메뉴 건너뛰기




Volumn 2, Issue 1, 2006, Pages 11-18

Transcriptional regulation of glucose sensors in pancreatic β cells and liver

Author keywords

Glucokinase (GK); Glucose sensor; Liver; Pancreatic cells; Transcription; Type 2 glucose transporter isoform (GLUT2)

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; GLUCOKINASE; GLUCOSE; GLUCOSE TRANSPORTER 2; INSULIN; STREPTOZOCIN; TROGLITAZONE;

EID: 33746163080     PISSN: 15733998     EISSN: None     Source Type: Journal    
DOI: 10.2174/157339906775473581     Document Type: Review
Times cited : (25)

References (92)
  • 1
    • 0026110135 scopus 로고
    • Banting lecture 1990. Beta-cells in type II diabetes mellitus
    • Porte D, Jr. Banting lecture 1990. Beta-cells in type II diabetes mellitus. Diabetes 1991; 40:166-80.
    • (1991) Diabetes , vol.40 , pp. 166-180
    • Porte Jr., D.1
  • 2
    • 0027953703 scopus 로고
    • Insulin action, diabetogenes, and the cause of type II diabetes
    • Banting Lecture
    • Kahn CR. Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes. Diabetes 1994; 43: 1066-84.
    • (1994) Diabetes , vol.43 , pp. 1066-1084
    • Kahn, C.R.1
  • 3
    • 0029037649 scopus 로고
    • Pathophysiology of insulin resistance in human disease
    • Reaven GM. Pathophysiology of insulin resistance in human disease. Physiol Rev 1995; 75:473-86.
    • (1995) Physiol Rev , vol.75 , pp. 473-486
    • Reaven, G.M.1
  • 4
    • 0035936763 scopus 로고    scopus 로고
    • New perspectives into the molecular pathogenesis and treatment of type 2 diabetes
    • Saltiel AR. New perspectives into the molecular pathogenesis and treatment of type 2 diabetes. Cell 2001; 104:517-29.
    • (2001) Cell , vol.104 , pp. 517-529
    • Saltiel, A.R.1
  • 5
    • 0030901308 scopus 로고    scopus 로고
    • Glucose effectiveness assessed under dynamic and steady state conditions. Comparability of uptake versus production components
    • Ader M, Ni TC and Bergman RN. Glucose effectiveness assessed under dynamic and steady state conditions. Comparability of uptake versus production components. J Clin Invest 1997; 99: 1187-99.
    • (1997) J Clin Invest , vol.99 , pp. 1187-1199
    • Ader, M.1    Ni, T.C.2    Bergman, R.N.3
  • 7
    • 0242333673 scopus 로고    scopus 로고
    • Identification of eight novel glucokinase mutations in Italian children with maturity-onset diabetes of the young
    • Mantovani V, Salardi S, Cerreta V, et al. Identification of eight novel glucokinase mutations in Italian children with maturity-onset diabetes of the young. Hum Mutat 2003; 22:338.
    • (2003) Hum Mutat , vol.22 , pp. 338
    • Mantovani, V.1    Salardi, S.2    Cerreta, V.3
  • 8
    • 0005978695 scopus 로고    scopus 로고
    • Studies of genetic variability of the glucose transporter 2 promoter in patients with type 2 diabetes mellitus
    • Moller AM, Jensen NM, Pildal J, et al. Studies of genetic variability of the glucose transporter 2 promoter in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab 2001; 86:2181-6.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 2181-2186
    • Moller, A.M.1    Jensen, N.M.2    Pildal, J.3
  • 9
    • 0028339799 scopus 로고
    • A mutation in the Glut2 glucose transporter gene of a diabetic patient abolishes transport activity
    • Mueckler M, Kruse M, Strube M, et al. A mutation in the Glut2 glucose transporter gene of a diabetic patient abolishes transport activity. J Biol Chem 1994; 269:17765-7.
    • (1994) J Biol Chem , vol.269 , pp. 17765-17767
    • Mueckler, M.1    Kruse, M.2    Strube, M.3
  • 10
    • 0024342083 scopus 로고
    • Differential expression and regulation of the glucokinase gene in liver and islets of Langerhans
    • Iynedjian PB, Pilot PR, Nouspikel T, et al. Differential expression and regulation of the glucokinase gene in liver and islets of Langerhans. Proc Natl Acad Sci U S A 1989; 86:7838-42.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 7838-7842
    • Iynedjian, P.B.1    Pilot, P.R.2    Nouspikel, T.3
  • 11
    • 0026625602 scopus 로고
    • Concordant glucose induction of glucokinase, glucose usage, and glucose-stimulated insulin release in pancreatic islets maintained in organ culture
    • Liang Y, Najafi H, Smith RM, et al. Concordant glucose induction of glucokinase, glucose usage, and glucose-stimulated insulin release in pancreatic islets maintained in organ culture. Diabetes 1992; 41:792-806.
    • (1992) Diabetes , vol.41 , pp. 792-806
    • Liang, Y.1    Najafi, H.2    Smith, R.M.3
  • 12
    • 0035054129 scopus 로고    scopus 로고
    • Cyclic adenosine 3′,5′-monophosphate increases pancreatic glucokinase activity and gene expression
    • Fernandez-Mejia C, Vega-Allende J, Rojas-Ochoa A, et al. Cyclic adenosine 3′,5′-monophosphate increases pancreatic glucokinase activity and gene expression. Endocrinology 2001; 142:1448-52.
