메뉴 건너뛰기




Volumn 16, Issue 4, 2003, Pages 637-646

Role of Toll-Like Receptors in Pathogen Recognition

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; DROSOPHILA PROTEIN; ENDOTOXIN; INTERLEUKIN 1 RECEPTOR; LIGAND; PATTERN RECOGNITION RECEPTOR; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

EID: 0142031430     PISSN: 08938512     EISSN: None     Source Type: Journal    
DOI: 10.1128/CMR.16.4.637-646.2003     Document Type: Review
Times cited : (491)

References (86)
  • 1
    • 0036318851 scopus 로고    scopus 로고
    • Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments
    • Ahmad-Nejad, P., H. Hacker, M. Rutz, S. Bauer, R. M. Vabulas, and H. Wagner. 2002. Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur. J. Immunol. 32:1958-1968.
    • (2002) Eur. J. Immunol. , vol.32 , pp. 1958-1968
    • Ahmad-Nejad, P.1    Hacker, H.2    Rutz, M.3    Bauer, S.4    Vabulas, R.M.5    Wagner, H.6
  • 2
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
    • Alexopoulou, L., A. C. Holt, R. Medzhitov, and R. A. Flavell. 2001. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature 413:732-738.
    • (2001) Nature , vol.413 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 3
    • 0036569028 scopus 로고    scopus 로고
    • Up-regulation of TLR9 gene expression by LPS in mouse macrophages via activation of NF-κB, ERK and p38 mitogen-activated protein kinase signal pathways
    • An, H., H. Xu, Y. Yu, M. Zhang, R. Qi, X. Yan, S. Liu, W. Wang, Z. Guo, Z. Qin, and X. Cao. 2002. Up-regulation of TLR9 gene expression by LPS in mouse macrophages via activation of NF-κB, ERK and p38 mitogen-activated protein kinase signal pathways. Immunol. Lett. 81:165-169.
    • (2002) Immunol. Lett. , vol.81 , pp. 165-169
    • An, H.1    Xu, H.2    Yu, Y.3    Zhang, M.4    Qi, R.5    Yan, X.6    Liu, S.7    Wang, W.8    Guo, Z.9    Qin, Z.10    Cao, X.11
  • 4
    • 0008824942 scopus 로고    scopus 로고
    • The domains of death: Evolution of the apoptosis machinery
    • Aravind, L., V. M. Dixit, and E. V. Koonin. 1999. The domains of death: evolution of the apoptosis machinery. Trends Biochem. Sci. 24:47-53.
    • (1999) Trends Biochem. Sci. , vol.24 , pp. 47-53
    • Aravind, L.1    Dixit, V.M.2    Koonin, E.V.3
  • 6
    • 0036266019 scopus 로고    scopus 로고
    • TLR4-dependent lipopolysaccharide signalling in epithelial cells is independent of extracellular protease activity
    • Backhed, F., S. Normark, and A. Richter-Dahlfors. 2002. TLR4-dependent lipopolysaccharide signalling in epithelial cells is independent of extracellular protease activity. Cell. Microbiol. 4:297-303.
    • (2002) Cell. Microbiol. , vol.4 , pp. 297-303
    • Backhed, F.1    Normark, S.2    Richter-Dahlfors, A.3
  • 8
    • 0033861419 scopus 로고    scopus 로고
    • The interleukin-1 receptor/Toll-like receptor superfamily: Signal generators for proinflammatory interleukins and microbial products
    • Bowie, A., and L. A. O'Neill. 2000. The interleukin-1 receptor/Toll-like receptor superfamily: signal generators for proinflammatory interleukins and microbial products. J. Leukoc. Biol. 67:508-514.
    • (2000) J. Leukoc. Biol. , vol.67 , pp. 508-514
    • Bowie, A.1    O'Neill, L.A.2
  • 9
    • 0032100444 scopus 로고    scopus 로고
    • Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: Evidence for a multi-gene receptor family in humans
    • Chaudhary, P. M., C. Ferguson, V. Nguyen, O. Nguyen, H. F. Massa, M. Eby, A. Jasmin, B. J. Trask, L. Hood, and P. S. Nelson. 1998. Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans. Blood 91:4020-4027.
