TLR4 as the mammalian endotoxin sensor

Current Topics in Microbiology and Immunology

Volumn 270, Issue , 2002, Pages 109-120

  Beutler, Bruce ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CD14 ANTIGEN; ENDOTOXIN; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; TOLL LIKE RECEPTOR 4;

BACTERIAL INFECTION; CHORDATA; DROSOPHILA; KNOCKOUT GENE; MAMMAL; MICROBIAL IMMUNITY; MOLECULAR CLONING; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS); CHORDATA; MAMMALIA;

EID: 0036451206     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-642-59430-4_7     Document Type: Review

References (48)

1. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA (2001) Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature 413:732-8
2. Anderson KV, Jurgens G, Nusslein-Volhard C (1985) Establishment of dorsal-ventral polarity in the Drosophila embryo: Genetic studies on the role of the Toll gene product. Cell 42:779-89
3. Bauer S, Kirschning CJ, Hacker H, Redecke V, Hausmann S, Akira S, Wagner H, Lipford GB (2001) Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc Natl Acad Sci USA 98:9237-42
4. Biswas C, Mandal C (1999) The role of amoebocytes in endotoxin-mediated coagulation in the innate immunity of Achatina fulica snails. Scand J Immunol 49:131-8
5. Boivin A (1946) Traveaux récents sur la constitution chimique et sur les propriétés biologiques des antigènes bactériens. Schweiz Z Pathol Bakteriol 9:505-41
6. Boivin A, Mesrobeanu L (1935) Recherches usr les antigènes somatiques et sur les endotoxines des bactéries. Rev Immunol 1:553-69
7. Chaudhary PM, Ferguson C, Nguyen V, Nguyen O, Massa HF, Eby M, Jasmin A, Trask BJ, Hood L, Nelson PS (1998) Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: Evidence for a multi-gene receptor family in humans. Blood 91:4020-7
8. Chow JC, Young DW, Golenbock DT, Christ WJ, Gusovsky F (1999) Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J Biol Chem 274:10689-92
9. Coutinho A, Forni L, Melchers F, Watanabe T (1977) Genetic defect in responsiveness to the B cell mitogen lipopolysaccharid. Eur J Immunol 7:325-8
10. Coutinho A, Meo T (1978) Genetic basis for unresponsiveness to lipopolysaccharide in C57BL/10Cr mice. Immunogenetics 7:17-24
11. Cross A, Asher L, Seguin M, Yuan L, Kelly N, Hammack C, Sadoff J, Gemski P Jr (1995) The importance of a lipopolysaccharide-initiated, cytokine-mediated host defense mechanism in mice against extraintestinally invasive Escherichia coli. J Clin Invest 96:676-86
12. Ding AH, Porteu F, Sanchez E, Nathan CF (1990) Downregulation of tumor necrosis factor receptors on macrophages and endothelial cells by microtubule depolymerizing agents. J Exp Med 171:715-27
13. Ding AH, Porteu F, Sanchez E, Nathan CF (1990) Shared actions of endotoxin and taxol on TNF receptors and TNF release. Science 248:370-2
14. Hemmi H, Takeuchi O, Kawai T, Kaisho T, Sato S, Sanjo H, Matsumoto M, Hoshino K, Wagner H, Takeda K, Akira S (2000) A Toll-like receptor recognizes bacterial DNA. Nature 408:740-5
15. Heppner G, Weiss DW (1965) High susceptibility of strain A mice to endotoxin and endotoxin-red blood cell mixtures. J Bacteriol 90:696-703
16. Inamori K, Koori K, Mishima C, Muta T, Kawabata S (2000) A horseshoe crab receptor structurally related to Drosophila Toll. J Endotoxin Res 6:397-9
17. Kawasaki K, Akashi S, Shimazu R, Yoshida T, Miyake K, Nishijima M (2000) Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol. J Biol Chem 275:2251-4
18. Kirschning CJ, Wesche H, Merrill AT, Rothe M (1998) Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide. J Exp Med 188:2091-7
19. Kuhns DB, Long Priel DA, Gallin JI (1997) Endotoxin and IL-1 hyporesponsiveness in a patient with recurrent bacterial infections. J Immunol 158:3959-64
20. Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA (1996) The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86:973-83
21. Lien E, Means TK, Heine H, Yoshimura A, Kusumoto S, Fukase K, Fenton MJ, Oikawa M, Qureshi N, Monks B, Finberg RW, Ingalls RR, Golenbock DT (2000) Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide. J Clin Invest 105:497-504
22. Luderitz O, Galanos C, Lehmann V, Nurminen M, Rietschel ET, Rosenfelder G, Simon M, Westphal O (1973) Lipid A: Chemical structure and biological activity. J Infect Dis 128:29
23. Luderitz O, Staub AM, Westphal O (1966) Immunochemistry of O and R antigens of Salmonella and related Enterobacteriaceae. Bacteriol Rev 30:192-255
