, GRIMM C, NABAUER M, KOGLIN J: Evidence for a role of toll-like receptor 4 in development of chronic allograft rejection after cardiac transplantation. Transplantation (2004) 78:1324-1331.
-
(2004)
Transplantation
, vol.78
, pp. 1324-1331
-
-
Methe, H.1
Zimmer, E.2
Grimm, C.3
Nabauer, M.4
Koglin, J.5
|