    • (1998) Blood , vol.91 , pp. 4020-4027
    • Chaudhary, P.M.1    Ferguson, C.2    Nguyen, V.3    Nguyen, O.4    Massa, H.F.5    Eby, M.6    Jasmin, A.7    Trask, B.J.8    Hood, L.9    Nelson, P.S.10
  • 10
    • 0037066464 scopus 로고    scopus 로고
    • Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila
    • Choe, K. M., T. Werner, S. Stoven, D. Hultmark, and K. V. Anderson. 2002. Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila. Science 296:359-362.
    • (2002) Science , vol.296 , pp. 359-362
    • Choe, K.M.1    Werner, T.2    Stoven, S.3    Hultmark, D.4    Anderson, K.V.5
  • 11
    • 0035911644 scopus 로고    scopus 로고
    • Identification of hTLR10: A novel human Toll-like receptor preferentially expressed in immune cells
    • Chuang, T., and R. J. Ulevitch. 2001. Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells. Biochim. Biophys. Acta 1518:157-161.
    • (2001) Biochim. Biophys. Acta , vol.1518 , pp. 157-161
    • Chuang, T.1    Ulevitch, R.J.2
  • 12
    • 0034456693 scopus 로고    scopus 로고
    • Three novel mammalian Toll-like receptors: Gene structure, expression, and evolution
    • Du, X., A. Poltorak, Y. Wei, and B. Beutler. 2000. Three novel mammalian Toll-like receptors: gene structure, expression, and evolution. Eur. Cytokine Netw. 11:362-371.
    • (2000) Eur. Cytokine Netw. , vol.11 , pp. 362-371
    • Du, X.1    Poltorak, A.2    Wei, Y.3    Beutler, B.4
  • 13
    • 0025774776 scopus 로고
    • Drosophila Toll and IL-1 receptor
    • Gay, N. J., and F. J. Keith. 1991. Drosophila Toll and IL-1 receptor. Nature 351:355-356.
    • (1991) Nature , vol.351 , pp. 355-356
    • Gay, N.J.1    Keith, F.J.2
  • 14
    • 0035881675 scopus 로고    scopus 로고
    • Cutting edge: Bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression
    • Gewirtz, A. T., T. A. Navas, S. Lyons, P. J. Godowski, and J. L. Madara. 2001. Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. J. Immunol. 167:1882-1885.
    • (2001) J. Immunol. , vol.167 , pp. 1882-1885
    • Gewirtz, A.T.1    Navas, T.A.2    Lyons, S.3    Godowski, P.J.4    Madara, J.L.5
  • 16
    • 0036234459 scopus 로고    scopus 로고
    • Missing pieces in the NF-κB puzzle
    • Ghosh, S., and M. Karin. 2002. Missing pieces in the NF-κB puzzle. Cell 109(Suppl.):S81-96.
    • (2002) Cell , vol.109 , Issue.SUPPL.
    • Ghosh, S.1    Karin, M.2
  • 17
    • 0037061450 scopus 로고    scopus 로고
    • The Drosophila immune response against gram-negative bacteria is mediated by a peptidoglycan recognition protein
    • Gottar, M., V. Gobert, T. Michel, M. Belvin, G. Duyk, J. A. Hoffmann, D. Ferrandon, and J. Royet. 2002. The Drosophila immune response against gram-negative bacteria is mediated by a peptidoglycan recognition protein. Nature 416:640-644.
    • (2002) Nature , vol.416 , pp. 640-644
    • Gottar, M.1    Gobert, V.2    Michel, T.3    Belvin, M.4    Duyk, G.5    Hoffmann, J.A.6    Ferrandon, D.7    Royet, J.8
  • 18
    • 0035165287 scopus 로고    scopus 로고
    • Cutting edge: Functional interactions between Toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin
    • Hajjar, A. M., D. S. O'Mahony, A. Ozinsky, D. M. Underhill, A. Aderem, S. J. Klebanoff, and C. B. Wilson. 2001. Cutting edge: functional interactions between Toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin. J. Immunol. 166:15-19.
    • (2001) J. Immunol. , vol.166 , pp. 15-19
    • Hajjar, A.M.1    O'Mahony, D.S.2    Ozinsky, A.3    Underhill, D.M.4    Aderem, A.5    Klebanoff, S.J.6    Wilson, C.B.7
  • 19
    • 0024299087 scopus 로고
    • The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein
    • Hashimoto, C., K. L. Hudson, and K. V. Anderson. 1988. The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein. Cell 52:269-279.
