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Hybridon signs research collaborations with leading medical institutions in Paris and Oslo to develop antisense therapies for asthma and cancer
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219076 Hybridon Inc PRESS RELEASE September 09
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219076 Hybridon signs research collaborations with leading medical institutions in Paris and Oslo to develop antisense therapies for asthma and cancer. Hybridon Inc PRESS RELEASE 1996 September 09
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(1996)
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0035997957
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Towards optimal design of second-generation immunomodulatory oligonucleotides
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449162
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449162 Towards optimal design of second-generation immunomodulatory oligonucleotides. Kandimalla ER, Yu D, Agrawal S CURR OPIN MOL THER 2002 4 2 122-129
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(2002)
Curr. Opin. Mol. Ther.
, vol.4
, Issue.2
, pp. 122-129
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Kandimalla, E.R.1
Yu, D.2
Agrawal, S.3
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3
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33644481454
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Hybridon's DNA molecules are potent immunomodulators
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465215 Hybridon Inc PRESS RELEASE September 26
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465215 Hybridon's DNA molecules are potent immunomodulators. Hybridon Inc PRESS RELEASE 2002 September 26
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(2002)
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Presentation given by Hybridon at the BIO CEO & Investor conference in New York
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481040 Hybridon Inc COMPANY PRESENTATION 2003 February 27
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481040 Presentation given by Hybridon at the BIO CEO & Investor conference in New York. Hybridon Inc COMPANY PRESENTATION 2003 February 27
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5
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33644482232
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Hybridon shows activity of IMOs in allergic asthma
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481557 Hybridon Inc PRESS RELEASE March 11
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481557 Hybridon shows activity of IMOs in allergic asthma. Hybridon Inc PRESS RELEASE 2003 March 11
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(2003)
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33644484111
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HYB-2055 to enter cancer trials
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484673 Hybridon Inc COMPANY COMMUNICATION April 04
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484673 HYB-2055 to enter cancer trials. Hybridon Inc COMPANY COMMUNICATION 2003 April 04
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(2003)
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33644484694
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Novel synthetic immunomodulatory oligonucleotides (IMO): Antitumor activity, chemosensitization, and pharmacokinetics
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485278 Abs 2838
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485278 Novel synthetic immunomodulatory oligonucleotides (IMO): Antitumor activity, chemosensitization, and pharmacokinetics. Wang H, Dubuisson J, Huang P, Kandimalla ER, Yu D, Agrawal S, Zhang R PROC AM ASSOC CANCER RES 2003 44 Abs 2838
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(2003)
Proc. Am. Assoc. Cancer Res.
, vol.44
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Wang, H.1
Dubuisson, J.2
Huang, P.3
Kandimalla, E.R.4
Yu, D.5
Agrawal, S.6
Zhang, R.7
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8
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33644493950
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Hybridon's immunomodulatory agent enters the clinic
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490212 Hybridon Inc PRESS RELEASE May 19
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490212 Hybridon's immunomodulatory agent enters the clinic. Hybridon Inc PRESS RELEASE 2003 May 19
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(2003)
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9
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0036219195
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CpG motifs in bacterial DNA and their immune effects
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493652
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493652 CpG motifs in bacterial DNA and their immune effects. Krieg AM ANNU REV IMMUNOL 2002 20 709-760
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(2002)
Annu. Rev. Immunol.
, vol.20
, pp. 709-760
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Krieg, A.M.1
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10
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0034043957
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CpG oligonucleotides are potent adjuvants for the activation of autoreactive encephalitogenic T cells in vivo
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493654
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493654 CpG oligonucleotides are potent adjuvants for the activation of autoreactive encephalitogenic T cells in vivo. Segal BM, Chang JT, Shevach EM J IMMUNOL 2000 164 11 5683-5688
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J. Immunol.
