Involvement of multiple loci on chromosome 3 in renal cell cancer development

Genes Chromosomes and Cancer

Volumn 19, Issue 2, 1997, Pages 59-76

  Van Den Berg, Anke ^a   Buys, Charles H C M ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER GENETICS; CARCINOGENESIS; CHROMOSOME 3; CHROMOSOME ANALYSIS; FAMILIAL CANCER; GENE LOCUS; GENE LOSS; GENE MUTATION; HUMAN; KIDNEY CARCINOMA; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; CARCINOMA, RENAL CELL; CHROMOSOMES, HUMAN, PAIR 3; GENETIC DISEASES, INBORN; HETEROZYGOTE; HIPPEL-LINDAU DISEASE; HUMANS; HYDROLASES; MICE; PROTEIN-TYROSINE-PHOSPHATASE; PROTEINS; RATS; TUMOR CELLS, CULTURED;

EID: 0030983281     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2264(199706)19:2<59::AID-GCC1>3.0.CO;2-Z     Document Type: Review

References (176)

1. Anglard P, Tory K, Brauch H, Weiss GH, Latif F, Merino MJ, Lerman MI, Zbar B, Linehan WM (1991) Molecular analysis of genetic changes in the origin and development of renal cell carcinoma. Cancer Res 51:1071-1077.
2. Ariyama T, Kimura T, Yamakawa K, Nakamura Y, Abe T, Inazawa J (1995) Precise ordering of 26 cosmid markers on chromosome region 3p23-p21.3 by two color FISH on human prophase chromosomes and stretched DNAs. Cytogenet Cell Genet 70:129-133.
3. Baily M, Bain C, Favrot MC, Ozturk M (1995) Somatic mutations of von Hippel-Lindau tumor-suppressor gene in European kidney cancer. Int J Cancer 63:660-664.
4. Berger R, Bloomfield CD, Sutherland GR (1985) Report of the committee on chromosome rearrangements in neoplasia and on fragile sites. HGM 8, Helsinki Conference. Cytogenet Cell Genet 40:490-535.
5. Bergerheim U, Nordenskjold M, Collins VP (1989) Deletion mapping in human renal cell carcinoma. Cancer Res 49:1390-1396.
6. Bernues M, Casadevall C, Miro R, Caballin MR, Villavicencio H, Salvador J, Zamarron A, Egozcue J (1995) Cytogenetic characterization of a familial papillary renal cell carcinoma. Cancer Genet Cytogenet 84:123-127.
7. Boldog FL, Gemmill RM, Wilke CM, Glover TW, Nilsson AS, Chandrasekharappa SC, Brown RS, Li FP, Drabkin HA (1993) Positional cloning of the hereditary renal cell carcinoma 3:8 chromosome translocation breakpoint. Proc Natl Acad Sci USA 90:8509-8513.
8. Boldog FL, Waggoner B, Glover TW, Chumakov I, Le Paslier D, Cohen D, Gemmill RM, Drabkin HA (1994) Intergrated YAC contig containing the 3p14.2 hereditary renal carcinoma 3;8 translocation breakpoint and the fragile site FRA3B. Genes Chromosom Cancer 11:216-221.
9. Brauch H, Tory K, Linehan WM, Weaver DJ, Lovell MA, Zbar B (1990) Molecular analysis of the short arm of chromosome 3 in five renal oncocytomas. J Urol 143:622-624.
10. Carroll PR, Murty VVS, Reuter V, Jhanwar S, Fair WR, Whitmore WF, Chaganti RSK (1987) Abnormalities at chromosome region 3p12-14 characterize clear cell renal carcinoma. Cancer Genet Cytogenet 26:253-259.
11. Chen F, Kishida T, Duh F-M, Renbaum P, Orcutt ML, Schmidt L, Zbar B (1995a) Suppression of growth of renal cell carcinoma cells by the Von Hippel-Lindau tumor suppressor gene. Cancer Res 55:4804-4807.
12. Chen F, Kishida T, Yao M, Hustad T, Glavec D, Dean M, Gnarra JR, Orcutt ML, Duh FM, Glenn G, Green J, Hsia YE, Lamiell J, Li H, Wei MH, Schmidt L, Tory K, Kuzmin I, Stackhouse T, Latif F, Linehan M, Lerman M, Zbar B (1995b) Germline mutations in the Von Hippel-Lindau disease tumor suppressor gene: Correlations with phenotype. Hum Mutat 5:66-75.
13. Cheng WS, Farrow GM, Zincke H (1991) The incidence of multicentricity in renal cell carcinoma. J Urol 146:1221-1223.
14. Cohen AJ, Li FP, Berg S, Marchetto DJ, Tsai S, Jacobs SC, Brown RS (1979) Hereditary renal-cell carcinoma associated with a chromosomal translocation. N Engl J Wed 301:592-595.
15. Crossey PA, Maher ER, Jones MH, Richards FM, Latif F, Phipps ME, Lush M, Foster K, Tory K, Green JS, Oostra B, Yates JRW, Linehan WM, Affara NA, Lerman M, Zbar B, Nakamura Y, Ferguson-Smith MA (1993) Genetic linkage between Von Hippel- Lindau disease and three microsatellite polymorphisms refines the localisation of the VHL locus. Hum Mol Genet 2:279-282.
16. Crossey PA, Foster K, Richards FM, Phipps ME, Latif F, Tory K, Jones MH, Bentley E, Kumar R, Lerman MI, Zbar B, Affara NA, Ferguson-Smith MA, Maher RR (1994a) Molecular genetic investigations of the mechanism of tumourigenesis in Von Hippl-Lindau disease: Analysis of allele loss in VHL tumours. Hum Genet 93:53-58.
17. Crossey PA, Richards FM, Foster K, Green JS, Prowse A, Latif F, Lerman MI, Zbar B, Affara NA, Ferguson-Smith MA, Maher ER (1994b) Identification of intragenic mutations in the Von Hippel- Lindau disease tumour suppressor gene and correlation with disease phenotype. Hum Mol Genet 3:1303-1308.
