Dehydroepiandrosterone (DHEA) protects hippocampal cells from oxidative stress-induced damage

Molecular Brain Research

Volumn 66, Issue 1-2, 1999, Pages 35-41

  Bastianetto, Stéphane ^a   Ramassamy, Charles ^a   Poirier, Judes ^a,b   Quirion, Rémi ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Alzheimer's disease; Antioxidant; Free radical; Neuroprotection; Neurosteroid

Indexed keywords

FERROUS SULFATE; HYDROGEN PEROXIDE; NEUROSTEROID; NITROPRUSSIDE SODIUM; PRASTERONE;

ALZHEIMER DISEASE; ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEGENERATIVE DISEASE; FETUS; HIPPOCAMPUS; NEUROLOGIC DISEASE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

ADJUVANTS, IMMUNOLOGIC; AGED; AGING; ALZHEIMER DISEASE; ANIMALS; CELLS, CULTURED; DEHYDROEPIANDROSTERONE; FEMALE; FERRIC COMPOUNDS; HIPPOCAMPUS; HUMANS; HYDROGEN PEROXIDE; LIPID PEROXIDATION; MALE; NEURONS; NEUROPROTECTIVE AGENTS; NEUTRAL RED; NITRIC OXIDE; NITROPRUSSIDE; OXIDANTS; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; SULFHYDRYL REAGENTS; TETRAZOLIUM SALTS;

EID: 0033586349     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(99)00002-9     Document Type: Article

References (35)

