A prospective cohort study of genetic and perinatal influences in the etiology of schizophrenia

Schizophrenia Bulletin

Volumn 26, Issue 2, 2000, Pages 351-366

  Cannon, Tyrone D ^a   Rosso, Isabelle M ^b   Hollister, J Megginson ^c   Bearden, Carrie E ^b   Sanchez, Laura E ^b   Hadley, Trevor ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Age at onset; Fetal hypoxia; Obstetric complications; Schizophrenia

Indexed keywords

ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FETUS HYPOXIA; GENETICS; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROTOXICITY; ONSET AGE; PREGNANCY COMPLICATION; PRIORITY JOURNAL; RISK FACTOR; SCHIZOIDISM; SCHIZOPHRENIA;

EID: 0033931443     PISSN: 05867614     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.schbul.a033458     Document Type: Article

References (86)

1. Adamson, S.J.; Alessandri, L.M.; Badawi, N.; Burton, P.R.; Pemberton, P.J.; and Stanley, F. Predictors of neonatal encephalopathy in full-term infants. British Medical Journal, 311:598-602, 1995.
2. Akbarian, S.; Vinuela, A.; Kim, J.J.; Potkin, S.G.; Bunney, W.E., Jr.; and Jones, E.G. Distorted distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase neurons in temporal lobe of schizophrenics implies anomalous cortical development. Archives of General Psychiatry, 50:178-187, 1993.
3. American Psychiatric Association. DSM-IV: Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: APA, 1994.
4. Arabin, B.; Snyjders, R.; Mohnhaupt, A.; Ragosch, V.; and Nicolaides, K. Evaluation of the fetal assessment score in pregnancies at risk for intrauterine hypoxia. American Journal of Obstetrics and Gynecology, 169:549-554, 1993.
5. Arnold, S.E.; Hyman, B.T.; Van Hoesen, G.W.; and Damasio, A.R. Some cytoarchitectural abnormalities of the entorhinal cortex in schizophrenia. Archives of General Psychiatry, 48:625-632, 1991.
6. Bracha, H.S.; Torrey, E.F.; Gottesman, I.I.; Bigelow, L.B.; and Cunniff, C. Second-trimester markers of fetal size in schizophrenia: A study of monozygotic twins. American Journal of Psychiatry, 149:1355-1361, 1992.
7. Bresnahan, M.A.; Brown, A.S.; Schaefer, C.A.; Begg, M.D.; Wyatt, R.J.; and Susser, E.S. Incidence and cumulative risk of treated schizophrenia in the Prenatal Determinants of Schizophrenia Study. Schizophrenia Bulletin, 26(2):297-308, 2000.
8. Buka, S.L.; Tsuang, M.T.; and Lipsitt, L.P. Pregnancy/delivery complications and psychiatric diagnosis: A prospective study. Archives of General Psychiatry, 50:151-156, 1993.
9. Cannon, T.D. Abnormalities of brain structure and function in schizophrenia: Implications for aetiology and pathophysiology. Annals of Medicine, 28:533-539, 1996.
10. Cannon, T.D. On the nature and mechanisms of obstetric influences in schizophrenia: A review and synthesis. International Review of Psychiatry, 9:387-397, 1997.
11. Cannon, T.D.; Kaprio, J.; Lonnqvist, J.; Huttunen, M.; and Koskenvuo, M. The genetic epidemiology of schizophrenia in a Finnish twin cohort: A population-based modeling study. Archives of General Psychiatry, 55:67-74, 1998a.
12. Cannon, T.D., and Marco, E. Structural brain abnormalities as indicators of vulnerability to schizophrenia. Schizophrenia Bulletin, 20(1):89-102, 1994.
13. Cannon, T.D.; Mednick, S.A.; Parnas, J.; Schulsinger, F.; Praestholm, J.; and Vestergaard, A. Developmental brain abnormalities in the offspring of schizophrenic mothers: I. Contributions of genetic and perinatal factors. Archives of General Psychiatry, 50:551-564, 1993.
14. Cannon, T.D.; van Erp, T.G.; Huttunen, M.; Lonnqvist, J.; Salonen, O.; Valanne, L.; Poutanen, V.P.; Standertskjold-Nordenstam, C.G.; Gur, R.E.; and Yan, M. Regional gray matter, white matter, and cerebrospinal fluid distributions in schizophrenic patients, their siblings, and controls. Archives of General Psychiatry, 55:1084-1091, 1998b.
