Trisomy 7-harbouring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas

Nature Genetics

Volumn 20, Issue 1, 1998, Pages 66-69

  Zhuang, Zhengping ^a   Park, Won Sang ^a   Pack, Svetlana ^a   Schmidt, Laura ^b   Vortmeyer, Alexander O ^a   Pak, Evgenia ^a   Pham, Thu ^a   Weil, Robert J ^a   Candidas, Sonja ^c   Lubensky, Irina A ^a   Marston Linehan, W ^a   Zbar, Berton ^d   Weirich, Gregor ^d  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT;

ALLELE; ANIMAL CELL; ARTICLE; CHROMOSOME 7Q; CONTROLLED STUDY; FAMILIAL CANCER; FLUORESCENCE IN SITU HYBRIDIZATION; GENE MUTATION; HUMAN; HUMAN TISSUE; KIDNEY CARCINOMA; MOUSE; NONHUMAN; ONCOGENE; ONCOGENE C MET; PAPILLARY CARCINOMA; PRIORITY JOURNAL; TRISOMY 7;

ADULT; CARCINOMA, PAPILLARY; CHROMOSOMES, HUMAN, PAIR 7; FEMALE; GENETIC MARKERS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KIDNEY NEOPLASMS; MALE; MUTATION; PEDIGREE; POLYMERASE CHAIN REACTION; PROTO-ONCOGENE PROTEINS C-MET; TRISOMY;

EID: 17344373892     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/1727     Document Type: Article

References (11)

1. Zbar, B. et al. Hereditary papillary renal carcinoma. J. Urol. 153, 907-912 (1995).
2. Schmidt, L. et al. Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. Nature Genet. 16, 68-73 (1997).
3. Kovacs, G. Molecular cytogenetics of renal tumours. Adv. Cancer Res. 62, 89-124 (1993).
4. Schmidt, L. et al. Two North American families with hereditary papillary renal carcinoma and identical novel mutations in the MET proto-oncogene. Cancer Res. 58, 1719-1722 (1998).
5. Rowley, J.D. Biological implications of consistent chromosome rearrangements in leukemia and lymphoma. Cancer Res. 44, 3159-3168 (1984).
6. Bianchi, A.B., Aldaz, C.M. & Conti, C.J. Nonrandom duplication of the chromosome bearing a mutated Ha-ras-1 allele in mouse skin tumours. Proc. Natl Acad. Sci. USA 87, 6902-6906 (1990).
7. Bremner, R. & Balmain, A. Genetic changes in skin tumour progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7. Cell 61, 407-417 (1990).
8. Wirschubsky, Z., Wiener, F., Spira, J., Sümegi, J. & Klein, G. Triplication of one chromosome no. 15 with an altered c-myc containing EcoRI fragment and elimination of the normal homologue in a T-cell lymphoma line of AKR origin (TIKAUT). Int. J. Cancer 33, 477-481 (1984).
9. Jeffers, M. et al. Activating mutations for the MET tyrosine kinase receptor in human cancer. Proc. Natl Acad. Sci. USA 94, 11445-11450 (1997).
10. Knudson, A.G. Genetics of human cancer. Ann. Rev. Genet. 20, 231-251 (1986).
11. Pinkel, D. et al. Fluorescence in situ hybridization with human chromosome-specific libraries: detection of the trisomy 21 and translocations of chromosome 4. Proc. Natl Acad. Sci. USA 85, 9138-914 (1988).