-
1
-
-
14644440800
-
The genetic basis of cancer of kidney cancer: Implications for gene-specific clinical management
-
Linehan WM, Grubb RL, Coleman JA, et al: The genetic basis of cancer of kidney cancer: implications for gene-specific clinical management BJU Int 2005;95(suppl 2):2-7.
-
(2005)
BJU Int
, vol.95
, Issue.2 SUPPL.
, pp. 2-7
-
-
Linehan, W.M.1
Grubb, R.L.2
Coleman, J.A.3
-
2
-
-
2342583527
-
Searching for the hereditary causes of renal-cell carcinoma
-
Pavlovich CP, Schmidt LS: Searching for the hereditary causes of renal-cell carcinoma. Nat Rev Cancer 2004;4:381-393.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 381-393
-
-
Pavlovich, C.P.1
Schmidt, L.S.2
-
3
-
-
33644838854
-
Genetic alterations and histopathologic findings in familial renal cell carcinoma
-
Hansel DE: Genetic alterations and histopathologic findings in familial renal cell carcinoma. Histol Histopathol 2006;21:437-444.
-
(2006)
Histol Histopathol
, vol.21
, pp. 437-444
-
-
Hansel, D.E.1
-
4
-
-
0026057382
-
Nonhomologous chromatid exchange in hereditary and sporadic renal cell carcinomas
-
USA
-
Kovacs G, Kung HF: Nonhomologous chromatid exchange in hereditary and sporadic renal cell carcinomas. Proc Natl Acad Sci USA 1991;88:194-198.
-
(1991)
Proc Natl Acad Sci
, vol.88
, pp. 194-198
-
-
Kovacs, G.1
Kung, H.F.2
-
5
-
-
0030983281
-
Involvement of multiple loci on chromosome 3 in renal cell cancer development
-
Van den Berg A, Buys CHCM: Involvement of multiple loci on chromosome 3 in renal cell cancer development. Genes Chromosomes Cancer 1997;19:59-76.
-
(1997)
Genes Chromosomes Cancer
, vol.19
, pp. 59-76
-
-
Van Den Berg, A.1
Buys, C.H.C.M.2
-
6
-
-
0034624697
-
Combined LOH/CGH analysis proves the existence of interstitial 3p deletions in renal cell carcinoma
-
Alimov A, Kost-Alimova M, Liu J, et al: Combined LOH/CGH analysis proves the existence of interstitial 3p deletions in renal cell carcinoma. Oncogene 2000;19:1392-1399.
-
(2000)
Oncogene
, vol.19
, pp. 1392-1399
-
-
Alimov, A.1
Kost-Alimova, M.2
Liu, J.3
-
7
-
-
0015043748
-
Mutation and cancer: Statistical study of retinoblastoma
-
USA
-
Knudson AG: Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA 1971;68:820-823.
-
(1971)
Proc Natl Acad Sci
, vol.68
, pp. 820-823
-
-
Knudson, A.G.1
-
8
-
-
0026080061
-
Cytogenetics of renal cell carcinomas associated with von Hippel-Lindau disease
-
Kovacs G, Emanuel A, Neumann HP, et al: Cytogenetics of renal cell carcinomas associated with von Hippel-Lindau disease. Genes Chromosomes Cancer 1991;3:256-262.
-
(1991)
Genes Chromosomes Cancer
, vol.3
, pp. 256-262
-
-
Kovacs, G.1
Emanuel, A.2
Neumann, H.P.3
-
9
-
-
0027954044
-
Mutations of the VHL tumour suppressor gene in renal carcinoma
-
Gnarra JR, Tory K, Weng Y, et al: Mutations of the VHL tumour suppressor gene in renal carcinoma. Nat Genet 1994;7:85-90.
-
(1994)
Nat Genet
, vol.7
, pp. 85-90
-
-
Gnarra, J.R.1
Tory, K.2
Weng, Y.3
-
10
-
-
0030992453
-
Familial non-VHL non-papillary clear-cell renal cancer
-
Teh BT, Giraud S, Sari NF, et al: Familial non-VHL non-papillary clear-cell renal cancer. Lancet 1997;349:848-849.
-
(1997)
Lancet
, vol.349
, pp. 848-849
-
-
Teh, B.T.1
Giraud, S.2
Sari, N.F.3
-
11
-
-
0034026499
-
Familial clear cell renal cell carcinoma (FCRC): Clinical features and mutation analysis of the VHL, MET, and CUL2 candidate genes
-
Woodward ER, Clifford SC, Astuti D, et al: Familial clear cell renal cell carcinoma (FCRC): clinical features and mutation analysis of the VHL, MET, and CUL2 candidate genes. J Med Genet 2000;37:348-353.
-
(2000)
J Med Genet
, vol.37
, pp. 348-353
-
-
Woodward, E.R.1
Clifford, S.C.2
Astuti, D.3
-
12
-
-
0034116801
-
Role of chromosome 3p12-p21 tumour suppressor genes in clear cell renal cell carcinoma: Analysis of VHL dependent and VHL independent pathways of tumorigenesis
-
Martinez A, Fullwood P, Kishida T, et al: Role of chromosome 3p12-p21 tumour suppressor genes in clear cell renal cell carcinoma: analysis of VHL dependent and VHL independent pathways of tumorigenesis. Mol Pathol 2000;53:137-144.
-
(2000)
Mol Pathol
, vol.53
, pp. 137-144
-
-
Martinez, A.1
Fullwood, P.2
Kishida, T.3
-
13
-
-
0032529647
-
Physical and functional mapping of a tumor suppressor locus for renal cell carcinoma within chromosome 3q12
-
Lott ST, Lovell M, Naylor SL, et al: Physical and functional mapping of a tumor suppressor locus for renal cell carcinoma within chromosome 3q12. Cancer Res 1998;58:3533-3537.
-
(1998)
Cancer Res
, vol.58
, pp. 3533-3537
-
-
Lott, S.T.1
Lovell, M.2
Naylor, S.L.3
-
14
-
-
0033568344
-
Novel tumor suppressor locus in human chromosome region 3p14.2
-
Jülicher K, Marquitan G, Werner N, et al: Novel tumor suppressor locus in human chromosome region 3p14.2. J Natl Cancer Inst 1999;91:1563-1568.
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 1563-1568
-
-
Jülicher, K.1
Marquitan, G.2
Werner, N.3
-
15
-
-
0033135042
-
The genetic locus NRC-1 within chromosome 3p12 mediates tumor suppression in renal cell carcinoma independently of histological type, tumor microenvironment, and VHL mutation
-
Lovell M, Lott ST, Wong P, et al: The genetic locus NRC-1 within chromosome 3p12 mediates tumor suppression in renal cell carcinoma independently of histological type, tumor microenvironment, and VHL mutation. Cancer Res 1999;59:2182-2189.
-
(1999)
Cancer Res
, vol.59
, pp. 2182-2189
-
-
Lovell, M.1
Lott, S.T.2
Wong, P.3
-
16
-
-
0033990876
-
Loss of expression of the DDR1 gene at chromosome segment 3p21.1 in renal cell carcinoma
-
Wang L, Darling J, Zhang JS, et al: Loss of expression of the DDR1 gene at chromosome segment 3p21.1 in renal cell carcinoma. Genes Chromosomes Cancer 2000;27:1-10.
-
(2000)
Genes Chromosomes Cancer
, vol.27
, pp. 1-10
-
-
Wang, L.1
Darling, J.2
Zhang, J.S.3
-
17
-
-
0035912820
-
Candidate TSG, RASSF1A, from human chromosome 3p21.3 is involved in kidney tumorigenesis
-
USA
-
Dreijerink K, Braga E, Kuzmin I, et al: Candidate TSG, RASSF1A, from human chromosome 3p21.3 is involved in kidney tumorigenesis. Proc Natl Acad Sci USA 2001;98:7504-7509.
-
(2001)
Proc Natl Acad Sci
, vol.98
, pp. 7504-7509
-
-
Dreijerink, K.1
Braga, E.2
Kuzmin, I.3
-
18
-
-
0035795676
-
Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression
-
Burbee DG, Forgacs E, Zöchbauer-Müller S, et al: Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression. J Natl Cancer Inst 2001;93:691-699.
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 691-699
-
-
Burbee, D.G.1
Forgacs, E.2
Zöchbauer-Müller, S.3
-
19
-
-
0033168833
-
Transforming growth factor-beta type II receptor confers tumor suppressor activity in murine renal carcinoma (renca) cells
-
Engel JD, Kundu SD, Yang T, et al: Transforming growth factor-beta type II receptor confers tumor suppressor activity in murine renal carcinoma (renca) cells. Urology 1999;54:164-170.