18. Crotty TB, Lawrence KM, Moertel CA, Bartelt DH, Batts KP, Dewald GW, Farrow GM, Jenkins RB (1992) Cytogentic analysis of six renal oncocytomas and a chromophobe cell renal carcinoma, evidence that -y, -1 may be a characteristic anomaly in renal oncocytomas. Cancer Genet Cytogenet 61:61-66.
19. Dal Cin P, Li FP, Prout GR, Huben RP, Limon J, Ferti-Passantonopoulou A, Richie JP, Sandberg AA (1988) Involvement of chromosomes 3 and 5 in renal cell carcinoma. Cancer Genet Cytogenet 35:41-46.
20. Dal Cin P, Gaeta J, Huben R, Li FP, Prout GR, Sandberg AA (1989) Renal cortical tumours - Cytogenetic Characterization. Am J Clin Pathol 92:408-414.
21. Dayal H, Kinman J (1983) Epidemiology of kidney cancer. Semin Oncol 10:366-377.
22. De Jong B, Oosterhuis JW, Idenburg VJS, Castedo SMMJ, Dam A, Mensink HJA (1988) Cytogenetics of 12 cases of renal adenocarcinoma. Cancer Genet Cytogenet 30:53-61.
23. Dobin SM, Harris CP, Reynolds JA, Coffield S, Klugo RC, Peterson RF, Speights VO (1992) Cytogenetic abnormalities in renal oncocytic neoplasms. Genes Chromosom Cancer 4:25-31.
24. Drabkin HA, Bradley C, Hart I, Bleskan J, Li FP, Pattrerson D (1985) Translocation of c-myc in the hereditary renal cell associated with a t(3;8)(p14.2;q24.13) chromosomal translocation. Proc Natl Acad Sci USA 82:6980-6984.
25. Druck T, Kastury K, Hadaczek P, Podolski J, Toloczko A, Sikorski A, Ohta M, LaForgia S, Lasota J, McCue P, Lubinski J, Huebner K (1995) Loss of heterozygosity at the familial RCCt(3;8) locus in most clear cell renal carcinomas. Cancer Res 55:5348-5353.
26. Duan DR, Pause A, Burgess WH, Aso T, Chen DYT, Garrett KP, Conaway RC, Conaway JW, Linehan WM, Klausner RD (1995) Inhibition of transcription elongation by the VHL tumor suppressor protein. Science 269:1402-1406.
27. Eker R, Mossige J (1961) A dominant gene for renal adenomas in the rat. Nature 189:858-859.
28. Eker R, Massige J, Johannesson JV, Aars H (1181) Hereditary renal adenomas and adenocarcinomas in rats. Diagn Histopathol 4:99-110.
29. El-Naggar AK, Batsakis JG, Wang G, Lee M-S (1993) PCR-based RFLP screening of the commonly deleted 3p loci in renal cortical neoplasms. Diagn Mol Pathol 2:269-276.
30. Erlandsson R, Boldog F, Sumegi J, Klein G (1988) Do human renal cell carcinomas arise by a double loss mechanism. Cancer Genet Cytogenet 36:197-202.
31. Erlandsson R, Bergerheim USR, Boldog F, Marcsek Z, Kunimi K, Lin BYT, Ingvarsson S, Castresana JS, Lee WH, Lee E, Klein G, Sumegi J (1990) A gene near the D3F15S2 site on 3p is expressed in normal kidney but not or only at a severely reduced level in 11 of 15 renal cell carcinomas (RCC). Oncogene 5:1207-1211.
32. Erlandsson R, Boldog F, Persson B, Zaharovsky ER, Allikmers RL, Sumegi J, Klein G, Jornvall H (1991) The gene from the short arm of chromosome 3, at D3F15S2, frequently deleted in renal cell carcinoma, encodes acylpeptide hydrolase. Oncogene 6:1293-1295.
33. European Chromosome 16 Tuberous Selerosis Consortium (1993) Identification and characterization of the tuberous sclerosis gene on chromosome 16. Cell 75:1305-1315.
34. Everitt JI, Goldsworthy TL, Wolf DC, Walker CL (1992) Hereditary renal cell carcinoma in the Eker rat: A rodent familial cancer syndrome. J Urol 148:1932-1936.
35. Foster K, Crossey PA, Cairns P, Hetherington JW, Richards FM, Jones MH, Bentley E, Affara NA, Ferguson-Smith MA, Maher ER (1994a). Molecular genetic investigation of sporadic renal cell carcinoma: Analysis of allele loss on chromosomes 3p, 5q, 11p, 17 and 22. Br J Cancer 69:230-234.
36. Foster K, Prowse A, van den Berg A, Fleming S, Hulsbeek MMF, Crossey PA, Richards FM, Cairns P, Affara NA, Ferguson-Smith MA, Buys CHCM, Maher ER (1994b) Somatic mutations of the Von Hippel-Lindau disease tumour suppressor gene in non-familial clear cell renal carcinoma. Hum Mol Genet 3:2169-2173.
37. Fryer AE, Chalmers A, Connor JM, Fraser I, Povey S, Yates AD, Yates JRW, Osborne JP (1987) Evidence that the gene for tuberous sclerosis is on chromosome 9. Lancet 1:659-661.
38. Gao J, Naglich JG, Laidlaw J, Whaley JM, Seizinger BR, Kley N (1995) Cloning and characterization of a mouse gene with homology to the human Von Hippel-Lindau disease tumor suppressor gene: Implications for the potential organisation of the human Von Hippel-Lindau gene. Cancer Res 55:743-747.
39. Gemmill RM, Coyle-Morris J, Ware-Uribe L, Pearson N, Hecht F, Brown RS, Li FP, Drabkin HA (1189) A 1.5 megabase restriction map surrounding MYC does not include the translocation breakpoint in familial renal cell carcinoma. Genomics 4:28-35.