15. Cannon, T.D.; van Erp, T.G.M.; Huttunen, M.; Lönnqvist, J.; Salonen, O.; Valanne, L.; Poutanen, V.P.; and Ständertskjöld-Nordenstam, C.G. Perinatal hypoxia and regional gray matter, white matter, and cerebrospinal fluid distributions in schizophrenic patients, their siblings, and controls. In review.
16. Cannon, T.D.; Zorrilla, L.E.; Shtasel, D.; Gur, R.E.; Gur, R.C.; Marco, E.J.; Moberg, P.; and Price, R.A. Neuropsychological functioning in siblings discordant for schizophrenia and healthy volunteers. Archives of General Psychiatry, 51:651-661, 1994.
17. Choi, D.W., and Rothman, S.M. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. Annual Review of Neuroscience, 13:171-182, 1990.
18. Csernansky, J.G., and Bardgett, M.E. Limbic-cortical neuronal damage and the pathophysiology of schizophrenia. Schizophrenia Bulletin, 24(2):231-248, 1998.
19. Dalman, C.; Allebeck, P.; Cullberg, J.; Grunewald, C.; and Koster, M. Obstetric complications and the risk of schizophrenia: A longitudinal study of a national birth cohort. Archives of General Psychiatry, 56:234-240, 1999.
20. DeLisi, L.E.; Goldin, L.R.; Maxwell, M.E.; Kazuba, D.M.; and Gershon, E.S. Clinical features of illness in siblings with schizophrenia or schizoaffective disorder. Archives of General Psychiatry, 44:891-896, 1987.
21. Done, D.J.; Johnstone, E.C.; Frith, C.D.; Golding, J.; Shepherd, P.M.; and Crow, T.J. Complications of pregnancy and delivery in relation to psychosis in adult life: Data from the British perinatal mortality survey sample. British Medical Journal, 302:1576-1580, 1991.
22. Eagles, J.M.; Gibson, I.; Bremner, M.H.; Clunie, F.; Ebmeier, K.P.; and Smith, N.C. Obstetric complications in DSM-III schizophrenics and their siblings. Lancet, 335:1139-1141, 1990.
23. Falkai, P., and Bogerts, B. Cell loss in the hippocampus of schizophrenics. European Archives of Psychiatry and Neurological Sciences, 236:154-161, 1986.
24. Feinberg, I. Schizophrenia: Caused by a fault in programmed synaptic elimination during adolescence? Journal of Psychiatric Research, 17:319-334, 1982.
25. Fischer, M. Genetic and environmental factors in schizophrenia: A study of schizophrenic twins and their families. Acta Psychiatrica Scandinavica Supplementum, 238:9-142, 1973.
26. Fish, B.; Marcus, J.; Hans, S.L.; Auerbach, J.G.; and Perdue, S. Infants at risk for schizophrenia: Sequelae of a genetic neurointegrative defect: A review and replication analysis of pandysmaturation in the Jerusalem Infant Development Study. Archives of General Psychiatry, 49:221-235, 1992.
27. Foerster, A.; Lewis, S.W.; Owen, M.J.; and Murray, R.M. Low birth weight and a family history of schizophrenia predict poor premorbid functioning in psychosis. Schizophrenia Research, 5:13-20, 1991.
28. Garey, L.J.; Ong, W.Y.; Patel, T.S.; Kanani, M.; Davis, A.; Hornstein, C.; and Bauer, M. Reduction in dendritic spine number on cortical pyramidal neurons in schizophrenia. [Abstract]. Society for Neuroscience Abstracts, 21:237, 1995.
29. Glantz, L.A., and Lewis, D.A. Assessment of spine density on layer III pyramidal cells in the prefrontal cortex of schizophrenic subjects. [Abstract]. Society for Neuroscience Abstracts, 21:239, 1995.
30. Glantz, L.A., and Lewis, D.A. Reduction of synaptophysin immunoreactivity in the prefrontal cortex of subjects with schizophrenia: Regional and diagnostic specificity. Archives of General Psychiatry, 54:943-952, 1997.
31. Gottesman, I.I., and Bertelsen, A. Confirming unexpressed genotypes for schizophrenia: Risks in the offspring of Fischer's Danish identical and fraternal discordant twins. Archives of General Psychiatry, 46:867-872, 1989.
32. Grace, A.A. Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: A hypothesis for the etiology of schizophrenia. Neuroscience, 41:1-24, 1991.