-
(1999)
Urology
, vol.54
, pp. 164-170
-
-
Engel, J.D.1
Kundu, S.D.2
Yang, T.3
-
20
-
-
0030918629
-
Acquisition of TGF-beta 1 resistance: An important progression factor in human renal cell carcinoma
-
Ramp U, Jaquet K, Reinecke P, et al: Acquisition of TGF-beta 1 resistance: an important progression factor in human renal cell carcinoma. Lab Invest 1997;76:739-739.
-
(1997)
Lab Invest
, vol.76
, pp. 739-739
-
-
Ramp, U.1
Jaquet, K.2
Reinecke, P.3
-
21
-
-
0141974555
-
Absence of expression of transforming growth factor-beta type II receptor is associated with an aggressive growth pattern in a murine renal carcinoma cell line, Renca
-
Kundu SD, Kim IY, Zelner D, et al: Absence of expression of transforming growth factor-beta type II receptor is associated with an aggressive growth pattern in a murine renal carcinoma cell line, Renca. J Urol 1998;160:1883-1888.
-
(1998)
J Urol
, vol.160
, pp. 1883-1888
-
-
Kundu, S.D.1
Kim, I.Y.2
Zelner, D.3
-
22
-
-
0035028286
-
Transforming growth factor-beta pathway in human renal cell carcinoma and surrounding normal-appearing renal parenchyma
-
Cardillo MR, Lazzereschi D, Gandini O, et al: Transforming growth factor-beta pathway in human renal cell carcinoma and surrounding normal-appearing renal parenchyma. Anal Quant Cytol Histol 2001;23:109-117.
-
(2001)
Anal Quant Cytol Histol
, vol.23
, pp. 109-117
-
-
Cardillo, M.R.1
Lazzereschi, D.2
Gandini, O.3
-
23
-
-
0033911180
-
Elevated plasma TGF-beta1 in renal disease: Cause or consequence?
-
Junker U, Haufe CC, Nuske K, et al: Elevated plasma TGF-beta1 in renal disease: cause or consequence? Cytokine 2000;12:1084-1091.
-
(2000)
Cytokine
, vol.12
, pp. 1084-1091
-
-
Junker, U.1
Haufe, C.C.2
Nuske, K.3
-
24
-
-
0034282782
-
Alterations of the DNA repair gene OGG1 in human clear cell carcinomas of the kidney
-
Audebert M, Chevillard S, Levalois C, et al: Alterations of the DNA repair gene OGG1 in human clear cell carcinomas of the kidney. Cancer Res 2000;60:4740-4744.
-
(2000)
Cancer Res
, vol.60
, pp. 4740-4744
-
-
Audebert, M.1
Chevillard, S.2
Levalois, C.3
-
26
-
-
0034660401
-
The tcf17 gene at chromosome 5q is not involved in the development of conventional renal cell carcinoma
-
Bugert P, Pesti T, Kovacs G: The tcf17 gene at chromosome 5q is not involved in the development of conventional renal cell carcinoma. Int J Cancer 2000;86:806-810.
-
(2000)
Int J Cancer
, vol.86
, pp. 806-810
-
-
Bugert, P.1
Pesti, T.2
Kovacs, G.3
-
27
-
-
0034009646
-
Molecular cytogenetic analysis of 17 renal cancer cell lines: Increased copy number at 5q31-33 in cell lines from nonpapillary carcinomas
-
Yang ZQ, Yoshida MA, Fukuda Y, et al: Molecular cytogenetic analysis of 17 renal cancer cell lines: increased copy number at 5q31-33 in cell lines from nonpapillary carcinomas. Jpn J Cancer Res 2000;91:156-163.
-
(2000)
Jpn J Cancer Res
, vol.91
, pp. 156-163
-
-
Yang, Z.Q.1
Yoshida, M.A.2
Fukuda, Y.3
-
28
-
-
1542615083
-
p53 Pathway in renal cell carcinoma is repressed by a dominant mechanism
-
Gurova KV, Hill JE, Razorenova OV, et al: p53 Pathway in renal cell carcinoma is repressed by a dominant mechanism. Cancer Res 2004;64:1951-1958.
-
(2004)
Cancer Res
, vol.64
, pp. 1951-1958
-
-
Gurova, K.V.1
Hill, J.E.2
Razorenova, O.V.3
-
29
-
-
0041566451
-
Molecular genetics of renal cell carcinoma
-
Vogelzang NJ, Scardino PT, Shipley WU, Coffey DS (eds): Philadelphia, Lippincott, Williams & Wilkins
-
Walther MM, Enquist EG, Jennings SB, et al: Molecular genetics of renal cell carcinoma; in Vogelzang NJ, Scardino PT, Shipley WU, Coffey DS (eds): Comprehensive Textbook of Genitourinary Oncology, ed 2. Philadelphia, Lippincott, Williams & Wilkins, 2000, pp 116-128.
-
(2000)
Comprehensive Textbook of Genitourinary Oncology, Ed 2
, pp. 116-128
-
-
Walther, M.M.1
Enquist, E.G.2
Jennings, S.B.3
-
30
-
-
0026596436
-
Mutations in the ras protooncogenes are rare events in renal cell cancer
-
Rochlitz CF, Peter S, Wiliroth G, et al: Mutations in the ras protooncogenes are rare events in renal cell cancer. Eur J Cancer 1992;28:333-336.
-
(1992)
Eur J Cancer
, vol.28
, pp. 333-336
-
-
Rochlitz, C.F.1
Peter, S.2
Wiliroth, G.3
-
31
-
-
0036007743
-
Gene amplification and over expression of HER2 in renal cell carcinoma
-
Latif Z, Waters AD, Bartlett JMS, et al: Gene amplification and over expression of HER2 in renal cell carcinoma. BJU Int 2002;89:5-9.
-
(2002)
BJU Int
, vol.89
, pp. 5-9
-
-
Latif, Z.1
Waters, A.D.2
Bartlett, J.M.S.3
-
32
-
-
0024399829
-
Correlation of c-myc expression with nuclear pleomorphism in human renal cell carcinoma
-
Kinouchi T, Saiki S, Naoe T, et al: Correlation of c-myc expression with nuclear pleomorphism in human renal cell carcinoma. Cancer Res 1989;49:3627-3630.
-
(1989)
Cancer Res
, vol.49
, pp. 3627-3630
-
-
Kinouchi, T.1
Saiki, S.2
Naoe, T.3
-
33
-
-
0021320926
-
Expression of cellular oncogenes in human malignancies
-
Slamon DJ, deKernion JB, Verma IM, et al: Expression of cellular oncogenes in human malignancies. Science 1984;224:256-262.
-
(1984)
Science
, vol.224
, pp. 256-262
-
-
Slamon, D.J.1
Dekernion, J.B.2
Verma, I.M.3
-
34
-
-
0026800751
-
Epidermal growth factor and transforming growth factor alpha stimulate or inhibit proliferation of a human renal adenocarcinoma cell line depending on cell status: Differentiation of the two pathways by G protein involvement
-
Argiles A, Kraft N, Ootaka T, et al: Epidermal growth factor and transforming growth factor alpha stimulate or inhibit proliferation of a human renal adenocarcinoma cell line depending on cell status: differentiation of the two pathways by G protein involvement. Cancer Res 1992;52:4356-4560.
-
(1992)
Cancer Res
, vol.52
, pp. 4356-4560
-
-
Argiles, A.1
Kraft, N.2
Ootaka, T.3
-
35
-
-
0025323946
-
Modulation of pro-epidermal growth factor, pro-transforming growth factor alpha and epidermal growth factor receptor gene expression in human renal carcinomas
-
Petrides PE, Bock S, Bovens J, Hofmann R, Jakse G: Modulation of pro-epidermal growth factor, pro-transforming growth factor alpha and epidermal growth factor receptor gene expression in human renal carcinomas. Cancer Res 1990;50:3934-3939.
-
(1990)
Cancer Res
, vol.50
, pp. 3934-3939
-
-
Petrides, P.E.1
Bock, S.2
Bovens, J.3
Hofmann, R.4
Jakse, G.5
-
36
-
-
0026752792
-
Growth regulation of human renal carcinoma cells: Role of transforming growth factor alpha
-
Atlas I, Mendelsohn J, Baselga J, et al: Growth regulation of human renal carcinoma cells: role of transforming growth factor alpha. Cancer Res 1992;52:3335-3339.