40. Gnarra JR, Tory K, Weng Y, Schmidt L, Wei MH, Li H, Latif F, Liu S, Chen F, Duh F-M, Lubensky I, Duan DR, Florence C, Porzzatti R, Walther MM, Bander NH, Grossman HB, Brauch H, Pomer S, Brooks JD, Isaacs WB, Lerman Ml, Zbar B, Linehan WM (1994) Mutations of the VHL tumour suppressor gene in renal carcinoma. Nature Genet 7:85-90.
41. Griffin JP, Hughes GV, Peeling WB (1967) A survey of the familial incidence of adenocarcinoma of the kidney. Br J Urol 39:63-66.
42. Guinan PD, Vogelzang NJ, Fremgen AM, Chmiel JS, Sylvester JL, Sener SF, Imperato JP, members of the Cancer Incidence and End Results Committee (1995) Renal cell carcinoma: Tumor size, stage and survival. J Urol 153:901-903.
43. Hagemeyer A, Hoehn W, Smit (1979) Cytogenetic analysis of human renal carcinoma cell lines of common origin (NC65). Cancer Res 39:4662-4665.
44. Harbour JW, Lai SL, Gazdar AF, Minna JD, Kaye FJ (1990) Expression in lung cancer of a transcribed sequence at the DNF15S2 locus at chromosome 3p21. Anticancer Res 10:23-28.
45. Hecht F, Sutherland GR (1984) Fragile sites and cancer breakpoints. Cancer Genet Cytogenet 12:179-181.
46. Henn W, Zwergel T, Wullich B, Thonnes M, Zang KD, Seitz G (1993) Bilateral multicentric papillary renal tumors with heteroclonal origin based on tissue specific karyotype instability. Cancer 72:1315-1318.
47. Herman JG, Latif F, Weng Y, Lerman MI, Zbar B, Liu S, Samid D, Duan D-SR, Gnarra JR, Linehan WM, Baylin SB (1994) Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci USA 91:9700-9704.
48. Hino O, Klein-Szanto AJP, Freed JJ,Testa JR, Brown DQ, Vilensky M, Yeung RS, Tartof KD, Knudson AG (1993a) Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer. Proc Natl Acad Sci USA 90:327-331.
49. Hino O, Mitani H, Nishizawa M, Katsuyama H, Kobayashi E, Hirayama Y (1993b) A novel renal cell carcinoma susceptibility gene maps on chromosome 10 in the Eker rat. Jpn J Cancer 84:1106-1109.
50. Hino O, Kobayashi T, Tsuchiya H, Kikuchi Y, Kobayashi E, Mitani H, Hirayama Y (1994) The predisposing gene of the Eker rat inherited cancer syndrome is tightly linked to the tuberous sclerosis (Tsc2) gene. Biochem Biophys Res Commun 203:1302-1308.
51. Hosoe S, Brauch H, Latif F, Glenn G, Daniel L, Bale S, Choyke P, Gorin M, Oldfield E, Bergman A, Goodman J, Orcutt ML, Hampsch K, Delisio J, Modi W, McBride W, Anglard P, Weiss G, Walther MM, Linehan WM, Lerman MI, Zbar B (1990) Localization of the Von Hippel-Lindau disease gene to a small region of chromosome 3. Genomics 8:34-640.
52. Hughson MD, Johnson LD, Silva FG, Kovacs G (1993) Nonpapillary and papillary renal cell carcinoma: A cytogenetic and phenotypic study. Modern Pathol 6:449-456.
53. Iliopoulos O, Kibel A, Gray S, Kaelin WG (1995) Tumour suppression by the human von Hippel Lindau gene product. Nature Med 1:822-826.
54. Jacobs SC, Berg SI, Raussell KL (1980) Synchronous bilateral renal cell carcinoma: Total surgical excision. Cancer 46:2341-2345.
55. Kandt RS, Haines JL, Smith M, Northrup H, Gardner RJM, Short MP, Dumars K, Roach ES, Steingold S, Wall S, Blanton SH, Flodman P, Kwiatkowski DJ, Jewell A, Weber JL, Roses AD, Pericak-Vance MA (1992) Linkage of an Important gene locus for tuberous selerosis to a chromosome 16 marker for polycystic kidney disease. Nature Genet 2:37-41.
56. Kaplan R, Morse B, Huebner K, Croce C, Howk R, Ravera M, Ricca G, Jaye M, Schlessinger J (1990) Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked proteintyrosine-phosphatases expressed in brain. Proc Natl Acad Sci USA 87:7000-7004.
57. Kastury K, Ohta M, Lasota J, Moir D, Dorman T, LaForgia S, Druck T, Huebner K (1996) Structure of the human receptor tyrosine phosphatase gamma gene (PTPRG) and relation to the familial RCC t(3;8) chromosome translocation. Genomics 32:225-235.
58. Kholodnyuk I, Kost-Alimova M, Kashuba V, Gizatulin R, Szeles A, Stanbridge EJ, Zabarovsky ER, Klein G, Imreh S (1996) A 3p21.3 region is preferentially eliminated from human chromosome 3/mouse microcell hybrids during tumor growth in SCID mice. Genes Chromosom Cancer, in press.
59. Kibel A, Illopoulos O, DeCaprio JA, Kaelin WG (1995) Binding of the Von Hippel-Lindau tumor suppressor protein to elongins B and C. Science 269:1444-1446.
60. Kikuchi Y, Kobayashi F, Nishizawa M, Hamazaki S, Okada S, Hino O (1995) Cloning of the rat homologue of the Von Hippel-Lindau tumor suppressor gene and its non-somatic mutation in rat renal cell carcinomas. Jpn J Cancer Res 86:905-909.
61. Killary AM, Wolf ME, Giambernardi TA, Naylor SL (1992) Definition of a tumor suppressor locus within human chromosome 3p21-p22. Proc Natl Acad Sci USA 89:10877-10881.
62. King CR, Schimke RN, Arthur T, Davoren B, Collins D (1987) Proximal 3p deletion in renal cell carcinoma cells from a patient with Von Hippel-Lindau disease. Cancer Genet Cytogenet 27:345-348.
63. Kobayashi T, Hirayama Y, Kobayashi E, Kubo Y, Hino O (1995) A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer. Nature Genet 9:70-74.
