BETA2 activates transcription from the upstream glucokinase gene promoter in islet β-cells and gut endocrine cells

Diabetes

Volumn 52, Issue 2, 2003, Pages 403-408

  Moates, J Michael ^a,b,d   Nanda, Sarmistha ^a   Cissell, Michelle A ^c   Tsai, Ming Jet ^a   Stein, Roland ^c  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b DEPARTMENT OF VETERANS AFFAIRS   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOKINASE; HELIX LOOP HELIX PROTEIN; NEUROGENIC DIFFERENTIATION FACTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA PROTEIN COMPLEX; E BOX ELEMENT; ENDOCRINE CELL; ENZYME ACTIVITY; GASTROINTESTINAL TRACT; GENE ACTIVITY; GENETIC TRANSFECTION; IMMUNOPRECIPITATION; KIDNEY CELL; MATURITY ONSET DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REPORTER GENE; SEQUENCE HOMOLOGY; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CLONING, MOLECULAR; CONSERVED SEQUENCE; DNA-BINDING PROTEINS; DUODENUM; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOKINASE; HELIX-LOOP-HELIX MOTIFS; HUMANS; INTESTINAL MUCOSA; ISLETS OF LANGERHANS; KINETICS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; RNA, MESSENGER; TRANS-ACTIVATORS; TRANSFECTION;

EID: 0037315195     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.2.403     Document Type: Article

References (49)