1. Akwa Y., Morfin R.F., Robel P., Baulieu E.-E. Neurosteroid metabolism. 7α-Hydroxylation of dehydroepiandrosterone and pregnenolone by rat brain microsomes. Biochem. J. 288:1992;959-964.
2. Akwa Y., Sananès N., Gouézou M., Robel P., Baulieu E.-E., Le Goascogne C. Astrocytes and neurosteroids: metabolism of pregnenolone and dehydroepiandrosterone. Regulation by cell density. J. Cell Biol. 121:1993;135-143.
3. Araghiniknam M., Chung S., Nelson-White T., Eskelson C., Watson R.R. Antioxidant activity of discorea and dehydroepiandrosterone (DHEA) in older humans. Life Sci. 59:1996;PL147-PL157.
4. Araghiniknam M., Zhang Z., Jiang S., Call O., Eskelson C.D., Watson R.R. Cytokine dysregulation and increased oxidation is prevented by dehydroepiandrosterone in mice infected with murine leukemia retrovirus. Proc. Soc. Exp. Biol. Med. 216:1997;386-391.
5. Aragno M., Brignardello E., Tamagno E., Gatto V., Danni O., Boccuzzi G. Dehydroepiandrosterone administration prevents the oxidative damage induced by acute hyperglycemia in rats. J. Endocrinol. 155:1997;233-240.
6. Aragno M., Tamagno E., Boccuzzi G., Brignardello E., Chiarpotto E., Pizzini A., Danni O. Dehydroepiandrosterone pretreatment protects rats against the pro-oxidant and necrogenic effects of carbon tetrachloride. Biochem. Pharmacol. 46:1993;1689-1694.
7. Aubert I., Araujo D.M., Cécyre D., Robitaille Y., Gauthier S., Quirion R. Comparative alterations of nicotinic and muscarinic binding sites in Alzheimer's and Parkinson's diseases. J. Neurochem. 58:1992;529-541.
8. Bastianetto S., Quirion R. Any facts behind the DHEA hype? Trends Pharmacol. Sci. 18:1997;447-449.
9. Baulieu E.-E., Robel P. Dehydroepiandrosterone and dehydroepiandrosterone sulfate as neuroactive neurosteroids. J. Endocrinol. 150:1996;S221-S239.
10. Behl C., Skutella T., Lezoualc'h F., Post A., Widmann M., Newton C.J., Holsboer F. Neuroprotection against oxidative stress by estrogens: structure-activity relationship. Mol. Pharmacol. 51:1997;535-541.
11. Boccuzzi G., Aragno M., Seccia M., Brignardello E., Tamagno E., Albano E., Danni O., Bellomo G. Protective effect of dehydroepiandrosterone against copper-induced lipid peroxidation in the rat. Free Radic. Biol. Med. 22:1997;1289-1294.
12. Compagnone N.A., Mellon S.H. Dehydroepiandrosterone: a potential signalling molecule for neocortical organization during development. Proc. Natl. Acad. Sci. U.S.A. 95:1998;4678-4683.
13. Fautz R., Husein B., Hechenberger C. Application of the neutral red assay (NR assay) to monolayer cultures of primary hepatocytes: rapid colorimetric viability determination for the unscheduled DNA synthesis test (UDS). Mutat. Res. 253:1991;173-179.
14. Halliwell B. Reactive oxygen species and the central nervous system. J. Neurochem. 59:1992;1609-1623.
15. Kasa P., Rakonczay Z., Gulya K. The cholinergic system in Alzheimer's disease. Prog. Neurobiol. 52:1997;511-535.
16. Kimonides V.G., Khatibi N.H., Svendsen C.N., Sofroniew M.V., Herbert J. Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity. Proc. Natl. Acad. Sci. U.S.A. 95:1998;1852-1857.
17. Knapstein P., David A., Wu C.-H., Archer D.F., Flickinger G.L., Touchstone J.C. Metabolism of free and sulfoconjugated DHEA in brain tissue in vivo and in vitro. Steroids. 11:1968;885-896.
18. Lacroix C., Fiet J., Benais J.-P., Gueux B., Bonete R., Villette J.-M., Gourmel B., Dreux C. Simultaneous radioimmunoassay of progesterone, andros-4-enedione, pregnenolone, dehydroepiandrosterone and 17-hydroxyprogesterone in specific regions of human brain. J. Steroid Biochem. 28:1987;317-325.
19. Lee T.C., Lai G.J., Kao S.L., Ho I.-C., Wu C.-W. Protection of rat tracheal epithelial cell line from paraquat toxicity by inhibition of glucose-6-phosphate dehydrogenase. Biochem. Pharmacol. 45:1993;1143-1147.
20. Liu Y., Peterson D.A., Kimura H., Schubert D. Mechanism of cellular 3-(4,5-dimethylthiazol-2-yl)-22,5-diphenyltetrazoliumbromide (MTT) reduction. J. Neurochem. 69:1997;581-593.
21. Longcope C. Dehydroepiandrosterone metabolism. J. Endocrinol. 150:1996;S125-S127.
22. Maiese K., Boniece I., DeMeo D., Wagner J.A. Peptide growth factors protect against ischemia in culture by preventing nitric oxide toxicity. J. Neurosci. 13:1993;3034-3040.
23. Maurice T., Su T.P., Privat A. Sigma (sigma 1) receptor agonists and neurosteroids attenuate B25-35-amyloid peptide-induced amnesia in mice through a common mechanism. Neuroscience. 83:1998;413-428.
24. Meyer J.H., Gruol D.L. Dehydroepiandrosterone sulfate alters synaptic potentials in area CA1 of the hippocampal slices. Brain Res. 633:1994;253-261.
25. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animals tissues by thiobarbituric acid reaction. Anal. Biochem. 95:1979;351-358.
26. Rhodes M.E., Li P.-K., Burke A.M., Johnson D.A. Enhanced plasma DHEAS, brain acetylcholine and memory mediated by steroid sulfatase inhibition. Brain Res. 773:1997;28-32.
27. Roberts E., Bologa L., Flood J.F., Smith G.E. Effects of dehydroepiandrosterone and its sulfate on brain tissue in culture and on memory in mice. Brain Res. 406:1987;357-362.
28. Rom W.N., Harkin T. Dehydroepiandrosterone inhibits the spontaneous release of superoxide radical by alveolar macrophages in vitro in asbestosis. Environ. Res. 55:1991;145-156.
29. Rose K.A., Stapleton G., Dott K., Kieny M.P., Best R., Schwarz M., Russell D.W., Bjorkhem I., Seckl J., Lathe R. Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone. Proc. Natl. Acad. Sci. U.S.A. 94:1997;4925-4930.
30. Sankarapandi S., Zweier J.L., Mukherjee G., Quinn M.T., Huso D.L. Measurement and characterization of superoxide generation in microglial cells: evidence for an NADPH oxidase-dependent pathway. Arch. Biochem. Biophys. 353:1998;312-321.
31. Sims N.R. Energy metabolism, oxidative stress and neuronal degeneration in Alzheimer's disease. Neurodegeneration. 5:1996;435-440.
32. Smith C.D., Carney J.M., Starke-Reed P.E., Olivier C.N., Stadtman E.R., Floyd R.A., Markesbery W.R. Excess brain protein oxidation and enzyme dysfunction in normal aging and Alzheimer disease. Proc. Natl. Acad. Sci. U.S.A. 88:1991;10540-10543.
33. Smith M.A., Perry G., Richey P.L., Sayre L.M., Anderson V.E., Beal M.F., Kowall N. Oxidative damage in Alzheimer's disease. Nature. 382:1996;120-121.
34. Whitcomb J.M., Schwartz A.G. Dehydroepiandrosterone and 16α-Br-epiandrosterone inhibit 12-O-tetradecanolylphorbol-13-acetate stimulation of superoxide radical production by human polymorphonuclear leukocytes. Carcinogenesis. 6:1985;333-335.
35. White E.L., Ross L.J., Schmid S.M., Kelloff G.J., Steele V.E., Hill D.L. Screening of potential cancer preventing chemicals for induction of glutathione in rat liver cells. Oncol. Rep. 5:1998;507-512.