64. Kohno T, Sekine T, Tobisu K, Oshimura M, Yokota J (1993) Chromosome 3p deletion in a renal cell carcinoma cell line established from a patient with Von Hippel-Lindau disease. Jpn J Clin Oncol 23:226-231.
65. Kok K, Naylor SL, Buys CHCM (1996) Deletions of the short arm of chromosome 3 in solid tumors and the search for suppressor genes. Adv Cancer Res, in press.
66. Kovacs G (1990) Application of molecular cytogenetic techniques to the evaluation of renal parenchymal tumors. J Cancer Res Clin Oncol 116:318-323.
67. Kovacs, G (1993) Molecular differential pathology of renal cell tumours. Histopatholgy 22:1-8.
68. Kovacs G (1994) The value of molecular genetic analysis in the diagnosis prognosis of renal cell tumours. World J Urol 12:64-68.
69. Kovacs G, Frisch S (1989) Clonal chromosome abnormalities in tumor cells from patients with sporadic renal cell carcinomas. Cancer Res 49:651-659.
70. Kovacs G, Hoene E (1987) Multifocal renal cell carcinoma: A cytogenetic study. Virchows Arch A 412:79-82.
71. Kovacs G, Hoene E (1988) Loss of der(3) in renal carcinoma cells of a patient with constitutional t(3;12). Hum Genet 78:148-150.
72. Kovacs G, Kung HF (1991) Nonhomologous chromatid exchange in hereditary and sporadic renal cell carcinomas. Proc Natl Acad Sci USA 88:194-198.
73. Kovacs G, Szucs S, De Riese W, Baumgartel H (1987) Specific chromosome aberration in human renal cell carcinoma. Int J Cancer 40:171-178.
74. Kovacs G, Erlandsson R, Boldog F, Ingvarsson S, Muller-Brechlin R, Klein G, Sugmegi J (1988) Consistent chromosome 3p deletion and loss of heterozygosity in renal cell carcinoma. Proc Natl Acad Sci USA 85:1571-1575.
75. Kovacs G, Brusa P, De Riese W (1989a) Tissue-specific expression of a constitutional 3;6 translocation: Development of multiple bilateral renal-cell carcinomas. Int J Cancer 43:422-427.
76. Kovacs G, Welter C, Wilkens L, Blin N, Deriese W (1989b) Renal oncocytoma - A phenotypic and genotypic entity of renal parenchymal tumors. Am J Pathol 134:967-971.
77. Kovacs G, Wilkens L, Papp T, de Riese W (1989c) Differentiation between papillary and nonpapillary renal cell carcinomas by DNA analysis. J Natl Cancer Inst 81:527-530.
78. Kovacs G, Emanuel A, Neumann HP, Kung HF (1991a) Cytogenetics of renal cell carcinomas associated with Von Hippel-Lindau disease. Genes Chromosom Cancer 3:256-262.
79. Kovacs G, Fuzesi L, Emanuel A, Kung H-F (1991b) Cytogenetics of papillary renal cell tumors. Genes Chromosom Cancer 3:249-255.
80. Kovacs A, Störkel S, Thoenes W, Kovacs G (1992) Mitochondrial and chromosomal DNA alterations in human chromophobe renal cell carcinomas. J Pathol 167:273-277.
81. LaForgia S, Morse B, Levy J, Barnea G, Cannizzaro LA, Li F, Nowell PC, Boghosian-Sell L, Gliek J, Weston A, Harris CC, Drabkin H, Patterson D, Croce CM, Schlessinger J, Huebner K (1991) Receptor protein-tyrosine phosphatase γ is a candidate tumor suppressor gene at human chromosome region 3p21. Proc Natl Acad Sci USA 88;5036-5040.
82. Latif F, Tory K, Gnarra J, Yao M, Duh F-M, Orcutt ML, Stackhouse T, Kuzmin I, Modi W, Geil L, Schmidt L, Zhou F, Li H, Wei MH, Chen F, Glenn G, Choyke P, Walther MM, Weng Y, Duan D-SR, Dean M, Glavac D, Richards FM, Crossey PA, Ferguson-Smith MA, Le Paslier D, Chumakov I, Cohen D, Chinault AG, Maher ER, Linehan WM, Zbar B, Lerman MI (1993) Identification of the Von Hippel-Lindau disease tumor suppressor gene. Science 260:1317-1320.
83. Lee S, Chen DYT, Humphrey JS, Gnarra JR, Linehan WM, Klausner RD (1996) Nuclear/cytoplasmic localisation of the Von Hippel-Lindau tumor suppressor gene product is determined by cell density. Proc Natl Acad Sci USA 93:1770-1775.
84. Li FP, Decker H-JH, Zbar B, Stanton VP, Kovacs G, Seizinger BR, Aburatani H, Sandberg AA, Berg S, Hosoe S, Brown RS (1993) Clinical and genetic studies of renal cell carcinomas in a family with a constitutional chromosome 3;8 translocation. Ann Intern Med 118:106-111.
85. Lisitsyn NA, Lisitsina NM, Calbagni G, Barker P, Sanchez CA, Gnarra J, Linehan WM, Reid BJ, Wigler MH (1995) Comparative genomic analysis of tumors: Detection of DNA losses and amplification. Proc Natl Acad Sci USA, 92:151-155.
86. Lubinski J, Hadaczek P, Podolski J, Toloczko A, Sikorski A, McCue P, Druck T, Huebner K (1994) Common regions of deletions in chromosome regions 3p 12 and 3p 14.2 in primary clear cell renal carcinomas. Cancer Res 54:3710-3713.
87. Maher ER, Yates JRW, Ferguson-Smith MA (1990a) Statistical analysis of the two stage mutation model in von Hippel-Lindau disease, and in sporadic cerebellar haemangioblastoma and renal cell carcinoma. J Med Genet 27:311-314.
88. Maher ER, Yates JRW, Harries R, Benjamin C, Harris R, Moore AT, Ferguson-Smith MA (1990b) Clinical features and natural history of Von Hippel-Lindau disease. Q J Med 283:1151-1163.