-
(1992)
Cancer Res
, vol.52
, pp. 3335-3339
-
-
Atlas, I.1
Mendelsohn, J.2
Baselga, J.3
-
37
-
-
0025030976
-
Epidermal growth factor receptor gene analysis in renal cell carcinoma
-
Gomella LG, Anglard P, Sargent ER, et al: Epidermal growth factor receptor gene analysis in renal cell carcinoma. J Urol 1990;143:191-193.
-
(1990)
J Urol
, vol.143
, pp. 191-193
-
-
Gomella, L.G.1
Anglard, P.2
Sargent, E.R.3
-
38
-
-
0035852630
-
Role of transforming growth factor-α in von Hippel-Lindau (VHL) (-/-) clear cell renal carcinoma cell proliferation: A possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis
-
USA
-
De Paulsen N, Brychzy A, Fournier MC, et al: Role of transforming growth factor-α in von Hippel-Lindau (VHL) (-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis. Proc Natl Acad Sci USA 2001;98:1387-1392.
-
(2001)
Proc Natl Acad Sci
, vol.98
, pp. 1387-1392
-
-
De Paulsen, N.1
Brychzy, A.2
Fournier, M.C.3
-
39
-
-
0026550760
-
Truncated fibronectin. An autologous growth-promoting substance secreted by renal carcinoma cells
-
Kochevar GJ, Stanek JA, Rucker EB: Truncated fibronectin. An autologous growth-promoting substance secreted by renal carcinoma cells. Cancer 1992;69:2311-2315.
-
(1992)
Cancer
, vol.69
, pp. 2311-2315
-
-
Kochevar, G.J.1
Stanek, J.A.2
Rucker, E.B.3
-
40
-
-
0028121002
-
Hepatocyte growth factor elevates the activity levels of glycolipid sulfotransferases in renal cell carcinoma cells
-
Kobayashi T, Honke K, Gasa S, et al: Hepatocyte growth factor elevates the activity levels of glycolipid sulfotransferases in renal cell carcinoma cells. Eur J Biochem 1994;219:407-413.
-
(1994)
Eur J Biochem
, vol.219
, pp. 407-413
-
-
Kobayashi, T.1
Honke, K.2
Gasa, S.3
-
41
-
-
0026785102
-
Secretion of autocrine growth-promoting activity by renal-carcinoma cells treated with 5-fluorouracil
-
Nishimura N, Kanda S, Yogi Y, et al: Secretion of autocrine growth-promoting activity by renal-carcinoma cells treated with 5-fluorouracil. Int J Cancer 1992;52:105-109.
-
(1992)
Int J Cancer
, vol.52
, pp. 105-109
-
-
Nishimura, N.1
Kanda, S.2
Yogi, Y.3
-
42
-
-
0026077975
-
End stage renal disease serum contains a specific renal cell growth factor
-
Klotz LH, Kulkarni C, Mills G: End stage renal disease serum contains a specific renal cell growth factor. J Urol 1991;145:156-160.
-
(1991)
J Urol
, vol.145
, pp. 156-160
-
-
Klotz, L.H.1
Kulkarni, C.2
Mills, G.3
-
44
-
-
0034949144
-
Morphologic typing of papillary renal cell carcinoma: Comparison of growth kinetics and patient survival in 66 cases
-
Delahunt B, Eble JN, McCredie MR, et al: Morphologic typing of papillary renal cell carcinoma: comparison of growth kinetics and patient survival in 66 cases. Hum Pathol 2001;32:590-595.
-
(2001)
Hum Pathol
, vol.32
, pp. 590-595
-
-
Delahunt, B.1
Eble, J.N.2
McCredie, M.R.3
-
45
-
-
0032813906
-
Hereditary and sporadic papillary renal carcinomas with c-met mutations share a distinct morphological phenotype
-
Lubensky IA, Schmidt L, Zhuang Z, et al: Hereditary and sporadic papillary renal carcinomas with c-met mutations share a distinct morphological phenotype. Am J Pathol 1999;155:517-526.
-
(1999)
Am J Pathol
, vol.155
, pp. 517-526
-
-
Lubensky, I.A.1
Schmidt, L.2
Zhuang, Z.3
-
46
-
-
0031794033
-
Chromosomal imbalances in papillary renal cell carcinoma: Genetic differences between histological subtypes
-
Jiang F, Richter J, Schraml P, et al: Chromosomal imbalances in papillary renal cell carcinoma: genetic differences between histological subtypes. Am J Pathol 1998;153:1467-1473.
-
(1998)
Am J Pathol
, vol.153
, pp. 1467-1473
-
-
Jiang, F.1
Richter, J.2
Schraml, P.3
-
48
-
-
0034860286
-
Genomic imbalances in 61 renal cancers from the proximal tubulus detected by comparative genomic hybridization
-
Reutzel D, Mende M, Naumann S, et al: Genomic imbalances in 61 renal cancers from the proximal tubulus detected by comparative genomic hybridization. Cytogenet Cell Genet 2001;93:221-227.
-
(2001)
Cytogenet Cell Genet
, vol.93
, pp. 221-227
-
-
Reutzel, D.1
Mende, M.2
Naumann, S.3
-
49
-
-
0035872397
-
Fusion of a novel gene, RCC17, to the TFE3 gene in t(X;17) (p11.2;q25.3)-bearing papillary renal cell carcinomas
-
Heimann P, El Housni H, Ogur G, et al: Fusion of a novel gene, RCC17, to the TFE3 gene in t(X;17) (p11.2;q25.3)-bearing papillary renal cell carcinomas. Cancer Res 2001;61:4130-4135.
-
(2001)
Cancer Res
, vol.61
, pp. 4130-4135
-
-
Heimann, P.1
El Housni, H.2
Ogur, G.3
-
50
-
-
0030463172
-
Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)-positive papillary renal cell carcinomas
-
USA
-
Weterman MAJ, Wilbrink M, Geurts van Kessel A: Fusion of the transcription factor TFE3 gene to a novel gene, PRCC, in t(X;1)(p11;q21)- positive papillary renal cell carcinomas. Proc Natl Acad Sci USA 1996;93:15294-15298.
-
(1996)
Proc Natl Acad Sci
, vol.93
, pp. 15294-15298
-
-
Weterman, M.A.J.1
Wilbrink, M.2
Van Geurts Kessel, A.3
-
51
-
-
0025061096
-
TFE3: A helix-loop-helix protein that activates transcription through the immunoglobulin enhancer μE3 motif
-
Beckmann H, Su LK, Kadesh T: TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer μE3 motif. Genes Dev 1990;4:167-179.
-
(1990)
Genes Dev
, vol.4
, pp. 167-179
-
-
Beckmann, H.1
Su, L.K.2
Kadesh, T.3
-
52
-
-
0034610764
-
Nuclear localization and transactivating capacities of the papillary renal cell carcinoma-associated TFE3 and PRCC (fusion) proteins
-
Weterman MAJ, van Groningen JM, Jansen A, et al: Nuclear localization and transactivating capacities of the papillary renal cell carcinoma-associated TFE3 and PRCC (fusion) proteins. Oncogene 2000;19:69-74.
-
(2000)
Oncogene
, vol.19
, pp. 69-74
-
-
Weterman, M.A.J.1
Van Groningen, J.M.2
Jansen, A.3
-
53
-
-
0035932394
-
Transformation capacities of the papillary renal cell carcinoma-associated PRCCTFE3 and TFE3PRCC fusion genes
-
Weterman MAJ, van Groningen JM, den Hartog A, et al: Transformation capacities of the papillary renal cell carcinoma-associated PRCCTFE3 and TFE3PRCC fusion genes. Oncogene 2001;20:1414-1424.
-
(2001)
Oncogene
, vol.20
, pp. 1414-1424
-
-
Weterman, M.A.J.1
Van Groningen, J.M.2
Den Hartog, A.3
-
54
-
-
0035253403
-
Mitotic checkpoints: From yeast to cancer
-
Wassmann K, Benezra R: Mitotic checkpoints: from yeast to cancer. Curr Opin Genet Dev 2001;11:83-90.
-
(2001)
Curr Opin Genet Dev
, vol.11
, pp. 83-90
-
-
Wassmann, K.1
Benezra, R.2
-
55
-
-
0035878111
-
MAD2B is an inhibitor of the anaphase-promoting complex
-
Chen J, Fang G: MAD2B is an inhibitor of the anaphase-promoting complex. Genes Dev 2001;15:1765-1770.
