Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium

Journal of Clinical Investigation

Volumn 104, Issue 3, 1999, Pages 271-280

  Frantz, Stefan ^a   Kobzik, Lester ^b   Kim, Young Dae ^a   Fukazawa, Ryuji ^a   Medzhitov, Ruslan ^c   Lee, Richard T ^a   Kelly, Ralph A ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1BETA; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ARTICLE; DROSOPHILA; HEART FAILURE; HEART MUSCLE CELL; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 0032701642     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI6709     Document Type: Article

References (46)

1. Kelly, R.A., Balligand, J.-L., and Smith, T.W. 1996. Nitric oxide and cardiac function. Circ. Res. 79:363-380.
2. Kelly, R.A., and Smith, T.W. 1997. Cytokines and cardiac contractile function [editorial]. Circulation. 95:778-781.
3. Meldrum, D.R. 1998. Tumor necrosis factor in the heart. Am. J. Physiol. 274:R577-R595.
4. Bristow, M.R. 1998. Tumor necrosis factor-α and cardiomyopathy. Circulation. 97:1340-1341.
5. Fearon, D.T. 1997. Seeking wisdom in innate immunity. Nature. 388:323-324.
6. Medzhitov, R., and Janeway, C.A., Jr. 1997. Innate immunity: the virtues of a nonclonal system of recognition. Cell. 91:295-298.
7. Ezekowitz, R.A.B., and Hoffman, J. 1998. Innate immunity. The blossoming of innate immunity. Curr. Opin. Immunol. 10:9-11.
8. Anderson, K. V. 1998. Pinning down positional information: dorsal-ventral polarity in the Drosophila embryo. Cell. 95:439-442.
9. Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J.M., and Hoffmann, J.A. 1996. The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell. 86:973-983.
10. Williams, M.J., Rodriguez, A., Kimbrell, D.A., and Eldon, E.D. 1997. The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense. EMBO J. 16:6120-6130.
11. Medzhitov, R., Preston-Hurlburt, P., and Janeway, C.A., Jr. 1997. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature. 388:394-397.
12. Rock, F.L., Hardiman, G., Timans, J.C., Kastelein, R.A., and Bazan, J.F. 1998. A family of human receptors structurally related to Drosophila Toll. Proc. Natl. Acad. Sci. USA. 95:588-593.
13. Gay, N.J., and Keith, F.J. 1991. Drosophila Toll and IL-1 receptor. Nature. 351:355-356.
14. Muzio, M., Natoli, G., Saccani, S., Levrero, M., and Mantovani, A. 1998. The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6). J. Exp. Med. 187:2097-2101.
15. Medzhitov, R., et al. 1998. MyD88 is an adapter protein in the hToll/IL-1 receptor family signaling pathways. Mol. Cell. 2:253-258.
16. Burns, K., et al. 1998. MyD88, an adapter protein involved in interleukin-1 signaling. J. Biol. Chem. 273:12203-12209.
17. Janeway, C.A., Jr. 1998. Presidential Address to the American Association of Immunologists. The road less traveled by: the role of innate immunity in the adaptive immune response. J. Immunol. 161:539-544.
18. Medzhitov, R., and Janeway, C.A., Jr. 1998. Self-defense: the fruit fly style. Proc. Natl. Acad. Sci. USA. 95:429-430.
19. Springhorn, J.P., Ellingsen, O., Berger, H.-J., Kelly, R.A., and Smith, T.W. 1992. Transcriptional regulation in cardiac muscle. Coordinate expression of Id with a neonatal phenorype during development and following a hypertrophic stimulus in adult rat ventricular myocytes in vitro. J. Biol. Chem. 267:14360-14365.
20. Ellingsen, O., et al. 1993. Adult rat ventricular myocytes cultured in defined medium: phenotype and electromechanical function. Am. J. Physiol. 265:H747-H754.
21. Nishida, M., et al. 1993. Isolation and characterization of human and rat cardiac microvascular endothelial cells. Am. J. Physiol. 264:H639-H652.