    • (2001) Endocrinology , vol.142 , pp. 1448-1452
    • Fernandez-Mejia, C.1    Vega-Allende, J.2    Rojas-Ochoa, A.3
  • 13
    • 0025161423 scopus 로고
    • Alternative splicing of glucokinase mRNA in rat liver
    • Hayzer DJ and Iynedjian PB. Alternative splicing of glucokinase mRNA in rat liver. Biochem J 1990; 270:261-3.
    • (1990) Biochem J , vol.270 , pp. 261-263
    • Hayzer, D.J.1    Iynedjian, P.B.2
  • 14
    • 0345678192 scopus 로고
    • Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein
    • Fukumoto H, Seino S, Imura H, et al. Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein. Proc Natl Acad Sci U S A 1988; 85:5434-8.
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 5434-5438
    • Fukumoto, H.1    Seino, S.2    Imura, H.3
  • 15
    • 0028799359 scopus 로고
    • Cloning and characterization of rat pancreatic beta-cell/liver type glucose transporter gene: A unique exon/intron organization
    • Ahn YH, Kim JW, Han GS, ef al. Cloning and characterization of rat pancreatic beta-cell/liver type glucose transporter gene: a unique exon/ intron organization. Arch Biochem Biophys 1995; 323: 387-96.
    • (1995) Arch Biochem Biophys , vol.323 , pp. 387-396
    • Ahn, Y.H.1    Kim, J.W.2    Han, G.S.3
  • 16
    • 0026605802 scopus 로고
    • A polymorphic (CA)n repeat element maps the human glucokinase gene (GCK) to chromosome 7p
    • Matsutani A, Janssen R, Donis-Keller H, et al. A polymorphic (CA)n repeat element maps the human glucokinase gene (GCK) to chromosome 7p. Genomics 1992; 12:319-25.
    • (1992) Genomics , vol.12 , pp. 319-325
    • Matsutani, A.1    Janssen, R.2    Donis-Keller, H.3
  • 17
    • 0024575138 scopus 로고
    • The amino acid sequence of rat liver glucokinase deduced from cloned cDNA
    • Andreone TL, Printz RL, Pilkis SJ, et al. The amino acid sequence of rat liver glucokinase deduced from cloned cDNA. J Biol Chem 1989; 264:363-9.
    • (1989) J Biol Chem , vol.264 , pp. 363-369
    • Andreone, T.L.1    Printz, R.L.2    Pilkis, S.J.3
  • 18
    • 0025297993 scopus 로고
    • Glucokinase gene structure. Functional implications of molecular genetic studies
    • Magnuson MA. Glucokinase gene structure. Functional implications of molecular genetic studies. Diabetes 1990; 39: 523-7.
    • (1990) Diabetes , vol.39 , pp. 523-527
    • Magnuson, M.A.1
  • 19
    • 0034853485 scopus 로고    scopus 로고
    • Clinical review 135: The importance of beta-cell failure in the development and progression of type 2 diabetes
    • Kahn SE. Clinical review 135: The importance of beta-cell failure in the development and progression of type 2 diabetes. J Clin Endocrinol Metab 2001; 86:4047-58.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4047-4058
    • Kahn, S.E.1
  • 20
    • 0025242034 scopus 로고
    • Underexpression of beta cell high Km glucose transporters in noninsulin-dependent diabetes
    • Johnson JH, Ogawa A, Chen L, et al. Underexpression of beta cell high Km glucose transporters in noninsulin-dependent diabetes. Science 1990; 250:546-9.
    • (1990) Science , vol.250 , pp. 546-549
    • Johnson, J.H.1    Ogawa, A.2    Chen, L.3
  • 22
    • 0034604731 scopus 로고    scopus 로고
    • Transgenic reexpression of GLUT1 or GLUT2 in pancreatic beta cells rescues GLUT2-null mice from early death and restores normal glucose-stimulated insulin secretion
    • Thorens B, Guillam MT, Beermann F, et al. Transgenic reexpression of GLUT1 or GLUT2 in pancreatic beta cells rescues GLUT2-null mice from early death and restores normal glucose-stimulated insulin secretion. J Biol Chem 2000; 275:23751-8.
    • (2000) J Biol Chem , vol.275 , pp. 23751-23758
    • Thorens, B.1    Guillam, M.T.2    Beermann, F.3
  • 23
    • 0032898369 scopus 로고    scopus 로고
    • Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase
    • Postic C, Shiota M, Niswender KD, et al. Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem 1999; 274:305-15.
    • (1999) J Biol Chem , vol.274 , pp. 305-315
    • Postic, C.1    Shiota, M.2    Niswender, K.D.3
  • 24
    • 0024372988 scopus 로고
    • Regulation of the expression of the L-type pyruvate kinase gene in adult rat hepatocytes in primary culture
    • Decaux JF, Antoine B and Kahn A. Regulation of the expression of the L-type pyruvate kinase gene in adult rat hepatocytes in primary culture. J Biol Chem 1989; 264:11584-90.
    • (1989) J Biol Chem , vol.264 , pp. 11584-11590
    • Decaux, J.F.1    Antoine, B.2    Kahn, A.3
  • 25
    • 0026582071 scopus 로고
    • Cell-specific carbohydrate metabolism regulates S14 gene transcription
    • Goto Y and Mariash CN. Cell-specific carbohydrate metabolism regulates S14 gene transcription. Diabetes 1992; 41:339-46.