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Segal, B.M.1
Chang, J.T.2
Shevach, E.M.3
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11
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33644480141
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The Immune Response Corporation evaluates a second-generation HIV vaccine candidate incorporating Hybridon's immunomodulatory oligonucleotide technology
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496379 Immune Response Corp PRESS RELEASE July 09
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496379 The Immune Response Corporation evaluates a second-generation HIV vaccine candidate incorporating Hybridon's immunomodulatory oligonucleotide technology. Immune Response Corp PRESS RELEASE 2003 July 09
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(2003)
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Hybridon presents preclinical data showing immunological and antitumor activity of novel synthetic immunomodulatory oligonucleotides
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497303 Hybridon Inc PRESS RELEASE July 15
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497303 Hybridon presents preclinical data showing immunological and antitumor activity of novel synthetic immunomodulatory oligonucleotides. Hybridon Inc PRESS RELEASE 2003 July 15
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(2003)
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Immunomodulatory oligodeoxynucleotides containing CpG and synthetic YpG, CpR, and YpR motifs induce strong innate immune responses and mediate potent antitumor activity in nude mice bearing tumor xenografts
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497998 Abs 6462
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497998 Immunomodulatory oligodeoxynucleotides containing CpG and synthetic YpG, CpR, and YpR motifs induce strong innate immune responses and mediate potent antitumor activity in nude mice bearing tumor xenografts. Kandimalla ER, Yu D, Bhagat L, Tang J, Wang H, Zhang R, Yang M, Wang J, Hoffman RM, Agrawal S PROC AM ASSOC CANCER RES 2003 44 Abs 6462
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(2003)
Proc. Am. Assoc. Cancer Res.
, vol.44
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Kandimalla, E.R.1
Yu, D.2
Bhagat, L.3
Tang, J.4
Wang, H.5
Zhang, R.6
Yang, M.7
Wang, J.8
Hoffman, R.M.9
Agrawal, S.10
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14
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Hybridon's second-generation immunomodulatory oligonucleotides prevent development of allergic asthma in mouse models in preclinical studies
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504597 Hybridon Inc PRESS RELEASE September 11
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504597 Hybridon's second-generation immunomodulatory oligonucleotides prevent development of allergic asthma in mouse models in preclinical studies. Hybridon Inc PRESS RELEASE 2003 September 11
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(2003)
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Immune Response licenses Amplivax for HIV vaccine development
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508192 Immune Response Corp PRESS RELEASE October 09
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508192 Immune Response licenses Amplivax for HIV vaccine development. Immune Response Corp PRESS RELEASE 2003 October 09
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(2003)
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World Allergy Organization - XVIII ICACI
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510112 Vancouver, Canada. Iddb author IDDB MEETING REPORT September 07-12
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510112 World Allergy Organization - XVIII ICACI (Part I), Vancouver, Canada. Iddb author IDDB MEETING REPORT 2003 September 07-12
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Self-stabilized CpG DNAs optimally activate human B cells and plasmacytoid dendritic cells
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511707
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511707 Self-stabilized CpG DNAs optimally activate human B cells and plasmacytoid dendritic cells. Cong YP, Song SS, Bhagat L, Pandey RK, Yu D, Kandimalla ER, Agrawal S BIOCHEM BIOPHYS RES COMMUN 2003 310 4 1133-1139
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(2003)
Biochem. Biophys. Res. Commun.
, vol.310
, Issue.4
, pp. 1133-1139
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Cong, Y.P.1
Song, S.S.2
Bhagat, L.3
Pandey, R.K.4
Yu, D.5
Kandimalla, E.R.6
Agrawal, S.7
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18
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0036090792
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Medicinal chemistry and therapeutic potential of CpG DNA
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515022
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515022 Medicinal chemistry and therapeutic potential of CpG DNA. Agrawal S, Kandimalla ER TRENDS MOL MED 2002 8 3 114-121
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Trends Mol. Med.
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Agrawal, S.1
Kandimalla, E.R.2
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33644484928
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A phase I placebo-controlled study in volunteers of escalating doses of HYB2055, a second-generation immunomodulatory agent based on CpG DNA
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515312 Abs C100
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515312 A phase I placebo-controlled study in volunteers of escalating doses of HYB2055, a second-generation immunomodulatory agent based on CpG DNA. Martin R, Sullivan T, Bhagat L, Kandimalla E, Wang D, Zhao Q, Burton C, Bryson P, Ng T, Binney S, Handy L, Agrawal S CLIN CANCER RES 2003 9 16 Suppl 1 Abs C100
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(2003)
Clin. Cancer Res.