22. Michael, L.H., et al. 1995. Myocardial ischemia and reperfusion: a murine model. Am. J. Physiol. 269:H2147-H2154.
23. Chomczynski, P., and Sacchi, N. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
24. Balligand, J.-L., et al. 1995. Induction of NO synthase in rat cardiac microvascular endothelial cells by IL-1 beta and IFN-gamma. Am. J. Physiol. 268:H1293-H1303.
25. Arstall, M.A., and Kelly, R.A. 1998. The role of nitric oxide in ventricular dysfunction. J. Card. Fail. 3:249-260.
26. Kapadia, S.R., et al. 1997. Hemodynamic regulation of tumor necrosis factor-α gene and protein expression in adult feline myocardium. Circ. Res. 81:187-195.
27. Taylor, B.S., et al. 1998. Multiple NF-κB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene. J. Biol. Chem. 273:15148-15156.
28. Bryant, D., et al. 1998. Cardiac failure in transgenic mice with myocardial expression of tumor necrosis factor-α. Circulation. 97:1375-1381.
29. Kubota, T., et al. 1997. Dilated cardiomyopathy in transgenic mice with cardiac-specific overexpression of tumor necrosis factor-α. Circ. Res. 81:627-635.
30. de Beider, A.J., et al. 1993. Nitric oxide synthase activities in human myocardium. Lancet. 341:84-85.
31. Haywood, G.A., et al. 1996. Expression ofinducible nitric oxide synthase in human heart failure. Circulation. 93:1087-1094.
32. Habib, F.M., et al. 1996. Tumor necrosis factor and inducible nitric oxide synthase in dilated cardiomyopathy. Lancet. 347:1151-1155.
33. Satoh, M., et al. 1997. Inducible nitric oxide synthase and tumor necrosis factor-α in myocardium in human dilated cardiomyopathy. J. Am. Coll. Cardiol. 29:716-724.
34. Bottazzi, B., et al. 1997. Multimer formation and ligand recognition by the long pentraxin PTX3. Similarities and differences with the short pentraxins C-reactive protein and serum amyloid P component. J. Biol. Chem. 272:32817-32823.
35. Yasojima, K., Schwab, C., McGeer, E.G., and McGeer, P.L. 1998. Human heart generates complement proteins that are upregulated and activated after myocardial infarction. Circ. Res. 83:860-869.
36. Yasojima, K., Kilgore, K.S., Washington, R.A., Lucchesi, B.R., and McGeer, P.L. 1998. Complement gene expression by rabbit heart. Upregulation by ischemia and reperfusion. Circ. Res. 82:1224-1230.
37. Zhang, F.X., et al. 1999. Bacterial lipopolysaccharide activates nuclear factor-κB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes. J. Biol. Chem. 274:7611-7614.
38. Mizuguchi, K., Parker, J.S., Blundell, T.L., and Gay, N.J. 1998. Getting knotted: a model for the structure and activation of Spätzle. Trends Biochem. Sci. 23:239-242.
39. Yang, R.-B., et al. 1998. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signaling. Nature. 395:284-288.
40. Kirschning, C.J., Wesche, H., Ayres, T.M., and Rothe, M. 1998. Human Toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide. J. Exp. Med. 188:2091-2097.
41. Poltorak, A., et al. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science. 282:2085-2088.
42. Hoshino, K., et al. 1999. Cutting edge: toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162:3749-3752.
43. Savill, J. 1998. Phagocytic docking without shocking. Nature. 392:442-443.
44. Devitt, A., et al. 1998. Human CD14 mediates recognition and phagocytosis of apoptoticcells. Nature. 392:505-509.
45. Franc, N.C., Dimarz, J.-L., Lagueux, M., Hoffmann, J., and Ezekowitz, R.A.B. 1996. Croquemort, a novel Drosophila hemocyte/macrophage receptor that recognizes apoptotic cells. Immunity. 4:431-443.
46. Oka, K., et al. 1998. Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells. Proc. Natl. Acad. Sci. USA. 95:9535-9540.