    • (1992) Diabetes , vol.41 , pp. 339-346
    • Goto, Y.1    Mariash, C.N.2
  • 26
    • 0029044495 scopus 로고
    • Induction of fatty-acid-synthase gene expression by glucose in primary culture of rat hepatocytes. Dependency upon glucokinase activity
    • Prip-Buus C, Perdereau D, Foufelle F, et al. Induction of fatty-acid-synthase gene expression by glucose in primary culture of rat hepatocytes. Dependency upon glucokinase activity. Eur J Biochem 1995; 230:309-15.
    • (1995) Eur J Biochem , vol.230 , pp. 309-315
    • Prip-Buus, C.1    Perdereau, D.2    Foufelle, F.3
  • 27
    • 0030877118 scopus 로고    scopus 로고
    • Mechanisms by which carbohydrates regulate expression of genes for glycolytic and lipogenic enzymes
    • Girard J, Ferre P and Foufelle F. Mechanisms by which carbohydrates regulate expression of genes for glycolytic and lipogenic enzymes. Annu Rev Nutr 1997; 17:325-52.
    • (1997) Annu Rev Nutr , vol.17 , pp. 325-352
    • Girard, J.1    Ferre, P.2    Foufelle, F.3
  • 28
    • 0029797027 scopus 로고    scopus 로고
    • Evidence from transgenic mice that glucokinase is rate limiting for glucose utilization in the liver
    • Ferre T, Riu E, Bosch F, el al. Evidence from transgenic mice that glucokinase is rate limiting for glucose utilization in the liver. Faseb J 1996; 10:1213-8.
    • (1996) Faseb J , vol.10 , pp. 1213-1218
    • Ferre, T.1    Riu, E.2    Bosch, F.3
  • 29
    • 0031022573 scopus 로고    scopus 로고
    • Expression of human hepatic glucokinase in transgenic mice liver results in decreased glucose levels and reduced body weight
    • Hariharan N, Farrelly D, Hagan D, et al. Expression of human hepatic glucokinase in transgenic mice liver results in decreased glucose levels and reduced body weight. Diabetes 1997; 46:11-6.
    • (1997) Diabetes , vol.46 , pp. 11-16
    • Hariharan, N.1    Farrelly, D.2    Hagan, D.3
  • 30
    • 0030884675 scopus 로고    scopus 로고
    • Effects of increased glucokinase gene copy number on glucose homeostasis and hepatic glucose metabolism
    • Niswender KD, Shiota M, Postic C, et al. Effects of increased glucokinase gene copy number on glucose homeostasis and hepatic glucose metabolism. J Biol Chem 1997; 272:22570-5.
    • (1997) J Biol Chem , vol.272 , pp. 22570-22575
    • Niswender, K.D.1    Shiota, M.2    Postic, C.3
  • 31
    • 0038831257 scopus 로고    scopus 로고
    • Liver hyperplasia and paradoxical regulation of glycogen metabolism and glucose-sensitive gene expression in GLUT2-null hepatocytes. Further evidence for the existence of a membrane-based glucose release pathway
    • Burcelin R, del Carmen Munoz M, Guillam MT, et al. Liver hyperplasia and paradoxical regulation of glycogen metabolism and glucose-sensitive gene expression in GLUT2-null hepatocytes. Further evidence for the existence of a membrane-based glucose release pathway. J Biol Chem 2000; 275:10930-6.
    • (2000) J Biol Chem , vol.275 , pp. 10930-10936
    • Burcelin, R.1    del Carmen Munoz, M.2    Guillam, M.T.3
  • 32
    • 0034674711 scopus 로고    scopus 로고
    • Identification of transsacting factors responsible for the tissue-specific expression of human glucose transporter type 2 isoform gene. Cooperative role of hepatocyte nuclear factors 1alpha and 3beta
    • Cha JY, Kim H, Kim KS, et al. Identification of transsacting factors responsible for the tissue-specific expression of human glucose transporter type 2 isoform gene. Cooperative role of hepatocyte nuclear factors 1alpha and 3beta. J Biol Chem 2000; 275:18358-65.
    • (2000) J Biol Chem , vol.275 , pp. 18358-18365
    • Cha, J.Y.1    Kim, H.2    Kim, K.S.3
  • 33
    • 0030695445 scopus 로고    scopus 로고
    • The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism
    • Stoffel M and Duncan SA. The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism. Proc Natl Acad Sci USA 1997; 94:13209-14.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 13209-13214
    • Stoffel, M.1    Duncan, S.A.2
  • 34
    • 0032533174 scopus 로고    scopus 로고
    • CCAAT/enhancer binding protein regulates the promoter activity of the rat GLUT2 glucose transporter gene in liver cells
    • Kim JW and Ahn YH. CCAAT/enhancer binding protein regulates the promoter activity of the rat GLUT2 glucose transporter gene in liver cells. Biochem J 1998; 336 (Pt 1):83-90.
    • (1998) Biochem J , vol.336 , Issue.PART 1 , pp. 83-90
    • Kim, J.W.1    Ahn, Y.H.2
  • 35
    • 18744385555 scopus 로고    scopus 로고
    • Identification and characterization of peroxisome proliferator response element in the mouse GLUT2 promoter
    • Im SS, Kim JW, Kim TH, et al. Identification and characterization of peroxisome proliferator response element in the mouse GLUT2 promoter. Exp Mol Med 2005; 37:101-10.