89. Maher ER, Bentley E, Yates JRW, Latif F, Lerman M, Zbar B, Affara NA, Ferguson-Smith MA (1991) Mapping of the Non Hippel-Lindau disease locus to a small region of chromosome 3p by genetic linkage analysis. Genomics 10:957-960.
90. Morita R, Ishikawa J, Tsutsumi M, Hikiji K, Tsukada Y, Kamidono S, Maeda S, Nakamura Y (1991) Allelotype of renal cell carcinoma. Cancer Res 51:820-823.
91. Mukamel E, Konichezky M, Engelstein D, Servadio C (1988) Incidental small renal tumors accompanying clinically overt renal cell carcinoma. J Urol 140:22-24.
92. Naylor SL, Marshall A, Hensel C, Martinez PF, Holley B, Sakaguchi AY (1989) The DNF15S2 locus at 3p21 is transcribed in normal lung and small cell lung cancer. Genomics 4:355-361.
93. Naylor SL, Carritt B, Boileau C, Beroud C, Alexander C, Allderdice P, Alimov A, Ashworth T, Bonifas J, Bugert P, Buys CHCM, Chipperfield MA, Deng G, Drabkin HA, Gemmill RM, Grompe M, Joensuu T, Jonasdottir A, Gizatullin R, Krols L, Leach RJ, Lott ST, Killary A, Martinson T, Messian L, O'Connell P, Opalka B, Plaetke R, Sankila EM, Smith DI, Strachen T, van den Berg A, Zabarovsky E (1996) Report on the Sixth International Workshop on Human Chromosome 3 Mapping 1995. Cytogenet Cell Genet 72:255-270.
94. Negrini M, Monaco C, Vorechovsky I, Ohta M, Druck T, Baffa R, Huebner K, Croce CM (1996) The FHIT gene at 3p14.2 is abnormal in breast carcinomas. Cancer Res 56:3173-3179.
95. Ogawa O, Kakehi Y, Ogawa K, Koshiba M, Sugiyama T, Yoshida O (1991) Allelic loss at chromosome 3p characterizes clear cell phenotype of renal cell carcinoma. Cancer Res 51:949-953.
96. Ogawa O, Habuchi T, Kakehi Y, Koshiba M, Sugiyama T, Yoshida O (1992) Allelic losses at chromosome 17p in human renal cell carcinoma are inversely related to allelic losses at chromosome 3p. Cancer Res 52:1881-1885.
97. Ohmura H, Tahara H, Suzuki M, Ide T, Shimuzu M, Yoshida MA, Tahara JW, Barrett JC, Oshimura M (1995) Restoration of the cellular senescence program and repression of telomerase by human chromosome 3. Jpn J Cancer Res 86:899-404.
98. Ohta M, Inoue H, Cotticelli MG, Kastury K, Baffa R, Palazzo, Siprashvili Z, Mori M, McCue P, Druck T, Croce CM, Huebner K (1996) The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell 84:587-597.
99. Paradee W, Mullins C, He Z, Glover T, Wilke C, Opalka B, Schutte J, Smith DI (1995) Precise localisation of aphidicolin-induced breakpoints on the short arm of human chromosome 3. Genomics 27:358-361.
100. Paradee W, Wilke C, Wang L, Shridhar R, Mullins CM, Hoge A, Glover TW, Smith DI (1996) A 350-kb cosmid contig in 3p14.2 that crosses the t(3;8) hereditary renal cell carcinoma translocation breakpoint and 17 aphidicolin-induced FRA3B breakpoints. Genomics 35:87-93.
101. Pathak S, Strong LC, Ferrell RE, Trindade A (1982) Familial renal cell carcinoma with a 3;11 chromosome translocation limited to tumor cells. Science 217:939-941.
102. Polascik TJ, Cairns P, Epstein JI, Fuzesi L, Ro JY, Marshall FF, Sidransky D, Schoenberg M (1996) Distal nephron renal tumors: Microsatellite allelotype. Cancer Res 56:1892-1895.
103. Popescu NC, Zimonjic D, DiPaolo JA (1990) Viral integration, fragile sites, and proto-oncogenes in human neoplasia. Hum Genet 84:383-386.
104. Poston CD, Jaffe GS, Lubensky IA, Solomon D, Zbar B, Linehan WM, Walther MM (1995) Characterization of the renal pathology of a familial form of renal cell carcinoma associated with Von Hippel-Lindau disease: Clinical and molecular genetic implications. J Urol 153:22-26
105. Presti JC, Rao PH, Chen Q, Reuter VE, Li FP, Fair WR, Jhanwar SC (1991) Histopathological, cytogenetic, and molecular characterisation of renal cortical tumors. Cancer Res 51:1544-1552.
106. Presti JC, Reuter VE, Cordon-Cardo C, Mazumdar M, Fair WR, Jhanwar SC (1993) Allelic deletions in renal tumors: Histopathological correlations. Cancer Res 53:5780-5783.
107. Psihramis KE, Althausen AF, Yoshida MA, Prout GR, Sundberg AA (1986) Chromosome anomalies suggestive of malignant tranformation in bilateral oncocytoma, J Urol 136:892-895.
108. Rassool FV, Le Bean MM, Shen ML, Neilly ME, Espinosa R, Ong ST, Boldog F, Drabkin H, McCarroll, McKeithan TW (1996) Direct cloning of DNA sequences from the common fragile site region at chromosome band 3p14.2. Genomics 35:109-117.
109. Richards FM, Maher ER, Latif F, Phipps ME, Tory K, Lush M, Crossey PA, Oostra B, Gustavson KH, Green J, Turner G, Yates JRW, Linehan WM, Affara NA, Lerman M, Zbar B, Ferguson-Smith MA (1993) Detailed genetic mapping of the Yon Hippel-Lindau disease tumour suppressor gene. J Med Genet 30:104-107.