-
(2001)
Genes Dev
, vol.15
, pp. 1765-1770
-
-
Chen, J.1
Fang, G.2
-
56
-
-
0036284778
-
The anaphase-promoting complex: Proteolysis in mitosis and beyond
-
Peters JM: The anaphase-promoting complex: proteolysis in mitosis and beyond. Mol Cell 2002;9:931-943.
-
(2002)
Mol Cell
, vol.9
, pp. 931-943
-
-
Peters, J.M.1
-
57
-
-
0035878126
-
Inhibition of Cdh1-APC by MAD2L2: A novel mechanism of regulating Cdhl
-
Pfleger CM, Salic A, Lee E, et al: Inhibition of Cdh1-APC by MAD2L2: a novel mechanism of regulating Cdhl. Genes Dev 2001;15:1759-1764.
-
(2001)
Genes Dev
, vol.15
, pp. 1759-1764
-
-
Pfleger, C.M.1
Salic, A.2
Lee, E.3
-
58
-
-
9844230424
-
Fusion of the splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma
-
Clark J, Lu YJ, Sidhar S, Parker C, et al: Fusion of the splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma. Oncogene 1997;15:2233-2239.
-
(1997)
Oncogene
, vol.15
, pp. 2233-2239
-
-
Clark, J.1
Lu, Y.J.2
Sidhar, S.3
Parker, C.4
-
59
-
-
0035843141
-
PRCC, the commonest TFE3 fusion partner in papillary renal carcinoma is associated with pre-mRNA splicing factors
-
Skalsky YM, Ajuh PM, Parker C, et al: PRCC, the commonest TFE3 fusion partner in papillary renal carcinoma is associated with pre-mRNA splicing factors. Oncogene 2001;20:178-187.
-
(2001)
Oncogene
, vol.20
, pp. 178-187
-
-
Skalsky, Y.M.1
Ajuh, P.M.2
Parker, C.3
-
60
-
-
0033535530
-
Novel mutations of the MET proto-oncogene in papillary renal carcinomas
-
Schmidt L, Junker K, Nakaigawa N, et al: Novel mutations of the MET proto-oncogene in papillary renal carcinomas. Oncogene 1999;18:2343-2350.
-
(1999)
Oncogene
, vol.18
, pp. 2343-2350
-
-
Schmidt, L.1
Junker, K.2
Nakaigawa, N.3
-
61
-
-
0034628444
-
Mapping of the 7q31 subregion common to the small chromosome 7 derivatives from two sporadic papillary renal cell carcinomas: Increased copy number and overexpression of the MET proto-oncogene
-
Glukhova L, Lavialle C, Fauvet D, et al: Mapping of the 7q31 subregion common to the small chromosome 7 derivatives from two sporadic papillary renal cell carcinomas: increased copy number and overexpression of the MET proto-oncogene. Oncogene 2000;19:754-761.
-
(2000)
Oncogene
, vol.19
, pp. 754-761
-
-
Glukhova, L.1
Lavialle, C.2
Fauvet, D.3
-
62
-
-
3042609752
-
Pathological and molecular biological aspects of the renal epithelial neoplasms, up-to-date
-
Nagashima Y, Inayama Y, Kato Y, et al: Pathological and molecular biological aspects of the renal epithelial neoplasms, up-to-date. Pathol Int 2004;54:377-386.
-
(2004)
Pathol Int
, vol.54
, pp. 377-386
-
-
Nagashima, Y.1
Inayama, Y.2
Kato, Y.3
-
63
-
-
0029890634
-
Allelic losses at chromosomes 1p, 2p, 6p, 10p, 13q, 17p, and 21q significantly correlate with the chromophobe subtype of renal cell carcinoma
-
Schwerdtle RF, Storkel S, Neuhaus C, et al: Allelic losses at chromosomes 1p, 2p, 6p, 10p, 13q, 17p, and 21q significantly correlate with the chromophobe subtype of renal cell carcinoma. Cancer Res 1996, 56:2927-2930.
-
(1996)
Cancer Res
, vol.56
, pp. 2927-2930
-
-
Schwerdtle, R.F.1
Storkel, S.2
Neuhaus, C.3
-
64
-
-
0035874947
-
VHL and FHIT locus loss of heterozygosity is common in all renal cancer morphotypes but differs in pattern and prognostic significance
-
Velickovic M, Delahunt B, Storkel S, et al: VHL and FHIT locus loss of heterozygosity is common in all renal cancer morphotypes but differs in pattern and prognostic significance. Cancer Res 2001;61:4815-4819.
-
(2001)
Cancer Res
, vol.61
, pp. 4815-4819
-
-
Velickovic, M.1
Delahunt, B.2
Storkel, S.3
-
65
-
-
0031038176
-
Mutation of the p53 tumour suppressor gene occurs preferentially in the chromophobe type of renal cell tumour
-
Contractor H, Zariwala M, Bugert P, et al: Mutation of the p53 tumour suppressor gene occurs preferentially in the chromophobe type of renal cell tumour. J Pathol 1997;181:136-139.
-
(1997)
J Pathol
, vol.181
, pp. 136-139
-
-
Contractor, H.1
Zariwala, M.2
Bugert, P.3
-
66
-
-
0000939691
-
Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome
-
Nickerson M, Warren M, Toro J, et al: Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome. Cancer Cell 2002;2:157-164.
-
(2002)
Cancer Cell
, vol.2
, pp. 157-164
-
-
Nickerson, M.1
Warren, M.2
Toro, J.3
-
67
-
-
0026700660
-
Collecting duct carcinoma: Cytogenetic characterization
-
Fuzesi L, Cober M, Mittermayer C: Collecting duct carcinoma: cytogenetic characterization. Histopathology 1992;21:155-160.
-
(1992)
Histopathology
, vol.21
, pp. 155-160
-
-
Fuzesi, L.1
Cober, M.2
Mittermayer, C.3
-
68
-
-
0031829990
-
Characterisation of a collecting duct carcinoma by cytogenetic analysis and comparative genomic hybridisation
-
Verdorfer I, Culig Z, Hobisch A, et al: Characterisation of a collecting duct carcinoma by cytogenetic analysis and comparative genomic hybridisation. Int J Oncol 1998;13:461-464.
-
(1998)
Int J Oncol
, vol.13
, pp. 461-464
-
-
Verdorfer, I.1
Culig, Z.2
Hobisch, A.3
-
69
-
-
0041819704
-
The basic biology and immunobiology of renal cell carcinoma: Considerations for the clinician
-
Uzzo RG, Cairns P, Al-Saleem T, Hudes G, Haas N, Greenberg RE, Kolenko V: The basic biology and immunobiology of renal cell carcinoma: considerations for the clinician. Urol Clin North Am 2003;30:423-426.
-
(2003)
Urol Clin North Am
, vol.30
, pp. 423-426
-
-
Uzzo, R.G.1
Cairns, P.2
Al-Saleem, T.3
Hudes, G.4
Haas, N.5
Greenberg, R.E.6
Kolenko, V.7
-
70
-
-
0027240519
-
Identification of the von Hippel-Lindau disease tumor suppressor gene
-
Latif F, Tory K, Gnarra JR, et al: Identification of the von Hippel-Lindau disease tumor suppressor gene. Science 1993;260:1317-1320.
-
(1993)
Science
, vol.260
, pp. 1317-1320
-
-
Latif, F.1
Tory, K.2
Gnarra, J.R.3
-
71
-
-
0023024017
-
Genetics of human cancer
-
Knudson AG Jr: Genetics of human cancer. Annu Rev Genet 1986;20:231-251.
-
(1986)
Annu Rev Genet
, vol.20
, pp. 231-251
-
-
Knudson Jr., A.G.1
-
72
-
-
7844234770
-
Improved detection of germline mutations in the von Hippel-Lindau disease tumor suppressor gene
-
Stolle C, Glenn G, Zbar B, et al: Improved detection of germline mutations in the von Hippel-Lindau disease tumor suppressor gene. Hum Mutat 1998;12:417-423.
-
(1998)
Hum Mutat
, vol.12
, pp. 417-423
-
-
Stolle, C.1
Glenn, G.2
Zbar, B.3
-
73
-
-
0031004284
-
Somatic inactivation of the VHL gene in von Hippel-Lindau disease tumors
-
Prowse AH, Webster AR, Richards FM, et al: Somatic inactivation of the VHL gene in von Hippel-Lindau disease tumors. Am J Hum Genet 1997;60:765-771.