    • (2005) Exp Mol Med , vol.37 , pp. 101-110
    • Im, S.S.1    Kim, J.W.2    Kim, T.H.3
  • 36
    • 0033864402 scopus 로고    scopus 로고
    • Identification and functional characterization of the peroxisomal proliferator response element in rat GLUT2 promoter
    • Kim HI, Kim JW, Kim SH, et al. Identification and functional characterization of the peroxisomal proliferator response element in rat GLUT2 promoter. Diabetes 2000; 49:1517-24.
    • (2000) Diabetes , vol.49 , pp. 1517-1524
    • Kim, H.I.1    Kim, J.W.2    Kim, S.H.3
  • 37
    • 0034796418 scopus 로고    scopus 로고
    • Hepatic over-expression of peroxisome proliferator activated receptor gamma2 in the ob/ob mouse model of non-insulin dependent diabetes mellitus
    • Rahimian R, Masih-Khan E, Lo M, et al. Hepatic over-expression of peroxisome proliferator activated receptor gamma2 in the ob/ob mouse model of non-insulin dependent diabetes mellitus. Mol Cell Biochem 2001; 224:29-37.
    • (2001) Mol Cell Biochem , vol.224 , pp. 29-37
    • Rahimian, R.1    Masih-Khan, E.2    Lo, M.3
  • 38
    • 0027384997 scopus 로고
    • IPF1, a homeodomain-containing transactivator of the insulin gene
    • Ohlsson H, Karlsson K and Edlund T. IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J 1993; 12: 4251-9.
    • (1993) EMBO J , vol.12 , pp. 4251-4259
    • Ohlsson, H.1    Karlsson, K.2    Edlund, T.3
  • 39
    • 0030457705 scopus 로고    scopus 로고
    • Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor
    • Waeber G, Thompson N, Nicod P, et al. Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor. Mol Endocrinol 1996; 10:1327-34.
    • (1996) Mol Endocrinol , vol.10 , pp. 1327-1334
    • Waeber, G.1    Thompson, N.2    Nicod, P.3
  • 40
    • 0037066694 scopus 로고    scopus 로고
    • Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding
    • Chakrabarti SK, James JC and Mirmira RG. Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding. J Biol Chem 2002; 277:13286-93.
    • (2002) J Biol Chem , vol.277 , pp. 13286-13293
    • Chakrabarti, S.K.1    James, J.C.2    Mirmira, R.G.3
  • 41
    • 0035048253 scopus 로고    scopus 로고
    • Hepatic nuclear factor 1-alpha directs nucleosomal hyperacetylation to its tissue-specific transcriptional targets
    • Parrizas M, Maestro MA, Boj SF, et al. Hepatic nuclear factor 1-alpha directs nucleosomal hyperacetylation to its tissue-specific transcriptional targets. Mol Cell Biol 2001; 21:3234-43.
    • (2001) Mol Cell Biol , vol.21 , pp. 3234-3243
    • Parrizas, M.1    Maestro, M.A.2    Boj, S.F.3
  • 42
    • 0036091921 scopus 로고    scopus 로고
    • Overexpression of dominant-negative mutant hepatocyte nuclear fctor-1 alpha in pancreatic beta-cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced beta-cell proliferation, and diabetes
    • Yamagata K, Nammo T, Moriwaki M, et al. Overexpression of dominant-negative mutant hepatocyte nuclear fctor-1 alpha in pancreatic beta-cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced beta-cell proliferation, and diabetes. Diabetes 2002; 51:114-23.
    • (2002) Diabetes , vol.51 , pp. 114-123
    • Yamagata, K.1    Nammo, T.2    Moriwaki, M.3
  • 43
    • 0036323652 scopus 로고    scopus 로고
    • Foxa2 controls Pdx1 gene expression in pancreatic beta-cells in vivo
    • Lee CS, Sund NJ, Vatamaniuk MZ, et al. Foxa2 controls Pdx1 gene expression in pancreatic beta-cells in vivo. Diabetes 2002; 51: 2546-51.
    • (2002) Diabetes , vol.51 , pp. 2546-2551
    • Lee, C.S.1    Sund, N.J.2    Vatamaniuk, M.Z.3
  • 44
    • 0035900778 scopus 로고    scopus 로고
    • Foxa3 (hepatocyte nuclear factor 3gamma) is required for the regulation of hepatic GLUT2 expression and the maintenance of glucose homeostasis during a prolonged fast
    • Shen W, Scearce LM, Brestelli JE, et al. Foxa3 (hepatocyte nuclear factor 3gamma) is required for the regulation of hepatic GLUT2 expression and the maintenance of glucose homeostasis during a prolonged fast. J Biol Chem 2001; 276: 42812-7.
    • (2001) J Biol Chem , vol.276 , pp. 42812-42817
    • Shen, W.1    Scearce, L.M.2    Brestelli, J.E.3
  • 45
    • 0033930942 scopus 로고    scopus 로고
    • Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function
    • Gannon M, Ray MK, Van Zee Y., et al. Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function. Development 2000; 127:2883-95.