110. Richards FM, Crossey PA, Phipps ME, Foster K, Latif F, Evans G, Sampson J, Lerman MI, Zbar B, Affara NA, Ferguson-Smith MA, Maher ER (1994) Detailed mapping of germline deletions of the Non Hippel-Lindau disease tumour suppressor gene. Hum Mol Genet 3:595-598.
111. Robbing SL, Cotran RS, Kumar V (eds) (1989) Robbins Pathologic Basis of Disease: The Kidney, 4th ed. Philadelphia: W.B. Saunders, pp 1074-1081.
112. Sampson JR, Patel A, Mee AD (1995) Multifocal renal cell carcinoma in sibs from a chromosome 9 linked (Tsc1) tuberous sclerosis family. J Med Genet 32:848-850.
113. Sanchez Y, El-Naggar A, Pathak S, Killary AM (1994) A tumor suppressor locus within human chromosome 3p14-p12 mediates rapid cell death of renal cell carcinoma in vivo. Proc Natl Acad Sci USA 91:3383-3387.
114. Schwerdtle R, Störkel S, Neuhaus C, Brauch H, Weidt K, Brenner W, Hohenfellner R, Huber C, Decker HJ (1996) Allelic losses at chromosomes 1p, 2p, 6p, 10p, 13q, 17p, and 21q significantly correlate with the chromophobe subtype of renal cell carcinoma. Cancer Res 56:2927-2930.
115. Seizinger BR, Rouleau GA, Ozelius LJ, Lane AH, Farmer GE, Lamiell LM, Haines J, Yuen JWM, Collins D, Majoor-Krakauer D, Bonner T, Mathew C, Rubenstein A, Halperin J, McConkie-Rosell A, Green JS, Trofatter JA, Ponder BA, Eierman L, Bowmer MI, Schimke R, Oostra B, Aronin N, Smith DI, Drabkin H, Waziri MH, Hobbs WJ, Martuza RL, Conneally PM, Hsia YE, Gusella JF (1988) Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma. Nature 332:268-269.
116. Seizinger BR, Smith DI, Filling-Katz MR, Neumann H, Green JS, Choyke PL, Anderson KM, Freiman RN, Klauck SM, Whaley J, Decker H-JH, Hsia YE, Collins D, Halperin J, Lamiell JM, Oostra B, Waziri MH, Gorin MB, Scherer G, Bradkin HA, Aronin N, Schinzel A, Martuza RL, Gusella JF, Haines JL (1991) Genetic flanking markers refine diagnostic criteria and provide insights into the genetics of Von Hippel-Lindnu disease. Proc Natl Acad Sci USA 88:2864-2868.
117. Shimizu M, Yokota J, Mori N, Shuin T, Shinoda T, Terada M, Oshimura M (1990) Introduction of normal chromosome 3p modulates the tumorigenicity of a human renal cell carcinoma cell line. Oncogene 5:185-194.
118. Shridhar V, Rivard S, Shridhar R, Mullins C, Bostick L, Sakr W, Crignon D, Smith DI (1996) A gene from human chromosomal band 3p21.1 encodes a highly conserved arginine rich protein and is mutated in renal cell carcinomas. Oncogene 12:1931-1939.
119. Shuin T, Kondo K, Torigoe S, Kishida T, Kubota M, Nagashima Y, Kitamura H, Latif F, Zbar B, Lerman MI, Yao M (1994) Frequent somatic mutations and loss of heterozygosity of the Von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas. Cancer Res 54:2852-2855.
120. Skinner DG, Colvin RB, Vermillion CD, Pfister RC, Leadbetter WF (1971) Diagnosis and management of renal cell carcinoma. A clinical and pathological study of 309 cases. Cancer 28:1165-1177.
121. Smeets DFCM, Scheres JMJC, Hustinx TWJ (1984) The fragile site on chromosome 3. Hum Genet 67:351.
122. Sozzi G, Alder H, Tornielli S, Corletto V, Baffa R, Veronese ML, Negrini M, Pilotti S, Pierotti MA, Huebner K, Croce CM (1996a) Aberrant FHIT transcripts in Merkel cell carcinoma. Cancer Res 56:2472-2474.
123. Sozzi G, Veronese ML, Negrini M, Baffa R, Cotticelli MG, Inoue H, Tornielli S, Pilotti S, De Gregorio L, Pastorino U, Pierotti MA, Ohta M, Huebner K, Croce CM (1996b) The FHIT gene at 3p14.2 is abnormal in lung cancer. Cell 85:17-26.
124. Speicher MR, Schoell B, du Manoir S, Schrock E, Ried T, Cremer T, Storikel S, Kovacs A, Kovacs G (1994) Specific loss of chromosomes 1, 2, 6, 10, 13, 17, and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridization. Am J Pathol 145:356-364.
125. Stein WD, Stein AD (1995) Familial and sporadic human renal cell carcinoma: Evidence against a double loss mechanism of carcinogenisis. J Clin Epidemiol 48:767-777.
126. Störkel S, van den Berg E (1995) Morphological classification of cancer. World J Urol 13:153-158.
127. Syrjanen KJ (1979) Renal adenomatosis. Scand J Urol Nephrol 13:329-334.
128. Szucs S, Muller-Brechlin R, DeRiese W, Kovacs G (1987) Deletion 3p: The only chromosome loss in a primary renal cell carcinoma. Cancer Genet Cytogenet 26:369-373.
129. Thiagalingham S, Lisitsyn NA, Hamaguchi M, Wigler MH, Willson JKV, Markowitz SD, Leach FS, Kinzler KW, Vogelstein B (1996) Evaluation of the FHIT gene in colorectal cancer. Cancer Res 56:2936-2939.
130. Thoenes W, Störkel S, Rumpelt HJ (1986) Histopathology and classification of renal-cell tumours (adenomas, oncocytomas and carcinomas). The basic cytological and histopathological elements and their use for diagnostics. Pathol Res Pract 181:125-143.
131. Thoenes W, Störkel S, Rumpelt HJ, Mull R (1990) Cytomorphological typing of renal cell carcinoma - A new approach. Eur Urol 18(Suppl):6-9.