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Martin, R.1
Sullivan, T.2
Bhagat, L.3
Kandimalla, E.4
Wang, D.5
Zhao, Q.6
Burton, C.7
Bryson, P.8
Ng, T.9
Binney, S.10
Handy, L.11
Agrawal, S.12
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20
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33644493294
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HYB-2055, a novel immunomodulatory oligonucleotide induces potent innate and adaptive immune responses and shows broad spectrum antitumor activity in murine syngeneic tumor models
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515313 Abs C101
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515313 HYB-2055, a novel immunomodulatory oligonucleotide induces potent innate and adaptive immune responses and shows broad spectrum antitumor activity in murine syngeneic tumor models. Wang D, Li Y, Yu D, Kandimalla ER, Agrawal S CLIN CANCER RES 2003 9 16 Suppl 1 Abs C101
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(2003)
Clin. Cancer Res.
, vol.9
, Issue.16 SUPPL. 1
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Wang, D.1
Li, Y.2
Yu, D.3
Kandimalla, E.R.4
Agrawal, S.5
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21
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20344389073
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A phase I study of a second-generation immunomodulatory oligonucleotide (HYB2055) in patients with advanced solid malignancies
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515314 Abs C111
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515314 A phase I study of a second-generation immunomodulatory oligonucleotide (HYB2055) in patients with advanced solid malignancies. Hwang JJ, Martin R, Fox-Sinclair ES, Bahrani A, Sullivan T, Park S, Agrawal S, Burns T, Waxdal M, Marshall JL CLIN CANCER RES 2003 9 16 Suppl 1 Abs C111
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(2003)
Clin. Cancer Res.
, vol.9
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Hwang, J.J.1
Martin, R.2
Fox-Sinclair, E.S.3
Bahrani, A.4
Sullivan, T.5
Park, S.6
Agrawal, S.7
Burns, T.8
Waxdal, M.9
Marshall, J.L.10
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22
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Preclinical antitumor evaluation of a second-generation immunomodulatory oligonucleotide (IMO), HYB2055, alone and in combination with taxotere and gemcitabine
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515315 Abs C115
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515315 Preclinical antitumor evaluation of a second-generation immunomodulatory oligonucleotide (IMO), HYB2055, alone and in combination with taxotere and gemcitabine. Wang H, Huang P, Kandimalla ER, Yu D, Agrawal S, Zhang R CLIN CANCER RES 2003 9 16 Suppl 1 Abs C115
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Clin. Cancer Res.
, vol.9
, Issue.16 SUPPL. 1
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Wang, H.1
Huang, P.2
Kandimalla, E.R.3
Yu, D.4
Agrawal, S.5
Zhang, R.6
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23
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A dinucleotide motif in oligonucleotides shows potent immunomodulatory activity and overrides species-specific recognition observed with CpG motif
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515808
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515808 A dinucleotide motif in oligonucleotides shows potent immunomodulatory activity and overrides species-specific recognition observed with CpG motif. Kandimalla ER, Bhagat L, Zhu FG, Yu D, Cong YP, Wang D, Tang JX, Tang JY, Knetter CF, Lien E, Agrawal S PROC NATL ACAD SCI USA 2003 100 24 14303-14308
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(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
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Kandimalla, E.R.1
Bhagat, L.2
Zhu, F.G.3
Yu, D.4
Cong, Y.P.5
Wang, D.6
Tang, J.X.7
Tang, J.Y.8
Knetter, C.F.9
Lien, E.10
Agrawal, S.11
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24
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Hybridon second-generation IMO's show potential for asthma
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528469 Hybridon Inc PRESS RELEASE March 23
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528469 Hybridon second-generation IMO's show potential for asthma. Hybridon Inc PRESS RELEASE 2004 March 23
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(2004)
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Hybridon presents preclinical data demonstrating 2nd-generation immunomodulatory oligonucleotides inhibit tumor growth alone and in combination with Herceptin and Rituxan
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529604 Hybridon Inc PRESS RELEASE March 30
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529604 Hybridon presents preclinical data demonstrating 2nd-generation immunomodulatory oligonucleotides inhibit tumor growth alone and in combination with Herceptin and Rituxan. Hybridon Inc PRESS RELEASE 2004 March 30
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(2004)
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Hybridon successfully completes phase I healthy volunteer trial of HYB2055, its lead 2nd-generation immunomodulatory oligonucleotide
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529909 Hybridon Inc PRESS RELEASE March 31
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529909 Hybridon successfully completes phase I healthy volunteer trial of HYB2055, its lead 2nd-generation immunomodulatory oligonucleotide. Hybridon Inc PRESS RELEASE 2004 March 31
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(2004)
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Immunological activity of HYB2055, a TLR-9 agonist, in healthy volunteers
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530551 Abs 4707
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530551 Immunological activity of HYB2055, a TLR-9 agonist, in healthy volunteers. Sullivan T, Bhagat L, Kandimalla E, Martin R, Wang D, Zhao Q, Handy L, Binney S, Burton C, Bryson P, Ng T, Agrawal S PROC AM ASSOC CANCER RES 2004 45 Abs 4707
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(2004)
Proc. Am. Assoc. Cancer Res.