-
(1997)
Am J Hum Genet
, vol.60
, pp. 765-771
-
-
Prowse, A.H.1
Webster, A.R.2
Richards, F.M.3
-
74
-
-
0004752789
-
Von Hippel-Lindau syndrome: Clinical and molecular considerations for the urologist
-
Uzzo RG, Novick AC: von Hippel-Lindau syndrome: clinical and molecular considerations for the urologist. AUA Update Ser 1999;18:137-144.
-
(1999)
AUA Update Ser
, vol.18
, pp. 137-144
-
-
Uzzo, R.G.1
Novick, A.C.2
-
75
-
-
0028938702
-
Von Hippel-Lindau disease: Genetic, clinical, and imaging features
-
Choyke PL, Glenn GM, Walther MM, et al: von Hippel-Lindau disease: genetic, clinical, and imaging features. Radiology 1995;194:629-642.
-
(1995)
Radiology
, vol.194
, pp. 629-642
-
-
Choyke, P.L.1
Glenn, G.M.2
Walther, M.M.3
-
76
-
-
0028981766
-
Germline mutations in the von Hippel-Lindau disease tumor suppressor gene: Correlations with phenotype
-
Chen F, Kishida T, Yao M, et al: Germline mutations in the von Hippel-Lindau disease tumor suppressor gene: correlations with phenotype. Hum Mutat 1995;5:66-75.
-
(1995)
Hum Mutat
, vol.5
, pp. 66-75
-
-
Chen, F.1
Kishida, T.2
Yao, M.3
-
77
-
-
0028030581
-
Identification of intragenic mutations in the von Hippel-Lindau disease tumour suppressor gene and correlation with disease phenotype
-
Crossey PA, Richards FM, Foster K, et al: Identification of intragenic mutations in the von Hippel-Lindau disease tumour suppressor gene and correlation with disease phenotype. Hum Mol Genet 1994;3:1303-1308.
-
(1994)
Hum Mol Genet
, vol.3
, pp. 1303-1308
-
-
Crossey, P.A.1
Richards, F.M.2
Foster, K.3
-
78
-
-
0032555217
-
A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor
-
USA 1
-
Schoenfeld A, Davidowitz E, Burk R: A second major native von Hippel-Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor. Proc Natl Acad Sci USA 1 1998;95:8817-8822.
-
(1998)
Proc Natl Acad Sci
, vol.95
, pp. 8817-8822
-
-
Schoenfeld, A.1
Davidowitz, E.2
Burk, R.3
-
79
-
-
0033602089
-
Alternate choice of initiation codon produces a biologically active product of the von Hippel Lindau gene with tumor suppressor activity
-
Blankenship C, Naglich J, Whaley J, et al: Alternate choice of initiation codon produces a biologically active product of the von Hippel Lindau gene with tumor suppressor activity. Oncogene 1999;18:1529-1535.
-
(1999)
Oncogene
, vol.18
, pp. 1529-1535
-
-
Blankenship, C.1
Naglich, J.2
Whaley, J.3
-
80
-
-
4644363095
-
The von Hippel-Lindau tumor suppressor gene and kidney cancer
-
Kaelin WG Jr: The von Hippel-Lindau tumor suppressor gene and kidney cancer. Clin Cancer Res 2004;10(suppl):6290-6295.
-
(2004)
Clin Cancer Res
, vol.10
, Issue.SUPPL.
, pp. 6290-6295
-
-
Kaelin Jr., W.G.1
-
81
-
-
0037307858
-
The von Hippel-Lindau tumor suppressor protein: New insights into oxygen sensing and cancer
-
Kim W, Kaelin WG Jr: The von Hippel-Lindau tumor suppressor protein: new insights into oxygen sensing and cancer. Curr Opin Genet Dev 2003;13:55-60.
-
(2003)
Curr Opin Genet Dev
, vol.13
, pp. 55-60
-
-
Kim, W.1
Kaelin Jr., W.G.2
-
82
-
-
0042342564
-
The von Hippel-Lindau protein, vascular endothelial growth factor, and kidney cancer
-
George DJ, Kaelin WG Jr: The von Hippel-Lindau protein, vascular endothelial growth factor, and kidney cancer. N Engl J Med 2003;349:419-421.
-
(2003)
N Engl J Med
, vol.349
, pp. 419-421
-
-
George, D.J.1
Kaelin Jr., W.G.2
-
83
-
-
17944375360
-
Elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein A, Gleadle J, McNeill L, et al: Elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 2001;107:43-54.
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.1
Gleadle, J.2
McNeill, L.3
-
84
-
-
0041465022
-
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia
-
Berra E, Benizri E, Ginouves A, et al: HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia. EMBO J 2003;22:4082-4090.
-
(2003)
EMBO J
, vol.22
, pp. 4082-4090
-
-
Berra, E.1
Benizri, E.2
Ginouves, A.3
-
85
-
-
0037108807
-
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
-
USA
-
Ivan M, Haberberger T, Gervasi DC, et al: Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor. Proc Natl Acad Sci USA 2002;99:13459-13464.
-
(2002)
Proc Natl Acad Sci
, vol.99
, pp. 13459-13464
-
-
Ivan, M.1
Haberberger, T.2
Gervasi, D.C.3
-
86
-
-
0035834409
-
A conserved family of prolyl-4-hydroxylases that modify HIF
-
Bruick R, McKnight S: A conserved family of prolyl-4-hydroxylases that modify HIF. Science 2001;294:1337-1340.
-
(2001)
Science
, vol.294
, pp. 1337-1340
-
-
Bruick, R.1
McKnight, S.2
-
88
-
-
0035859692
-
HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation
-
USA
-
Yu F, White S, Zhao Q, et al: HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc Natl Acad Sci USA 2001;98:9630-9635.
-
(2001)
Proc Natl Acad Sci
, vol.98
, pp. 9630-9635
-
-
Yu, F.1
White, S.2
Zhao, Q.3
-
89
-
-
0035917808
-
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
-
Jaakkola P, Mole D, Tian Y, et al: Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 2001;292:468-472.
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.2
Tian, Y.3
-
90
-
-
0035925098
-
Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects
-
Hockel M, Vaupel P: Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst 2001;93:266-276.
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 266-276
-
-
Hockel, M.1
Vaupel, P.2
-
91
-
-
12944266844
-
The expression of hypoxia-inducible factor 1alpha is a favorable independent prognostic factor in renal cell carcinoma
-
Lidgren A, Hedberg Y, Grankvist K, et al: The expression of hypoxia-inducible factor 1alpha is a favorable independent prognostic factor in renal cell carcinoma. Clin Cancer Res 2005;1:1129-1135.
-
(2005)
Clin Cancer Res
, vol.1
, pp. 1129-1135
-
-
Lidgren, A.1
Hedberg, Y.2
Grankvist, K.3
-
92
-
-
0033776536
-
Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
-
Ohh M, Park CW, Ivan M, et al: Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein. Nat Cell Biol 2000;2:423-427.
-
(2000)
Nat Cell Biol
, vol.2
, pp. 423-427
-
-
Ohh, M.1
Park, C.W.2
Ivan, M.3
-
93
-
-
0142219359
-
Pathobiology, prognosis, and targeted therapy for renal cell carcinoma. Exploiting the hypoxia-induced pathway
-
Pantuck AJ, Zeng G, Belldegrum AS, et al: Pathobiology, prognosis, and targeted therapy for renal cell carcinoma. Exploiting the hypoxia-induced pathway. Clin Cancer Res 2003;9:4641-4652.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 4641-4652
-
-
Pantuck, A.J.1
Zeng, G.2
Belldegrum, A.S.3
-
94
-
-
0035941291
-
The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C
-
Okuda H, Saitoh K, Hirai S, et al: The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C J Biol Chem 2001;276:43611-43617.
-
(2001)
J Biol Chem
, vol.276
, pp. 43611-43617
-
-
Okuda, H.1
Saitoh, K.2
Hirai, S.3
-
95
-
-
17144445958
-
An important von Hippel-Lindau tumor suppressor domain mediates Sp1-binding and self-association
-
Cohen H, Zhou M, Welsh A, et al: An important von Hippel-Lindau tumor suppressor domain mediates Sp1-binding and self-association. Biochem Biophys Res Commun 1999;266:43-50.
-
(1999)
Biochem Biophys Res Commun
, vol.266
, pp. 43-50
-
-
Cohen, H.1
Zhou, M.2
Welsh, A.3
-
96
-
-
0035955745
-
The von Hippel-Lindau protein interacts with heteronuclear ribonucleoprotein a2 and regulates its expression
-
Pioli PA, Rigby WF: The von Hippel-Lindau protein interacts with heteronuclear ribonucleoprotein a2 and regulates its expression. J Biol Chem 2001;276:40346-40352.