132. Thrash-Bingham CA, Greenberg RE, Howard S, Bruzel A, Bremer M, Goll A, Salazar H, Freed JJ, Tartof KD (1995) Comprehensive allelotyping of human renal cell carcinomas using microsatellite DNA probes. Proc Natl Acad Sci USA 92:2854-2858.
133. Thrash-Bingham CA, Salazar H, Greenberg RE, Tartof KD (1996) Loss of heterozygosity studies indicate that chromosome arm 1p harbors a tumor suppressor gene for renal oncocytomas. Genes Chromosom Cancer 16:64-67.
134. Todd MC, Xiang RH, Garcia DK, Kerbacher KE, Moore SL, Hensel CH, Liu P, Siciliano MJ, Kok K, van den Herg A, Veldhuis P, Buys CHCM, Killary AM, Naylor SL (1996) An 80 Kb P1 clone from chromosome 3p21.3 suppresses tumor growth in vivo. Oncogene, 13:2387-2396.
135. Tory K, Brauch H, Linehan M, Barba D, Oldfield E, Filling-Katz M, Seizinger B, Nakamura Y, White R, Marshall FF, Lerman MI, Zbar B (1989) Specific genetic change in tumors associated with Von Hippel-Lindau disease. J Natl Cancer Inst 81:1097-1101.
136. Tsuchiya H, Iseda T, Hino O (1996) Identification of a novel protein (VBP-1) binding to the Von Hippel-Lindau (VHL) tumor suppressor gene product. Cancer Res 56:2881-2885.
137. Tsukamoto T, Takahashi T, Ueda R, Hibi R, Saito H, Takahashi T (1992) Molecular analysis of the protein phosphatase γ gene in human lung cancer cell lines. Cancer Res 52:3506-3509.
138. van den Berg A, Kok K, Timmer T, Draaijers TG, Van der Veen AY, Veldhuis PMJF, Naylor SL, Buys CHCM (1995a) A homozygous deletion in a king adenocareinoma cell line just telomeric to the t(3;8) breakpoint [abstract]. Sixth International Workshop on Human Chromosome 3, Genome Database. G00-677-042.
139. van den Berg A, Van der Veen AY, Hulsbeek MMF, Kovacs G, Gemmill RM, Drabkin HA, Buys CHCM (1995b) Defining the position of the breakpoint of the constitutional t(3;6) occurring in a family with renal cell carcinoma. Genes Chromosom Cancer 12:224-228.
140. van den Berg A, Hulsbeek MMF, de Jong D, Kok K, Veldhuis PMJF, Roche J, Buys CHCM (1996) Major role for a 3p21 region and lack of involvement of the t(3:8) breakpoint region in the development of renal cell carcinoma suggested by loss of heterozygosity analysis. Genes Chromosom Cancer 15:64-72.
141. van den Berg A, Dijkhuizen T, Draijers TG, Hulsbeek MMF, Maher ER, van den Berg E, Störkel S, Buys CHCM (1997a) Analysis of multiple renal cell adenomas and carcinomas suggests allelic loss at 3p21 to be a prerequisite for malignant development. Genes Chromosom Cancer, in press.
142. van den Berg A, Draaijers TG, Kok K, Timmer T, Van der Veeh AY, Veldhuis PMJF, de Leij L, Gerhartz CD, Naylor SL, Smith DI, Buys CHCM (1997b) Normal FHIT transcripts in renal cell cancer and lung cancer-derived cell lines, including a cell line with a homozygous deletion in the FRA3B region. Genes Chromasom Cancer, in press.
143. van den Berg E, Van der Hout AH, Oosterhuis JW, Störkel S, Dijkhuizen T, Dam A, Zweers HMM, Mensink HJA, Buys CHCM, de Jong B (1993) Cytogenetic analysis of epithelial renal-cell tumours: Relationship with a new histopathological classification. Int J Cancer 55:223-227.
144. van den Berg E, Dijkhuizen T, Oosterhuis JW, Geurts van Kessel A, de Jong B, Störkel S (1997c) Cytogenetic classification of renal cell cancer. Cancer Genet Cytogenet, in press.
145. Van der Hout AH, Kok K, van den Berg A, Oosterhuis JW, Carritt B, Buys CHCM (1998) Direct molecular analysis of a deletion of 3p in tumors from patients with sporadic renal cell carcinoma. Cancer Genet Cytogenet 32:281-285.
146. Van der Hout AH, Van der Vlies P, Wijmenga C, Li FP, Oosterhuis JW, Buys CHCM (1991) The region of common allelic losses in sporadic renal cell carcinoma is bordered by the loci D3S2 and THRB. Genomics 11:537-542.
147. Van der Hout AH, Van den Berg E, Van der Vlies P, Dijkhuizen T, Störkel S, Oosterhuis JW, Buys CHCM (1993) Loss of heterozygos- ity at the short arm of chromosome 3 in renal cell cancer correlates with the cytological tumour type. Int J Cancer 53:353-357.
148. Vermillion CD, Skinner DG, Pfister RC (1972) Bilateral renal cell carcinoma. J Urol 108:219-222.
149. Viets DH, Vaughan ED, Howards SS (1477) Experience gained from the management of 9 cases of bilateral renal cell carcinoma. J Urol 118:937-940.
150. Visser O, Coebergh JWW, Schouten LJ (1991) Incidence of Cancer in The Netherlands. Third Report of the Netherlands Cancer Registry. Utrecht: SIG Health Care Information.
151. Walker C, Ahn YT, Everitt J, Yuan X (1996) Renal cell carcinoma development in the rat independent of alterations at the VHL gene locus. Mol Carcinog 15:154-161.
152. Walther MM, Lubensky IA, Venzon D, Zbar B, Linehan WM (1995) Prevalence of microscopic lesions in grossly normal renal parenchyma from parients with Von Hippei-Lindau disease, sporadic renal cell carcinoma and no renal disease: Clinical implications. J Ural 154:2010-2015.
153. Wang N, Perkins KL (1984) Involvement of band 3p14 in t(3;8) hereditary renal carcinoma. Cancer Genet Cytogenet 11:479-481.