    • (2000) Development , vol.127 , pp. 2883-2895
    • Gannon, M.1    Ray, M.K.2    Van Zee, Y.3
  • 46
    • 0031050249 scopus 로고    scopus 로고
    • cAMP prevents the glucose-mediated stimulation of GLUT2 gene transcription in hepatocytes
    • Rencurel F, Waeber G, Bonny C, et al. cAMP prevents the glucose-mediated stimulation of GLUT2 gene transcription in hepatocytes. Biochem J 1997; 322 (Pt 2):441-8.
    • (1997) Biochem J , vol.322 , Issue.PART 2 , pp. 441-448
    • Rencurel, F.1    Waeber, G.2    Bonny, C.3
  • 47
    • 0029911503 scopus 로고    scopus 로고
    • Effect of troglitazone on insulin sensitivity and pancreatic beta-cell function in women at high risk for NIDDM
    • Berkowitz K, Peters R, Kjos SL, et al. Effect of troglitazone on insulin sensitivity and pancreatic beta-cell function in women at high risk for NIDDM. Diabetes 1996; 45:1572-9.
    • (1996) Diabetes , vol.45 , pp. 1572-1579
    • Berkowitz, K.1    Peters, R.2    Kjos, S.L.3
  • 48
    • 0032989265 scopus 로고    scopus 로고
    • A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat
    • Brown KK, Henke BR, Blanchard SG, et al. A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat. Diabetes 1999; 48:1415-24.
    • (1999) Diabetes , vol.48 , pp. 1415-1424
    • Brown, K.K.1    Henke, B.R.2    Blanchard, S.G.3
  • 49
    • 0033613181 scopus 로고    scopus 로고
    • Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats
    • Higa M, Zhou YT, Ravazzola M, et al. Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats. Proc Natl Acad Sci USA 1999; 96:11513-8.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 11513-11518
    • Higa, M.1    Zhou, Y.T.2    Ravazzola, M.3
  • 50
    • 0038187621 scopus 로고    scopus 로고
    • Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
    • Puigserver P, Rhee J, Donovan J, et al. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature 2003; 423:550-5.
    • (2003) Nature , vol.423 , pp. 550-555
    • Puigserver, P.1    Rhee, J.2    Donovan, J.3
  • 51
    • 20044388364 scopus 로고    scopus 로고
    • Glucose-Stimulated Upregulation of GLUT2 Gene Is Mediated by Sterol Response Element-Binding Protein-1c in the Hepatocytes
    • Im SS, Kang SY, Kim SY, et al. Glucose-Stimulated Upregulation of GLUT2 Gene Is Mediated by Sterol Response Element-Binding Protein-1c in the Hepatocytes. Diabetes 2005; 54:1684-91.
    • (2005) Diabetes , vol.54 , pp. 1684-1691
    • Im, S.S.1    Kang, S.Y.2    Kim, S.Y.3
  • 52
    • 0027186590 scopus 로고
    • Evidence for a transient inhibitory effect of insulin on GLUT2 expression in the liver: Studies in vivo and in vitro
    • Postic C, Burcelin R, Rencurel F, et al. Evidence for a transient inhibitory effect of insulin on GLUT2 expression in the liver: studies in vivo and in vitro. Biochem J 1993; 293 (Pt 1):119-24.
    • (1993) Biochem J , vol.293 , Issue.PART 1 , pp. 119-124
    • Postic, C.1    Burcelin, R.2    Rencurel, F.3
  • 53
    • 0028101926 scopus 로고
    • Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut
    • Jetton TL, Liang Y, Pettepher CC, et al. Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut. J Biol Chem 1994; 269:3641-54.
    • (1994) J Biol Chem , vol.269 , pp. 3641-3654
    • Jetton, T.L.1    Liang, Y.2    Pettepher, C.C.3
  • 54
    • 0026687778 scopus 로고
    • Multiple elements in the upstream glucokinase promoter contribute to transcription in insulinoma cells
    • Shelton KD, Franklin AJ, Khoor A, et al. Multiple elements in the upstream glucokinase promoter contribute to transcription in insulinoma cells. Mol Cell Biol 1992; 12:4578-89.
    • (1992) Mol Cell Biol , vol.12 , pp. 4578-4589
    • Shelton, K.D.1    Franklin, A.J.2    Khoor, A.3
  • 55
    • 0029938124 scopus 로고    scopus 로고
    • Characterization of the Pal motifs in the upstream glucokinase promoter: Binding of a cell type-specific protein complex correlates with transcriptional activation
    • Moates JM, Shelton KD and Magnuson MA. Characterization of the Pal motifs in the upstream glucokinase promoter: binding of a cell type-specific protein complex correlates with transcriptional activation. Mol Endocrinol 1996; 10:723-31.
    • (1996) Mol Endocrinol , vol.10 , pp. 723-731
    • Moates, J.M.1    Shelton, K.D.2    Magnuson, M.A.3
  • 56
    • 0028149890 scopus 로고
    • Insulin-promoter-factor 1 is required for pancreas development in mice
    • Jonsson J, Carlsson L, Edlund T, et al. Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 1994; 371:606-9.
    • (1994) Nature , vol.371 , pp. 606-609
    • Jonsson, J.1    Carlsson, L.2    Edlund, T.3
  • 57
    • 0028057602 scopus 로고
    • Positive and negative regulatory elements are involved in transcriptional control of the rat glucokinase gene in the insulin producing cell line HIT M2.2.2
    • Leibiger IB, Walther R, Pett U, et al. Positive and negative regulatory elements are involved in transcriptional control of the rat glucokinase gene in the insulin producing cell line HIT M2.2.2. FEBS Lett 1994; 337:161-6.
