Neuroactive steroids are altered in schizophrenia and bipolar disorder: Relevance to pathophysiology and therapeutics

Neuropsychopharmacology

Volumn 31, Issue 6, 2006, Pages 1249-1263

  Marx, Christine E ^a,b   Stevens, Robert D ^a   Shampine, Lawrence J ^a,b   Uzunova, Veska ^c   Trost, William T ^a,b   Butterfield, Marian I ^a,b   Massing, Mark W ^b   Hamer, Robert M ^d   Morrow, A Leslie ^d   Lieberman, Jeffrey A ^e  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DURHAM VA MEDICAL CENTER   (United States)

^c NOVARTIS PHARMA AG   (Switzerland)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e College of Physicians and Surgeons ^*  (United States)

Author keywords

Bipolar disorder; DHEA; Neuroactive steroid; Post mortem; Pregnenolone; Schizophrenia

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID RECEPTOR; CARBAMAZEPINE; CLOZAPINE; FLUOXETINE; FLUPHENAZINE; HALOPERIDOL; HYDROCORTISONE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROLEPTIC AGENT; NEUROSTEROID; OLANZAPINE; PRASTERONE; PREGNENOLONE; RISPERIDONE; SEROTONIN UPTAKE INHIBITOR;

ADULT; ARTICLE; BIPOLAR DISORDER; BLOOD SAMPLING; BRAIN FUNCTION; BRAIN TISSUE; CADAVER; CINGULATE GYRUS; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GABAERGIC TRANSMISSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MYELINATION; NEUROPROTECTION; OXIDATIVE STRESS; PARIETAL LOBE; PATHOPHYSIOLOGY; POST HOC ANALYSIS; PRIORITY JOURNAL; SCHIZOPHRENIA;

ANALYSIS OF VARIANCE; BIPOLAR DISORDER; BRAIN; CASE-CONTROL STUDIES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEPRESSION; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; MALE; MODELS, MOLECULAR; POSTMORTEM CHANGES; SCHIZOPHRENIA; SEX FACTORS; STEROIDS;

EID: 33745650483     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1300952     Document Type: Article

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