    • (1988) Cell , vol.52 , pp. 269-279
    • Hashimoto, C.1    Hudson, K.L.2    Anderson, K.V.3
  • 23
    • 0034662239 scopus 로고    scopus 로고
    • Cutting edge: Repurification of lipopolysaccharide eliminates signaling through both human and murine Toll-like receptor 2
    • Hirschfeld, M., Y. Ma, J. H. Weis, S. N. Vogel, and J. J. Weis. 2000. Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine Toll-like receptor 2. J. Immunol. 165:618-622.
    • (2000) J. Immunol. , vol.165 , pp. 618-622
    • Hirschfeld, M.1    Ma, Y.2    Weis, J.H.3    Vogel, S.N.4    Weis, J.J.5
  • 24
    • 0036570169 scopus 로고    scopus 로고
    • Quantitative expression of Toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    • Hornung, V., S. Rothenfusser, S. Britsch, A. Krug, B. Jahrsdorfer, T. Giese, S. Endres, and G. Hartmann. 2002. Quantitative expression of Toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J. Immunol. 168:4531-4537.
    • (2002) J. Immunol. , vol.168 , pp. 4531-4537
    • Hornung, V.1    Rothenfusser, S.2    Britsch, S.3    Krug, A.4    Jahrsdorfer, B.5    Giese, T.6    Endres, S.7    Hartmann, G.8
  • 25
    • 0033120081 scopus 로고    scopus 로고
    • Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
    • Hoshino, K., O. Takeuchi, T. Kawai, H. Sanjo, T. Ogawa, Y. Takeda, K. Takeda, and S. Akira. 1999. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162:3749-3752.
    • (1999) J. Immunol. , vol.162 , pp. 3749-3752
    • Hoshino, K.1    Takeuchi, O.2    Kawai, T.3    Sanjo, H.4    Ogawa, T.5    Takeda, Y.6    Takeda, K.7    Akira, S.8
  • 26
    • 0033973826 scopus 로고    scopus 로고
    • Signaling mechanisms in the antimicrobial host defense of Drosophila
    • Imler, J. L., and J. A. Hoffmann. 2000. Signaling mechanisms in the antimicrobial host defense of Drosophila. Curr. Opin. Microbiol. 3:16-22.
    • (2000) Curr. Opin. Microbiol. , vol.3 , pp. 16-22
    • Imler, J.L.1    Hoffmann, J.A.2
  • 27
    • 0037025399 scopus 로고    scopus 로고
    • The extracellular Toll-like receptor 2 domain directly binds peptidoglycan derived from Staphylococcus aureus
    • Iwaki, D., H. Mitsuzawa, S. Murakami, H. Sano, M. Konishi, T. Akino, and Y. Kuroki. 2002. The extracellular Toll-like receptor 2 domain directly binds peptidoglycan derived from Staphylococcus aureus. J. Biol. Chem. 277:24315-24320.
    • (2002) J. Biol. Chem. , vol.277 , pp. 24315-24320
    • Iwaki, D.1    Mitsuzawa, H.2    Murakami, S.3    Sano, H.4    Konishi, M.5    Akino, T.6    Kuroki, Y.7
  • 29
    • 0036709969 scopus 로고    scopus 로고
    • A universal role for MyD88 in TLR/IL-1 receptor-mediated signaling
    • Janssens, S., and R. Beyaert. 2002. A universal role for MyD88 in TLR/IL-1 receptor-mediated signaling. Trends Biochem. Sci. 27:474-482.
    • (2002) Trends Biochem. Sci. , vol.27 , pp. 474-482
    • Janssens, S.1    Beyaert, R.2
  • 30
    • 0028815388 scopus 로고
    • Soluble CD14 truncated at amino acid 152 binds lipopolysaccharide (LPS) and enables cellular response to LPS
    • Juan, T. S., M. J. Kelley, D. A. Johnson, L. A. Busse, E. Hailman, S. D. Wright, and H. S. Lichenstein. 1995. Soluble CD14 truncated at amino acid 152 binds lipopolysaccharide (LPS) and enables cellular response to LPS. J. Biol. Chem. 270:1382-1387.
