Studies of genetic variability of the glucose transporter 2 promoter in patients with type 2 diabetes mellitus

Journal of Clinical Endocrinology and Metabolism

Volumn 86, Issue 5, 2001, Pages 2181-2186

  Møller, Ann M ^a   Jensen, Niels M ^a   Pildal, Julie ^a   Drivsholm, Thomas ^b   Borch Johnsen, Knut ^b   Urhammer, Søren A ^a   Hansen, Torben ^a   Pedersen, Oluf ^a  

^a STENO DIABETES CENTER   (Denmark)

^b GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE TRANSPORTER; GLUCOSE TRANSPORTER 2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; DENMARK; FEMALE; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEIC ACID BASE SUBSTITUTION; NUCLEOTIDE SEQUENCE; ORAL GLUCOSE TOLERANCE TEST; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; TATA BOX; TRANSCRIPTION INITIATION;

ADULT; AGED; DENMARK; DIABETES MELLITUS, TYPE 2; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GLUCOSE TOLERANCE TEST; GLUCOSE TRANSPORTER TYPE 2; HUMANS; MALE; MIDDLE AGED; MONOSACCHARIDE TRANSPORT PROTEINS; PROMOTER REGIONS (GENETICS); VARIATION (GENETICS);

EID: 0005978695     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.86.5.2181     Document Type: Article

References (19)

1. Doria A, Plengvidhya N. 2000 Recent advances in the genetics of maturity- onset diabetes of the young and other forms of autosomal dominant diabetes. Curr Opin Endocrinol Diabetes. 7:203-210.
2. Newgard CB, Quaade C, Hughes SD, Milburn JL. 1990 Glucokinase and glucose transporter expression in liver and islets: implications for control of glucose homoeostasis. Biochem Soc Trans. 18:851-853.
3. Matschinsky FM. 1990 Glucokinase as glucose sensor and metabolic signal generator in pancreatic β-cells and hepatocytes. Diabetes. 39:647-652.
4. Shepherd PR, Kahn BB. 1999 Glucose transporters and insulin action: implications for insulin resistance and diabetes mellitus. N Engl J Med. 341:248-257.
5. Guillam MT, Hummler E, Schaerer E, et al. 1997 Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2. Nat Genet. 17:327-330.
6. Valera A, Solanes G, Fernandez-Alvarez J, et al. 1994 Expression of GLUT-2 antisense RNA in β-cells of transgenic mice leads to diabetes. J Biol Chem. 269:28543-28546.
7. Santer R, Schneppenheim R, Dombrowski A, Gotze H, Steinmann B, Schaub J. 1997 Mutations in GLUT2, the gene for the liver-type glucose transporter, in patients with Fanconi-Bickel syndrome. Nat Genet. 17:324-326.
8. Janssen RC, Bogardus C, Takeda J, Knowler WC, Thompson DB. 1994 Linkage analysis of acute insulin secretion with GLUT2 and glucokinase in Pima Indians and the identification of a missense mutation in GLUT2. Diabetes. 43:558-563.
9. Matsubara A, Tanizawa Y, Matsutani A, Kaneko T, Kaku K. 1995 Sequence variations of the pancreatic islet/liver glucose transporter (GLUT2) gene in Japanese subjects with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 80:3131-3135.
10. Tanizawa Y, Riggs AC, Chiu KC, et al. 1994 Variability of the pancreatic islet β cell/liver (GLUT 2) glucose transporter gene in NIDDM patients. Diabetologia. 37:420-427.
11. Mueckler M, Kruse M, Strube M, Riggs AC, Chiu KC, Permutt MA. 1994 A mutation in the Glut2 glucose transporter gene of a diabetic patient abolishes transport activity. J Biol Chem. 269:17765-17767.
12. Hansen T, Andersen CB, Echwald SM, et al. 1997 Identification of a common amino acid polymorphism in the p85α regulatory subunit of phosphatidyl- inositol 3-kinase: effects on glucose disappearance constant, glucose effectiveness, and the insulin sensitivity index. Diabetes. 46:494-501.
13. Jonsson J, Carlsson L, Edlund T, Edlund H. 1994 Insulin-promoter-factor 1 is required for pancreas development in mice. Nature. 371:606-609.
14. Chen WS, Manova K, Weinstein DC, et al. 1994 Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev. 8:2466-2477.
15. Ahlgren U, Jonsson J, Jonsson L, Simu K, Edlund H. 1998 β-cell-specific inactivation of the mouse Ipf1/Pdx1 gene results in loss of the β-cell phenotype and maturity onset diabetes. Genes Dev. 12:1763-1768.
16. Stoffel M, Duncan SA. 1997 The maturity-onset diabetes of the young (MODY1) transcription factor HNF4α regulates expression of genes required for glucose transport and metabolism. Proc Natl Acad Sci USA. 94:13209-13214.
17. Yamagata K, Moriwaki M, Nammo T, et al. 2000 Dominant negative HNF-1α mutant affects the normal development of pancreatic β cells. Diabetes. 49[Suppl 1]:A198.
18. Ban N, Yamada Y, Someya Y, Ihara Y, Tsuda K, Seino Y. 2000 HNF-1α recruits the transcriptional coactivator p300 on the human GLUT2 gene promoter. Diabetes. 49[Suppl 1]:A175.
19. Waeber G, Thompson N, Nicod P, Bonny C. 1996 Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor. Mol Endocrinol. 10:1327-1334.