-
(2001)
J Biol Chem
, vol.276
, pp. 40346-40352
-
-
Pioli, P.A.1
Rigby, W.F.2
-
97
-
-
0344838401
-
Von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination
-
USA
-
Kuznetsova AV, Meller J, Schnell PO, et al: von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination. Proc Natl Acad Sci USA 2003;100:2706-2711.
-
(2003)
Proc Natl Acad Sci
, vol.100
, pp. 2706-2711
-
-
Kuznetsova, A.V.1
Meller, J.2
Schnell, P.O.3
-
98
-
-
0042466570
-
Identification of the RNA polymerase II subunit hsRPB7 as a novel target of the von Hippel-Lindau protein
-
Na X, Duan HO, Messing EM, et al: Identification of the RNA polymerase II subunit hsRPB7 as a novel target of the von Hippel-Lindau protein. EMBO J 2003;22:4249-4259.
-
(2003)
EMBO J
, vol.22
, pp. 4249-4259
-
-
Na, X.1
Duan, H.O.2
Messing, E.M.3
-
99
-
-
0037131189
-
The von Hippel-Lindau (VHL) tumor suppressor stabilizes novel PHD protein Jade-1
-
Zhou MI, Wang H, Ross JJ, et al: The von Hippel-Lindau (VHL) tumor suppressor stabilizes novel PHD protein Jade-1. J Biol Chem 2002;277:39887- 39898.
-
(2002)
J Biol Chem
, vol.277
, pp. 39887-39898
-
-
Zhou, M.I.1
Wang, H.2
Ross, J.J.3
-
100
-
-
0037085456
-
Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein
-
Li Z, Na X, Wang D, et al: Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. J Biol Chem 2002;277:4656-4662.
-
(2002)
J Biol Chem
, vol.277
, pp. 4656-4662
-
-
Li, Z.1
Na, X.2
Wang, D.3
-
101
-
-
0032085240
-
The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix
-
Ohh M, Yauch RL, Lonergan KM, et al: The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix. Mol Cell 1998;1:959-968.
-
(1998)
Mol Cell
, vol.1
, pp. 959-968
-
-
Ohh, M.1
Yauch, R.L.2
Lonergan, K.M.3
-
102
-
-
0037223823
-
Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL
-
Hergovich A, Lisztwan J, Barry R, et al: Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL. Nat Cell Biol 2003;5:64-70.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 64-70
-
-
Hergovich, A.1
Lisztwan, J.2
Barry, R.3
-
103
-
-
23844527189
-
Mechanism of von Hippel-Lindau protein-mediated suppression of nuclear factor kappa B activity
-
An J, Rettig MB: Mechanism of von Hippel-Lindau protein-mediated suppression of nuclear factor kappa B activity. Mol Cell Biol 2005;25:7546-7556.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 7546-7556
-
-
An, J.1
Rettig, M.B.2
-
104
-
-
24744445823
-
Concomitant deregulation of HIF1alpha and cell cycle proteins in VHL-mutated renal cell carcinomas
-
Atkins DJ, Gingert C, Justnhoven C, et al: Concomitant deregulation of HIF1alpha and cell cycle proteins in VHL-mutated renal cell carcinomas. Virchows Arch 2005;447:634-642.
-
(2005)
Virchows Arch
, vol.447
, pp. 634-642
-
-
Atkins, D.J.1
Gingert, C.2
Justnhoven, C.3
-
105
-
-
13944252559
-
Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma
-
Petrella BL, Lohi J, Brinckerhoff CE: Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma. Oncogene 2005;3:1043-1052.
-
(2005)
Oncogene
, vol.3
, pp. 1043-1052
-
-
Petrella, B.L.1
Lohi, J.2
Brinckerhoff, C.E.3
-
106
-
-
32944457801
-
Von Hippel-Lindau tumor suppressor protein regulates the assembly of intercellular junctions in renal cancer cells through hypoxia-inducible factor-independent mechanisms
-
Calzada MJ, Esteban MA, Feijoo-Cuaresma M, et al: von Hippel-Lindau tumor suppressor protein regulates the assembly of intercellular junctions in renal cancer cells through hypoxia-inducible factor-independent mechanisms. Cancer Res 2006;66:1553-1560.
-
(2006)
Cancer Res
, vol.66
, pp. 1553-1560
-
-
Calzada, M.J.1
Esteban, M.A.2
Feijoo-Cuaresma, M.3
-
107
-
-
22744447144
-
Identification of novel VHL target genes and relationship to hypoxic response pathways
-
Maina EN, Morris MR, Zatyka M, et al: Identification of novel VHL target genes and relationship to hypoxic response pathways. Oncogene 2005;30:4549-4558.
-
(2005)
Oncogene
, vol.30
, pp. 4549-4558
-
-
Maina, E.N.1
Morris, M.R.2
Zatyka, M.3
-
108
-
-
0033983875
-
Prevalence of microscopic tumors in normal appearing renal parenchyma from patients with hereditary papillary renal cancer
-
Ornstein DK, Lubensky IA, Venzon D, et al: Prevalence of microscopic tumors in normal appearing renal parenchyma from patients with hereditary papillary renal cancer. J Urol 2000;163:431-433.
-
(2000)
J Urol
, vol.163
, pp. 431-433
-
-
Ornstein, D.K.1
Lubensky, I.A.2
Venzon, D.3
-
109
-
-
17344381429
-
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas
-
Schmidt L, Duh F-M, Chen F, et al: Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. Nat Genet 1997;16:68-73.
-
(1997)
Nat Genet
, vol.16
, pp. 68-73
-
-
Schmidt, L.1
Duh, F.-M.2
Chen, F.3
-
110
-
-
0022387730
-
The human met oncogene is related to the tyrosine kinase oncogenes
-
Dean M, Park M, Le Beau MM, et al: The human met oncogene is related to the tyrosine kinase oncogenes. Nature 1985;318:385-388.
-
(1985)
Nature
, vol.318
, pp. 385-388
-
-
Dean, M.1
Park, M.2
Le Beau, M.M.3
-
111
-
-
0032514365
-
Duplication and overexpression of the mutant allele of the MET proto-oncogene in multiple hereditary papillary renal cell tumours
-
Fischer J, Palmedo G, von Knobloch R, et al: Duplication and overexpression of the mutant allele of the MET proto-oncogene in multiple hereditary papillary renal cell tumours. Oncogene 1998;17:733-739.
-
(1998)
Oncogene
, vol.17
, pp. 733-739
-
-
Fischer, J.1
Palmedo, G.2
Von Knobloch, R.3
-
112
-
-
17344373892
-
Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas
-
Zhuang Z, Park WS, Pack S, et al: Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas. Nat Genet 1998;20:66-69.
-
(1998)
Nat Genet
, vol.20
, pp. 66-69
-
-
Zhuang, Z.1
Park, W.S.2
Pack, S.3
-
113
-
-
0032564341
-
The mutationally activated Met receptor mediates motility and metastasis
-
USA
-
Jeffers M, Fiscella M, Webb CP, et al: The mutationally activated Met receptor mediates motility and metastasis. Proc Natl Acad Sci USA 1998;95:14417-14422.
-
(1998)
Proc Natl Acad Sci
, vol.95
, pp. 14417-14422
-
-
Jeffers, M.1
Fiscella, M.2
Webb, C.P.3
-
114
-
-
0028897350
-
Hereditary papillary renal cell carcinoma: Clinical studies in 10 families
-
Zbar B, Glenn G, Lubensky I, et al: Hereditary papillary renal cell carcinoma: clinical studies in 10 families. J Urol 1995;153:907-912.
-
(1995)
J Urol
, vol.153
, pp. 907-912
-
-
Zbar, B.1
Glenn, G.2
Lubensky, I.3
-
115
-
-
18544365990
-
Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer
-
Tomlinson IP, Alam NA, Rowan AJ, et al: Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nat Genet 2002;30:406-410.
-
(2002)
Nat Genet
, vol.30
, pp. 406-410
-
-
Tomlinson, I.P.1
Alam, N.A.2
Rowan, A.J.3
-
116
-
-
0037713729
-
Mutations in the fumarate hydratase gene cause hereditary leiomyomatosis and renal cell cancer in families in North America
-
Toro JR, Nickerson ML, Wei MH, et al: Mutations in the fumarate hydratase gene cause hereditary leiomyomatosis and renal cell cancer in families in North America. Am J Hum Genet 2003;73:95-106.