    • (1995) J. Biol. Chem. , vol.270 , pp. 1382-1387
    • Juan, T.S.1    Kelley, M.J.2    Johnson, D.A.3    Busse, L.A.4    Hailman, E.5    Wright, S.D.6    Lichenstein, H.S.7
  • 32
    • 0035903288 scopus 로고    scopus 로고
    • Subsets of human dendritic cell precursors express different Toll-like receptors and respond to different microbial antigens
    • Kadowaki, N., S. Ho, S. Antonenko, R. W. Malefyt, R. A. Kastelein, F. Bazan, and Y. J. Liu. 2001. Subsets of human dendritic cell precursors express different Toll-like receptors and respond to different microbial antigens. J. Exp. Med. 194:863-869.
    • (2001) J. Exp. Med. , vol.194 , pp. 863-869
    • Kadowaki, N.1    Ho, S.2    Antonenko, S.3    Malefyt, R.W.4    Kastelein, R.A.5    Bazan, F.6    Liu, Y.J.7
  • 33
    • 0034927975 scopus 로고    scopus 로고
    • Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice
    • Kaisho, T., and S. Akira. 2001. Dendritic-cell function in Toll-like receptor- and MyD88-knockout mice. Trends Immunol. 22:78-83.
    • (2001) Trends Immunol. , vol.22 , pp. 78-83
    • Kaisho, T.1    Akira, S.2
  • 34
    • 0031774181 scopus 로고    scopus 로고
    • Human Toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide
    • Kirschning, C. J., H. Wesche, T. Merrill Ayres, and M. Rothe. 1998. Human Toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide. J. Exp. Med. 188:2091-2097.
    • (1998) J. Exp. Med. , vol.188 , pp. 2091-2097
    • Kirschning, C.J.1    Wesche, H.2    Merrill Ayres, T.3    Rothe, M.4
  • 36
    • 0036476320 scopus 로고    scopus 로고
    • From A to Z on CpG
    • Krieg, A. M. 2002. From A to Z on CpG. Trends Immunol. 23:64-65.
    • (2002) Trends Immunol. , vol.23 , pp. 64-65
    • Krieg, A.M.1
  • 40
    • 0030595339 scopus 로고    scopus 로고
    • The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    • Lemaitre, B., E. Nicolas, L. Michaut, J. M. Reichhart, and J. A. Hoffmann. 1996. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86:973-983.
    • (1996) Cell , vol.86 , pp. 973-983
    • Lemaitre, B.1    Nicolas, E.2    Michaut, L.3    Reichhart, J.M.4    Hoffmann, J.A.5
  • 41
    • 0031446642 scopus 로고    scopus 로고
    • Drosophila host defense: Differential induction of antimicrobial peptide genes after infection by various classes of microorganisms
    • Lemaitre, B., J. M. Reichhart, and J. A. Hoffmann. 1997. Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms. Proc. Natl. Acad. Sci. USA 94:14614-41619.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 14614-41619
    • Lemaitre, B.1    Reichhart, J.M.2    Hoffmann, J.A.3
  • 44
    • 0037025213 scopus 로고    scopus 로고
    • Activation of Drosophila Toll during fungal infection by a blood serine protease
    • Ligoxygakis, P., N. Pelte, J. A. Hoffmann, and J. M. Reichhart. 2002. Activation of Drosophila Toll during fungal infection by a blood serine protease. Science 297:114-116.
    • (2002) Science , vol.297 , pp. 114-116
    • Ligoxygakis, P.1    Pelte, N.2    Hoffmann, J.A.3    Reichhart, J.M.4
  • 45
    • 0035941066 scopus 로고    scopus 로고
    • The serine protease inhibitor antithrombin III inhibits LPS mediated NF-κB activation by TLR-4
    • Mansell, A., A. Reinicke, D. M. Worrall, and L. A. O'Neill. 2001. The serine protease inhibitor antithrombin III inhibits LPS mediated NF-κB activation by TLR-4. FEBS Lett. 508:313-317.
    • (2001) FEBS Lett. , vol.508 , pp. 313-317
    • Mansell, A.1    Reinicke, A.2    Worrall, D.M.3    O'Neill, L.A.4
  • 46
    • 0037066427 scopus 로고    scopus 로고
    • The danger model: A renewed sense of self
    • Matzinger, P. 2002. The danger model: a renewed sense of self. Science 296:301-305.