    • (1994) FEBS Lett , vol.337 , pp. 161-166
    • Leibiger, I.B.1    Walther, R.2    Pett, U.3
  • 58
    • 0029909387 scopus 로고    scopus 로고
    • The human glucokinase gene beta-cell-type promoter: An essential role of insulin promoter factor 1/PDX-1 in its activation in HIT-T15 cells
    • Watada H, Kajimoto Y, Umayahara Y, et al. The human glucokinase gene beta-cell-type promoter: an essential role of insulin promoter factor 1/ PDX-1 in its activation in HIT-T15 cells. Diabetes 1996; 45:1478-88.
    • (1996) Diabetes , vol.45 , pp. 1478-1488
    • Watada, H.1    Kajimoto, Y.2    Umayahara, Y.3
  • 59
    • 0345073682 scopus 로고    scopus 로고
    • Induction of Mad expression leads to augmentation of insulin gene transcription
    • Patane G, Kaneto H, Toschi E, et al. Induction of Mad expression leads to augmentation of insulin gene transcription. Biochem Biophys Res Commun 2003; 303:1199-208.
    • (2003) Biochem Biophys Res Commun , vol.303 , pp. 1199-1208
    • Patane, G.1    Kaneto, H.2    Toschi, E.3
  • 60
    • 0035907378 scopus 로고    scopus 로고
    • A pancreatic beta - Cell-specific enhancer in the human PDX-1 gene is regulated by hepatocyte nuclear factor 3beta (HNF-3beta), HNF-1alpha, and SPs transcription factors
    • Ben-Shushan E, Marshak S, Shoshkes M, et al. A pancreatic beta - cell-specific enhancer in the human PDX-1 gene is regulated by hepatocyte nuclear factor 3beta (HNF-3beta), HNF-1alpha, and SPs transcription factors. J Biol Chem 2001; 276:17533-40.
    • (2001) J Biol Chem , vol.276 , pp. 17533-17540
    • Ben-Shushan, E.1    Marshak, S.2    Shoshkes, M.3
  • 61
    • 0035512077 scopus 로고    scopus 로고
    • Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism
    • Shih DQ, Screenan S, Munoz KN, et al. Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism. Diabetes 2001; 50: 2472-80.
    • (2001) Diabetes , vol.50 , pp. 2472-2480
    • Shih, D.Q.1    Screenan, S.2    Munoz, K.N.3
  • 62
    • 0037123437 scopus 로고    scopus 로고
    • Foxa2 (HNF3beta) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release
    • Wang H, Gauthier BR, Hagenfeldt-Johansson KA, et al. Foxa2 (HNF3beta) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release. J Biol Chem 2002; 277:17564-70.
    • (2002) J Biol Chem , vol.277 , pp. 17564-17570
    • Wang, H.1    Gauthier, B.R.2    Hagenfeldt-Johansson, K.A.3
  • 63
    • 0032525981 scopus 로고    scopus 로고
    • Beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes
    • Ahlgren U, Jonsson J, Jonsson L, et al. beta-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes. Genes Dev 1998; 12: 1763-8.
    • (1998) Genes Dev , vol.12 , pp. 1763-1768
    • Ahlgren, U.1    Jonsson, J.2    Jonsson, L.3
  • 64
    • 0037315195 scopus 로고    scopus 로고
    • BETA2 activates transcription from the upstream glucokinase gene promoter in islet beta-cells and gut endocrine cells
    • Moates JM, Nanda S, Cissell MA, et al. BETA2 activates transcription from the upstream glucokinase gene promoter in islet beta-cells and gut endocrine cells. Diabetes 2003; 52:403-8.
    • (2003) Diabetes , vol.52 , pp. 403-408
    • Moates, J.M.1    Nanda, S.2    Cissell, M.A.3
  • 65
    • 12144286826 scopus 로고    scopus 로고
    • Orphan Nuclear Receptor Small Heterodimer Partner, a Novel Corepressor for a Basic Helix-Loop-Helix Transcription Factor BETA2/NeuroD
    • Kim JY, Chu K, Kim HJ, et al. Orphan Nuclear Receptor Small Heterodimer Partner, a Novel Corepressor for a Basic Helix-Loop-Helix Transcription Factor BETA2/NeuroD. Mol Endocrinol 2004; 18: 776-90.
    • (2004) Mol Endocrinol , vol.18 , pp. 776-790
    • Kim, J.Y.1    Chu, K.2    Kim, H.J.3
  • 66
    • 0032578484 scopus 로고    scopus 로고
    • Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion
    • Wang MY, Koyama K, Shimabukuro M, et al. Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion. Proc Natl Acad Sci USA 1998; 95:11921-6.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 11921-11926
    • Wang, M.Y.1    Koyama, K.2    Shimabukuro, M.3
  • 67
    • 0036310015 scopus 로고    scopus 로고
    • Peroxisomal proliferator-activated receptor-gamma upregulates glucokinase gene expression in beta-cells
    • Kim HI, Cha JY, Kim SY, et al. Peroxisomal proliferator-activated receptor-gamma upregulates glucokinase gene expression in beta-cells. Diabetes 2002; 51:676-85.
    • (2002) Diabetes , vol.51 , pp. 676-685
    • Kim, H.I.1    Cha, J.Y.2    Kim, S.Y.3
  • 68
    • 0029151863 scopus 로고
    • Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications
    • Unger RH. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes 1995; 44: 863-70.