24. d mice. FEMS Immunol Med Microbiol 13:235-8
25. Medzhitov R, Preston-Hurlburt P, Janeway CA, Jr. (1997) A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388:394-7
26. Michalek SM, Moore RN, McGhee JR, Rosenstreich DL, Mergenhagen SE (1980) The primary role of lymphoreticular cells in the mediation of host responses to bacterial endotoxin. J Infec Dis 141:55-63
27. Mitchell CR, Kempton JB, Scott-Tyler B, Trune DR (1997) Otitis media incidence and impact on the auditory brain stem response in lipopolysaccharide-nonresponsive C3H/HeJ mice. Otolaryngol Head Neck Surg 117:459-64
28. Miura Y, Miyake K, Yamashita Y, Shimazu R, Copeland NG, Gilbert DJ, Jenkins NA, Inazawa J, Abe T, Kimoto M (1996) Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64). Genomics 38:299-304
29. Miura Y, Shimazu R, Miyake K, Akashi S, Ogata H, Yamashita Y, Narisawa Y, Kimoto M (1998) RP105 is associated with MD-1 and transmits an activation signal in human B cells. Blood 92:2815-22
30. Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1994) Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. DNA Res 1:27-35
31. O'Brien AD, Rosenstreich DL, Scher I, Campbell GH, MacDermott RP, Formal SB (1980) Genetic control of susceptibility to Salmonella typhimurium in mice: Role of the LPS gene. J Immunol 124:20-4
32. Pfeiffer R (1892) Untersuchungen über das choleragift. Z Hygiene 11:393-412
33. Poltorak A, He X, Smirnova I, Liu M-Y, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg MA, Ricciardi-Castagnoli P, Layton B, Beutler B (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene. Science 282:2085-8
34. Poltorak A, Ricciardi-Castagnoli P, Citterio A, Beutler B (2000) Physical contact between LPS and Tlr4 revealed by genetic complementation. Proc Nat Acad Sci USA 97:2163-2167
35. Poltorak A, Smirnova I, Clisch R, Beutler B (2000) Limits of a deletion spanning Tlr4 in C57BL/10ScCr mice. J Endotoxin Res 6:51-56
36. Poltorak A, Smirnova I, He XL, Liu MY, Van Huffel C, McNally O, Birdwell D, Alejos E, Silva M, Du X, Thompson P, Chan EKL, Ledesma J, Roe B, Clifton S, Vogel SN, Beutler B (1998) Genetic and physical mapping of the Lps locus-identification of the toll-4 receptor as a candidate gene in the critical region. Blood Cells Molecules & Diseases 24:340-55
37. Rock FL, Hardiman G, Timans JC, Kastelein RA, Bazan JF (1998) A family of human receptors structurally related to Drosophila Toll. Proc Natl Acad Sci USA 95:588-93
38. Schromm AB, Lien E, Henneke P, Chow JC, Yoshimura A, Heine H, Latz E, Monks BG, Schwartz DA, Miyake K, Golenbock DT (2001) Molecular genetic analysis of an endotoxin nonresponder mutant cell line: A point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling. J Exp Med 194:79-88
39. Shimazu R, Akashi S, Ogata H, Nagai Y, Fukudome K, Miyake K, Kimoto M (1999) MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med 189:1777-1782
40. Taguchi T, Mitcham JL, Dower SK, Sims JE, Testa JR (1996) Chromosomal localization of TIL, a gene encoding a protein related to the Drosophila transmembrane receptor Toll, to human chromosome 4p14. Genomics 32:486-8
41. Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, Takeda K, Akira S (1999) Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components. Immunity 11:443-451
42. Tobias PS, Soldau K, Ulevitch RJ (1986) Isolation of a lipopolysaccharide-binding acute phase reactant from rabbit serum. J Exp Med 164:777-93
43. Watson J, Kelly K, Largen M, Taylor BA (1978) The genetic mapping of a defective LPS response gene in C3H/HeJ mice. J Immunol 120:422-4
44. Watson J, Riblet R, Taylor BA (1977) The response of recombinant inbred strains of mice to bacterial lipopolysaccharides. J Immunol 118:2088-93
45. Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC (1990) CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249:1431-3
46. Wright SD, Tobias PS, Ulevitch RJ, Ramos RA (1989) Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particle for recognition by a novel receptor on macrophages. J Exp Med 170:1231-41
47. Yang R-B, Mark MR, Gray A, Huang A, Xie MH, Zhang M, Goddard A, Wood WI, Gurney AL, Godowski PJ (1998) Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signaling. Nature 395:284-8
48. Yoshida S, Goto Y, Miyamoto H, Fujio H, Mizuguchi Y (1991) Association of Lps gene with natural resistance of mouse macrophages against Legionella pneumophila. FEMS Microbiol Immunol 4:51-6