    • (2002) Science , vol.296 , pp. 301-305
    • Matzinger, P.1
  • 47
    • 0032716031 scopus 로고    scopus 로고
    • The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors
    • Means, T. K., E. Lien, A. Yoshimura, S. Wang, D. T. Golenbock, and M. J. Fenton. 1999. The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors. J. Immunol. 163:6748-6755.
    • (1999) J. Immunol. , vol.163 , pp. 6748-6755
    • Means, T.K.1    Lien, E.2    Yoshimura, A.3    Wang, S.4    Golenbock, D.T.5    Fenton, M.J.6
  • 48
    • 0035524488 scopus 로고    scopus 로고
    • Toll-like receptors and innate immunity
    • Medzhitov, R. 2001. Toll-like receptors and innate immunity. Nat. Rev. Immunol. 1:135-145.
    • (2001) Nat. Rev. Immunol. , vol.1 , pp. 135-145
    • Medzhitov, R.1
  • 49
    • 0030666222 scopus 로고    scopus 로고
    • Innate immunity: The virtues of a nonclonal system of recognition
    • Medzhitov, R., and C. A. Janeway, Jr. 1997. Innate immunity: the virtues of a nonclonal system of recognition. Cell 91:295-298.
    • (1997) Cell , vol.91 , pp. 295-298
    • Medzhitov, R.1    Janeway C.A., Jr.2
  • 50
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    • Medzhitov, R., P. Preston-Hurlburt, and C. A. Janeway, Jr. 1997. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388:394-397.
    • (1997) Nature , vol.388 , pp. 394-397
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway C.A., Jr.3
  • 51
    • 0035856990 scopus 로고    scopus 로고
    • Drosophila Toll is activated by gram-positive bacteria through a circulating peptidoglycan recognition protein
    • Michel, T., J. M. Reichhart, J. A. Hoffmann, and J. Royet. 2001. Drosophila Toll is activated by gram-positive bacteria through a circulating peptidoglycan recognition protein. Nature 414:756-759.
    • (2001) Nature , vol.414 , pp. 756-759
    • Michel, T.1    Reichhart, J.M.2    Hoffmann, J.A.3    Royet, J.4
  • 52
    • 0032146713 scopus 로고    scopus 로고
    • Mouse MD-1, a molecule that is physically associated with RP105 and positively regulates its expression
    • Miyake, K., R. Shimazu, J. Kondo, T. Niki, S. Akashi, H. Ogata, Y. Yamashita, Y. Miura, and M. Kimoto. 1998. Mouse MD-1, a molecule that is physically associated with RP105 and positively regulates its expression. J. Immunol. 161:1348-1353.
    • (1998) J. Immunol. , vol.161 , pp. 1348-1353
    • Miyake, K.1    Shimazu, R.2    Kondo, J.3    Niki, T.4    Akashi, S.5    Ogata, H.6    Yamashita, Y.7    Miura, Y.8    Kimoto, M.9
  • 55
    • 0034650427 scopus 로고    scopus 로고
    • Cutting edge: Heat shock protein 60 is a putative endogenous ligand of the Toll-like receptor-4 complex
    • Ohashi, K., V. Burkart, S. Flohe, and H. Kolb. 2000. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the Toll-like receptor-4 complex. J. Immunol. 164:558-561.
    • (2000) J. Immunol. , vol.164 , pp. 558-561
    • Ohashi, K.1    Burkart, V.2    Flohe, S.3    Kolb, H.4
  • 57
    • 0036864723 scopus 로고    scopus 로고
    • Wanted: A molecular basis for specificity in Toll-like receptor signal transduction
    • O'Neill, L. A. 2002. Wanted: a molecular basis for specificity in Toll-like receptor signal transduction. Mol. Cell 10:969-971.
    • (2002) Mol. Cell , vol.10 , pp. 969-971
    • O'Neill, L.A.1
  • 58
    • 0036166242 scopus 로고    scopus 로고
    • The Drosophila Toll-9 activates a constitutive antimicrobial defense
    • Ooi, J. Y., Y. Yagi, X. Hu, and Y. T. Ip. 2002. The Drosophila Toll-9 activates a constitutive antimicrobial defense. EMBO Rep. 3:82-87.