33. Gunther-Genta, F.; Bovet, P.; and Hohlfeld, P. Obstetric complications and schizophrenia: A case-control study. British Journal of Psychiatry, 164:165-170, 1994.
34. Hambrecht, M.; Maurer, K.; and Hafner, H. Evidence for a gender bias in epidemiological studies of schizophrenia. Schizophrenia Research, 8:223-231, 1993.
35. Hanson, D.R.; Gottesman, I.I.; and Heston, L.L. Some possible childhood indicators of adult schizophrenia inferred from children of schizophrenics. British Journal of Psychiatry, 129:142-154, 1976.
36. Heun, R., and Maier, W. The role of obstetric complications in schizophrenia. Journal of Nervous and Mental Disease, 181:220-226, 1993.
37. Hultman, C.M.; Ohman, A.; Cnattingius, S.; Wieselgren, I.M.; and Lindstrom, L.H. Prenatal and neonatal risk factors for schizophrenia. British Journal of Psychiatry, 170:128-133, 1997.
38. Jacobsen, B., and Kinney, D.K. Perinatal complications in adopted and non-adopted schizophrenics and their controls: Preliminary results. Acta Psychiatrica Scandinavica, 285:337-351, 1980.
39. Jakob, H., and Beckmann, H. Prenatal developmental disturbances in the limbic allocortex in schizophrenics. Journal of Neural Transmission, 65:303-326, 1986.
40. Jeste, D.V., and Lohr, J.B. Hippocampal pathologic findings in schizophrenia: A morphometric study. Archives of General Psychiatry, 46:1019-1024, 1989.
41. Jonsson, S.A.; Luts, A.; Guldberg-Kjaer, N.; and Brun, A. Hippocampal pyramidal cell disarray correlates negatively to cell number: Implications for the pathogenesis of schizophrenia. European Archives of Psychiatry and Clinical Neuroscience, 247:120-127, 1997.
42. Kendell, R.E.; Juszczak, E.; and Cole, S.K. Obstetric complications and schizophrenia: A case control study based on standardised obstetric records. British Journal of Psychiatry, 168:556-561, 1996.
43. Keshavan, M.S.; Anderson, S.; and Pettegrew, J.W. Is schizophrenia due to excessive synaptic pruning in the prefrontal cortex? The Feinberg hypothesis revisited. Journal of Psychiatric Research, 28:239-265, 1994.
44. Kinney, D.K.; Levy, D.L.; Yurgelun-Todd, D.A.; Medoff, D.; LaJonchere, C.M.; and Radford-Paregol, M. Season of birth and obstetrical complications in schizophrenics. Journal of Psychiatric Research, 28:499-509, 1994.
45. Kovelman, J.A., and Scheibel, A.B. A neurohistological correlate of schizophrenia. Biological Psychiatry, 19:1601-1621, 1984.
46. Kuchna, I. Quantitative studies of human newborns' hippocampal pyramidal cells after perinatal hypoxia. Folia Neuropathologica, 32:9-16, 1994.
47. Lane, E.A., and Albee, G.W. Comparative birth weights of schizophrenics and their siblings. Journal of Psychology, 64:227-231, 1966.
48. Lewis, S.W., and Murray, R.M. Obstetric complications, neurodevelopmental deviance, and risk of schizophrenia. Journal of Psychiatric Research, 21:413-421, 1987.
49. Low, J.A.; Simpson, L.L.; and Ramsey, D.A. The clinical diagnosis of asphyxia responsible for brain damage in the human fetus. American Journal of Obstetrics and Gynecology, 167:11-15, 1992.
50. Low, J.A.; Simpson, L.L.; Tonni, G.; and Chamberlain, S. Limitations in the clinical prediction of intrapartum fetal asphyxia. American Journal of Obstetrics and Gynecology, 172:801-804, 1995.
51. Maier, R.F.; Gunther, A.; Vogel, M.; Dudenhausen, J.W.; and Obladen, M. Umbilical venous erythropoietin and umbilical arterial pH in relation to morphologic placental abnormalities. Obstetrics and Gynecology, 84:81-87, 1994.
52. Marcus, J.; Auerbach, J.; Wilkinson, L.; and Burack, C.M. Infants at risk for schizophrenia: The Jerusalem Infant Development Study. Archives of General Psychiatry, 38:703-713, 1981.
53. Markow, T.A., and Gottesman, I.I. Fluctuating dermatoglyphic asymmetry in psychotic twins. Psychiatry Research, 29:37-43, 1989.