-
(2003)
Am J Hum Genet
, vol.73
, pp. 95-106
-
-
Toro, J.R.1
Nickerson, M.L.2
Wei, M.H.3
-
117
-
-
26944467604
-
Missense mutations in fumarate hydratase in multiple cutaneous and uterine leiomyomatosis and renal cell cancer
-
Alam NA, Olpin S, Rowan A, et al: Missense mutations in fumarate hydratase in multiple cutaneous and uterine leiomyomatosis and renal cell cancer. J Mol Diagn 2005;7:437-443.
-
(2005)
J Mol Diagn
, vol.7
, pp. 437-443
-
-
Alam, N.A.1
Olpin, S.2
Rowan, A.3
-
118
-
-
11144284227
-
Evidence of increased microvessel density and activation of the hypoxia pathway in tumours from the hereditary leiomyomatosis and renal cell cancer syndrome
-
Pollard P, Wortham N, Barclay E, et al: Evidence of increased microvessel density and activation of the hypoxia pathway in tumours from the hereditary leiomyomatosis and renal cell cancer syndrome. J Pathol 2005;205:41-49.
-
(2005)
J Pathol
, vol.205
, pp. 41-49
-
-
Pollard, P.1
Wortham, N.2
Barclay, E.3
-
119
-
-
20244378963
-
Evaluation and management of renal tumors in the Birt-Hogg-Dubé syndrome
-
Pavlovich CP, Grubb RL 3rd, Hurley K, et al: Evaluation and management of renal tumors in the Birt-Hogg-Dubé syndrome. J Urol 2005 173:1482-1486.
-
(2005)
J Urol
, vol.173
, pp. 1482-1486
-
-
Pavlovich, C.P.1
Grubb III, R.L.2
Hurley, K.3
-
120
-
-
21044457377
-
Germline BHD-mutation spectrum and phenotype analysis of a large cohort of families with Birt-Hogg-Dubé syndrome
-
Schmidt LS, Nickerson ML, Warren MB, et al: Germline BHD-mutation spectrum and phenotype analysis of a large cohort of families with Birt-Hogg-Dubé syndrome. Am J Hum Genet 2005;76:1023-1033.
-
(2005)
Am J Hum Genet
, vol.76
, pp. 1023-1033
-
-
Schmidt, L.S.1
Nickerson, M.L.2
Warren, M.B.3
-
121
-
-
0041633905
-
Inactivation of BHD in sporadic renal tumors
-
Khoo SK, Kahnoski K, Sugimura J et al: Inactivation of BHD in sporadic renal tumors. Cancer Res 2003;63:4583-4587.
-
(2003)
Cancer Res
, vol.63
, pp. 4583-4587
-
-
Khoo, S.K.1
Kahnoski, K.2
Sugimura, J.3
-
122
-
-
10744230490
-
A germ-line insertion in the Birt-Hogg-Dubé (BHD) gene gives rise to the Nihon rat model of inherited renal cancer
-
USA
-
Okimoto K, Sakurai J, Kobayashi T, et al: A germ-line insertion in the Birt-Hogg-Dubé (BHD) gene gives rise to the Nihon rat model of inherited renal cancer. Proc Natl Acad Sci USA 2004 101:2023-2027.
-
(2004)
Proc Natl Acad Sci
, vol.101
, pp. 2023-2027
-
-
Okimoto, K.1
Sakurai, J.2
Kobayashi, T.3
-
123
-
-
0345530997
-
A mutation in the canine BHD gene is associated with hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis in the German shepherd dog
-
Lingaas F, Comstock KE, Kirkness EF, et al: A mutation in the canine BHD gene is associated with hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis in the German shepherd dog. Hum Mol Genet 2003;12:3043-3053.
-
(2003)
Hum Mol Genet
, vol.12
, pp. 3043-3053
-
-
Lingaas, F.1
Comstock, K.E.2
Kirkness, E.F.3
-
125
-
-
3342906998
-
Expression of Birt-Hogg-Dubé mRNA in normal and neoplastic human tissues
-
Warren MB, Torres-Cabala CA, Turner ML, et al: Expression of Birt-Hogg-Dubé mRNA in normal and neoplastic human tissues. Mod Pathol 2004;17:998-1011.
-
(2004)
Mod Pathol
, vol.17
, pp. 998-1011
-
-
Warren, M.B.1
Torres-Cabala, C.A.2
Turner, M.L.3
-
126
-
-
2442485921
-
Cloning of a new familial t(3;8) translocation associated with conventional renal cell carcinoma reveals a 5 kb microdeletion and no gene involved in the rearrangement
-
Rodriíguez-Perales S, Meléndez B, Gribble SM, et al: Cloning of a new familial t(3;8) translocation associated with conventional renal cell carcinoma reveals a 5 kb microdeletion and no gene involved in the rearrangement. Hum Mol Genet 2004;13:983-990.
-
(2004)
Hum Mol Genet
, vol.13
, pp. 983-990
-
-
Rodriíguez-Perales, S.1
Meléndez, B.2
Gribble, S.M.3
-
127
-
-
0018736628
-
Hereditary renal-cell carcinoma associated with a chromosomal translocation
-
Cohen, AJ, Li FP, Berg S, et al: Hereditary renal-cell carcinoma associated with a chromosomal translocation. N Engl J Med 1979;301:592-595.
-
(1979)
N Engl J Med
, vol.301
, pp. 592-595
-
-
Cohen, A.J.1
Li, F.P.2
Berg, S.3
-
128
-
-
0024517466
-
Tissue-specific expression of a constitutional 3;6 translocation: Development of multiple bilateral renal-cell carcinomas
-
Kovacs G, Brusa P, De Riese W: Tissue-specific expression of a constitutional 3;6 translocation: development of multiple bilateral renal-cell carcinomas. Int J Cancer 1989;43:422-427.
-
(1989)
Int J Cancer
, vol.43
, pp. 422-427
-
-
Kovacs, G.1
Brusa, P.2
De Riese, W.3
-
129
-
-
15144359971
-
A familial case of renal cell carcinoma and a t(2;3) chromosome translocation
-
Koolen MI, van der Meyden AP, Bodmer D: A familial case of renal cell carcinoma and a t(2;3) chromosome translocation. Kidney Int 1998;53:273-275.
-
(1998)
Kidney Int
, vol.53
, pp. 273-275
-
-
Koolen, M.I.1
Van Der Meyden, A.P.2
Bodmer, D.3
-
130
-
-
0033532936
-
Renal cell cancer: Chromosome 3 translocations as risk factors
-
van Kessel A, Wijnhoven H, Bodmer D, et al: Renal cell cancer: chromosome 3 translocations as risk factors. J Natl Cancer Inst 1999;91:1159-1160.
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 1159-1160
-
-
Van Kessel, A.1
Wijnhoven, H.2
Bodmer, D.3
-
131
-
-
18244401418
-
Characterization of a familial RCC-associated t(2;3)(q33;q21) chromosome translocation
-
Podolski J, Byrski T, Zajaczek S, et al: Characterization of a familial RCC-associated t(2;3)(q33;q21) chromosome translocation. J Hum Genet 2001;46:685-693.
-
(2001)
J Hum Genet
, vol.46
, pp. 685-693
-
-
Podolski, J.1
Byrski, T.2
Zajaczek, S.3
-
132
-
-
0035060261
-
Molecular analysis of a familial case of renal cell cancer and a t(3;6)(q12;q15)
-
Eleveld MJ, Bodmer D, Merkx G, et al: Molecular analysis of a familial case of renal cell cancer and a t(3;6)(q12;q15). Genes Chromosomes Cancer 2001;31:23-32.
-
(2001)
Genes Chromosomes Cancer
, vol.31
, pp. 23-32
-
-
Eleveld, M.J.1
Bodmer, D.2
Merkx, G.3
-
133
-
-
0035084097
-
Association of a novel constitutional translocation t(1q;3q) with familial renal cell carcinoma
-
Kanayama H, Lui WO, Takahashi M, et al: Association of a novel constitutional translocation t(1q;3q) with familial renal cell carcinoma. J Med Genet 2001;38:165-170.
-
(2001)
J Med Genet
, vol.38
, pp. 165-170
-
-
Kanayama, H.1
Lui, W.O.2
Takahashi, M.3
-
134
-
-
0000191647
-
Mechanism of tumorigenesis of renal carcinomas associated with the constitutional chromosome 3;8 translocation
-
Schmidt L, Li F, Brown RS, et al: Mechanism of tumorigenesis of renal carcinomas associated with the constitutional chromosome 3;8 translocation. Cancer J Sci Am 1995;1:191.
