Cortical Bcl-2 protein expression and apoptotic regulation in schizophrenia

Biological Psychiatry

Volumn 48, Issue 7, 2000, Pages 641-650

  Jarskog, L Fredrik ^a   Gilmore, John H ^a   Selinger, Elzbieta S ^a   Lieberman, Jeffrey A ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Bcl 2; Neurodegeneration; Neurodevelopment; Neuroprotection; Schizophrenia

Indexed keywords

NEUROLEPTIC AGENT; PROTEIN BCL 2;

ADULT; AGED; APOPTOSIS; ARTICLE; AUTOPSY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN TISSUE; HYPOTHESIS; MALE; NERVE CELL DIFFERENTIATION; NERVE DEGENERATION; NEUROPATHOLOGY; NEUROPROTECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHIZOPHRENIA; TEMPORAL CORTEX;

ADULT; APOPTOSIS; BIPOLAR DISORDER; BLOTTING, WESTERN; DEPRESSIVE DISORDER, MAJOR; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; MALE; MIDDLE AGED; PROTO-ONCOGENE PROTEINS C-BCL-2; REFERENCE VALUES; SCHIZOPHRENIA; TEMPORAL LOBE;

EID: 0034307192     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(00)00988-4     Document Type: Article

References (59)

1. The Bcl-2 protein family; Arbiters of cell survival
2. Maldistribution of interstitial neurons in prefrontal white matter of the brains of schizophrenic patients
3. Distorted distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase neurons in temporal lobe of schizophrenics implies anomalous cortical development
4. Absence of neurodegeneration and neural injury in the cerebral cortex in a sample of elderly patients with schizophrenia
5. Deficits in small interneurons in prefrontal and cingulate cortices of schizophrenic and schizoaffective patients
6. Common pattern of cortical pathology in childhood-onset and adult-onset schizophrenia as identified by proton magnetic resonance spectroscopic imaging
7. Intellectual deficits in first-episode schizophrenia; Evidence for progressive deterioration
8. Neural apoptosis
9. Apoptosis and schizophrenia; Is the tumour suppressor gene, p53, a candidate susceptibility gene?
10. Proton magnetic resonance spectroscopy in the frontal and temporal lobes of neuroleptic naive patients with schizophrenia
11. Apoptotic features of selective neuronal death in ischemia, epilepsy and gp120 toxicity
12. Bcl-2 promotes regeneration of severed axons in mammalian CNS
13. The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS
14. Reduction in temporal lobe size in siblings with schizophrenia; A magnetic resonance imaging study
15. Severity of symptoms in chronically institutionalized geriatric schizophrenic patients
16. Ventricular enlargement in poor-outcome schizophrenia
17. Schizophrenia as a chronic active brain process; A study of progressive brain structural change subsequent to the onset of schizophrenia
18. In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobes
19. Subgenual prefrontal cortex abnormalities in mood disorders
20. Obstetric complications and schizophrenia; A meta-analysis
21. Exposure to infection and brain development; Cytokines in the pathogenesis of schizophrenia
22. Mitochondria and apoptosis
23. A follow-up magnetic resonance imaging study of schizophrenia; Relationship of neuroanatomical changes to clinical and neurobehavioral measures
24. The neuropathology of schizophrenia; A critical review of the data and their interpretation
25. Developmental expression of Bcl-2 protein in human cortex
26. Alteration of proteins regulating apoptosis, Bcl-2, Bcl-x, Bax, Bak, Bad, ICH-1 and CPP32, in Alzheimer's disease
27. Heterogeneity of the psychoses; Is there a neurodegenerative psychosis?
28. Brain abnormality in schizophrenia. A systematic and quantitative review of volumetric magnetic resonance imaging studies
29. Is schizophrenia a neurodegenerative disorder? A clinical and neurobiological perspective
30. Programmed cell death; Implications for neuropsychiatric disorders
31. Upregulation of the antiapoptotic protein Bcl-2 may be an early event in neurodegeneration; Studies on Parkinson's and incidental Lewy Body disease
32. A selective review of recent North American long-term followup studies of schizophrenia
33. Adult schizophrenia following prenatal exposure to an influenza epidemic
34. Bcl-2 protein is increased in the brain from Parkinsonian patients
35. Aging-associated changes in human brain
36. Cell death during development of the nervous system
37. Pronounced reductions of total neuron number in mediodorsal thalamic nucleus and nucleus accumbens in schizophrenics
38. Total nerve cell number in neocortex in chronic schizophrenics and controls estimated using optical dissectors
39. Alzheimer disease and related neurodegenerative diseases in elderly patients with schizophrenia
40. Neuronal and glial somal size in the prefrontal cortex; A postmortem morphometric study of schizophrenia and Huntington disease
41. Childhood-onset schizophrenia; Progressive ventricular change during adolescence
42. Progressive cortical change during adolescence in childhood onset schizophrenia; A longitudinal MRI study
43. Immunoreactivity for Bcl-2 protein within neurons in the Alzheimer's disease brain increases with disease severity
44. Abnormally high neuronal density in the schizophrenic cortex; A morphometric analysis of prefrontal area 9 and occipital area 17
45. The anatomy of mood disorders-review of structural neuroimaging studies
46. Mechanisms and genes of cellular suicide
47. Temporal lobe pathology in schizophrenia; A quantitative magnetic resonance imaging study
48. Apoptosis in the pathogenesis and treatment of disease
49. The Stanley Foundation brain collection and neuropathology consortium
50. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair
51. Expression of Bcl-2 in adult human brain regions with special reference to neurodegenerative disorders
52. Implications of normal brain development for the pathogenesis of schizophrenia
53. Is schizophrenia a progressive neurodevelopmental disorder? Toward a unitary pathogenetic mechanism
54. Neuroleptics and the natural course of schizophrenia
55. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2
56. Reduced number of mediodorsal and anterior thalamic neurons in schizophrenia
57. Bcl-2 inhibits death of central neural cells induced by multiple agents
58. Cerebral gray matter volume deficits in first episode psychosis
59. Widespread cerebral gray matter volume deficits in schizophrenia