    • (2002) EMBO Rep. , vol.3 , pp. 82-87
    • Ooi, J.Y.1    Yagi, Y.2    Hu, X.3    Ip, Y.T.4
  • 62
    • 0034007076 scopus 로고    scopus 로고
    • Physical contact between lipopolysaccharide and Toll-like receptor 4 revealed by genetic complementation
    • Poltorak, A., P. Ricciardi-Castagnoli, S. Citterio, and B. Beutler. 2000. Physical contact between lipopolysaccharide and Toll-like receptor 4 revealed by genetic complementation. Proc. Natl. Acad. Sci. USA 97:2163-2167.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 2163-2167
    • Poltorak, A.1    Ricciardi-Castagnoli, P.2    Citterio, S.3    Beutler, B.4
  • 63
    • 0037061482 scopus 로고    scopus 로고
    • Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli
    • Ramet, M., P. Manfruelli, A. Pearson, B. Mathey-Prevot, and R. A. Ezekowitz. 2002. Functional genomic analysis of phagocytosis and identification of a Drosophila receptor for E. coli. Nature 416:644-648.
    • (2002) Nature , vol.416 , pp. 644-648
    • Ramet, M.1    Manfruelli, P.2    Pearson, A.3    Mathey-Prevot, B.4    Ezekowitz, R.A.5
  • 64
    • 0036679732 scopus 로고    scopus 로고
    • Of mice and men: Species variations of Toll-like receptor expression
    • Rehli, M. 2002. Of mice and men: species variations of Toll-like receptor expression. Trends Immunol. 23:375-378.
    • (2002) Trends Immunol. , vol.23 , pp. 375-378
    • Rehli, M.1
  • 65
    • 0036838909 scopus 로고    scopus 로고
    • Cutting edge: Impaired Toll-like receptor expression and function in aging
    • Renshaw, M., J. Rockwell, C. Engleman, A. Gewirtz, J. Katz, and S. Sambhara. 2002. Cutting edge: impaired Toll-like receptor expression and function in aging. J. Immunol. 169:4697-4701.
    • (2002) J. Immunol. , vol.169 , pp. 4697-4701
    • Renshaw, M.1    Rockwell, J.2    Engleman, C.3    Gewirtz, A.4    Katz, J.5    Sambhara, S.6
  • 68
    • 0033532629 scopus 로고    scopus 로고
    • MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
    • Shimazu, R., S. Akashi, H. Ogata, Y. Nagai, K. Fukudome, K. Miyake, and M. Kimoto. 1999. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J. Exp. Med. 189:1777-1782.
    • (1999) J. Exp. Med. , vol.189 , pp. 1777-1782
    • Shimazu, R.1    Akashi, S.2    Ogata, H.3    Nagai, Y.4    Fukudome, K.5    Miyake, K.6    Kimoto, M.7
  • 69
    • 0034681434 scopus 로고    scopus 로고
    • Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to proinflammatory signaling pathways
    • Slack, J. L., K. Schooley, T. P. Bonnert, J. L. Mitcham, E. E. Qwarnstrom, J. E. Sims, and S. K. Dower. 2000. Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to proinflammatory signaling pathways. J. Biol. Chem. 275:4670-4678.
    • (2000) J. Biol. Chem. , vol.275 , pp. 4670-4678
    • Slack, J.L.1    Schooley, K.2    Bonnert, T.P.3    Mitcham, J.L.4    Qwarnstrom, E.E.5    Sims, J.E.6    Dower, S.K.7
  • 70
    • 0036232737 scopus 로고    scopus 로고
    • Toll-like receptor 1 inhibits Toll-like receptor 4 signaling in endothelial cells
    • Spitzer, J. H., A. Visintin, A. Mazzoni, M. N. Kennedy, and D. M. Segal. 2002. Toll-like receptor 1 inhibits Toll-like receptor 4 signaling in endothelial cells. Eur. J. Immunol. 32:1182-1187.
    • (2002) Eur. J. Immunol. , vol.32 , pp. 1182-1187
    • Spitzer, J.H.1    Visintin, A.2    Mazzoni, A.3    Kennedy, M.N.4    Segal, D.M.5
  • 71
    • 0033213590 scopus 로고    scopus 로고
    • Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
    • Takeuchi, O., K. Hoshino, T. Kawai, H. Sanjo, H. Takada, T. Ogawa, K. Takeda, and S. Akira. 1999. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11:443-451.