54. McCreadie, R.G.; Hall, D.J.; Berry, I.J.; Robertson, L.J.; Ewing, J.I.; and Geals, M.F. The Nithsdale Schizophrenia Surveys: X. Obstetric complications, family history and abnormal movements. British Journal of Psychiatry, 160:799-805, 1992.
55. McNeil, T.F. Obstetric factors and perinatal injuries. In: Tsuang, M.T., and Simpson, J.C., eds. Handbook of Schizophrenia: Nosology, Epidemiology and Genetics. Amsterdam, The Netherlands: Elsevier Science Publishers, 1988. pp. 319-343.
56. McNeil, T.F.; Cantor-Graae, E.; and Sjostrom, K. Obstetric complications as antecedents of schizophrenia: Empirical effects of using different obstetric complication scales. Journal of Psychiatric Research, 28:519-530, 1994.
57. Mednick, S.A.; Cannon, T.D.; and Barr, C.E. Obstetric events and adult schizophrenia. In: Mednick, S.A., Cannon, T.D., Barr, C.E., and Lyon, M., eds. Fetal Neural Development and Adult Schizophrenia. New York, NY: Cambridge University Press, 1991. pp. 115-133.
58. Mirdal, G.K.; Mednick, S.A.; Schulsinger, F.; and Fuchs, F. Perinatal complications in children of schizophrenic mothers. Acta Psychiatrica Scandinavica, 50:553-568, 1974.
59. Nelson, M.D.; Saykin, A.J.; Flashman, L.A.; and Riordan, H.J. Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging: A meta-analytic study. Archives of General Psychiatry, 55:433-440, 1998.
60. Nimgaonkar, V.L.; Wessely, S.; and Murray, R.M. Prevalence of familiality, obstetric complications, and structural brain damage in schizophrenic patients. British Journal of Psychiatry, 153:191-197, 1988.
61. Niswader, K.R., and Gordon, M. The collaborative perinatal study of the National Institute of Neurological Diseases and Stroke: The Women and Their Pregnancies. Philadelphia, PA: W.B. Saunders, 1972.
62. O'Callaghan, E.; Gibson, T.; Colohan, H.A.; Buckley, P.; Walshe, D.G.; Larkin, C.; and Waddington, J.L. Risk of schizophrenia in adults born after obstetric complications and their association with early onset of illness: A controlled study. British Medical Journal, 305:1256-1259, 1992.
63. Olney, J.W., and Farber, N.B. Glutamate receptor dysfunction and schizophrenia. Archives of General Psychiatry, 52:998-1007, 1995.
64. Parnas, J.; Schulsinger, F.; Teasdale, T.W.; Schulsinger, H.; Feldman, P.M.; and Mednick, S.A. Perinatal complications and clinical outcome within the schizophrenia spectrum. British Journal of Psychiatry, 140:416-420, 1982.
65. Pollack, M.; Woerner, M.G.; Goodman, W.; and Greenberg, I.M. Childhood development patterns of hospitalized adult schizophrenic and nonschizophrenic patients and their siblings. American Journal of Orthopsychiatry, 36:510-517, 1966.
66. Pollin, W., and Stabenau, J.R. Biological, psychological and historical differences in a series of monozygotic twins discordant for schizophrenia. In: Rosenthal, D., and Kety, S.S., eds. The Transmission of Schizophrenia. London, U.K.: Pergamon Press, 1968. pp. 317-332.
67. Rees, S.; Mallard, C.; Breen, S.; Stringer, M.; Cock, M.; and Harding, R. Fetal brain injury following prolonged hypoxemia and placental insufficiency: A review. Comparative Biochemistry and Physiology, 119:653-660, 1998.
68. Reveley, A.M.; Reveley, M.A.; and Murray, R.M. Cerebral ventricular enlargement in non-genetic schizophrenia: A controlled twin study. British Journal of Psychiatry, 144:89-93, 1984.
69. Rieder, R.O.; Broman, S.H.; and Rosenthal, D. The offspring of schizophrenics: II. Perinatal factors and IQ. Archives of General Psychiatry, 34:789-799, 1977.
70. Rosso, I.M.; Cannon, T.D.; Huttunen, T.; Huttunen, M.O.; Lönnqvist, J.; and Gasperoni, T.L. Obstetric risk factors for early-onset schizophrenia in a Finnish birth cohort. American Journal of Psychiatry, in press.
