Overexpression of dominant-negative mutant hepatocyte nuclear factor-1α in pancreatic β-cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced β-cell proliferation, and diabetes

Diabetes

Volumn 51, Issue 1, 2002, Pages 114-123

  Yamagata, Kazuya ^a,c   Nammo, Takao ^c   Moriwaki, Makoto ^b   Ihara, Arisa ^c   Iizuka, Katsumi ^a   Yang, Qin ^b   Satoh, Tomomi ^c   Li, Ming ^a   Uenaka, Rikako ^b   Okita, Kohei ^a   Iwahashi, Hiromi ^b   Zhu, Qian ^b   Cao, Yang ^b   Imagawa, Akihisa ^a   Tochino, Yoshihiro ^a   Hanafusa, Toshiaki ^a   Miyagawa, Jun Ichiro ^a   Matsuzawa, Yuji ^a  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA MEDICAL COLLEGE   (Japan)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; GLUCOSE; GLUCOSE TRANSPORTER 2; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; INSULIN; NUCLEAR FACTOR I; UNCLASSIFIED DRUG; UVOMORULIN;

AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CELL ADHESION; CELL COMMUNICATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOARCHITECTURE; GENE MUTATION; GENE OVEREXPRESSION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HYPERGLYCEMIA; INSULIN RELEASE; MATURITY ONSET DIABETES MELLITUS; MITOSIS INHIBITION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

EID: 0036091921     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.1.114     Document Type: Article

References (33)

1. Maturity-onset diabetes of the young (MODY)
2. Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)
3. Hepatic nuclear factor 1 (HNF1) shows a wider distribution than products of its known target genes in developing mouse
4. Maturity-onset diabetes of the young: Clinical heterogeneity explained by genetic heterogeneity
5. Altered insulin secretory responses to glucose in diabetic and nondiabetic subjects with mutations in the diabetes susceptibility gene MODY 3 on chromosome 12
6. Characterization of the MODY 3 diabetes
7. Defective insulin secretion in hepatocyte nuclear factor 1α-deficient mice
8. Defective pancreatic β-cell glycolytic signaling in hepatocyte nuclear factor-α-deficient mice
9. Mutation P291fsinsC in the transcription factor hepatocyte nuclear factor-1α is dominant negative
10. Identification of a putative cell adhesion domain of uvomorulin
11. Impaired insulin biosynthetic capacity in a rat model for non-insulin-dependent diabetes: Studies with dexamethasone
12. Demonstration of two different processes of β-cell regeneration in a new diabetic mouse model induced by selective perfusion of alloxan
13. Role of Olf-1 and Pax- 6 transcription factors in neurodevelopment
14. Stable overexpression of the glucose-6 phosphatase catalytic subunit attenuates glucose sensitivity of insulin secretion from a mouse pancreatic beta-cell line
15. Overexpression of parathyroid hormone-related protein in the pancreatic islets of transgenic mice causes islet hyperplasia, hyperinsulinemia, and hypoglycemia
16. Sexual dimorphism of pancreatic β-cell degeneration in transgenic mice expressing an insulin-ras hybrid gene
17. Dominant negative suppression of HNF-1α function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic β-cell line
18. Cadherins regulate aggregation of pancreatic β-cells in vivo
19. Expression of neural cell adhesion molecule (N-CAM) in rat islets and its role in islet cell type segregation
20. Morphogenetic roles of classic cadherins
21. 2+ and insulin secretory responses of MIN 6 pseudoislets
22. Rapid and reversible secretion changes during uncoupling of rat insulin-producing cells
23. Mechanisms for the coordination of intercellular calcium signaling in insulin-secreting cells
24. Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome
25. Laron dwarfism and non-insulin dependent diabetes mellitus in the hnf-1α knock out mouse
26. Overexpression of Bcl-XL in beta cells prevents cell death but impairs mitochondrial signal for insulin secretion
27. Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia
28. Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas
29. Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic β cells
30. Regulation in vitro of an L-CAM enhancer by homeobox genes HoxD9 and HNF-1
31. Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2
32. Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release