    • (1999) Immunity , vol.11 , pp. 443-451
    • Takeuchi, O.1    Hoshino, K.2    Kawai, T.3    Sanjo, H.4    Takada, H.5    Ogawa, T.6    Takeda, K.7    Akira, S.8
  • 74
  • 75
    • 0034641738 scopus 로고    scopus 로고
    • Toll-related receptors and the control of antimicrobial peptide expression in Drosophila
    • Tauszig, S., E. Jouanguy, J. A. Hoffmann, and J. L. Imler. 2000. Toll-related receptors and the control of antimicrobial peptide expression in Drosophila. Proc. Natl. Acad. Sci. USA 97:10520-10525.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 10520-10525
    • Tauszig, S.1    Jouanguy, E.2    Hoffmann, J.A.3    Imler, J.L.4
  • 76
    • 0036606913 scopus 로고    scopus 로고
    • Lipopolysaccharide recognition: CD14, TLRs and the LPS activation cluster
    • Triantafilou, M., and K. Triantafilou. 2002. Lipopolysaccharide recognition: CD14, TLRs and the LPS activation cluster. Trends Immunol. 23:301-304.
    • (2002) Trends Immunol. , vol.23 , pp. 301-304
    • Triantafilou, M.1    Triantafilou, K.2
  • 77
    • 0027291534 scopus 로고
    • Recognition of bacterial endotoxins by receptor-dependent mechanisms
    • Ulevitch, R. J. 1993. Recognition of bacterial endotoxins by receptor-dependent mechanisms. Adv. Immunol. 53:267-289.
    • (1993) Adv. Immunol. , vol.53 , pp. 267-289
    • Ulevitch, R.J.1
  • 78
    • 0033592748 scopus 로고    scopus 로고
    • The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
    • Underhill, D. M., A. Ozinsky, A. M. Hajjar, A. Stevens, C. B. Wilson, M. Bassetti, and A. Aderem. 1999. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 401:811-815.
    • (1999) Nature , vol.401 , pp. 811-815
    • Underhill, D.M.1    Ozinsky, A.2    Hajjar, A.M.3    Stevens, A.4    Wilson, C.B.5    Bassetti, M.6    Aderem, A.7
  • 81
    • 0033557176 scopus 로고    scopus 로고
    • Toll, a new piece in the puzzle of innate immunity
    • Wright, S. D. 1999. Toll, a new piece in the puzzle of innate immunity. J. Exp. Med. 189:605-609.
    • (1999) J. Exp. Med. , vol.189 , pp. 605-609
    • Wright, S.D.1
  • 82
    • 0025166114 scopus 로고
    • CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
    • Wright, S. D., R. A. Ramos, P. S. Tobias, R. J. Ulevitch, and J. C. Mathison. 1990. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249:1431-1433.
    • (1990) Science , vol.249 , pp. 1431-1433
    • Wright, S.D.1    Ramos, R.A.2    Tobias, P.S.3    Ulevitch, R.J.4    Mathison, J.C.5
  • 83
    • 0024464813 scopus 로고
    • Lipopolysaccharide (LPS) binding protein opsonizes LPS bearing particles for recognition by a novel receptor on macrophages
    • Wright, S. D., P. S. Tobias, R. J. Ulevitch, and R. A. Ramos. 1989. Lipopolysaccharide (LPS) binding protein opsonizes LPS bearing particles for recognition by a novel receptor on macrophages. J. Exp. Med. 170:1231-1241.
    • (1989) J. Exp. Med. , vol.170 , pp. 1231-1241
    • Wright, S.D.1    Tobias, P.S.2    Ulevitch, R.J.3    Ramos, R.A.4
  • 84
    • 0034597766 scopus 로고    scopus 로고
    • Structural basis for signal transduction by the Toll/interleukin-1 receptor domains
    • Xu, Y., X. Tao, B. Shen, T. Horng, R. Medzhitov, J. L. Manley, and L. Tong. 2000. Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature 408:111-115.
    • (2000) Nature , vol.408 , pp. 111-115
    • Xu, Y.1    Tao, X.2    Shen, B.3    Horng, T.4    Medzhitov, R.5    Manley, J.L.6    Tong, L.7
  • 86
    • 0037080024 scopus 로고    scopus 로고
    • Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines
    • Zarember, K. A., and P. J. Godowski. 2002. Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J. Immunol. 168:554-561.
    • (2002) J. Immunol. , vol.168 , pp. 554-561
    • Zarember, K.A.1    Godowski, P.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.