71. Rothbard, A.B.; Schinnar, A.P.; Hadley, T.R.; and Rovi, J.I. Integration of mental health data on hospital and community services. Administrative Policy in Mental Health, 18:91-99, 1990.
72. Roy, M.A.; Flaum, M.A.; Gupta, S.; Jaramillo, L.; and Andreasen, N.C. Epidemiological and clinical correlates of familial and sporadic schizophrenia. Acta Psychiatrica Scandinavica, 89:324-328, 1994.
73. Rutt, C.N., and Offord, D.R. Prenatal and perinatal complications in childhood schizophrenics and their siblings. Journal of Nervous and Mental Disease, 152:324-331, 1971.
74. Sacker, A.; Done, D.J.; Crow, T.J.; and Golding, J. Antecedents of schizophrenia and affective illness: Obstetric complications. British Journal of Psychiatry, 166:734-741, 1995.
75. Salafia, C.M.; Minior, V.K.; Lopez-Zeno, J.A.; Whittington, S.S.; Pezzullo, J.C.; and Vintzileos, A.M. Relationship between placental histologic features and umbilical cord blood gases in preterm gestations. American Journal of Obstetrics and Gynecology, 173:1058-1064, 1995.
76. Selemon, L.D.; Rajkowska, G.; and Goldman-Rakic, P.S. Abnormally high neuronal density in the schizophrenic cortex: A morphometric analysis of prefrontal area 9 and occipital area 17. Archives of General Psychiatry, 52:805-818, 1995.
77. Selemon, L.D.; Rajkowska, G.; and Goldman-Rakic, P.S. Elevated neuronal density in prefrontal area 46 in brains from schizophrenic patients: Application of a three-dimensional, stereologic counting method. Journal of Comparative Neurology, 392:402-412, 1998.
78. Stokes, M.E.; Davis, C.S.; and Koch, G.G. Categorical Data Analysis Using the SAS System. Cary, NC: SAS Institute, 1995.
79. Suddath, R.L.; Casanova, M.F.; Goldberg, T.E.; Daniel, D.G.; Kelsoe, J.R., Jr.; and Weinberger, D.R. Temporal lobe pathology in schizophrenia: A quantitative magnetic resonance imaging study. American Journal of Psychiatry, 146:464-472, 1989.
80. Torrey, E.F.; Hersh, S.P.; and McCabe, K.D. Early childhood psychosis and bleeding during pregnancy: A prospective study of gravid women and their offspring. Journal of Autism and Childhood Schizophrenia, 5:287-297, 1975.
81. Torrey, E.F.; Taylor, E.H.; Bracha, H.S.; Bowler, A.E.; McNeil, T.F.; Rawlings, R.R.; Quinn, P.O.; Bigelow, L.B.; Rickler, K.; Sjostrom, K.; Higgins, E.S.; and Gottesman, I.I. Prenatal origin of schizophrenia in a subgroup of discordant monozygotic twins. Schizophrenia Bulletin, 20(3):423-432, 1994.
82. Verdoux, H.; Geddes, J.R.; Takei, N.; Lawrie, S.M.; Bovet, P.; Eagles, J.M.; Heun, R.; McCreadie, R.G.; McNeil, T.F.; O'Callaghan, E.; Stöber, G.; Willinger, M.U.; Wright, P.; and Murray, R.M. Obstetric complications and age at onset in schizophrenia: An international collaborative meta-analysis of individual patient data. American Journal of Psychiatry, 154:1220-1227, 1997.
83. Volpe, J.J. Hypoxic-ischemic encephalopathy: Neuropathology and pathogenesis. Neurology of the Newborn. 3rd ed. Philadelphia, PA: W.B. Saunders, 1995.
84. Woerner, M.G.; Pollack, M.; and Klein, D.F. Birth weight and length in schizophrenics personality disorders and their siblings. British Journal of Psychiatry, 118:461-464, 1971.
85. Woerner, M.G.; Pollack, M.; and Klein, D.F. Pregnancy and birth complications in psychiatric patients: A comparison of schizophrenic and personality disorder patients with their siblings. Acta Psychiatrica Scandinavica, 49:712-721, 1973.
86. Yue, X.; Mehmet, H.; Penrice, J.; Cooper, C.; Cady, E.; Wyatt, J.S.; Reynolds, E.O.; Edwards, A.D.; and Squier, M.V. Apoptosis and necrosis in the newborn piglet brain following transient cerebral hypoxia-ischaemia. Neuropathology and Applied Neurobiology, 23:16-25, 1997.