, vol.45
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Sullivan, T.1
Bhagat, L.2
Kandimalla, E.3
Martin, R.4
Wang, D.5
Zhao, Q.6
Handy, L.7
Binney, S.8
Burton, C.9
Bryson, P.10
Ng, T.11
Agrawal, S.12
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A phase I study of HYB2055 in patients (pts) with advanced solid malignancies
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545444 Abs 3111
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545444 A phase I study of HYB2055 in patients (pts) with advanced solid malignancies. Hwang JJ, Park S, Amin A, Martin RR, Sullivan T, Burns T, Agrawal S, Waxdal MJ, Malik S, Marshall JL PROC AM SOC CLIN ONCOL 2004 23 Abs 3111
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Proc. Am. Soc. Clin. Oncol.
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Hwang, J.J.1
Park, S.2
Amin, A.3
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Agrawal, S.7
Waxdal, M.J.8
Malik, S.9
Marshall, J.L.10
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Positive Phase I Results for Hybridon's anticancer oligo
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572029 Hybridon Inc PRESS RELEASE November 22
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572029 Positive phase I results for Hybridon's anticancer oligo. Hybridon Inc PRESS RELEASE 2004 November 22
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(2004)
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Modulation of toll-like receptor 9 responses through synthetic immunostimulatory motifs of DNA
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572083
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572083 Modulation of toll-like receptor 9 responses through synthetic immunostimulatory motifs of DNA. Agrawal S, Kandimalla ER ANN NY ACAD SCI 2003 1002 30-42
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Ann. NY Acad. Sci.
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572095 Secondary structures in CpG oligonucleotides affect immunostimulatory activity. Kandimalla ER, Bhagat L, Cong YP, Pandey RK, Yu D, Zhao Q, Agrawal S BIOCHEM BIOPHYS RES COMMUN 2003 306 4 948-953
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Biochem. Biophys. Res. Commun.
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Yu, D.5
Zhao, Q.6
Agrawal, S.7
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Immunomodulatory oligonucleotides containing CpR and RpG dinucleotide motifs augment long-term immune responses to HBsAg
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572106 Abs 558.14
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572106 Immunomodulatory oligonucleotides containing CpR and RpG dinucleotide motifs augment long-term immune responses to HBsAg. Li Y, Fugang Z, Kandimalla E, Agrawal S FASEB J 2004 18 4-5 Abs 558.14
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FASEB J.
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572108 Novel immunomodulatory oligonucleotides prevent development of allergic airway inflammation and airway hyperresponsiveness in asthma. Agrawal DK, Edwan J, Kandimalla ER, Yu D, Bhagat L, Wang D, Agrawal S INT IMMUNOPHARMACOL 2004 18 4-5 Abs 558.14
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Int. Immunopharmacol.
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Agrawal, S.7
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572135 Modulation of ovalbumin-induced Th2 responses by second-generation immunomodulatory oligonucleotides in mice. Zhu FG, Kandimalla ER, Yu D, Tang JX, Agrawal S INTERNATIONAL IMMUNOPHARMACOLOGY 2004 4 7 851-862
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International Immunopharmacology
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Hybridon's TLR-9 agonist shows preclinical promise
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588111 Hybridon Inc PRESS RELEASE March 03
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588111 Hybridon's TLR-9 agonist shows preclinical promise. Hybridon Inc PRESS RELEASE 2005 March 03
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(2005)
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A second-generation immunomodulatory oligonucleotide agonist of TLR9 shows antitumor activity and enhances effects of chemotherapy, radiation and antibody therapy in vitro and in vivo
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Zhang, R.9
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Hybridon announces oral presentation of results for phase I trial of IMOxine at ASCO 2005
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601414 Hybridon Inc PRESS RELEASE May 16
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601414 Hybridon announces oral presentation of results for phase I trial of IMOxine at ASCO 2005. Hybridon Inc PRESS RELEASE 2005 May 16
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(2005)
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