-
(1995)
Cancer J Sci Am
, vol.1
, pp. 191
-
-
Schmidt, L.1
Li, F.2
Brown, R.S.3
-
135
-
-
17344368130
-
An alternative route for multistep tumorigenesis in a novel case of hereditary renal cell cancer and a t(2;3)(q35;q21) chromosome translocation
-
Bodmer D, Eleveld MJ, Ligtenberg MJ, et al: An alternative route for multistep tumorigenesis in a novel case of hereditary renal cell cancer and a t(2;3)(q35;q21) chromosome translocation. Am J Hum Genet 1998;62:1475-1483.
-
(1998)
Am J Hum Genet
, vol.62
, pp. 1475-1483
-
-
Bodmer, D.1
Eleveld, M.J.2
Ligtenberg, M.J.3
-
136
-
-
18744377728
-
Renal medullary carcinoma and ABL gene amplification
-
Simpson L, He X, Pins M, et al: Renal medullary carcinoma and ABL gene amplification. J Urol 2005 173:1883-1888.
-
(2005)
J Urol
, vol.173
, pp. 1883-1888
-
-
Simpson, L.1
He, X.2
Pins, M.3
-
137
-
-
1542398693
-
Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
-
Atkins MB, Hidalgo M, Stadler WM, et al: Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma. J Clin Oncol 2004;22:909-918.
-
(2004)
J Clin Oncol
, vol.22
, pp. 909-918
-
-
Atkins, M.B.1
Hidalgo, M.2
Stadler, W.M.3
-
138
-
-
2442510143
-
Phase II trial of PS-341 in patients with renal cell cancer: A University of Chicago phase II consortium study
-
Davis NB, Taber DA, Ansari RH, et al: Phase II trial of PS-341 in patients with renal cell cancer: a University of Chicago phase II consortium study. J Clin Oncol 2004;22:115-119.
-
(2004)
J Clin Oncol
, vol.22
, pp. 115-119
-
-
Davis, N.B.1
Taber, D.A.2
Ansari, R.H.3
-
139
-
-
0036219609
-
Hsp90 inhibitors as novel cancer chemotherapeutic agents
-
Neckers L: Hsp90 inhibitors as novel cancer chemotherapeutic agents. Trends Mol Med 2002;8(suppl):55-61.
-
(2002)
Trends Mol Med
, vol.8
, Issue.SUPPL.
, pp. 55-61
-
-
Neckers, L.1
-
140
-
-
0035048449
-
Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes
-
Kim MS, Kwon HJ, Lee YM, et al: Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes. Nat Med 2001;7:437-443.
-
(2001)
Nat Med
, vol.7
, pp. 437-443
-
-
Kim, M.S.1
Kwon, H.J.2
Lee, Y.M.3
-
141
-
-
1242271198
-
Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: Mechanism and therapeutic implications
-
Rapisarda A, Uranchimeg B, Sordet O, et al: Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications. Cancer Res 2004;64:1475-1482.
-
(2004)
Cancer Res
, vol.64
, pp. 1475-1482
-
-
Rapisarda, A.1
Uranchimeg, B.2
Sordet, O.3
-
142
-
-
4444369682
-
Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha
-
Welsh S, Williams R, Kirkpatrick L, et al: Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha. Mol Cancer Ther 2004;3:233-244.
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 233-244
-
-
Welsh, S.1
Williams, R.2
Kirkpatrick, L.3
-
143
-
-
10744231706
-
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
-
Mabjeesh NJ, Escuin D, LaVallee TM, et al: 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell 2003;3:363-375.
-
(2003)
Cancer Cell
, vol.3
, pp. 363-375
-
-
Mabjeesh, N.J.1
Escuin, D.2
Lavallee, T.M.3
-
144
-
-
4644276593
-
Preliminary antitumor activity of BAY 43-9006 in metastatic renal cell carcinoma and other advanced refractory solid tumors in a phase II randomized discontinuation trial (RDT)
-
Ratain MJ, Flaherty KT, Stadler WM, et al: Preliminary antitumor activity of BAY 43-9006 in metastatic renal cell carcinoma and other advanced refractory solid tumors in a phase II randomized discontinuation trial (RDT). Proc Am Soc Clin Oncol 2004;23:381.
-
(2004)
Proc Am Soc Clin Oncol
, vol.23
, pp. 381
-
-
Ratain, M.J.1
Flaherty, K.T.2
Stadler, W.M.3
-
145
-
-
0042343801
-
A randomized trial of bevacizumab, an antivascular endothelial growth factor antibody, for metastatic renal cancer
-
Yang JC, Haworth L, Sherry RM, et al: A randomized trial of bevacizumab, an antivascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 2003;349:427-434.
-
(2003)
N Engl J Med
, vol.349
, pp. 427-434
-
-
Yang, J.C.1
Haworth, L.2
Sherry, R.M.3
-
146
-
-
12444251187
-
Phase II trial of antiepidermal growth factor receptor antibody C225 in patients with advanced renal cell carcinoma
-
Motzer RJ, Amato R, Todd M, et al: Phase II trial of antiepidermal growth factor receptor antibody C225 in patients with advanced renal cell carcinoma. Invest New Drugs 2003;21:99-101.
-
(2003)
Invest New Drugs
, vol.21
, pp. 99-101
-
-
Motzer, R.J.1
Amato, R.2
Todd, M.3
-
147
-
-
0001303066
-
Phase II trial of ZD (Iressa), an EGF inhibitor, in patients with advanced renal cell carcinoma
-
Drucker BJ, Schwartz L, Marion S, et al: Phase II trial of ZD (Iressa), an EGF inhibitor, in patients with advanced renal cell carcinoma. Proc Am Soc Clin Oncol 2002;21:181.
-
(2002)
Proc Am Soc Clin Oncol
, vol.21
, pp. 181
-
-
Drucker, B.J.1
Schwartz, L.2
Marion, S.3
-
148
-
-
0037386774
-
Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase
-
Ciardiello F, Caputo R, Damiano V, et al: Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor receptor tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase. Clin Cancer Res 2003;9:1546-1556.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 1546-1556
-
-
Ciardiello, F.1
Caputo, R.2
Damiano, V.3
-
149
-
-
33644833910
-
Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
-
Motzer RJ, Michaelson MD, Redman BG et al: Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol 2006;1; 24:16-24.
-
(2006)
J Clin Oncol
, vol.24
, pp. 16-24
-
-
Motzer, R.J.1
Michaelson, M.D.2
Redman, B.G.3
-
150
-
-
11144355748
-
Phase I study to determine the safety, tolerability and immunostimulatory activity of thalidomide analogue CC-5013 in patients with metastatic malignant melanoma and other advanced cancers
-
Bartlett JB, Michael A, Clarke IA, et al: Phase I study to determine the safety, tolerability and immunostimulatory activity of thalidomide analogue CC-5013 in patients with metastatic malignant melanoma and other advanced cancers. Br J Cancer 2004;90:955-961.
-
(2004)
Br J Cancer
, vol.90
, pp. 955-961
-
-
Bartlett, J.B.1
Michael, A.2
Clarke, I.A.3
-
151
-
-
11144354471
-
A phase II trial of chimeric monoclonal antibody G250 for advanced renal cell carcinoma patients
-
Bleumer I, Knuth A, Oosterwijk E, et al: A phase II trial of chimeric monoclonal antibody G250 for advanced renal cell carcinoma patients. Br J Cancer 2004;90:985-990.
-
(2004)
Br J Cancer
, vol.90
, pp. 985-990
-
-
Bleumer, I.1
Knuth, A.2
Oosterwijk, E.3
-
152
-
-
33746387427
-
Carbonic anhydrase IX expression predicts outcome of interleukin 2 therapy for renal cancer
-
Atkins M, Regan M, McDermott D, et al: Carbonic anhydrase IX expression predicts outcome of interleukin 2 therapy for renal cancer. Clin Cancer Res 2005;15:3601-3603.
-
(2005)
Clin Cancer Res
, vol.15
, pp. 3601-3603
-
-
Atkins, M.1
Regan, M.2
McDermott, D.3
-
153
-
-
4644239258
-
Genetic basis of cancer of the kidney disease-specific approaches to therapy
-
Linehan WM, Vasselli J, Srinivasan R, et al: Genetic basis of cancer of the kidney disease-specific approaches to therapy. Clin Cancer Res 2004;10(suppl):6282-6289.
-
(2004)
Clin Cancer Res
, vol.10
, Issue.SUPPL.
, pp. 6282-6289
-
-
Linehan, W.M.1
Vasselli, J.2
Srinivasan, R.3
|