    • (1995) Diabetes , vol.44 , pp. 863-870
    • Unger, R.H.1
  • 69
    • 0033305606 scopus 로고    scopus 로고
    • Effect of retinoic acid on glucokinase activity and gene expression and on insulin secretion in primary cultures of pancreatic islets
    • Cabrera-Valladares G, German MS, Matschinsky FM, et al. Effect of retinoic acid on glucokinase activity and gene expression and on insulin secretion in primary cultures of pancreatic islets. Endocrinology 1999; 140:3091-6.
    • (1999) Endocrinology , vol.140 , pp. 3091-3096
    • Cabrera-Valladares, G.1    German, M.S.2    Matschinsky, F.M.3
  • 70
    • 2542497646 scopus 로고    scopus 로고
    • Identification of a novel PDX-1 binding site in the human insulin gene enhancer
    • Le Lay J, Matsuoka TA, Henderson E, et al. Identification of a novel PDX-1 binding site in the human insulin gene enhancer. J Biol Chem 2004; 279:22228-35.
    • (2004) J Biol Chem , vol.279 , pp. 22228-22235
    • Le Lay, J.1    Matsuoka, T.A.2    Henderson, E.3
  • 71
    • 0032516081 scopus 로고    scopus 로고
    • ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand
    • Kim JB, Wright HM, Wright M, et al. ADD1/SREBP1 activates PPARgamma through the production of endogenous ligand. Proc Natl Acad Sci USA 1998; 95:4333-7.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 4333-4337
    • Kim, J.B.1    Wright, H.M.2    Wright, M.3
  • 72
    • 0032793068 scopus 로고    scopus 로고
    • Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1 /sterol regulatory element binding protein 1: Implications for adipocyte differentiation and metabolism
    • Fajas L, Schoonjans K, Gelman L, et al. Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism. Mol Cell Biol 1999; 19:5495-503.
    • (1999) Mol Cell Biol , vol.19 , pp. 5495-5503
    • Fajas, L.1    Schoonjans, K.2    Gelman, L.3
  • 73
    • 1642546212 scopus 로고    scopus 로고
    • Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: Modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR)
    • Diraison F, Parton L, Ferre P, et al. Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR). Biochem J 2004; 378:769-78.
    • (2004) Biochem J , vol.378 , pp. 769-778
    • Diraison, F.1    Parton, L.2    Ferre, P.3
  • 74
    • 0035265835 scopus 로고    scopus 로고
    • Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells
    • Leibiger B, Leibiger IB, Moede T, et al. Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells. Mol Cell 2001; 7: 559-70.
    • (2001) Mol Cell , vol.7 , pp. 559-570
    • Leibiger, B.1    Leibiger, I.B.2    Moede, T.3
  • 75
    • 0035265835 scopus 로고    scopus 로고
    • Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells
    • Leibiger B, Leibiger IB, Moede T, et al. Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells. Mol Cell 2001; 7: 559-70.
    • (2001) Mol Cell , vol.7 , pp. 559-570
    • Leibiger, B.1    Leibiger, I.B.2    Moede, T.3
  • 76
    • 0023850224 scopus 로고
    • Stimulation by insulin of glucokinase gene transcription in liver of diabetic rats
    • Iynedjian PB, Gjinovci A and Renold AE. Stimulation by insulin of glucokinase gene transcription in liver of diabetic rats. J Biol Chem 1988; 263:740-4.
    • (1988) J Biol Chem , vol.263 , pp. 740-744
    • Iynedjian, P.B.1    Gjinovci, A.2    Renold, A.E.3
  • 77
    • 0033636523 scopus 로고    scopus 로고
    • Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
    • Michael MD, Kulkarni RN, Postic C, et al. Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell 2000; 6:87-97.
    • (2000) Mol Cell , vol.6 , pp. 87-97
    • Michael, M.D.1    Kulkarni, R.N.2    Postic, C.3
  • 78
    • 0024791538 scopus 로고
    • Transcriptional induction of glucokinase gene by insulin in cultured liver cells and its repression by the glucagon-cAMP system
    • Iynedjian PB, Jotterand D, Nouspikel T, et al. Transcriptional induction of glucokinase gene by insulin in cultured liver cells and its repression by the glucagon-cAMP system. J Biol Chem 1989; 264: 21824-9.
    • (1989) J Biol Chem , vol.264 , pp. 21824-21829
    • Iynedjian, P.B.1    Jotterand, D.2    Nouspikel, T.3
  • 79
    • 0024462439 scopus 로고
    • An alternate promoter in the glucokinase gene is active in the pancreatic beta cell
    • Magnuson MA and Shelton KD. An alternate promoter in the glucokinase gene is active in the pancreatic beta cell. J Biol Chem 1989; 264:15936-42.
    • (1989) J Biol Chem , vol.264 , pp. 15936-15942
    • Magnuson, M.A.1    Shelton, K.D.2
  • 80
    • 0032568557 scopus 로고    scopus 로고
    • Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice
    • Horton JD, Bashmakov Y, Shimomura I, et al. Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice. Proc Natl Acad Sci USA 1998; 95:5987-92.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 5987-5992
    • Horton, J.D.1    Bashmakov, Y.2    Shimomura, I.3
  • 81
    • 0031963963 scopus 로고    scopus 로고
    • Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1
    • Kim JB, Sarraf P, Wright M, et al. Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1. J Clin Invest 1998; 101:1-9.