1. Printz RL, Magnuson MA, Granner DK: Mammalian glucokinase. Annu Rev Nutr 13:463-496, 1993
2. Matschinsky FM: Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes. Diabetes 39:647-652, 1990
3. Jetton TL, Liang Y, Pettepher CC, Zimmerman EC, Cox FG, Horvath K, Matchinsky FM, Magnuson MA: Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut. J Biol Chem 269:3641-3654, 1994
4. Maekawa F, Toyoda Y, Torii N, Miwa I, Thompson RC, Foster DL, Tsukahara S, Tsukamura H, Maeda K: Localization of glucokinase-like immunoreactivity in the rat lower brain stem: for possible location of brain glucose-sensing mechanisms. Endocrinology 141:375-384, 2000
5. Roncero I, Alvarez E, Vazquez P, Blazquez E: Functional glucokinase isoforms are expressed in rat brain. J Neurochem 74:1848-1857, 2000
6. Lynch RM, Tompkins LS, Brooks HL, Dunn-Meynell AA, Levin BE: Localization of glucokinase gene expression in the rat brain. Diabetes 49:693-700, 2000
7. Cheung AT, Dayanandan B, Lewis JT, Korbutt GS, Rajotte RV, Bryer-Ash M, Boylan MO, Wolfe MM, Kieffer TJ: Glucose-dependent insulin release from genetically engineered K cells. Science 290:1959-1962, 2000
8. Schuit FC, Huypens P, Heimberg H, Pipeleers DG: Glucose sensing in pancreatic β-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus. Diabetes 50:1-11, 2001
9. Magnuson MA: Glucokinase gene structure: functional implications of molecular genetic studies. Diabetes 39:523-527, 1990
10. Shelton KD, Franklin A, Khoor A, Beechem J, Magnuson MA: Multiple elements in the upstream glucokinase promoter are necessary for transcription in insulinoma cells. Mol Cell Biol 12:4578-4589, 1992
11. Jetton TL, Moates JM, Lindner J, Wright CV, Magnuson MA: Targeted oncogenesis of hormone-negative pancreatic islet progenitor cells. Proc Natl Acad Sci U S A 95:8654-8659, 1998
12. Leibiger IB, Walther R, Pert U, Leibiger B: Positive and negative regulatory elements are involved in transcriptional control of the rat glucokinase gene in the insulin producing cell line HIT M2.2.2. FEBS Lett 337:161-166, 1994
13. Moates JM, Shelton KD, Magnuson MA: Characterization of the Pal motifs in the upstream glucokinase promoter: binding of a cell type-specific protein complex correlates with transcriptional activation. Mol Endocrinol 10:723-731, 1996
14. Leibiger B, Walther R, Leibiger IB: The role of the proximal CTAAT-box of the rat glucokinase upstream promoter in transcriptional control in insulin-producing cells. Biol Chem Hoppe Seyler 375:93-98, 1994
15. Ohlsson H, Karlsson K, Edlund T: IPF-1, a homeodomain-containing transactivator of the insulin gene. EMBO J 12:4251-4259, 1993
16. Waeber G, Thompson N, Nicod P, Bonny C: Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor. Mol Endocrinol 10:1327-1334, 1996
17. Postic C, Niswender KD, Decaux JF, Parsa R, Shelton KD, Gouhot B, Pettepher CC, Granner DK, Girard J, Magnuson MA: Cloning and characterization of the mouse glucokinase gene locus and identification of distal liver-specific DNase I hypersensitive sites. Genomics 29:740-750, 1995
18. Lee JE, Hollenberg SM, Snider L, Turner DL, Lipnick N, Weintraub H: Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helixloop-helix protein. Science 268:836-844, 1995
19. Naya FJ, Huang HP, Qiu Y, Mutoh H, DeMayo FJ, Leiter AB, Tsai MJ: Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev 11:2323-2334, 1997
20. Liu M, Pleasure SJ, Collins AE, Noebels JL, Naya FJ, Tsai MJ, Lowenstein DH: Loss of BETA2/NeuroD leads to malformation of the dentate gyrus and epilepsy. Proc Natl Acad Sci U S A 97: 865-870, 2000 (published erratum appears in Proc Natl Acad Sci U S A 97:5679, 2000)
21. Kim WY, Fritzsch B, Serls A, Bakel LA, Huang EJ, Reichardt LF, Barth DS, Lee JE: NeuroD-null mice are deaf due to a severe loss of the inner ear sensory neurons during development. Development 128:417-426, 2001
22. Huang HP, Liu M, El-Hodiri HM, Chu K, Jamrich M, Tsai MJ: Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3. Mol Cell Biol 20:3292-3307, 2000
23. Naya FJ, Stellrecht CMM, Tsai MJ: Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. Gen and Dev 9:1009-10019, 1995
24. Luo X, Sawadogo M: Functional domains of the transcription factor USF2: atypical nuclear localization signals and context-dependent transcriptional activation domains. Mol Cell Biol 16:1367-1375, 1996
25. Miyazaki J, Arald K, Yamato E, Ikegami H, Asano T, Shibasaki Y, Oka Y, Yamamura K: Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology 127:126-132, 1990
26. Murre C, McCaw PS, Baltimore D: A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell 56:777-783, 1989
27. Shieh SY, Tsai MJ: Cell-specific and ubiquitous factors are responsible for the enhancer activity of the rat insulin II gene. J Biol Chem 266:16708-16714, 1991
28. Whelan J, Cordle SR, Henderson E, Weil PA, Stein R: Identification of a pancreatic beta-cell insulin gene transcription factor that binds to and appears to activate cell-type-specific expression: its possible relationship to other cellular factors that bind to a common insulin gene sequence. Mol Cell Biol 10:1564-1572, 1990
29. German MS, Blaner MA, Nelson C, Moss LG, Rutter WJ: Two related helix-loop-helix proteins participate in separate cell-specific complexes that bind the insulin enhancer. Mol Endocrinol 5:292-299, 1991
30. Therrien M, Drouin J: Cell-specific helix-loop-helix factor required for pituitary expression of the pro-opiomelanorcortin gene. Mol Cell Biol 13:2342-2353, 1993
31. Mutoh H, Fung BP, Naya FJ, Tsai MJ, Nishitani J, Leiter AB: The basic helix-loop-helix transcription factor BETA2/NeuroD is expressed in mammalian enteroendocrine cells and activates secretin gene expression. Proc Natl Acad Sci U S A 94:3560-3564, 1997
32. Orlando V, Strutt H, Paro R: Analysis of chromatin structure by in vivo formaldehyde cross-linking. Methods 11:205-214, 1997
33. Crane-Robinson C, Wolffe AP: Immunological analysis of chromatin: FIS and CHIPS. Trends Genet 14:477-480, 1998
34. Matschinsky FM: Banting Lecture 1995: a lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm. Diabetes 45:223-241, 1996
35. Sawadogo M, Roeder RG: Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box region. Cell 43:165-175, 1985
36. Dumonteil E, Laser B, Constant I, Philippe J: Differential regulation of the glucagon and insulin I gene promoters by the basic helix-loop-helix transcription factors E47 and BETA2. J Biol Chem 273:19945-19954, 1998
37. Mutoh H, Naya FJ, Tsai MJ, Leiter AB: The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretinexpressing enteroendocrine cells. Genes Dev 12:820-830, 1998
38. Poulin G, Turgeon B, Drouin J: NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene. Mol Cell Biol 17:6673-6682, 1997
39. Miyata T, Maeda T, Lee JE: NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus. Genes Dev 13:1647-1652, 1999
40. Watada H, Kajimoto Y, Umayahara Y, Matsuoka T, Kaneto H, Fujitani Y, Kamada T, Kawamori R, Yamasaki Y: The human glucokinase gene β-cell-type promoter: an essential role of insulin promoter factor I/PDX-1 in its activation in HIT-T15 cells. Diabetes 45:1478-1488, 1996
41. Peshavaria M, Gamer L, Henderson E, Teitelman G, Wright CVE, Stein R: XLHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor. Mol Endocrinol 8:806-816, 1994
42. Bretherton-Watt D, Gore N, Boam DS: Insulin upstream factor I and a novel ubiquitous factor bind to the human islet amyloid polypeptide/amylin gene promoter. Biochem J 313:495-502, 1996
43. Carty MD, Liliquist JS, Peshavaria M, Stein R, Soeller WC: Identification of cis- and trans-active factors regulating human islet amyloid polypeptide gene expression in pancreatic beta cells. J Biol Chem 272:11986-11993, 1997
44. Watada H, Kajimoto Y, Kaneto H, Matsuoka T, Fujitani Y, Miyazald J, Yamasaki Y: Involvement of the homeodomain-containing transcription factor PDX-1 in islet amyloid polypeptide gene transcription. Biochem Biophys Res Commun 229:746-751, 1996
45. Qiu Y, Guo M, Huang S, Stein R: Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47. Mol Cell Biol 22:412-420, 2002
46. Froguel P, Vaxillaire M, Sun F, Velho G, Zouali H, Butel MO, Lesage S, Vionnet N, Clement K, Fougerousse F, et al: Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus. Nature 356:162-164, 1992
47. Stoffers DA, Zinkin NT, Stanojevic V, Clarke WL, Habener JF: Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nat Genet 15:106-110, 1997
48. Dutta S, Bonner-Weir S, Montminy M, Wright C: Regulatory factor linked to late-onset diabetes? Nature 392:30-32, 1998
49. Malecki MT, Jhala US, Antonellis A, Fields L, Doria A, Orban T, Saad M, Warrarn JH, Montminy M, Krolewski AS: Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus. Nat Genet 23:323-328, 1999