154. Wang N, Soldat L, Fan S, Figemshau S, Clayman R, Fraley E (1983) The consistent involvement of chromosome 3 and 6 aberrations in renal cell carcinoma [abstract]. Am J Hum Genet 35:73A.
155. Wang N, Testa JR, Smith DI (1993) Determination of the specificity of aphidicolin-induced breakage of the human 3p14.2 fragile site. Genomics 17:341-347.
156. Weaver DJ, Michalski K, Miles J (1988) Cytogenetic analysis in renal cell carcinoma: Correlation with tumor aggressiveness. Cancer Res 48:2887-2889.
157. Weaver DJ, Michalski K, Miles JH (1989) Cytogenetics of bilateral renal cell carcinoma. J Urol 142:697-700.
158. Whaley JM, Naglich J, Gelbert L, Hsia E, Lamiell JM, Green JS, Collins D, Neumann HPH, Laidlaw J, Li FP, Klein-Szanto AJP, Seizinger BR, Kiev N (1994) Germ-line mutations in the Von Hippel-Lindau tumor suppressor gene are similar to somatic Von Hippel-Lindau aberrations in sporadic renal cell carcinoma. Am J Hum Genet 55:1092-1102.
159. Whang M, O'Toole K, Bixon R, Brunetti J, Ikeguchi E, Olsson CA, Sawczuk TS, Benson MC (1995) The incidence of multifocal renal cell carcinoma in patients who are candidates for partial nephrectomy. J Urol 154:968-971.
160. Wilhelm M, Bugert P, Kenck C, Staehler G, Kovacs G (1995) Terminal deletion of chromosome 3p sequences in nonpapillary renal cell carcinomas: A breakpoint cluster between loci D3S1285 and D3S1603. Cancer Res 55:5383-5385.
161. Wilke CM, Guo SW.,Hall BK, Boldog F, Gemmill RM, Chandrasekharappa SC, Barcroft CL, Drabkin HA, Glover TW (1994) Multicolor FISH mapping of YAC clones in 3p14 and identification of a YAC spanning both FRA3B and the t(3;8) associated with hereditary renal cell carcinoma. Genomics 22:319-326.
162. Wilke CM, Hall BK, Hoge A, Paradee W, Smith DI, Glover TW (1996) FRA3B extends over a broad region and contains a spontaneous HPV16 intergration site: Direct evidence for the coincidence of viral intergration and fragile sites. Hum Mol Genet 5:187-195.
163. Wolman SR, Camuto PM, Golimbu Schinella R (1988) Cytogenetic, flow cytometric, and ultrastructural studies of twenty-nine nonfamilial human renal carcinomas. Cancer Res 48:2890-2897.
164. Yamakawa K, Morita R, Takahashi E, Hori T, Ishikawa J, Nakamura Y (1991) A detailed deletion mapping of the short arm of chromosome 3 in sporadic renal cell carcinoma. Cancer Res 51:4707-4711.
165. Yamakawa K, Takahasi E, Murata M, Okui K, Yokoyama S, Nakamura Y (1992) Detailed mapping around the breakpoint of (3;8) translocation in familial renal cell carcinoma and FRA3B. Genomics 14:412-416.
166. Yao M, Shuin T (1995) Familial renal cell carcinoma: Review of recent molecular genetics. Int J Urol 2:61-70.
167. Yao M, Latif F, Orcutt ML, Kuzmin I, Stackhouse T, Zhou FW, Tory K, Duh FM, Richards F, Maher E, LaForgia S, Huebner K, Le Paslier D, Linehan M, Lerman M, Zbar B (1993) Von Hippel-Lindau disease: Identification of deletion mutations by pulsed-field gel electrophoresis. Hum Genet 92:605-614.
168. Yeung RS, Buetow KH, Testa JR, Knudson AG (1993) Susceptibility to renal carcinoma in the Eker rat involves a tumor suppressor gene on chromosome 10. Proc Natl Acad Sci USA 90:8038-8042.
169. Yeung RS, Xiao GH, Jin F, Lee WC, Testa JR, Knudson AG (1994) Predisposition to renal carcinoma in the Eker rat is determined by germ line mutation of the tuberous sclerosis 2 (Tsc2) gene. Proc Natl Acad Sci USA 91:11413-11416.
170. Yoshida MA, Ohyashiki K, Ochi H, Gibas Z, Pontes JE, Prout GR, Huben R, Sandberg AA (1986a) Cytogenetic studies of tumor tissue from patients with non familial renal cell carcinoma. Cancer Res 46:2139-2147.
171. Yoshida MA, Ohyashiki K, Ochi H, Gibas Z, Prout GR, Pontes EJ, Huben R, Sandberg AA (1986b) Rearrangements of chromosome 3 in renal cell carcinoma. Cancer Genet Cytogenet 19:351-354.
172. Yoshida MA, Shimuyu M, Ikeuchi T, Tonomura A, Yokota J, Oshimura M (1994) In vitro growth suppression and morphological change in a human renal cell carcinoma cell line by the introduction of normal chromosome 3 via microcell fusion. Mol Carcinog 9:114-121.
173. Zbar B, Brauch H, Talmadge C, Linehan M (1987) Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma. Nature 327:721-724.
174. Zbar B, Tory K, Merino M, Schmidt L, Glenn G, Choyke P, Walther MM, Lerman M, Linehan WM (1994) Hereditary papillary renal cell carcinoma. J Urol 151:561-566.
175. Zbar B, Glenn G, Lubensky I, Choyke P, Walther MM, Magnusson G, Bergerheim USR, Pettersson S, Amin M, Hurley K, Linehan WM (1995) Hereditary pupillary renal cell carcinoma: Clinical studies in 10 families. J Urol 153:907-912.
176. Zeiger MA, Zbar B, Keiser H, Linehan WM, Gnarra JR (1995) Loss of heterozygosity on the short arm of chromosome 3 in sporadic, Von Hippel-Lindau disease associated, and familial pheochromocytoma. Genes Chromosom Cancer 13:151-156.