    • (1998) J Clin Invest , vol.101 , pp. 1-9
    • Kim, J.B.1    Sarraf, P.2    Wright, M.3
  • 82
    • 0032933626 scopus 로고    scopus 로고
    • ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose
    • Foretz M, Pacot C. Dugail I, et al. ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose. Mol Cell Biol 1999; 19:3760-8.
    • (1999) Mol Cell Biol , vol.19 , pp. 3760-3768
    • Foretz, M.1    Pacot, C.2    Dugail, I.3
  • 83
    • 0033598749 scopus 로고    scopus 로고
    • Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes
    • Shimomura I, Bashmakov Y, Ikemoto S, et al. Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes. Proc Natl Acad Sci USA 1999; 96: 13656-61.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 13656-13661
    • Shimomura, I.1    Bashmakov, Y.2    Ikemoto, S.3
  • 84
    • 0035514942 scopus 로고    scopus 로고
    • Adenovirus-mediated overexpression of sterol regulatory element binding protein-1c mimics insulin effects on hepatic gene expression and glucose homeostasis in diabetic mice
    • Becard D, Hainault I, Azzout-Marniche D, et al. Adenovirus-mediated overexpression of sterol regulatory element binding protein-1c mimics insulin effects on hepatic gene expression and glucose homeostasis in diabetic mice. Diabetes 2001; 50:2425-30.
    • (2001) Diabetes , vol.50 , pp. 2425-2430
    • Becard, D.1    Hainault, I.2    Azzout-Marniche, D.3
  • 85
    • 0033607176 scopus 로고    scopus 로고
    • Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes
    • Foretz M, Guichard C, Ferre P, et al. Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes. Proc Natl Acad Sci USA 1999; 96:12737-42.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 12737-12742
    • Foretz, M.1    Guichard, C.2    Ferre, P.3
  • 86
    • 3142677943 scopus 로고    scopus 로고
    • SREBP-1c mediates the insulin-dependent hepatic glucokinase expression
    • Kim SY, Kim HI, Kim TH, et al. SREBP-1c mediates the insulin-dependent hepatic glucokinase expression. J Biol Chem 2004; 279: 30823-9.
    • (2004) J Biol Chem , vol.279 , pp. 30823-30829
    • Kim, S.Y.1    Kim, H.I.2    Kim, T.H.3
  • 87
    • 1642576082 scopus 로고    scopus 로고
    • The transcription factors HIF-1 and HNF-4 and the coactivator p300 are involved in insulin-regulated glucokinase gene expression via the phosphatidylinositol 3-kinase/protein kinase B pathway
    • Roth U, Curth K, Unterman TG, et al. The transcription factors HIF-1 and HNF-4 and the coactivator p300 are involved in insulin-regulated glucokinase gene expression via the phosphatidylinositol 3-kinase/ protein kinase B pathway. J Biol Chem 2004; 279:2623-31.
    • (2004) J Biol Chem , vol.279 , pp. 2623-2631
    • Roth, U.1    Curth, K.2    Unterman, T.G.3
  • 88
    • 0032143525 scopus 로고    scopus 로고
    • Identification of upstream stimulatory factor as transriptional activator of the liver promoter of the glucokinase gene
    • Iynedjian PB. Identification of upstream stimulatory factor as transriptional activator of the liver promoter of the glucokinase gene. Biochem J 1998; 333 (Pt 3): 705-12.
    • (1998) Biochem J , vol.333 , Issue.PART 3 , pp. 705-712
    • Iynedjian, P.B.1
  • 89
    • 0036360938 scopus 로고    scopus 로고
    • Liver glucokinase gene expression is controlled by the onecut transcription factor hepatocyte nuclear factor-6
    • Lannoy VJ, Decaux JF, Pierreux CT, et al. Liver glucokinase gene expression is controlled by the onecut transcription factor hepatocyte nuclear factor-6. Diabetologia 2002; 45:1136-41.
    • (2002) Diabetologia , vol.45 , pp. 1136-1141
    • Lannoy, V.J.1    Decaux, J.F.2    Pierreux, C.T.3
  • 90
    • 0842307302 scopus 로고    scopus 로고
    • Liver glucokinase can be activated by peroxisome proliferator-activated receptor-gamma
    • Kim SY, Kim HI, Park SK, et al. Liver glucokinase can be activated by peroxisome proliferator-activated receptor-gamma. Diabetes 2004; 53 Suppl 1: S66-70.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 1
    • Kim, S.Y.1    Kim, H.I.2    Park, S.K.3
  • 91
    • 0035843966 scopus 로고    scopus 로고
    • Effect of retinoic acid on glucokinase activity and gene expression in neonatal and adult cultured hepatocytes
    • Cabrera-Valladares G, Matschinsky FM, Wang J, et al. Effect of retinoic acid on glucokinase activity and gene expression in neonatal and adult cultured hepatocytes. Life Sci 2001; 68:2813-24.
    • (2001) Life Sci , vol.68 , pp. 2813-2824
    • Cabrera-Valladares, G.1    Matschinsky, F.M.2    Wang, J.3
  • 92
    • 0037965630 scopus 로고    scopus 로고
    • Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue
    • Laffitte BA, Chao LC, Li J, et al. Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue. Proc Natl Acad Sci USA 2003; 100:5419-24.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 5419-5424
    • Laffitte, B.A.1    Chao, L.C.2    Li, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.